Jean-Nicolas Champagne, MD¹, Diego Villa, MD², Alina S. Gerrie, MD, FRCPC, MPH³, Christopher P. Venner, MD³, Graham W. Slack, MD^4*, Pedro Farinha⁵, Jeffrey W Craig, MD, PhD^6*, Laura Hilton, PhD⁷, Kerry J. Savage, MD, MSc⁷, David W. Scott, MBChB, PhD⁸ and Laurie H. H. Sehn, MD³

¹BC Cancer Vancouver, Vancouver, BC, Canada
²Centre for Lymphoid Cancer, BC Cancer – Vancouver Cancer Centre, Vancouver, BC, Canada
³Division of Medical Oncology, University of British Columbia, Vancouver, BC, Canada
⁴Department of Pathology, University of British Columbia, Vancouver, BC, Canada
⁵Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
⁶Department of Pathology, University of Virginia Health System, Charlottesville, VA
⁷BC Cancer, Vancouver, BC, Canada
⁸Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada

Alvaro J Alencar, MD¹, Susan M. Geyer, PhD², Electra D Paskett, PhD^3*, Levi D. Pederson, MS^4*, Travis Dockter^2*, Nilanjan Ghosh^5*, Kehinde Adekola, MBBS, MS⁶, Joseph M Unger, PhD^7*, Opeyemi Jegede^8*, Jonathan W. Friedberg, MD⁹, Brad S. Kahl, MD¹⁰, Shira N. Dinner, MD¹¹, Nancy L. Bartlett, MD¹², Kristie A. Blum, MD¹³ and John P. Leonard, MD¹⁴

¹Sylvester Comprehensive Cancer Center, Division of Hematology, University of Miami, Miller School of Medicine, Miami Beach, FL
²Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN
³Department of Internal Medicine, Division of Cancer Prevention and Control, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴Mayo Clinic, Rochester, MN
⁵Levine Cancer Institute, Atrium Health, Charlotte, NC
⁶Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL
⁷Fred Hutchinson Cancer Research Center, Seattle
⁸CIMAC-CIDC Network, Department of Data Science, Boston, MA
⁹Wilmot Cancer Center, University of Rochester, Rochester, NY
¹⁰Siteman Cancer Center, Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO
¹¹Alliance Protocol Operations Office, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago
¹²Siteman Cancer Center, Washington University Sch. of Med. Siteman Cancer Center, Saint Louis, MO
¹³Winship Cancer Institute of Emory University, Atlanta, GA
¹⁴Weill Cornell Medicine, New York, NY

Taylor R. Brooks, MD¹, Emily C. Zabor, DrPH^2*, Yohana B. Bedelu^2*, Nikita Dave³, Daniel J. Landsburg, MD³, Adrienne N. Nedved, PharmD^4*, Yucai Wang, MD, PhD⁵, Catherine Reinert^6*, Ajay Major, MD, MBA⁶, Megan Sears-Smith, MD^7*, Nilanjan Ghosh, MD, PhD⁷, Kiarash Salafian, MD^8*, Emily Ayers, MD⁸, Jordan Miller, PharmD^9*, Natalie Grover, MD¹⁰, Chelsea Peterson, DO¹¹, Cyrus Khan, MD^12*, Sean Patrick Patrick Bliven, MD¹³, Mayur S. Narkhede, MD¹³, Carrie I Ho, MD¹⁴, Stephen D. Smith, MD¹⁴, Alyssa Gibson^15*, Justin Kline, MD¹⁵, Suchitra Sundaram, MD¹⁶, Joshua Brody, MD^17*, Kelsey Baron, MD¹⁸, Boyu Hu, MD¹⁸, Daniel Trotier, MD¹⁹, Priyanka A. Pophali, MD²⁰, XI Yang, MD²¹, Yasmin H. Karimi, MD²¹, Marshall McKenna, MD^22*, Yun Kyoung Tiger, MD, PhD²², Alex Niu, MD^23*, Francisco Hernandez-Ilizaliturri, MD²³, Rodolfo Garza Morales, MD^24*, Javier Munoz, MD^24*, Fadzai Chinyengetere, MD, PhD^25*, Sandeep Dave, MD²⁵, Nayef Abdel-Razeq, MD^26*, Muhamad Alhaj Moustafa, M.D., M.S.²⁶, Paolo F. Caimi, MD²⁷ and Brian T. Hill, MD¹

