Balkrishan Sharma, PhD¹, Allison Remiker, MD^2*, Brenton Francisco, MD^3*, Cassie Sprague^4*, Rachel Lauren Cantrell, BS^4*, Leah Rosenfeldt^4*, Courtney Young^4*, Ivy Han^4*, Hem Kumar Tamang, PhD⁵, Matthew J. Flick, PhD^6,7* and Joseph S. Palumbo, MD^8,9

¹Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH
²Children's Wisconsin, Medical College of Wisconsin, Milwaukee, WI
³Jack and Lucy Clark Department of Pediatrics at the Icahn School of Medicine at Mount Sinai, New York, NY
⁴Division of Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁵Experimental Hematology, Cincinnati Children's Hospital, Cincinnati, OH
⁶University of North Carolina At Chapel Hill, Chapel Hill, NC
⁷UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁸Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH
⁹University of Cincinnati College of Medicine, Cincinnati

Daniël Verhoef, MSc, PhD^1,2*, Viola J.F. Strijbis, MSc^1,2*, Taina Gomes, PhD^2*, Jan Ohrstrom, MD^2*, Gerard Short, MBBS, MBA, MRCP^2*, Michael Zoerer, PhD^2* and Pieter H. Reitsma, PhD^1,2

¹Leiden University Medical Center, Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, Netherlands
²VarmX B.V., Leiden, Netherlands

Alfonso Rodriguez Espada, MD^1,2*, Amelia K Haj, MD, PhD^1,3,4, Sean J. Jurgens, MD, MSc^1,5,6*, Sharjeel A Chaudhry, MD^1,2,4,7,8*, Justine Ryu, MD^1,9, Seung Hoan Choi, PhD^1*, Harish Eswaran, MD¹⁰, Simone Sanna-Cherchi, MD^11*, Patrick Ellinor, MD, PhD^1,4,5*, Steven Grover, PhD¹² and Pavan K Bendapudi, MD^1,4,13,14

¹The Broad Institute of MIT and Harvard, Cambridge, MA
²Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA
³Department of Pathology, Massachusetts General Hospital, Cambridge, MA
⁴Harvard Medical School, Boston, MA
⁵Massachusetts General Hospital, Boston, MA
⁶Department of Experimental Cardiology, University of Amsterdam, Amsterdam, Netherlands
⁷Division of Cardiology, The Johns Hopkins University, School of Medicine, Baltimore, MD
⁸Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, LAUREL, MD
⁹Section of Hematology, Yale University School of Medicine, New Haven, CT
¹⁰Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
¹¹Division of Nephrology, Columbia University Irving Medical School, New York, NY
¹²University of North Carolina at Chapel Hill, Chapel Hill, NC
¹³Division of Thrombosis and Hemostasis, Beth Israel Deaconess Medical Center, Boston, MA
¹⁴Division of Hematology, Department of Medicine, Massachusetts General Hospital, Cambridge, MA

Yingying Li^1,2*, Lili Luo^1,2*, Jianghua Wu^3*, Zhong Wu^1*, Huiwen Jiang, PhD^1*, Zhaozhao Chen^1,4*, Jiachen Liu^1*, Jinhui Shu, Master^1*, Jingming Wang^1*, Min Xu^1*, Mengyi Du^1,4*, Jun Deng^1*, Yu Hu^1,2* and Heng Mei, md, phd^5*

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Hubei Clinical and Research Centre of Thrombosis and Haemostasis, Wuhan, China
³Medical oncology, Sichuan Cancer Hospital, Sichuan, China, Sichuan, China
⁴Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China
⁵Union Hospital, Tongji Medical College, HUST, Wuhan, China

Jordan E. Ulsh, BS^1*, Matthew W. Bunce, PhD^1*, John Welsh, PhD^2*, Mark Kahn, MD^3*, Kelly Annie Mercado, BS, MS^4*, Nicole Da Costa^4*, Yoav Dori, MD, PhD^5* and Rodney M. Camire, PhD¹

¹Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
²Deparment of Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
³Deparment of Medicine, The University of Pennsylvania Pereleman School of Medicine, Philadelphia, PA
⁴Department of Pediatrics, Division of Cardiology, The Children's Hosptial of Philadelphia, Philadelphia, PA
⁵Department of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, Philadelphia, PA

Matthew Locke^*, Jamie Jessica Albiez^*, Nicolas Receveur^*, Sandra Marbach^*, Nina Frey^*, Mukul Girotra^*, Mariella Wyssenbach^*, Lejla Bektic^* and Tovo David

F. Hoffmann-La Roche Ltd, Basel, Switzerland

Yuxin Zhang^1,2*, Shuo Liu^3*, Zhenzhen Zhao^4*, Keyu Lv^5*, Chao Fang⁵, Yue Han, MD, PhD^6*, Juhong Wu^7*, Depei Wu, MD, PhD⁸, Jingyu Zhang^2*, Aizhen Yang^3* and Yi Wu, MD, PhD^3*

¹Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou 215123, China., ???, AL, China
²Department of Hematology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Hematology, Shijiazhuang, China, Shijiazhuang, China
³Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou 215123, China., Suzhou, China
⁴Soochow University, Suzhou, China
⁵Tongji Medical College, HUST, Wuhan, China
⁶Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China
⁷College of Chemistry, Fuzhou University, Fuzhou, Fujian, China, Fuzhou, China
⁸Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China

Nathan Ponzar, PhD^1*, Suresh Kumar, PhD^2*, Kirthan Reddy^3*, Robert Flaumenhaft, MD, PhD⁴ and Nicola Pozzi, PhD¹

¹Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, Saint Louis, MO
²Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St Louis, MO
³Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO
⁴Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Newton, MA

Harish Eswaran, MD¹, Rohan Kasthuri, BS^2* and Steven Grover, PhD³

¹Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
²University of North Carolina Chapel Hill, Chapel Hill, NC
³University of North Carolina at Chapel Hill, Chapel Hill, NC

Maya Mardini^1*, Madeline N. Sample, BS^1*, Taryn M. Lanham, BS^1*, Dlovan F. D Mahmood, MS^1*, Xiaohong Song, MS^1*, Myunghee Kim^2*, Amanda Medina^2*, Paul Gregor^2* and Jeremy P. Wood, PhD^1,3,4

¹Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY
²Gismo Therapeutics Inc, Lexington, KY
³Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY
⁴Division of Cardiovascular Medicine Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY