66th ASH Annual Meeting: Germline RUNX1-Mediated Disease

Symposia: Scientific Workshop on Germline Predisposition to Hematopoietic Malignancies and Bone Marrow Failure Scientific Workshops

Room 6CF (San Diego Convention Center)

Moderators:

Abbye McEwen, MD, PhD, The University of Washington and Lea Cunningham, MD, ARRAY(0xf7d413c)

Disclosures:

No relevant conflicts of interest to declare.

This session will focus on how deleterious germline RUNX1 variants lead to abnormal platelets and hematopoietic malignancies (HMs); and how this knowledge can be used to design novel clinical trials that benefit patients.

Moderator Introduction

Abbye McEwen, MD, PhD

The University of Washington, Seattle, WA

Molecular and Phenotypic Analysis of RUNX1-Familial Platelet Disorder-to-Acute Myeloid Leukemia Progression Using a Novel RUNX1-FPD Mouse Model

Hiroki Goto, MD, PhD

Albert Einstein College of Medicine, Bronx, NY

Single Cell Transcriptome Analysis of CD34+ Cells from Patients with RUNX1-Fpdmm at Different Stages of Disease Progression

Erica Bresciani, PhD

NHGRI/NIH, Bethesda, MD

Reclassifying Variants of Uncertain Significance with Transcriptional Profiling

Kivilcim Ozturk, PhD

University of California San Diego, San Diego, CA

The Impact of Inflammatory and Prosurvival Pathways Inhibition in Rescuing Hematopoietic Differentiation Defects in Familial Platelet Disorder

Mona M.Hosseini, PhD, BS

Oregon Health and Science University, Portland, OR

Effects of Somatic BCOR Mutations on Hematopoiesis

Serine Avagyan, MD, PhD

University of California San Francisco, San Francisco, CA

Outcomes of Patients with Germline RUNX1 Hematologic Malignancies Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Analysis

Lea Cunningham, MD

National Institutes of Health, Bethesda, MD

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