-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

723.O2.6 723. Allogeneic Transplantation: Long-Term Follow up and Disease Recurrence: Exploring Biologic Mechanisms of Relapse and Survival

Symposia: Allogeneic Transplantation: Long-term Follow-up, Complications, and Disease Recurrence Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Acute Myeloid Malignancies, AML, MDS, Lymphoid Leukemias, Adult, Translational Research, CLL, Clinical Research, Genomics, Bioinformatics, Chronic Myeloid Malignancies, Diseases, Immune mechanism, Real-world evidence, Treatment Considerations, Biological therapies, Immunotherapy, Immunology, Lymphoid Malignancies, Computational biology, Adverse Events, Myeloid Malignancies, Biological Processes, Emerging technologies, Technology and Procedures, Human, Study Population, Measurable Residual Disease , Imaging, Transplantation (Allogeneic and Autologous), Omics technologies
Monday, December 9, 2024: 2:45 PM-4:15 PM
Room 6A (San Diego Convention Center)
Moderators:
Ben K. Tomlinson, MD, University of California, Davis and Betty K. Hamilton, MD, Cleveland Clinic Foundation
Disclosures:
Tomlinson: BMS: Consultancy, Research Funding.

This session consists of abstracts describing investigation of biologic mechanisms of relapse and outcomes after allogeneic transplant.
2:45 PM

Robert F. Wynn, MRCP, MD, FRCPath1*, Fernanda Volt, MSc2,3*, Srividhya Senthil, MBBS4*, Graziana Scigliuolo, PharmD5,6*, Chantal Kenzey, RA2*, Barbara Cappelli, MD5,6*, Annalisa Ruggeri, MD, PhD2,7*, Ryad Tamouza, MD, PhD8*, Vanderson Rocha, MD, PhD, MS2,9*, Li Yuan Chan10*, Ka Lok Chan, MD11*, Chloe Anthias, FRCPath12*, Regis Peffault De Latour13,14*, Ben Carpenter, MD15*, Adrian Bloor, Phd FRCP FRCPath16*, Marc Bierings, MD, PhD17, Nicolaas Schaap, MD, PhD18, Persis Jal Amrolia19*, Jan J. Cornelissen, MD, PhD20*, Kay Poulton, PhD, FRCPath21* and Éliane Gluckman2,6

1Royal Manchester Children's Hospital, Manchester, GBR
2Eurocord, Hôpital Saint Louis APHP, Institut de Recherche de Saint-Louis (IRSL) EA3518, Université de Paris Cité, Paris, France
3Eurocord, Paris, FRA
4Blood and Marrow Transplant Unit, Royal Manchester Children's Hospital, Manchester, United Kingdom
5Eurocord, Institut de Recherche de Saint-Louis (IRSL) EA3518, Université de Paris Cité, Paris, France
6Monacord, Centre Scientifique De Monaco, Monaco, Monaco
7Hematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
8Univ Paris Est Créteil, INSERM U955, IMRB, F-94010 Créteil, France., Créteil, France
9Service of Hematology, Transfusion and Cell Therapy, and Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31), Hospital das Clínicas, Faculty of Medicine, São Paulo University, São Paulo, Brazil., São Paulo, Brazil
10Royal Marsden NHS Foundation Trust, London, United Kingdom
11Royal Marsden NHS Trust, Manchester, United Kingdom
12Royal Marsden Hospital, Sutton, GBR
13Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France
14Hôpital Saint-Louis,, Paris, France
15University College London Hospitals NHS Foundation Trust, London, United Kingdom
16The Christie NHS Foundation Trust, Manchester, United Kingdom
17Princess Maxima Center/ University Hospital for Children (WKZ), Stem cell transplantation, Utrecht, Netherlands
18Radboud University Medical Centre, Nijmegen, NLD
19Bone Marrow Transplant Department, Great Ormond Street Hospital, London, United Kingdom
20Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
21Manchester Royal Infirmary, Manchester, GBR

3:00 PM

Livius Penter, MD1,2,3,4, Nicoletta Cieri, MD, PhD3,4,5, Katie Maurer, MD, PhD3,4,5, Marwan Kwok, MD, PhD, FRCPath, MRCP5,6,7,8, Haoxiang Lyu, BS9*, Wesley S Lu, BS9*, Giacomo Oliveira, PhD3,4,5*, Satyen H Gohil10*, Ignaty Leshchiner, PhD11*, Caleb Lareau, PhD12*, Leif S Ludwig, MD, PhD13*, Donna S. Neuberg, ScD14, Haesook T. Kim, PhD14, Shuqiang Li, PhD9*, Lars Bullinger15, Jerome Ritz, MD5, Gad Getz, PhD3,4,16*, Jacqueline S. Garcia, MD5, Robert J. Soiffer, MD5, Kenneth J. Livak, PhD5* and Catherine J. Wu, MD3,4,5*

1Department of Hematology, Oncology, and Cancer Immunology, Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Germany
2Department of Medical Oncology, Dana-Farber Cancer Institute, Berlin, Germany
3Harvard Medical School, Boston, MA
4Broad Institute of MIT and Harvard, Cambridge, MA
5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
6Institute of Cancer and Genomic Sciences, University of Birmingham, Bimingham, United Kingdom
7Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom
8Queen Elizabeth Hospital Birmingham, Centre for Clinical Haematology, Birmingham, United Kingdom
9Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
10Haematology, University College Hospital, London, United Kingdom
11Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA
12Memorial Sloan Kettering Cancer Center, New York, NY
13Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
14Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
15Department of Hematology, Oncology, and Cancer Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
16Department of Pathology, Massachusetts General Hospital, Boston, MA