¹Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Quantitative Health Sciences, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
³Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA
⁴Department of Pharmacy, Mayo Clinic, Rochester, MN
⁵Mayo Clinic, Rochester, MN
⁶University of Colorado Cancer Center, Aurora, CO
⁷Levine Cancer Institute, Charlotte, NC
⁸University of Virginia, Charlottesville, VA
⁹Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
¹⁰University of North Carolina, Chapel Hill, NC
¹¹Allegheny Health Network, Freedom, PA
¹²Allegheny Health Network, Pittsburgh, PA
¹³Department of Hematology Oncology, University of Alabama at Birmingham, Birmingham, AL
¹⁴Fred Hutchinson Cancer Center, Seattle, WA
¹⁵Comprehensive Cancer Center, University of Chicago Medicine, Chicago, IL
¹⁶Mount Sinai Icahn School of Medicine, New York, NY
¹⁷Icahn School of Medicine at Mount Sinai, New York, NY
¹⁸Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
¹⁹Carbone Cancer Center, University of Wisconsin, Madison, WI
²⁰Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI
²¹Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
²²Division of Hematology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ
²³Department of Medicine (Lymphoma Section), Roswell Park Comprehensive Cancer Center, Buffalo, NY
²⁴Mayo Clinic, Phoenix, AZ
²⁵Duke University, Durham, NC
²⁶Division of Hematology, Mayo Clinic, Jacksonville, FL
²⁷Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Giorgio Ottaviano^1*, Anna Alonso-Saladrigues, MD^2*, Valentin Ortiz-Maldonado, MD³, Jacques-Emmanuel Galimard, PhD^4*, Shatha Y. Farhan, MD⁵, Sowjanya Vuyyala, MBBS⁶, Eva Michel^4*, Fizza Imran^4*, Nuria Martinez-Cibrian^3*, Samppa Ryhänen, MD, PhD^7*, Andishe Attarbaschi, MD^8,9*, Stephan Mielke, MD¹⁰, Jurgen Kuball, MD¹¹, Antonio Perez Martinez, MD^12*, Yves Beguin, MD¹³, Arnon Nagler, MD¹⁴, Anne Sirvent^15*, Soeren Lykke Petersen, MD, MSc^16*, Pere Barba, MD¹⁷, Julia Marsal, MD^2*, Julio Delgado, MD, PhD^18*, Krzysztof Kalwak, MD, PhD^19*, Fabio Ciceri, MD^20*, Annalisa Ruggeri, MD, PhD^21*, Sebastian Giebel, MD, PhD^22*, Susana Rives^2* and Adriana Balduzzi, MD^1,23

¹Department of Pediatrics, Bone Marrow Transplant Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
²Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain
³Hospital Clínic de Barcelona, Barcelona, Spain
⁴EBMT Paris Study Unit, Saint Antoine Hospital, INSERM UMR-S 938, Sorbonne University, Paris, France
⁵Dept. of Stem Cell Transplant and Cellular Therapy, Henry Ford Hospital, Detroit, MI
⁶Hematology and Oncology, Mayo Clinic, Rochester, MN
⁷Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
⁸Department of Pediatric Hematology and Oncology, St. Anna Kinderspital, Vienna, Austria
⁹St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria
¹⁰Karolinska Comprehensive Cancer Center, Department of Cell Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska Institute, Stockholm, Sweden
¹¹Department of Hematology, University Medical Centre, Utrecht, Netherlands
¹²Pediatric Hematology-Oncology Department, La Paz University Hospital, Madrid, ESP
¹³Centre Hospitalier Universitaire of Liège, University of Liege, Liege, BEL
¹⁴Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv, Israel
¹⁵Pediatric BMT Unit, Montpellier, France
¹⁶Department of Hematology, Copenhagen University Hospital, Copenhagen, Denmark
¹⁷Deparment of Hematology, Vall Hebron Institute of Oncology (VHIO), Hospital Universitari Vall D'Hebron, La Garriga, Barcelona, Spain
¹⁸Oncoimmunotherapy Unit, Department of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain
¹⁹Department of Pediatric Bone Marrow Transplantation, Oncology, and Hematology, Wroclaw Medical University, Wroclaw, Poland
²⁰Hematology and Bone Marrow Transplantation Unit, I.R.C.C.S. San Raffaele Scientific Institute, Milan, Italy
²¹Hematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
²²Department of Hematology and Bone Marrow Transplantation, Maria Sklodowska-Curie Institute of Oncology, Gliwice, Poland
²³University of Milano-Bicocca, School of Medicine and Surgery, Monza, Italy

