66th ASH Annual Meeting: 711. Cell Collection and Manufacturing of HSPCs, CAR-T Cells, and Other Cellular Therapy Products: Poster I

Symposia: Cell Collection and Manufacturing of HSPCs, CAR-T Cells, and Other Cellular Therapy Products Oral and Poster Abstracts
Poster

Research, Sickle Cell Disease, Autoimmune disorders, Clinical trials, Adult, Clinical Practice (Health Services and Quality), Translational Research, Genetic Disorders, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Plasma Cell Disorders, CML, Clinical Research, Health outcomes research, Hemoglobinopathies, Chronic Myeloid Malignancies, Pediatric, Diseases, Immune Disorders, Cell expansion, Gene Therapy, Treatment Considerations, Biological therapies, Immunology, Immunotherapy, Real-world evidence, Clinical procedures, Adverse Events, Lymphoid Malignancies, Metabolism, Young adult , Biological Processes, Myeloid Malignancies, Emerging technologies, Technology and Procedures, Gene editing, Miscellaneous Cellular Therapies, Study Population, Natural Killer (NK) Cell Therapies, Human, Transplantation (Allogeneic and Autologous)

Halls G-H (San Diego Convention Center)

2089

Simplified Cell Therapy Manufacturing with Direct-from-Source T Cell Selection Workflow

Silin Sa, Ph.D.¹^* and Liping Yu, PhD²

¹Applied Cells, Santa Clara, CA
²Applied Cells, Inc., Santa Clara, CA

2090

Safety, Efficacy and Total Cost of Therapy of Decentralized, Point-of-Care Manufactured Anti-CD19 CAR-T Cells for Relapsed or Refractory B Cell Leukemia and Lymphoma: Results from the First Phase 1 Indian Trial (VELCART)

Palani Hamenth Kumar, PhD^*, Arun Kumar Arunachalam, MD^*, Mohammed Yasar, MSc^*, Phaneendra Venkateswara Rao Datari, MD^*, Uday Kulkarni, MD, DM, Sushil Selvarajan, MD, DM^*, Anu Korula, MD, DM, MRCP^*, Aby Abraham, MD, DM^*, Biju George, MD, DM and Vikram Mathews, MD, DM

Department of Haematology, Christian Medical College, Vellore, India

2091

Comparative Analysis of Dexamethasone-Enhanced Pre-Medication in Motixafortide-Induced Hematopoietic Stem Cell Mobilization for Multiple Myeloma: A Retrospective Study

Peter Abdelmessieh, MD¹, Brittany Ballas, PharmD²^*, Michael Styler, MD³, Rashmi Khanal, MD⁴, Forrest Ridgway, PharmD²^*, Michele Sorrentino, PharmD²^*, Henry C. Fung, FRCP, MBBChir⁵ and Asya Varshavsky-Yanovsky⁴^*

¹FOX-CHASE Cancer Center, Glen Mills, PA
²FOX-CHASE, Philadelphia, PA
³Bone Marrow Transplant and Cellular Therapies, Fox Chase Cancer Center, Philadelphia, PA
⁴Fox Chase Cancer Center, Philadelphia, PA
⁵Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA

2092

Eltrombopag Plus G-CSF for Peripheral Blood Stem Cell Mobilization: Interim Analysis of a Single Arm, Phase 2 Trial

Ta-Chuan Yu¹^*, Tai-Chung Huang, MD² and Shang-Ju Wu²^*

¹Department of internal medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
²Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

2093

Comparison of Cryopreserved Versus Non-Cryopreserved Strategies for Autologous Stemcell Transplantation in Multiple Myeloma in Two Centers in Uruguay

