Yoshitaka Zaimoku, MD, PhD^1,2, Kazuyoshi Hosomichi, PhD^3*, Noriaki Tsuji, MD, PhD^1*, Mikoto Tanabe, MD, PhD^1*, Noriharu Nakagawa, MD, PhD^1*, Takeshi Yoroidaka, MD, PhD^1*, Hiroki Mizumaki, MD^1*, Tatsuya Imi, MD, PhD^1*, Hiroyuki Maruyama, MD, PhD^1*, Kohei Hosokawa, MD, PhD ¹, Hiroyuki Takamatsu, MD, PhD¹, Hirohito Yamazaki, MD, PhD^1*, Kazuya Sakai, MD, PhD^4*, Ishikazu Mizuno, MD, PhD^5*, Toshihiro Miyamoto, MD, PhD¹ and Shinji Nakao, MD, PhD^1,6

¹Department of Hematology, Kanazawa University, Kanazawa, Japan
²Department of Infection Control and Prevention, Kanazawa University Hospital, Kanazawa, Japan
³Laboratory of Computational Genomics, School of Life Science, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
⁴Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan
⁵Hyogo Cancer Center, Akashi, Japan
⁶Japanese Red Cross Ishikawa Blood Center, Kanazawa, ISH, Japan

Joshua Glass, MD^1,2, Xingmin Feng, PhD^2*, Jichun Chen, PhD² and Neal S. Young, MD²

¹Children's National Hospital, Washington, DC
²Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

Jibran Durrani, MD¹, Xingmin Feng, PhD^2*, Joshua Glass, MD³, Zhijie Wu, MD, PhD^2*, Shouguo Gao, PhD^2*, Bhavisha A. Patel, MD², Jichun Chen, PhD², Neal S. Young, MD² and Emma M. Groarke, MD²

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, BETHESDA, MD
²Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
³Children's National Hospital, Washington, DC

Kohei Hosokawa, MD, PhD ¹, Jong Wook Lee, MD², Jun Ho Jang, MD^3*, Naoshi Obara, MD, PhD^4*, Masashi Sawa^5*, Kensuke Usuki, MD, PhD⁶, Gaku Oshikawa, MD^7*, Masahiro Kizaki, MD⁸, Koji Nagafuji, MD, PhD⁹, Ting-An Lin, MD^10*, Hitoshi Hanamoto, MD^11*, Yeung-Chul Mun, MD, PhD^12*, Toshiro Kawakita, MD, PhD^13*, Kazunori Imada, MD, PhD^14*, June-Won Cheong, MD, PhD¹⁵, Sung-Soo Park, MD, PhD^16*, Takayuki Tabayashi, MD, PhD^8*, Masaru Gamou^17*, Mami Shimizu^18*, Kenta Murotani, MD^19* and Hirohito Yamazaki, MD, PhD^20*

¹Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan
²Division of Hematology-Oncology, Hanyang University Seoul Hospital, Seoul, Korea, Republic of (South)
³Department of Hematology, Sungkyunkwan University Samsung Medical Center, Seoul, Korea, Republic of (South)
⁴Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan
⁵Department of Hematology and Oncology, Anjo Kosei Hospital, Anjyo, Japan
⁶NTT Medical Center Tokyo, Tokyo, Japan
⁷Department of Hematology, Japanese Red Cross Musashino Hospital, Musashino, Japan
⁸Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
⁹Department of Hematology, Kurume University Hospital, Kurume, Japan
¹⁰Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
¹¹Department of Hematology, Kindai University Nara Hospital, Ikoma, Japan
¹²Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea, Republic of (South)
¹³Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
¹⁴Department of Hematology, Japanese Red Cross Osaka Hospital, Osaka, Japan
¹⁵Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, Korea, Republic of (South)
¹⁶Division of Hematology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Korea, Republic of (South)
¹⁷Kyowa Kirin Co., Ltd., Chiyoda-Ku, Tokyo, Japan
¹⁸Kyowa Kirin Co., Ltd., Tokyo, Japan
¹⁹Biostatistics Center, Kurume University, Kurume, Japan
²⁰Division of Medical Safety, Kanazawa University Hospital, Kanazawa, Japan

Rio Takahashi^1*, Yoshitaka Zaimoku, MD, PhD², Kohei Hosokawa, MD, PhD ², Seishi Ogawa, MD, PhD^3,4,5, Yoshiyuki Takahashi⁶, Takako Miyamura⁷, Yasushi Onishi, MD, PhD^8*, Takashi Koike^9*, Tetsuya Nishida^10*, Naoyuki Uchida¹¹, Noriko Doki¹², Masatsugu Tanaka^13*, Tetsuya Eto^14*, Mitsuhiro Itagaki^15*, Masashi Sawa^16*, Yuta Hasegawa^17*, Takahiro Fukuda^18*, Makoto Onizuka¹⁹, Yoshiko Atsuta^20,21*, Shinji Nakao, MD, PhD² and Takamasa Katagiri^22*

¹Department of Clinical Laboratory Science, Kanazawa University, Kanazawa, ISH, Japan
²Department of Hematology, Kanazawa University, Kanazawa, Japan
³Kyoto University, Sakyoku, KYO, Japan
⁴Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
⁵Department of Medicine, Karolinska Institute, Stockholm, Sweden
⁶Department of Pediatrics, Nagoya University, Nagoya, Japan
⁷Department of Pediatrics, Osaka University Hospital, Osaka, Japan
⁸Department of Hematology, Tohoku University Hospital, Sendai, Japan
⁹Department of Pediatrics, Tokai University, Isehara, Japan
¹⁰Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan
¹¹Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations TORANOMON HOSPITAL, Tokyo, Japan
¹²Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
¹³Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
¹⁴Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
¹⁵Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan
¹⁶Department of Hematology and Oncology, Anjo Kosei Hospital, Anjyo, Japan
¹⁷Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
¹⁸Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
¹⁹Department of Hematology/Oncology, Tokai University, Isehara, Japan
²⁰Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University, Nagakute, Japan
²¹The Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan
²²Department of Clinical Laboratory Science, Kanazawa University, Kanazawa, Japan

Naoko Hosono, MD, PhD¹, Ken Ishiyama, MD, PhD², Hiroki Yamaguchi, MD³, Masahide Yamazaki, MD, PhD^4*, Hiroyuki Maruyama, MD, PhD^5*, Kensuke Usuki, MD, PhD⁶, Kazuki Tanimoto, MD, PhD^7*, Hiroyuki Sugiura, MD^8*, Noboru Asada, MD, PhD⁹, Seishi Ogawa, MD, PhD¹⁰, Yuzuru Kanakura, MD, PhD¹¹, Itaru Matsumura, MD¹², Koichi Akashi, MD, PhD^13* and Shinji Nakao, MD, PhD^14,15

¹Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
²Department of Hematology, National Center for Global Health and Medicine, Tokyo, Japan
³Department of Hematology, Nippon Medical School Hospital, Tokyo, Japan
⁴Keiju Medical Center, Nanao, Japan
⁵Kanazawa University Graduate School of Medical Science, Kanazawa-Shi, JPN
⁶NTT Medical Center Tokyo, Tokyo, Japan
⁷Division of Hematology and Oncology, Japanese Red Cross Fukuoka Hospital, Fukuoka, FKO, JPN
⁸Department of Hematology, Chugoku Central Hospital of Japan Mutual Aid Association of Public School Teachers, Fukuyama, Japan
⁹Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
¹⁰Kyoto University, Sakyoku, KYO, Japan
¹¹Department of Hematology, Sumitomo Hospital, Osaka, Japan
¹²Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan
¹³Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
¹⁴Department of Hematology, Kanazawa University, Kanazawa, Japan
¹⁵Japanese Red Cross Ishikawa Blood Center, Kanazawa, Japan

Phillip Scheinberg, MD¹, Diego Villa Cle, MD, MBA, PhD^2*, Berangere Devalet^3*, Valentina Giai, MD, PhD^4*, Cristina Barrenetxea Lekue, PhD^5*, Hsuan-Yu Lin^6*, Zsolt Nagy, MD^7*, Jun-ichi Nishimura, MD, PhD⁸, Jens Panse, MD^9,10, Agnieszka Piekarska^11*, Jörg Schubert, MD^12*, Kazutaka Sunami, MD, PhD¹³, Mustafa Yenerel^14*, Anita Appius, PhD^15*, Brittany Gentile, PhD^16*, Shino Iwase^17*, Himika Patel, PharmD^18*, Sasha Sreckovic, MD^19* and Austin G. Kulasekararaj, MD, MBBS, FRCPath, MRCP^20,21

¹Hospital A Beneficência Portuguesa, Sao Paulo, SP, Brazil
²Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil
³Department of Hematology, Université Catholique de Louvain (UCLouvain), CHU UCL Namur, Yvoir, Belgium
⁴Hematology, AOU Città della Salute e della Scienza di Torino, Turin, Italy
⁵Hospital Universitario de Basurto, Bilbao, Spain
⁶Division of Hematology/Oncology, Department of Internal Medicine,, Changhua Christian Hospital, Changhua, Taiwan
⁷Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary
⁸Osaka University Graduate School of Medicine, Osaka, Japan
⁹Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany
¹⁰Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany
¹¹Department of Hematology and Transplantology, Medical University of Gdansk, Gdansk, Poland
¹²Elblandklinikum Riesa, Riesa, Germany
¹³Department of Hematology, NHO, Okayama Medical Center, Okayama, Japan
¹⁴Istanbul University, Istanbul, Turkey
¹⁵F. Hoffmann-La Roche Ltd, Basel, Switzerland
¹⁶Genentech, Inc., South San Francisco, CA
¹⁷F. Hoffmann-La Roche Ltd, Basel, Switzerland, Basel, Switzerland
¹⁸Genentech, Inc., Simi Valley, CA
¹⁹Genentech, Inc, South San Francisco
²⁰King’s College Hospital-NHS Foundation Trust, NIHR/Wellcome King’s Clinical Research Facility, and King’s College London, London, United Kingdom
²¹King's College London, National Institute for Health and Care Research and Wellcome King’s Research Facility, London, United Kingdom

Eléonore Kaphan, MD^1*, Anouk Walter Petrich, MD^2*, Lise Larcher^3*, Thierry Leblanc^4*, Mony Fahd, MD MSc^5,6*, Benedicte Bruno^7*, Edouard Forcade, MD, PhD^8*, Cecile Renard, MD^9*, Arthur Sterin^10*, Michael Loschi, MD, PhD^11*, Elodie Lainey, PhD, PharmD^12*, Jean Soulier, MD^13,14*, Caroline Kannengiesser^15*, Gerard Socie, MD, PhD^16,17,18, Regis Peffault De Latour^{1,19,20,21,22*}, Jerome Lambert, MD, PhD^23* and Flore Sicre de Fontbrune, MD^24*

¹Hematology / Transplantation, Hospital St Louis, Paris, France
²Biostatistics and Medical Information Department, Saint Louis University Hospital, AP-HP, Université Paris Cité, Paris, France
³Hopital Saint-Louis and University De Paris, Paris, FRA
⁴Service d’Hematologie et d’Immunologie Pédiatrique, Centre de Reference Aplasies Medullaires Acquises et Constitutionnelles, Hôpital Robert-Debré, Assistance Publique Hôpitaux de Paris and Université Paris Cité, Paris, France
⁵Saint-Louis Academic Hospital, GHU Ap-HP Nord Université Paris Cité, French National Reference Center for Severe Aplastic Anemia, Paris, France
⁶Pediatric hematology and immunology department, Robert-Debré Hospital, GHU APHP Nord Université Paris-Cité, Paris, France
⁷Chru Lille, Jeanne De Flandre Hématologie Pédiatrique, Lille, FRA
⁸Service d'Hématologie Clinique et Thérapie Cellulaire, CHU Bordeaux, Hopital Haut-Leveque, Pessac, France
⁹Institute of Hematology and Pediatric Oncology, Lyon, France
¹⁰Department of Pediatric Hematology, Immunology and Oncology, APHM, La Timone Children Hospital, Department of Pediatric Hematology, Immunolog, Marseille, France
¹¹Hematology Department, Nice University Hospital, Nice, France
¹²Robert Debre Hospital, Paris, FRA
¹³Hopital Saint-Louis Centre Hayem 2ETG, Paris, France
¹⁴INSERM U944/CNRS UMR7212, Institut de Recherche Saint-Louis, Paris, France
¹⁵Assistance Publique-hôPitaux De Paris, Bichat, Paris, FRA
¹⁶INSERM UMR 976, Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), Paris, France
¹⁷Hematology / Transplantation, Hematology Transplantation, Paris, France
¹⁸French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Saint Louis Hospital and University Paris Diderot, Paris, France
¹⁹French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Paris, France
²⁰Hematology Branch, NHLBI, NIH, Bethesda, MD
²¹Severe Aplastic Anemia Working Party, European Group for Blood and Marrow Transplantation (EBMT), Leiden, Netherlands
²²Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC), Hôpital Henri Herriot, CHU, Lyon, France
²³Hôpital Saint Louis, Biostatistics and Medical Information Department, Saint Louis University Hospital, AP-HP, Université Paris Cité, Paris, FRA
²⁴Centre de Référence Aplasie Médullaire, Service d’Hématologie Greffe, Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France

Erika Ren, BSc^1*, Katayoun Elizabeth Khalilian, BS^1*, Mutlu Mete^2*, Carmelo Gurnari, MD, PhD^3,4, Jaroslaw Maciejewski⁵, Carlos Bravo-Perez, MD^5,6* and Taha Bat⁷

¹University of Texas Southwestern Medical Center, Dallas, TX
²Department of Information Science, University of North Texas, Denton, TX
³Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁴Cleveland Clinic Foundation, Cleveland, OH
⁵Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁶Centro Regional de Hemodonación, IMIB-Arrixaca, CIBERER, University of Murcia, Murcia, Spain
⁷Department of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX

Lauren T. Reiman, BSc^1*, My H. Vu, MS^2*, Michael Cotez-Bacolot, BS^3*, Brent L. Wood, MD, PhD^4,5 and Alexandra E. Kovach, MD^4,6*

¹Keck School of Medicine, University of Southern California, Los Angeles, CA
²Biostatistics, Children's Hospital Los Angeles, Los Angeles, CA
³Department of Pathology and Laboratory Medicine, Children's Hospital of Los Angeles, Los Angeles
⁴Keck School of Medicine of University of Southern California, Los Angeles, CA
⁵Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
⁶Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA

Elena E. Solomou, MD¹, Alkmini Anastasiadi^2*, Maria Papaioannou^3*, Maria Angelopoulou^4*, Panagiotis Zikos, MD^5*, Ioannis Assimakopoulos^6*, Maria Dimou, MD^7*, Panagiotis Tsaftaridis^8*, Jens Panse, MD^9,10 and Vasileios Tzounakas, PhD^11*

¹Department of Internal Medicine, University of Patras Medical School, Rion, Greece
²Department of Biochemistry, University of Patras Medical School, Patras, GRC
³1st Department of Internal Medicine, AHEPA University Hospital of Thessaloniki, Thessaloniki, Greece
⁴Hematology Department – BMT Unit, Laikon General Hospital, Athens, Greece
⁵Department of Hematology, Aghios Andreas General Hospital, Patras, Greece, Patras, Greece
⁶Department of Hematology, University of Athens Medical School , Laikon Hospital, ATHENS, GRC
⁷Department of Hematology and Bone Marrow transplantation Unit, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
⁸Laikon Hospital of Athens, Athens, GRC
⁹Center for Integrated Oncology - Aachen Bonn Cologne Duesseldorf (CIO-ABCD), Aachen, Germany
¹⁰Center for Integrated Oncology - Aachen Bonn Cologne Duesseldorf (CIO-ABCD), Aachen, Aachen, Germany
¹¹Department of Biochemistry, University of Patras Medical School, Patras, Greece

Lucy C Fox, BSc, FRACP, FRCPA, MBBS^1,2,3, Sally Hunter^4*, Stephen Ting, MBBS, FRACP, FRCPA, PhD^5,6, Le Thi Phuong Thao, PhD^7*, Stephane Heritier, PhD^8*, Anthony K. Mills, MBBS, FRACP, FRCPA⁹, Dominic Pepperell^10*, William S Stevenson, MBBS, FRACP, FRCPA, PhD^11*, Ilona Cunningham, MBBS FRACP FRCPA¹², Jennifer Curnow, MBBS, FRACP, FRCPA, PhD^13*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^14,15, Robin Filshie, PhD, FRACP, FRCPA¹⁶, Kylie Mason, MBBS, PhD, FRACP, FRCPA¹⁷, Sushrut S. Patil^18*, Sonali Ashok Sadawarte, MD, DM, FRACP, MBBS^19*, Frank Caleb Firkin^20*, Jeffrey Szer, MBBS^21,22, Paul Lacaze^23*, Kate Wilson^24*, Lisa Higgins^25*, Lauren Young, PhD^8*, Vanessa Fox, BSc^8*, Robyn Sutherland, BN, BSc^8*, Neil A Waters, BSc^26*, Erica M. Wood, MBBS, PhD, FRACP, FRCPA^27,28*, Zoe K McQuilten, MBBS, PhD^29,30 and Piers Blombery, MBBS^31,32

¹Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia
²Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
³Transfusion Research Unit, Monash University, Melbourne, Australia
⁴Peter MacCallum Cancer Centre, Melbourne, Australia
⁵Monash University-Alfred Health, Box Hill, Vic, AUS
⁶Department of Haematology, Eastern Health and Monash University, Elwood, VIC, Australia
⁷School of Public Health and Preventive Medicine, Monash University, Melbourne, AUS
⁸School of Public Health and Preventative Medicine, Monash University, Melbourne, Australia
⁹Division of Cancer Services, Princess Alexandra Hospital, Brisbane, QLD, Australia
¹⁰Fiona Stanley Hospital, Murdoch, AUS
¹¹Royal North Shore Hospital, Sydney, AUS
¹²Haematology Department Concord Hospital, Concord and University of Sydney, Sydney, Australia
¹³Westmead Hospital, Sydney, AUS
¹⁴University of Adelaide, Adelaide, SA, Australia
¹⁵Royal Adelaide Hospital, Adelaide, SA, Australia
¹⁶St. Vincent's Hospital Melbourne, Fitzroy, VIC, AUS
¹⁷Royal Melbourne Hospital, Parkville, VIC, AUS
¹⁸Department of Malignant Haematology & Stem Cell Transplantation, The Alfred Hospital, Melbourne, VIC, Australia
¹⁹Royal Hobart Hospital, Hobart, TAS, AUS
²⁰St. Vincent's Hospital, Fitzroy, VIC, AUS
²¹Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
²²Department of Medicine, The University of Melbourne, Parkville, VIC, Australia
²³Monash University, Melbourne, AUS
²⁴University of Sydney, Sydney, Australia
²⁵Monash University, Melbourne, Australia
²⁶Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, AUS
²⁷School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia
²⁸Monash Health, Melbourne, Australia
²⁹Department of Haematology, Monash Health, Melbourne, Australia
³⁰Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
³¹Peter Maccallum Cancer Centre, East Melbourne, VIC, Australia
³²Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia

Mengran Gao^1,2*, Ling Deng^1,2*, Xinrui Zhang^1,2*, Chunyan Liu^1,2* and Rong Fu, MD^1,2

¹Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China
²Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control, Tianjin, China

Yilin Liu^1*, Meili Ge^2*, Yingchang Mi, MD¹ and Jinbo Huang^1*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Flore Sicre de Fontbrune, MD^1*, Edouard Forcade, MD, PhD^2*, Louis Terriou, M.D^3*, Alice Garnier, MD^4*, Vincent Alcazer, MD^5*, Nicolas Daguindau^6*, Lynda Maafa^7*, Isabelle Brindel, PhD^8*, Regis Peffault de Latour, MD, PhD^9,10,11* and Sylvie Chevret^12*