Marco Cerrano, MD^1*, Lazzarotto Davide, MD^2*, Eleonora Boscaro^3*, Erika Borlenghi, MD^4*, Ilaria Tanasi, MD^5*, Patrizia Chiusolo, MD, PhD^6*, Paola Minetto, MD, PhD^7*, Francesco Grimaldi, MD^8*, Michelina Dargenio^9*, Matteo Leoncin^10*, Silvia Trappolini^11*, Cristina Papayannidis, MD, PhD^12*, Fabio Forghieri^13*, Carmela Gurrieri, MD^14*, Patrizia Zappasodi^15*, Roberta La Starza, MD^16*, Nicola Fracchiolla^17*, Federica Di Biase, MD^18*, Maria Ilaria Del Principe^19*, Marzia Defina^20*, Crescenza Pasciolla^21*, Benedetta Cambò^22*, Federico Mosna^23*, Daniela Pietrasanta^24*, Sabrina Mariani^25*, Valentina Mancini, MD^26*, Fabio Guolo, MD, PhD²⁷, Federico Lussana^28*, Elisabetta Todisco^29*, Mario Annunziata, MD^30*, Valeria Calafiore^31*, Maria Ciccone^32*, Matteo Piccini^33*, Matteo Emidio Dragani, MD^34*, Beatrice Sani^35*, Endri Mauro^36*, Claudia Basilico^37*, Beatrice De Marco^38*, Marco Antonacci^39*, Laura Forlani^40*, Monica Fumagalli, MD^41*, Fabio Trastulli, MD^42*, Monia Lunghi^43*, Prassede Salutari^44*, Sara Mastaglio, MD^45*, Sabina Chiaretti, MD, PhD⁴⁶, Anna Candoni^47*, Felicetto Ferrara, MD^48*, Giovanni Pizzolo, MD^49*, Robin Foà, MD^46* and Massimiliano Bonifacio, MD^50*

¹Division of Hematology, Department of Oncology, A.O.U. Città della Salute e della Scienza di Torino, Torino, To, Italy
²Clinica Ematologica e Centro Trapianti, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy
³Division of Hematology, Department of Oncology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy
⁴ASST Spedali Civili, Brescia, Department of Hematology, Brescia, Italy
⁵Division of Hematology, Departemnt of Medicine, Policlinico G.B.Rossi - AOUI Verona, Verona, ITA
⁶UOC Ematologia e Trapianto Cellule Staminali Emopoietiche, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Rome, Italy
⁷U.O. Clinica Ematologica, IRCCS. A.O.U.San Martino-IST, Genova, ITA
⁸Department of Clinical Medicine and Surgery, Hematology Unit, University of Naples Federico II, Napoli, Italy
⁹Hematology and Stem Cell Transplantation Unit, Vito Fazzi Hospital, Lecce, Italy
¹⁰Azienda Ulss3 Serenissima,Hematology Unit, Ospedale dell'Angelo, Venezia, Italy
¹¹S.O.D. Clinica Ematologica, Azienda Ospedaliero Universitaria delle Marche, Ancona, ITA
¹²S. Orsola-Malpighi Polyclinic, Bologna, ITA
¹³Universisty of Modena and Reggio Emilia, Modena, ITA
¹⁴Hematology Unit, Department of Medicine, University of Padova, Padova, Italy
¹⁵Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹⁶Hematology, CREO, Centro Ricerche Emato-Oncologiche, University of Perugia, Perugia, Italy
¹⁷Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
¹⁸Department of Molecular Biotechnology and Health Sciences, Division of Hematology, University of Torino, Torino, Italy
¹⁹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
²⁰Hematology and Transplantation, Siena, ITA
²¹Ematologia, Istituto Tumori Giovanni Paolo II- Bari, Bari, Italy
²²U.O.C. Ematologia e Centro Trapianti Midollo Osseo, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
²³Azienda Sanitaria dell'Alto Adige, Bolzano, ITA
²⁴Division of Hematology, Azienda Ospedaliera SS Arrigo E Biagio E Cesare Arrigo, Alessandria, ITA
²⁵Hematology Unit, Azienda Ospedaliera Universitaria Sant'Andrea, Sapienza University, Rome, ITA
²⁶Department of Hematology and Oncology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
²⁷Hematology Unit, Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy
²⁸Department of Oncology and Hematology, University of Milan and ASST Papa Giovanni XXIII, Bergamo, Italy
²⁹Hematology and Stem Cell Transplantation Division, European Institute of Oncology, Milan, Italy
³⁰Hematology, San Giuseppe Moscati Hospital, Aversa, Italy
³¹Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Palermo, ITA
³²Hematology Section, Department of Medical Sciences, AOU Arcispedale S.Anna, Ferrara, Italy
³³SOD Ematologia, Università di Firenze, AOU Careggi, Firenze, Italy
³⁴Ematologia, IRCCS AOU San Martino-IST, Genova, Italy
³⁵S.C.D.U. Ematologia, A. O. Ordine Mauriziano di Torino, Torino, Italy
³⁶Ospedale Ca' Foncello, TREVISO, ITA
³⁷Hematology Unit, ASST Sette Laghi-Ospedale di Circolo di Varese e Fondazione Macchi, Varese, Italy
³⁸UO Ematologia, ASST Spedali Civili di Brescia, Brescia, Italy
³⁹Div. of Hematology, Dept. of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy
⁴⁰Hematology Unit, Azienda Ospedale-Università Padova (AOPD), Padua, Italy
⁴¹Hematology Division and Bone Marrow Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁴²Ematologia, AORN A. Cardarelli, Napoli, Napoli, ITA
⁴³Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
⁴⁴Presidio Ospedaliero Pescara, Pescara, ITA
⁴⁵Hematology and Bone Marrow Transplant, Unit San Raffaele Scientific Institute, Milano, Milano, Italy
⁴⁶Department of Translational and Precision Medicine, Division of Hematology, Sapienza University, Rome, Italy
⁴⁷Hematology Unit, Section of Haematology, Dept. of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Modena, Italy
⁴⁸Division of Hematology, AORN Cardarelli, Naples, Napoli, Italy
⁴⁹Department of Engineering for Innovation Medicine, Section of Hematology, University of Verona, Verona, Italy
⁵⁰Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area, University of Verona, Verona, Italy