Byron Figueroa, MSc¹^*, Martin Ferrando, MD²^*, Sebastian Galeano, MD³, Gabriel Borelli, MD²^*, Eloisa Riva, MD, MEd⁴, Alberto Vásquez, MD²^*, Ana Carolina Oliver, MD⁴, Leticia Martinez, MD²^*, Victoria Irigoin, MD⁴^*, Rosanna De Giuda, MD²^*, Silvia Pierri, MD⁴^*, Claudia Martinez, MD²^*, Melanie Isern, MD⁴^*, Cristina Otero²^*, Romina Urrutia, MD⁴^*, Victoria Remedi²^*, Regis Gai, MD⁴^*, Maria Mori, MD²^*, Virginia Marcalain, MD⁴^*, Estefanía López²^*, Laura Bello, MD⁴^*, Camila Guidali, MD²^*, Lourdes Viano, MD⁴^*, Analia Olivera²^*, Martina Perdomo, BSc⁴^*, Virginia Moraes²^*, Ana Ines Landoni, MD²^* and Pablo Muxi, MD⁴

¹Bone marrow transplant unit, British Hospital, Guatemala, Uruguay
²Bone marrow transplant unit, Hospital Maciel, Montevideo, Uruguay
³Bone marrow transplant unit, British Hospital, Montevideo, Montevideo, Uruguay
⁴Bone marrow transplant unit, British Hospital, Montevideo, Uruguay

2094

Cellular Composition and Clinical Factors Influencing Manufacturing Outcomes for Anti-BCMA CAR T Cell Therapy in a Large Real-World Cohort of Relapsed/Refractory Multiple Myeloma

Vladan Vucinic, MD^*, David Fandrei, MSc^*, Janine Kirchberg^*, Enrica Bach, PhD^*, Mandy Brueckner^*, Kathleen Friedrich^*, Carmen Herling, MD^*, Madlen Jentzsch, MD^*, Georg-Nikolaus Franke, MD^*, Simone Heyn, MD^*, Uwe Platzbecker, MD and Maximilian Merz, MD

Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, Germany

2095

Gelofusine As Alternative to Dextran40 for Washing Cryopreserved Hematopoietic Stem Cell Products Prior to Infusion: Validation and Application to Clinical Practice

Stefania Nappo¹^*, Mario Toriello¹^*, Giovanna Maisto²^*, Francesco Topo¹^*, Lucia Gallo¹^*, Giovanni Castellano¹^*, Roberta Penta de Vera d'aragona¹^*, Emanuela Rossitti, MD, PhD fellow³^*, Alessandra Picardi, MD⁴^*, William G. Wierda⁵ and Francesco Paolo Tambaro, MD, PhD⁶

¹SSD Cryopreservation and B.a.S.C.O., Oncohematology Department, AORN Santobono-Pausilipon, Naples, Italy
²AORN Santobono-Pausilipon, Naples, Italy
³Stem Cell Transplantation and Cell Therapy Unit, AORN Santobono Pausilipon, Naples, Italy
⁴Stem Cell Transplant Program AORN Cardarelli, Naples and Biomedicine and Prevencion Department of Tor Vergata University, Rome, Naples / Rome, Italy
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Stem Cell Transplantation and Cell Therapy Unit, AORN Santobono Pausilipon, Napoli, Italy

2096

Assessing CAR-T Cell Product Quality: The Crucial Role of Metabolic and Persistence Analysis after Antigen Stimulation

Beatriz Guijarro-Albaladejo^*, Belén Sierro^*, Virginia Escamilla Gómez, PhD, MD^*, Paola Hernández-Díaz^*, María de la Rosa-Garrido^*, Inmaculada Carrasco Brocal^*, Jose Antonio Bejarano Garcia^*, Patricia Alcalde Mellado, MD^*, Alfonso Rodriguez Gil, PhD^*, Maribel Lara-Chica, PhD^*, José Antonio Pérez-Simón, PhD, MD and Estefania Garcia-Guerrero, PhD^*

Instituto de Biomedicina de Sevilla (Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Sevilla (US), Hospital Universitario Virgen del Rocío (HUVR))., Sevilla, Spain

2097

RNA-Lnp-Mediated CAR-T Cell Manufacturing: A Paradigm Shift in Precision Immunotherapy

