Romy De Laat-Kremers, PhD^1*, Shengshi Huang^2,3*, Hugo Ten Cate, MD^4,5, Marisa Ninivaggi^2*, Bas De Laat^2,6 and Katrien M.J. Devreese, PhD, MD^7,8*

¹Department of Data Analysis and Artificial Intelligence, Synapse Research Institute, Washington, MD
²Department of Functional Coagulation, Synapse Research Institute, Maastricht, Netherlands
³Department of Biochemistry, Maastricht University, Maastricht, Netherlands
⁴Departments of Internal medicine and Biochemistry, Maastricht University Medical Center, Maastricht, Netherlands
⁵Cardiovascular Research Institute Maastricht (CARIM) and department of Internal medicine, Maastricht University Medical Center, Maastricht, Netherlands
⁶Department of Data Analysis and Artificial Intelligence, Synapse Research Institute, Maastricht, Netherlands
⁷Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
⁸Coagulation Laboratory, Ghent University Hospital, Ghent, Belgium

Bryan Bouwens, MSc^1*, Elke Magdeleyns^1*, Stijn Agten^1*, Stella Thomassen^1*, Dennis Suylen^1*, Tilman M. Hackeng, PhD¹ and Rory R. Koenen^2*

¹Cardiovascular Research Institute Maastricht (CARIM), Dpt. of Biochemistry, Maastricht university(UM), Maastricht University Medical center (MUMC+), Maastricht, Netherlands
²CARIM - Biochemistry, Maastricht University, Maastricht, Netherlands

Sarah E Sartain, MD¹, Paula Jacobi^2*, Virginie Qian^3*, Mrinal Ranjan, MPH^4*, Saleh Bhar, M.D.^5*, Ang Li, MD, MS⁴ and Andrew Yee, PhD.^6*

¹Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX
²Department of Pediatrics, Section of Hematology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
³Southern Illinois University, Carbondale, IL
⁴Baylor College of Medicine, Houston, TX
⁵Department of Pediatrics, Divisions of Hematology, Oncology, and Critical Care Medicine, Cell Therapy and Bone Marrow Transplantation, Baylor College of Medicine/Texas Children's Hospital, Houston, TX
⁶Department of Pediatrics, Baylor College of Medicine, Houston, TX

Sooho S Myoung^1*, Samuel Francis, MD², Jonah Chen^3*, Grace M Lee⁴, Lubica Rauova, MD, PhD^5*, Mortimer Poncz, MD^5*, Douglas B. Cines, MD⁶, Maragatha Kuchibhatla^4*, Sanjay Khandelwal, PhD^7* and Gow Arepally³

¹Medical Scientist Training Program, The Ohio State University, Columbus, OH
²Emergency Medicine, Duke University School of Medicine, Durham, NC
³Division of Hematology, Duke University Medical Center, Durham, NC
⁴Duke University Medical Center, Durham, NC
⁵Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
⁶Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁷Duke University School of Medicine, Durham, NC

Amrita Sarkar, PhD¹, Conroy O Field, MS^2,3, Keith R. McCrae, MD⁴, Thomas L. Ortel, MD, PhD⁵, Gow Arepally, MD⁶, Roxanne Cofiell^7*, Sung-Kwon Kim^7*, Lubica Rauova, MD, PhD^1,8 and Mortimer Poncz, MD^3,8*

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Perelman School of Medicine Pharmacology Graduate Group, University of Pennsylvania, Philadelphia, PA
³Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH
⁵Division of Hematology, Duke University School of Medicine, Durham, NC
⁶Duke University School of Medicine, Durham, NC
⁷Alexion, AstraZeneca Rare Diseases, New Haven, CT
⁸Department of Pediatrics, University of Pennsylvania, Philadelphia, PA

Sarah E. Tashbook^1*, Tomasz W. Kaminski, PharmD^2*, Prithu Sundd, PhD^2,3 and Tomasz Brzoska, PhD^1,4

¹Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
²Thrombosis and Hemostasis Program, VERSITI Blood Research Institute and Blood Center of Wisconsin, Milwaukee, WI
³Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI
⁴Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA

Kim-Anh Nguyen-Peyre^1*, Marie-Sophie Meuleman, MD^2*, Gwellaouen Bodivit^3*, Christian Kassasseya, MD^4,5*, Xavier Decrouy, PhD^6*, Benoit Vingert, PhD^7,8*, Laura Bencheikh, PhD^5*, John Lambris, PhD^9,10*, France Pirenne, MD, PhD^11,12, Lubka T. Roumenina, PhD^13,14* and Pablo Bartolucci, MD, PhD^15,16*

¹INSERM U955 IMRB Team Pirenne, French Blood Establishment, Créteil Mondor, Créteil, FL, France
²INSERM, Centre de Recherche des Cordeliers, Paris France, Paris, FRA
³INSERM U955, IMRB, team Pirenne, French Blood Establishment, Créteil France, CRETEIL, FRA
⁴Henri Mondor Hospital - Emergency Department, Creteil, FRA
⁵INSERM U955, IMRB, team Pirenne, Créteil France, Créteil, France
⁶INSERM U955, IMRB, Imaging platform, Créteil France, Créteil, -- None selected --, France
⁷INSERM-U955, EFS, Institut Mondor, Université Paris-Est Créteil, Team 2 Transfusion et maladies du globule rouge, Laboratoire d´Excellence GR-Ex, Créteil, France
⁸Etablissement Français du Sang, Hôpital Henri Mondor, Creteil, FRA
⁹Department of Pathology & Laboratory Medicine, Philadelphia, PA
¹⁰University of Pennsylvania School, Philadelphia, PA
¹¹Transfusion et maladies du globule rouge - Equipe Pirenne, Institut Mondor de Recherche Biomedicale (IMRB), Creteil, France
¹²Etablissement Francais Du Sang - Université Paris-Est Créteil Hospital, Creteil, France
¹³Sorbonne Université, Paris, France
¹⁴Centre de Recherche des Cordeliers, INSERM, Paris, France
¹⁵Hematology Department, Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
¹⁶Université Paris-Est Créteil, INSERM U955, IMRB, Laboratory of excellence LABEX GRex, Créteil, France

James V Michael, PhD¹, Sanjay Khandelwal, PhD^2*, Antonios Tawk, MD^1*, Sophia Lazar, PhD^1*, Gow Arepally³ and Steven E McKenzie, MD, PhD¹

¹The Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA
²Duke University School of Medicine, Durham, NC
³Division of Hematology, Duke University Medical Center, Durham, NC

Bruna Cardoso Jacintho^1*, Guilherme Leonardi, PhD^2*, Bruna Mazetto^3,4*, José Oliveira, PhD^5*, Fabiola Zakia Monica^2*, Erich Vinicius De Paula, MD, PhD⁶ and Fernanda A. Orsi, MD, PhD^7*

¹School of Medical Sciences, University of Campinas (UNICAMP), Campinas, AC, Brazil
²Department of Translational Medicine (Pharmacology), University of Campinas (UNICAMP),, Campinas, Brazil
³University of Campinas (UNICAMP), Campinas, BRA
⁴Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI
⁵University of Campinas (UNICAMP), Campinas, LA, Brazil
⁶Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
⁷Department of Pathology, School of Medical Sciences, Unicamp, Campinas, Brazil

Amrita Sarkar, PhD¹, Santosh K Yadav, PhD^1*, Conroy O Field, MS^2,3, Kandace Gollomp, MD^3,4*, Keith R. McCrae, MD⁵, Thomas L. Ortel, MD, PhD⁶, Yves Gruel^7*, Jérôme Rollin^7*, Gowthami M Arepally, MD^8*, Lubica Rauova, MD, PhD^3,4*, Douglas B. Cines, MD⁹ and Mortimer Poncz, MD^3,4*

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Perelman School of Medicine Pharmacology Graduate Group, University of Pennsylvania, Philadelphia, PA
³Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Department of Pediatrics, University of Pennsylvania, Philadelphia, PA
⁵Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH
⁶Division of Hematology, Duke University School of Medicine, Durham, NC
⁷Department of Hemostasis, Université de Tours, Tours, France
⁸Division of Hematology, Duke University Medical Center, Durham
⁹Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Jing Yuan Tan, MBBS¹, Wan Hui Wong^1*, May Anne Cheong, MBBS, FRCPath (UK)^1*, Cecilia Cheng Lai Ngan, MBBS, FRCPA^2*, Wenshan Liu^1*, Choo Kheng Tan^1*, Hong Kheng Neo^1*, Lai Heng Lee, MBBS, FRCP(Edin)^1*, Heng Joo Ng, MBBS, FRCPath(UK)^1* and Chuen Wen Tan, MBBCh BAO, FRCPath (UK)^1*

¹Department of Haematology, Singapore General Hospital, Singapore, Singapore
²Department of Microbiology, Singapore General Hospital, Singapore, Singapore

Shruti Chaturvedi, MBBS¹, Yan Wang^2*, Moh-Lim Ong^2*, Arpita Nag^3*, Rui Song^4*, Lynn Huynh, MPH^4*, Jordan A. Burdeau^4*, Mei Sheng Duh^4* and Ramy Magdy Hanna^5*

¹Division of Hematology, Department of Medicine, Johns Hopkins Hospital, BALTIMORE, MD
²Alexion, AstraZeneca Rare Disease, Boston, MA
³Alexion, AstraZeneca Rare Disease, Boston, MA, USA, Boston, MA
⁴Analysis Group, Inc., Boston, MA
⁵University of California, Irvine, CA