3:15 PM

Simona Pagliuca, MD, PhD1, Carmelo Gurnari, MD, PhD2,3, Arda Durmaz, PhD4*, Ashwin Kishtagari, MBBS5, Zain Virk, BS6*, Lukasz P. Gondek, MD, PhD7, Matthew Guo, BA8*, Maria Bettinotti, PhD8, Mark B Juckett, M.D., M.H.C.M.9, Qing Cao, MSc10*, Suresh Kumar Balasubramanian, MD11,12, Vikram Dhillon13,14*, Ben K. Tomlinson, MD15,16, Koen van Besien, MD, PhD15,17, Alice Aarnink, PhD18*, Marie Thérèse Rubio, MD, PhD19*, Valeria Visconte, PhD20 and Jaroslaw Maciejewski20

1Department of Hematology, Nancy University Hospital, Vandœuvre-lès-Nancy, France, France
2Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
3Cleveland Clinic Foundation, Cleveland, OH
4Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, CLEVELAND, OH
5Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Franklin, TN
6Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
7Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
8Johns Hopkins Hospital - Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
9Department of Hematology, University of Minnesota, Minneapolis, MN
10Biostatistics and Informatics, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN
11Department of Oncology, Karmanos Cancer Institute/Wayne State University, Troy, MI
12Department of Oncology, Karmanos Cancer Institute/ Wayne State University, Detroit, MI
13Department of Hematology/Oncology, Neal Cancer Center/Houston Methodist Hospital, Houston, TX
14Wayne State University, Detroit, MI
15Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH
16University Hospitals Cleveland Medical Center, Cleaveland, OH
17Department of Hematology and Stem Cell Transplant, University Hospitals Seidman Cancer Center, Cleveland, OH
18HLA and Histocompatibility Laboratory, Nancy University Hospital, Vandeuvre-lès-Nancy, France
19Department of Hematology, Nancy University Hospital, Vandoeuvre-lès-Nancy, France
20Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH

3:30 PM

Katie Maurer, MD, PhD1,2,3, Florian Raths, PhD4*, Kenneth Gouin, PhD4*, Cameron Y Park, MS5,6*, Michael Lawson, PhD4*, Jake Koh, PhD4*, Martin Fabani, PhD4*, Kenneth J. Livak, PhD3,7*, Jerome Ritz, MD1,3, Robert J. Soiffer, MD1,8,9, Eli Glezer, PhD4*, Catherine J. Wu, MD1,2,3* and Elham Azizi, PhD5,6,10,11,12

1Harvard Medical School, Boston, MA
2Broad Institute of MIT and Harvard, Cambridge, MA
3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
4Singular Genomics, San Diego, CA
5Irving Institute for Cancer Dynamics, Columbia University, New York, NY
6Department of Biomedical Engineering, Columbia University, New York, NY
7Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
8Dana-Farber Cancer Inst., Boston, MA
9Brigham and Women's Hospital, Boston, MA
10Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY
11Data Science Institute, Columbia University, New York
12Department of Computer Science, Columbia University, New York

3:45 PM

Pier Rovatti, MD1*, Marco Punta, PhD1,2*, Giorgio Orofino, MD1,3,4*, Matteo Maria Naldini, MD, PhD5*, Matteo Giovanni Carrabba, MD4*, Massimo Bernardi, MD4*, Jacopo Peccatori, MD4*, Bernhard Gentner, MD4,5, Fabio Ciceri, MD3,4*, Luca Vago, MD, PhD1,3,4 and Cristina Toffalori, PhD1,3*

1Unit of Immunogenetics, Leukemia Genomics and Immunobiology, I.R.C.C.S. San Raffaele Scientific Institute, Milan, Italy
2Unit of Immunogenomics, I.R.C.C.S. Ospedale San Raffaele, Milan, Italy
3Vita-Salute San Raffaele University, Milan, Italy
4Hematology and Bone Marrow Transplantation Unit, I.R.C.C.S. San Raffaele Scientific Institute, Milan, Italy
5Translational Stem Cell and Leukemia Unit, I.R.C.C.S. San Raffaele Scientific Institute, Milan, Italy

4:00 PM

Angel Earle1*, Pankhil Shah2, Susan E. Steck, PhD, MPH, RDN, FAND3*, Jiajia Zhang, PhD3*, Nadine El Kalach, PhD3*, Lara E. Sucheston-Campbell, PhD, MS4, Stephen R. Spellman5*, Marcelo C. Pasquini, MD, MS6, Meilun He, MPH7*, Qianqian Zhu, PhD8*, Theresa E. Hahn, PhD9 and Alyssa I Clay-Gilmour, PhD3

1Department of Epidemiology and Biostatistics, University of South Carolina, Winnsboro, SC
2Department of Epidemiology and Biostatistics | Arnold School of Public Health, University of South Carolina, Lexington, SC
3Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC
4College of Pharmacy, The Ohio State University, Pleasanton, CA
5Center for International Blood and Marrow Transplant Research, Minneapolis, MN
6Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
7CIBMTR® (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, MN
8Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY
9Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY

*signifies non-member of ASH