Xiulian Sun¹^*, Sheng Zhao²^* and Wei Wang²^*

¹uBriGene Biosciences Inc., Germantown, MD
²uBriGene Biosciences Inc., Nanjing, China

2098

The Impact of Stem Cell Mobilization Regimen on Outcomes after Autologous Transplant for Multiple Myeloma

Aimee Marie Merino, MD¹^*, Ryan Shanley, MS²^*, Jenna Langer³^*, Faridullah Rashid⁴^*, Emily John³^*, Mark B Juckett, M.D., M.H.C.M.⁵, Jeffrey S Miller, MD⁶ and Daniel Weisdorf, MD⁴

¹Division of Hematology, Oncology and Transplantation, University of Minnesota, Woodbury, MN
²Biostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN
³UMN, MINNEAPOLIS, MN
⁴University of Minnesota, Minneapolis, MN
⁵Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
⁶Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN

2099

Safety and Efficacy of Etoposide Combined with G-CSF for Autologous Peripheral Blood Hematopoietic Stem Cell Mobilization in Newly Diagnosed Multiple Myeloma

Huimei Guo¹^*, Jia Liu¹^*, Hua Xue¹^*, Songying Zhao¹^*, Jing Wang¹^*, Jianmei Xu¹^*, Jiangbo Zhang¹^* and Yao Liu²

¹Affiliated Hospital of Hebei University, Baoding, China
²Chongqing University Cancer Hospital, Chongqing, China

2100

Preclinical Proof of Concept for Decentralized Manufacturing of a MAGE-A4/CD8alpha-Expressing Autologous T-Cell Therapy for Solid Tumors

Melissa Herman, PhD¹^*, Stefania Gobessi, PhD²^*, Laurens Sand, PhD²^*, Karolin Wagner, PhD²^*, Ryan Yuan, PhD²^*, Sterenn Davis, PhD¹^*, Ian Donaldson, PhD¹^*, Megan Butler, BSc¹^*, Natalie Bath, MSc¹^*, Robert Harris, PhD¹^*, Nathaniel Golden, BA³^*, Alex Tipping, PhD¹^*, Joseph Sanderson, PhD¹^*, John Mellors, MD⁴^* and Phillip Debnam, PhD¹^*

¹Adaptimmune, Abingdon, United Kingdom
²Galapagos, Oegstgeest, Netherlands
³Adaptimmune, Cambridge, MA
⁴Galapagos, Pittsburgh, PA

2100.1

Motixafortide for Hematopoietic Stem and Progenitor Cell Mobilization and Collection in Sickle Cell Disease

Alexis Kristine Leonard, MD¹, Akshay Sharma, MBBS², Yogindra Persaud, MD³^*, Parul Rai, MD, MBBS³, Darla Pickett³^*, Renee Massey, MPH³^*, Neha Das Gupta, PhD³^*, Subodh Selukar, PhD⁴^*, Salem M. Akel, PhD⁵^*, Leigh Poston³^*, Yan Zheng, MD, PhD⁶^*, Ella Sorani, PhD⁷^*, Irit Gliko Kabir, PhD⁸^*, Mitchell J Weiss, MD, PhD⁹, Stephen Gottschalk, MD², Julie Kanter, MD¹⁰, Matthew Hsieh, MD¹¹ and John Tisdale, MD¹²

¹Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
²Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN
³St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN
⁵St. Jude Children’s Research Hospital, Memphis, TN
⁶Pathology, St. Jude Children’s Research Hospital, Memphis, TN
⁷BiolineRx, Modi'in, Israel
⁸BioLineRx Ltd., Modiin, Israel
⁹Department of Hematology, St. Jude Childrens Research Hospital, Memphis, TN
¹⁰University of Alabama at Birmingham, Birmingham, AL
¹¹NHLBI, NIH-NHLBI-MCHB, Bethesda, MD
¹²National Institutes of Health, Bethesda, MD

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^*signifies non-member of ASH

711.P1.36 711. Cell Collection and Manufacturing of HSPCs, CAR-T Cells, and Other Cellular Therapy Products: Poster I