Evgenii Shumilov^1*, Rebecca Wurm-Kuczera, MD^2*, Vladan Vucinic, MD^3*, Maximilian Seib^1*, Udo Holtick^4*, Paolo Mazzeo^5,6*, Julia Katharina Scholz, MD^7*, Hristo Boyadzhiev^8,9*, Thomas Melchardt, MD^10*, Alexander Hölscher, MD^11*, Christian R Schultze-Florey, MD^12*, Giuliano Filippini Velazquez, MD^13*, Anna Ossami Saidy^14*, Vadim Lesan^15*, Ulf Schnetzke^16*, Andrea Kerkhoff, MD^1*, Ulrike Bacher^17*, Susanne Ghandili, MD^18*, Enver Aydilek^5*, Niklas Gebauer^19*, Thomas Weber^20*, Gerald Wulf^5*, Bertram Glass, MD^14*, Lorenz Thurner, MD¹⁵, Florian Heidel, MD¹², Christoph Schmid, MD^13*, Andreas Viardot, MD, PhD²¹, Mathias Hänel, MD²², Sascha Dietrich^11*, Thomas Pabst⁸, Francis A. Ayuk, M.D.^23*, Bastian von Tresckow²⁴, Björn Chapuy²⁵, Christiane Pott, MD^26*, Fabian Mueller, MD^27* and Georg Lenz¹

¹Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany
²Department of Hematology, Oncology, and Cancer Immunology, Charité -University Medical Center Berlin, Campus Benjamin Franklin, Berlin, Germany
³Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig, Leipzig, Saxony, Germany
⁴Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany
⁵Department of Hematology and Medical Oncology, University Hospital Goettingen, Goettingen, Germany
⁶Department of Hematology and Medical Oncology, INDIGHO laboratory, University Medical Center Goettingen, Goettingen, Germany
⁷Department of Internal Medicine 5, Hematology and Oncology, University Hospital Erlangen, Erlangen, Germany
⁸Department of Medical Oncology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland
⁹Habichtswald Hospital, Kassel, Germany
¹⁰3rd Medical Dept. with Haematology, Medical Oncology, Haemostaseology, Rheumatology and Infectiology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria
¹¹Department of Hematology, Oncology and Immunology, University Hospital of Duesseldorf, Duesseldorf, Germany
¹²Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹³Department of Hematology, University Hospital Augsburg, Augsburg, Germany
¹⁴Department of Hematology and Cell Therapy, Helios Klinikum Berlin-Buch, Berlin, Germany
¹⁵Department of Internal Medicine I (Oncology, Hematology, Clinical Immunology, and Rheumatology), Saarland University Medical School, Homburg, Germany
¹⁶Hematology and Medical Oncology, University Hospital Jena, Jena, Germany
¹⁷Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
¹⁸Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
¹⁹Department for Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
²⁰Department of Internal Medicine IV, Haematology and Oncology, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany
²¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²²Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany
²³Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
²⁴Department of Hematology and Stem Cell Transplantation, West German Cancer Center and German Cancer consortium (DKTK partner site Essen), University Hospital Essen, University of Duisburg-Essen, Essen, Germany
²⁵Department of Hematology, Oncology and Cancer Immunology, Charité - University Medical Center Berlin, Campus Benjamin Franklin, Berlin, Germany
²⁶Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein, Kiel, Germany
²⁷Department of Internal Medicine 5 - Hematology and Oncology, University Hospital of Erlangen, Erlangen, Germany