Filippo Russo^1,2*, Anthony Iscaro^2,3*, Roberta Marra, PhD^2,4*, Antonella Nostroso^2,3*, Barbara Eleni Rosato, PhD^2,3*, Manuela Dionisi^2*, Federica Maria Esposito^2,3*, Vanessa D’Onofrio^2,3*, Mariangela Manno^2,3*, Valentina Brancaleoni, PhD^5*, Simona Leoni^5*, Achille Iolascon, MD, PhD^2,3*, Irene Motta, MD^5,6, Immacolata Andolfo, PhD^2,3* and Roberta Russo^2,7*

¹Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Roma, Italy
²CEINGE - Advanced Biotechnology - Franco Salvatore, Naples, Italy
³Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy
⁴University of Naples Federico II, CEINGE Biotecnologie Avanzate, Naples, Italy, Naples, Italy
⁵SC Medicina Indirizzo Metabolico, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⁶Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
⁷CEINGE - Biotecnologie Avanzate Franco Salvatore, CEINGE - Biotecnologie Avanzate, Napoli, NA, Italy

Varun S. Sudunagunta, BA^1,2,3, Yi Chen, MD, PhD^1,3*, Russell Kunes, PhD^4*, Edna M. Stewart, BS^3,5*, Viviana Scoca, PhD^1,3*, John Pantazi, BA^3*, Hongxia Yan, PhD⁶, Jane J. Xu, PhD^1,3, Mohandas Narla, DSc⁶ and Aaron D. Viny, MD, MS^1,3

¹Department of Medicine, Division of Hematology-Oncology, Columbia University Irving Medical Center, New York, NY
²Columbia University Vagelos College of Physicians and Surgeons, New York, NY
³Columbia Stem Cell Initiative, New York, NY
⁴Department of Statistics, Columbia University, New York, NY
⁵Department of Bioengineering, Columbia University, New York, NY
⁶Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY

Corbin R Azucenas, BS^1,2, Aikaterini Voulgaridou, MD³, Maria Stewart^4*, Athina Ntoumaziou, MD^4*, Yasmin Elgammal, MD, MSc^4*, Katie Seu, PhD⁵ and Theodosia A. Kalfa, MD, PhD⁴

¹University of Cincinnati, Cincinnati, OH
²Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Indiana University School of Medicine, Indianapolis, IN
⁴Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

Zhangli Peng, PhD¹, Timothy Leong^1*, Nima Mostafazadeh^1* and Qiang Zhu, PhD^2*

¹Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL
²University of California San Diego, La Jolla, CA

Ravina Taak, PhD^1*, Dinesh Babu^2*, Manu Jamwal, PhD^3*, Dhavapriya Palani^4*, Prashant Sharma, MBBS, MD^5*, Prateek Bhatia, MD^6*, Deepak Bansal^6*, Shaji R Velayudhan, PhD^7* and Reena Das, MD⁸

¹Hematology, Postgraduate Institute of Medical Education and Research Chandigarh, Chandiagrh, AL, India
²Center for Stem Cell Research, Christian Medical College, Vellore, India, Vellore, India
³Hematology, Postgraduate Institute of Medical Education and Research Chandigarh, Chandigarh, IND
⁴Centre for Stem Cell Research,Christian Medical College, Vellore, Vellore, India
⁵Postgraduate Institute of Medical Education and Research Chandigarh, New Delhi, IND
⁶Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IND
⁷Hematology, Christian Medical College, Vellore, Vellore, India
⁸Postgraduate Institute of Medical Education & Research, Chandigarh, IND

Stephen C Rogers, PhD^1*, Zohreh Safari, PhD^2*, Mary E Brummet^2*, Daniel Bennett^3*, Emioluwa Odunaiya^3*, Adaora Eziemefe^3*, Jacqueline Nguyen^3*, Sarah Enjati^2*, Olivia Conelius^4*, Aaron Issaian^5*, Monika monikA.dzieciatkow^6*, Fabia Gamboni^7*, Jason Held, PhD^8*, Angelo D'Alessandro, PhD⁹, Luke S Dunaway, PhD^10*, Isakson Brant^11*, Miriam Cortese Krott, PhD^12* and Allan Doctor, MD¹³

¹University of Maryland School of Medicine, Baltimore, MD
²University of Maryland school of Medicine, Baltimore, MD
³university of MARYLAND, BALTIMORE, BALTIMORE, MD
⁴university of MARYLAND School of medicine, BALTIMORE, BALTIMORE, MD
⁵University of Colorado Anschutz Medical Campus, Aurora, CO
⁶Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO
⁷University of Colorado, Aurora, CO
⁸Washington University in St. Louis, St. Louis, MO
⁹Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
¹⁰Cardiovascular Research Center, University of Virginia, Charlottesville, VA
¹¹University of Virginia School of Medicine, Charlottesville, VA
¹²Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany
¹³University of Maryland, Baltimore, MD

Rahul Roy, MSc^1*, Prajwal Boddu, MD² and Manoj Pillai, MD¹

¹Yale University, New Haven, CT
²Yale University, East Lyme, CT

Julien Papoin, MS^1,2*, Vincent P Schulz, PhD^3*, Fatima Khan, MS^4*, Betsy J. Barnes, DPhil¹, Jeffrey Michael Lipton, MD, PhD^5,6, Laurie A. Steiner, MD⁷, Mohandas Narla, DSc⁸, Patrick G. Gallagher, MD⁹ and Lionel Blanc, PhD^10,11

¹Feinstein Institutes for Medical Research, Northwell, Manhasset, NY
²HEMATIM site CHU, University of Picardy Jules Verne, Amiens, France
³Department of Pediatrics, Yale University School of Medicine, New Haven, CT
⁴Peds Hem Onc, Feinstein Institutes for Medical Research, Northwell Health, manhasset, NY
⁵The Feinstein Institutes for Medical Research, Manhasset, NY
⁶Cohen Children's Medical Center of NY, New Hyde Park, NY
⁷Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY
⁸Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
⁹Center for Perinatal Research, Nationwide Childrens, Ohio State University, Columbus, OH
¹⁰Feinstein Institutes for Medical Research, Manhasset, NY
¹¹Department of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY

John Schell, MD, PhD¹, Emily Huntsman^2*, Tomer Yaron-Barir, PhD^3*, Jared Johnson, PhD^4* and Lewis Cantley, PhD^4*

¹Dana-Farber Cancer Institute, Somerville, MA
²Weill Cornell Medicine, New York City
³Columbia University, New York City
⁴Dana-Farber Cancer Institute, Boston, MA

Junshu Wu^1,2,3*, Hui Liu, MD, PhD^1,2,3*, Liyan Li^1,2,3*, Wei Wang^4*, Zhaoyun Liu, PhD^1,2,3* and Rong Fu, MD^1,2,3

¹Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China
²Tianjin Institute of Hematology, Tianjin, China
³Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control, Tianjin, China
⁴Shanghaitech University, Shanghai Institute For Advanced Immunochemical Studies And School Of Life Science And Technology, Shanghai, China

Moira M. Lancelot, MD

Pathology, Emory University School of Medicine, Atlanta, GA

Priti Azad, PhD¹, Ali Akbari^2*, Dan Zhou^1*, Orit Poulsen^3*, Prashant Mali^4*, Vineet Bafna^3* and Gabriel Haddad, MD^5*

¹University of California San diego, La Jolla, CA
²Harvard Medical School,, Boston
³UCSD, La Jolla, CA
⁴University of California San diego, La Jolla
⁵University of California San Diego, La Jolla, CA

Mouna Ouchari, PhD¹, Qinzi Xu, MD^1*, Akueba Bruce^1*, Ling Wang, PhD^2*, Elizabeth Rochon, PhD^1* and Mark T. Gladwin, MD^3*

