Symposia: Scientific Workshop on Understanding and Overcoming Tumor-intrinsic Resistance to CAR-T Therapies for Lymphoid Malignancies
Program: Scientific Workshops
Friday, December 6, 2024: 2:05 PM-2:41 PM
Room 28 A-D
(San Diego Convention Center)
Moderator:
and
Jonathan H. Schatz, MD, University of Miami
Disclosures:
No relevant conflicts of interest to declare.
The malignant genome is comparatively understudied for markers of resistance to CD19-directed CAR-T cells for the treatment of large B-cell lymphomas. Here we review two approaches that have revealed genomic resistance markers on samples from CAR-T treated lymphoma patients. Discussion will compare and contrast sample requirements and discovery power of these and other approaches and the importance of further characterizing findings in functional models.