¹Centre de Référence Aplasie Médullaire, Service d’Hématologie Greffe, Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France
²Service d'Hématologie Clinique et Thérapie Cellulaire, CHU Bordeaux, Hopital Haut-Leveque, Pessac, France
³Hopital Cl HURIEZ, LILLE, FRA
⁴CHU Nantes Hôpital Hôtel Dieu Hématologie Clinique, Nantes, France
⁵Hematology department, Centre Hospitalier Lyon Sud, Pierre Bénite, FRA
⁶Hematologie, Centre Hospitalier Annecy Genevois, Metz-Tessy, FRA
⁷Saint-Louis Hospital, GHU AP-HP Nord Université Paris Cité, French National Reference Center for Severe Aplastic Anemia, Paris, France
⁸Saint-Louis Hospital, GHU AP-HP Nord Université Paris Cité, French National Reference Center for Severe Aplastic Anemia, PARIS, France, FRA
⁹French Référence Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Paris, France
¹⁰Hôpital Saint-Louis, Université Paris Cité, Paris, France
¹¹Hematology and Transplant Unit, French National Reference Center for Aplastic Anemia, Hopital Saint Louis, APHP, Paris, France
¹²Biostatistics and Medical Information Department, Saint Louis Hospital, Assistance Publique — Hôpitaux de Paris (AP-HP), Paris, France

Zixi Yin^1*, Xiaofan Zhu, MD^2,3,4,5, Yang Wan, MD PhD^6*, Yangyang Gao^1* and Jun Li^7*

¹State Key Laboratory of Experimental Hematology Chinese Academy of Medical Sciences Institute of Hematology and Blood Diseases Hospital, Tianjin, China
²Tianjin Institutes of Health Science, Tianjin, China
³Hospital, Tianjin, China
⁴Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, Tianjin, China
⁵Tianjin Institutes of Health Science, Tianjin 301600, China
⁶Department of Pediatric Hematology and Oncology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences& Peking Union Medical College, Tianjin, China
⁷State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China

Austin G. Kulasekararaj, MD, MBBS, FRCPath, MRCP^1,2,3, Jaroslaw Czyz^4*, Catherine Flynn^5*, Gabriela Roncone Gastal^6*, Marek Hus^7*, Chrysavgi Lalayanni, MD^8*, Erfan Nur^9,10*, Phillip Scheinberg, MD¹¹, Yasutaka Ueda^12*, Alessandro Maria Vannucchi^13*, Maria Vidriales Vicente^14*, Iige Viigimaa^15*, Simon Buatois^16*, Alice C. Chang^17*, Sammy Chebon^16* and Alexander Röth, MD¹⁸

¹National Institute for Health Research and Wellcome King's Clinical Research Facility, London, United Kingdom
²King's College Hospital, London, United Kingdom
³Department of Hemato-oncology, Kings College London, London, United Kingdom
⁴Department of Hematology, Nicolaus Copernicus University, Bydgoszcz, Poland
⁵Department of Haematology, St. James' Hospital, Dublin, Ireland
⁶4. Centro de Hematologia e Oncologia (C.H.O.), Joinville, Brazil
⁷Department of Hemato Oncology and Bone Marrow Transplantation, Medical University of Lublin, Lubin, Poland
⁸Hematology Department – BMT Unit, G Papanicolaou Hospital, Thessaloniki, Greece
⁹Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
¹⁰Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
¹¹Division of Hematology, Hospital A Beneficencia Portuguesa de São Paulo, São Paulo, Brazil
¹²Osaka University Graduate School of Medicine, Osaka, Japan
¹³CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence and AOU Careggi, Florence, Italy
¹⁴Hospital Universitario de Salamanca, Salamanca, Spain
¹⁵Hematology Department, North Estonia Medical Centre, Tallinn, Estonia
¹⁶F. Hoffmann-La Roche Ltd, Basel, Switzerland
¹⁷Genentech, Inc., South San Francisco
¹⁸Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

Emma M. Groarke, MD¹, Jennifer Lotter, ms¹, Ivana Darden, RN^1*, Alfiya Bikineyeva, MD^2*, Uzoamaka Okeke^3*, Rachel Blair^2*, Julie Erb-Alvarez, MPH^2*, Jichun Chen, PhD¹, Xingmin Feng, PhD^1*, Jibran Durrani, MD⁴, Neal S. Young, MD¹ and Bhavisha A. Patel, MD¹

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²National Heart, Lung and Blood Institute, Bethesda, MD
³Office of Clinical Research Support Services, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda
⁴Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, BETHESDA, MD