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Examining the Malignant Genome in CAR-T Patients

Symposia: Scientific Workshop on Understanding and Overcoming Tumor-intrinsic Resistance to CAR-T Therapies for Lymphoid Malignancies Program: Scientific Workshops
Friday, December 6, 2024: 2:05 PM-2:41 PM
Room 28 A-D (San Diego Convention Center)
Moderator:
and Jonathan H. Schatz, MD, University of Miami
Disclosures:
No relevant conflicts of interest to declare.

The malignant genome is comparatively understudied for markers of resistance to CD19-directed CAR-T cells for the treatment of large B-cell lymphomas. Here we review two approaches that have revealed genomic resistance markers on samples from CAR-T treated lymphoma patients. Discussion will compare and contrast sample requirements and discovery power of these and other approaches and the importance of further characterizing findings in functional models.

Jonathan H. Schatz, MD

University of Miami, Miami, FL

Francesco Maura, MD

University of Miami, Coral Gables, FL

Ash A. Alizadeh, MD, PhD

Stanford University, San Mateo, CA