66th ASH Annual Meeting: 803. Emerging Tools, Techniques, and Artificial Intelligence in Hematology: Pioneering Tools for Tomorrow's Breakthroughs

Symposia: Emerging Tools, Techniques, and Artificial Intelligence in Hematology Oral and Poster Abstracts
Oral

Artificial intelligence (AI), Research, Acute Myeloid Malignancies, AML, Lymphoid Leukemias, ALL, Fundamental Science, Translational Research, APL, Drug development, CLL, Lymphomas, Assays, Bioinformatics, B Cell lymphoma, Genomics, Diseases, Treatment Considerations, Biological therapies, Immunology, Lymphoid Malignancies, Computational biology, Emerging technologies, Myeloid Malignancies, Biological Processes, Technology and Procedures, Gene editing, Profiling, Imaging, Machine learning, Molecular testing, Omics technologies

Marriott Grand Ballroom 2-4 (Marriott Marquis San Diego Marina)

Moderators:

Alexander Oeser, PhD, University of Leipzig and Manja Meggendorfer, PhD, MLL Munich Leukemia Laboratory

Disclosures:

No relevant conflicts of interest to declare.

4:30 PM

1057

Synthetic Bone Marrow Smears Are a Privacy-Preserving Substitute for Developing Accurate Leukemia Classification Models in Hematological Microscopy

Jan-Niklas Eckardt^1,2^*, Ishan Srivastava, MSc^3,4^*, Zizhe Wang, MSc⁵^*, Susann Winter, PhD²^*, Tim Schmittmann⁵^*, Sebastian Riechert, MSc³^*, Miriam Eva Helena Gediga, MD⁴^*, Anas Shekh Sulaiman, MD⁴^*, Martin M. K. Schneider, MD⁴^*, Freya Schulze, MD⁴^*, Christian Thiede, MD⁴, Katja Sockel, MD⁶^*, Frank P. Kroschinsky, MD, MBA⁴, Christoph Röllig, MD, MSc⁷^*, Martin Bornhäuser, MD^4,8,9^*, Karsten Wendt, PhD^3,5^* and Jan Moritz Middeke, MD^1,2^*

¹Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany
²Department of Internal Medicine I, University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany
³Else Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany
⁴Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁵Chair of Software Technology, Technical University Dresden, Dresden, Germany
⁶University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁷Department of Internal Medicine 1, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁸National Center for Tumor Diseases Dresden (NCT/UCC), Technical University Dresden, Dresden, Germany
⁹German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany

4:45 PM

1058

Computational Structural Genomics Meets Cryo-EM for the Analyses of Mitochondria-Encoded Enzyme Complexes: A Transformational Approach for Deep Variant Phenotyping in Myelodysplastic Neoplasms

Jing Dong, PhD^1,2, Michael T. Zimmermann, PhD²^*, Wael Saber, MD, MS^3,4 and Raul Urrutia, MD²^*

¹Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
²Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI
³Center for International Blood and Marrow Transplant Research, Minneapolis, MN
⁴Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI

5:00 PM

1059

Multimodal Spatial Transcriptomic Profiling Elucidates Niche-Specific Dynamics in Medullary and Extramedullary Acute Myeloid Leukemia

Enes Dasdemir, BS¹^*, Ivo Veletic, MD²^*, Christopher P. Ly, MS³^*, Andres E Quesada, MD⁴^*, Fatima Z Jelloul⁵^*, Pamella Borges⁶^*, Sreyashi Basu⁷^*, Sonali Jindal⁷^*, Zhiqiang Wang⁸^*, Alexander J Lazar⁹^*, Khalida M Wani⁷^*, Dinler A Antunes¹⁰^*, Patrick K. Reville, MD, MPH³, Preethi Gunaratne¹¹^*, Robert J Tower¹²^*, Padmanee Sharma¹³^* and Hussein A. Abbas, MD, PhD³

¹Department, The University of Texas at MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶University of Houston, Department of Biology and Biochemistry, Houston
⁷The University of Texas at MD Anderson Cancer center, Houston, TX
⁸University of Texas MD Anderson Cancer Center, Houston
⁹The University of Texas at MD Anderson Cancer centER, Houston, TX
¹⁰University of Houston, Houston, TX
¹¹Department of Biology and Biochemistry, University of Houston, Houston, TX
¹²UT Southwestern Medical Center, Dallas
¹³Immunobiology, Genitourinary Medical Oncology, The University of Texas at MD Anderson Cancer center, Houston, TX

5:15 PM

1060

CRISPR-TOF Platform: A Single-Cell Approach for Studying Kinase-Dependent Immune-Signaling Dynamics in Human Primary T Cells

Alessandra M. E. Holzem, MD^1,2^*, Xavier Rovira-Clave, PhD³^*, Alexandros Drainas, PhD⁴^*, Hans Christian Reinhardt, MD¹ and Julien Sage, PhD⁴^*

¹Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
²Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany
³Stanford University, Department of Pathology, Stanford, CA
⁴Stanford University, Departments of Pediatrics and Genetics, Stanford, CA

5:30 PM

1061

Multiomic Discovery of Neopeptides from Non-Canonical ORFs on SF3B1 Mutation-Driven lncRNAs in Leukemia

Supriyo Bhattacharya¹^*, Mike Fernandez, BS², Yiming Wu³^*, Meiling Jin, PhD⁴^* and Lili Wang, MD, PhD⁵

¹Integrative Genomics Core, Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA
²Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA
³Department of Systems Biology, City of Hope Comprehensive Cancer Center, Germantown, TN
⁴Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA
⁵Department of Systems Biology, City of Hope, Duarte, CA

5:45 PM

1062

Overcoming Immune Escape Via Targeting Akt-Wnt/β-Catenin By Artificial-Intelligence-Powered Peptide-Producing mRNAs

Zhe Yang, PhD¹, Negin Manshour²^*, Xi He, MD,. Ph.D.¹^*, Michael Epp¹^*, Jay Unruh, Ph.D.¹^*, Xinjian Mao, PhD¹, Ruochen Dong, Ph.D.¹, Dan Bradford¹^*, Shengping Huang, Ph.D¹^*, Fengyan Deng, Ph.D¹^*, Mark Hembree¹^*, Chongbei Zhao, Ph.D¹^*, Liang Xu, M.D., Ph.D.³^*, Dong Xu, Ph.D²^* and Linheng Li, Ph.D.^1,4

¹Stowers Institute for Medical Research, Kansas City, MO
²University of Missouri, Columbia, MO
³Department of Molecular Biosciences, University of Kansas, Lawrence, KS
⁴Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS

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^*signifies non-member of ASH

803.O1.6 803. Emerging Tools, Techniques, and Artificial Intelligence in Hematology: Pioneering Tools for Tomorrow's Breakthroughs