66th ASH Annual Meeting: 321. Coagulation and Fibrinolysis: Basic and Translational: Poster I

Symposia: Coagulation and Fibrinolysis: Basic and Translational Oral and Poster Abstracts
Poster

Research, Bleeding and Clotting, Bleeding disorders, Fundamental Science, Adult, Bispecific Antibody Therapy, Hemophilia, Translational Research, Assays, Thromboembolism, Diseases, Immune mechanism, Treatment Considerations, Biological therapies, Thrombotic disorders, Adverse Events, Biological Processes, Technology and Procedures, Study Population, Human, Pathogenesis, Animal model

Halls G-H (San Diego Convention Center)

1194

Fibrin and Fibrinogen Play Complex Opposing Roles in Metastasis

Balkrishan Sharma, PhD¹, Allison Remiker, MD²^*, Brenton Francisco, MD³^*, Cassie Sprague⁴^*, Rachel Lauren Cantrell, BS⁴^*, Leah Rosenfeldt⁴^*, Courtney Young⁴^*, Ivy Han⁴^*, Hem Kumar Tamang, PhD⁵, Matthew J. Flick, PhD^6,7^* and Joseph S. Palumbo, MD^8,9

¹Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH
²Children's Wisconsin, Medical College of Wisconsin, Milwaukee, WI
³Jack and Lucy Clark Department of Pediatrics at the Icahn School of Medicine at Mount Sinai, New York, NY
⁴Division of Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁵Experimental Hematology, Cincinnati Children's Hospital, Cincinnati, OH
⁶University of North Carolina At Chapel Hill, Chapel Hill, NC
⁷UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁸Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH
⁹University of Cincinnati College of Medicine, Cincinnati

1195

Vmx-C001 Prevents Rivaroxaban-Induced Bleeding in a Liver Injury Model in Cynomolgus Monkeys

Daniël Verhoef, MSc, PhD^1,2^*, Viola J.F. Strijbis, MSc^1,2^*, Taina Gomes, PhD²^*, Jan Ohrstrom, MD²^*, Gerard Short, MBBS, MBA, MRCP²^*, Michael Zoerer, PhD²^* and Pieter H. Reitsma, PhD^1,2

¹Leiden University Medical Center, Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, Netherlands
²VarmX B.V., Leiden, Netherlands

1196

Rare Germline Loss-of-Function Variants in C1-Inhibitor (SERPING1) Are Associated with Venous Thromboembolism in Population-Scale Sequencing Datasets

Alfonso Rodriguez Espada, MD^1,2^*, Amelia K Haj, MD, PhD^1,3,4, Sean J. Jurgens, MD, MSc^1,5,6^*, Sharjeel A Chaudhry, MD^1,2,4,7,8^*, Justine Ryu, MD^1,9, Seung Hoan Choi, PhD¹^*, Harish Eswaran, MD¹⁰, Simone Sanna-Cherchi, MD¹¹^*, Patrick Ellinor, MD, PhD^1,4,5^*, Steven Grover, PhD¹² and Pavan K Bendapudi, MD^1,4,13,14

¹The Broad Institute of MIT and Harvard, Cambridge, MA
²Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA
³Department of Pathology, Massachusetts General Hospital, Cambridge, MA
⁴Harvard Medical School, Boston, MA
⁵Massachusetts General Hospital, Boston, MA
⁶Department of Experimental Cardiology, University of Amsterdam, Amsterdam, Netherlands
⁷Division of Cardiology, The Johns Hopkins University, School of Medicine, Baltimore, MD
⁸Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, LAUREL, MD
⁹Section of Hematology, Yale University School of Medicine, New Haven, CT
¹⁰Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
¹¹Division of Nephrology, Columbia University Irving Medical School, New York, NY
¹²University of North Carolina at Chapel Hill, Chapel Hill, NC
¹³Division of Thrombosis and Hemostasis, Beth Israel Deaconess Medical Center, Boston, MA
¹⁴Division of Hematology, Department of Medicine, Massachusetts General Hospital, Cambridge, MA

1197

IL-1β Induce CAR-T-Associated Coagulopathy Via the Hsp90/Kallikrein/uPA Pathway

Yingying Li^1,2^*, Lili Luo^1,2^*, Jianghua Wu³^*, Zhong Wu¹^*, Huiwen Jiang, PhD¹^*, Zhaozhao Chen^1,4^*, Jiachen Liu¹^*, Jinhui Shu, Master¹^*, Jingming Wang¹^*, Min Xu¹^*, Mengyi Du^1,4^*, Jun Deng¹^*, Yu Hu^1,2^* and Heng Mei, md, phd⁵^*

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Hubei Clinical and Research Centre of Thrombosis and Haemostasis, Wuhan, China
³Medical oncology, Sichuan Cancer Hospital, Sichuan, China, Sichuan, China
⁴Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China
⁵Union Hospital, Tongji Medical College, HUST, Wuhan, China

1198

Human Lymphatic Fluid Supports Coagulation Driven Primarily By the Extrinsic Pathway

Jordan E. Ulsh, BS¹^*, Matthew W. Bunce, PhD¹^*, John Welsh, PhD²^*, Mark Kahn, MD³^*, Kelly Annie Mercado, BS, MS⁴^*, Nicole Da Costa⁴^*, Yoav Dori, MD, PhD⁵^* and Rodney M. Camire, PhD¹

¹Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
²Deparment of Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
³Deparment of Medicine, The University of Pennsylvania Pereleman School of Medicine, Philadelphia, PA
⁴Department of Pediatrics, Division of Cardiology, The Children's Hosptial of Philadelphia, Philadelphia, PA
⁵Department of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, Philadelphia, PA

1199

Preclinical Evaluation of NXT007 Using in Vitro and In Vivo Models of Hemostasis and Thrombosis

Matthew Locke^*, Jamie Jessica Albiez^*, Nicolas Receveur^*, Sandra Marbach^*, Nina Frey^*, Mukul Girotra^*, Mariella Wyssenbach^*, Lejla Bektic^* and Tovo David

F. Hoffmann-La Roche Ltd, Basel, Switzerland

1200

The C553-C581 Disulfide of Human Factor XI Is Crucial for Its Activation and Is Targeted By Thiol Isomerase Pdir

Yuxin Zhang^1,2^*, Shuo Liu³^*, Zhenzhen Zhao⁴^*, Keyu Lv⁵^*, Chao Fang⁵, Yue Han, MD, PhD⁶^*, Juhong Wu⁷^*, Depei Wu, MD, PhD⁸, Jingyu Zhang²^*, Aizhen Yang³^* and Yi Wu, MD, PhD³^*

¹Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou 215123, China., ???, AL, China
²Department of Hematology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Hematology, Shijiazhuang, China, Shijiazhuang, China
³Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou 215123, China., Suzhou, China
⁴Soochow University, Suzhou, China
⁵Tongji Medical College, HUST, Wuhan, China
⁶Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China
⁷College of Chemistry, Fuzhou University, Fuzhou, Fujian, China, Fuzhou, China
⁸Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China

1201

Nanonine, a Synthetic Nanobody Targeting Protein Disulfide Isomerase, Is a New Weapon in Our Antithrombotic Arsenal

Nathan Ponzar, PhD¹^*, Suresh Kumar, PhD²^*, Kirthan Reddy³^*, Robert Flaumenhaft, MD, PhD⁴ and Nicola Pozzi, PhD¹

¹Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, Saint Louis, MO
²Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St Louis, MO
³Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO
⁴Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Newton, MA

1202

Impact of Natural Variation in Coagulation Factor Zymogens on Contact Pathway-Initiated Thrombin Generation

Harish Eswaran, MD¹, Rohan Kasthuri, BS²^* and Steven Grover, PhD³

¹Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
²University of North Carolina Chapel Hill, Chapel Hill, NC
³University of North Carolina at Chapel Hill, Chapel Hill, NC

1203

Small Molecule Compounds for Heparin Reversal and Their Use in Heparin Quantitation

Maya Mardini¹^*, Madeline N. Sample, BS¹^*, Taryn M. Lanham, BS¹^*, Dlovan F. D Mahmood, MS¹^*, Xiaohong Song, MS¹^*, Myunghee Kim²^*, Amanda Medina²^*, Paul Gregor²^* and Jeremy P. Wood, PhD^1,3,4

¹Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY
²Gismo Therapeutics Inc, Lexington, KY
³Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY
⁴Division of Cardiovascular Medicine Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY

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^*signifies non-member of ASH

321.P1.29 321. Coagulation and Fibrinolysis: Basic and Translational: Poster I