¹University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland, USA, baltimore, MD
²Department of Orthopedics and Rehabilitation, University of Iowa, Iowa City, Iowa, USA, Lowa city, IA
³Department of Medicine, University of Maryland School of Medicine, Baltimore, MD

Harry Layton Lesmana, MD¹, Te Ling, PhD², Alexandria Haseley, MS, CGC^3*, Marissa Coleridge, MS, CGC^3* and John D. Crispino, PhD²

¹Department of Pediatric Hematology, Oncology and BMT, Cleveland Clinic, Cleveland, OH
²Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
³Department of Medical Genetics and Genomics, Cleveland Clinic, Cleveland, OH

Pinelopi Vryttia, MD^1*, Konstantina Theoharaki, BS^2*, Christina Apostolopoulou, MD^1*, Georgia Tzafa, BS^2*, Aggeliki Kondi, BS^2*, Eugenia Kazolia, BS^2*, Elina Vassilakou, BS^2*, Sotiris Karapatakis, BS^2*, Ioannis V Kostopoulos, PhD^2*, Ourania Tsitsilonis, MD, PhD^2*, Anthi Bouchla, MD, PhD^1*, Sotirios G. Papageorgiou, MD, PhD^1*, Thomas Thomopoulos, MD^1*, Vasiliki Pappa, MD, PhD¹ and Marianna Antonelou, PhD^2*

¹Second Department of Internal Medicine and Research Institute, Hematology Unit, National and Kapodistrian University of Athens, Medical School, University General Hospital "Attikon", Athens, Greece
²Department of Biology, School of Science, National and Kapodistrian University of Athens (NKUA), Athens, Greece

Athina Ntoumaziou, MD^1*, Duc Nguyen^2*, Yasmin Elgammal, MD, MSc^1*, Ammar Husami^3*, Wenying Zhang^3,4*, Kaitlin D Weaver, DO^5*, Jennifer L. Kasten, MD, MSc^6*, David D. Grier, MD^4,7*, Yi Tu, Zheng, PhD^1,4, Carolyn Lutzko, PhD^4,8*, Mary Risinger, PhD^1*, Jan Frayne, PhD^9*, Katie Seu, PhD^1,4 and Theodosia A. Kalfa, MD, PhD^1,4

¹Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
³Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
⁵Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁶Department of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁷Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati
⁸Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁹Department of Biochemistry, University of Bristol, Bristol, United Kingdom

Shilpa Sharma^1,2*, Johanna ten Hoeve, PhD^3*, Elizabeta Nemeth, PhD⁴ and Tomas Ganz, MD, PhD⁴

¹Veteran Affairs Greater Los Angeles Health Care System, Los Angeles, CA
²UCLA, Los Angeles, CA
³UCLA Metabolomics Center, Los Angeles
⁴Center for Iron Disorders, University of California, Los Angeles, Los Angeles, CA

Paola Bianchi, PhD, BSc¹, Azita Sharif, MD^2*, Cristina Vercellati, PhD^3*, Elisa Fermo, PhD^3*, Maria Laura Chiaretto^2*, Anna Marcello, PhD^3*, Anna Zaninoni, BSc^3*, Nadia Mirra, MD^4*, Simona Torricelli^2*, Virna De Zordi^2*, Stefania Bottalico^2*, Francesco Passamonti, MD^5,6*, Wilma Barcellini, MD^7*, Matteo Vidali, MD^2* and Anna Chiara Migliorini, MD^8*

¹Hematology Unit, Pathophysiology of Anemias Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy
²Clinical Pathology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Milan, Italy
³Hematology Unit, Pathophysiology of Anemias Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⁴Pediatric Clinic/DH, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Milan, Italy
⁵Dipartimento di Oncologia ed Onco-Ematologia, Università degli Studi di Milano, Milan, Italy
⁶SC Ematologia, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy
⁷Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⁸Clinical Pathology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy