-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

703.O1.6 703. Cellular Immunotherapies other than CAR-T Cells: Basic and Translational: Enhancing NK Cell Therapeutics

Symposia: Cellular Immunotherapies other than CAR-T Cells: Basic and Translational Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Combination therapy, Acute Myeloid Malignancies, AML, Translational Research, Drug development, Assays, Bispecific Antibody Therapy, Bioinformatics, Immune mechanism, Diseases, Cell expansion, Treatment Considerations, Biological therapies, Immunotherapy, Immunology, Biological Processes, Myeloid Malignancies, Technology and Procedures, Natural Killer (NK) Cell Therapies, Human, Omics technologies
Monday, December 9, 2024: 2:45 PM-4:15 PM
Marriott Grand Ballroom 8-9 (Marriott Marquis San Diego Marina)
Moderators:
Caroline Arber, MD, ARRAY(0xed8d724) and May Daher, MD, MD, The University of Texas MD Anderson Cancer Center
Disclosures:
Arber: Immatics: Patents & Royalties.

For this session we have selected six top scoring abstracts for oral presentation that address key questions in the field of NK cell based cellular immunotherapies. These basic and translational abstracts develop novel tools, engineering or combinatorial drug strategies with the goal to improve responses against AML and other hematologic malignancies.
2:45 PM

Jonas Bouhlal, MSc, BSc1,2,3*, Emmi Jokinen3,4,5*, Petra Nygren1,2,3*, Diogo Dias, MSc1,2,3,6*, Aleksandr Ianevski6*, Jay Klievink, M.Sc2,3,5*, Hanna Lähteenmäki, MSc1,2,3*, Essi Laajala, PhD1,2,3*, Hanna Duàn, MSc1,2,3*, Emmi Järvelä, MSc7*, Helka Göös, PhD7*, Matti Korhonen, MD, PhD7,8*, Salomé Decombis1,3,9*, Konstantin Matjusinski1,2,3*, Mikko Myllymäki, MD, PhD1,2,3, Maija Hollmén10*, Khalid Saeed, PhD2,3*, Dean Anthony Lee, MD, PhD11, Tero Aittokallio, PhD1,12,13,14*, Sara Gandolfi, MD, PhD1,2,3*, Olli Dufva, MD, PhD1,2,3,15* and Satu Mustjoki, MD, PhD2,3,16

1iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland
2Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
3Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
4Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
5iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
6Institute For Molecular Medicine Finland (FIMM), Helsinki, Finland
7Finnish Red Cross Blood Service, Helsinki, Finland
8Helsinki University Central Hospital Hospital for Children and Adolescents, Helsinki, FIN
9Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital, Nantes, France
10MediCity Research Laboratory, Department of Microbiology and Immunology, University of Turku, Turku, Finland
11Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH
12Institute for Cancer Research, Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway
13Centre for Biostatistics and Epidemiology (OCBE), Faculty of Medicine, University of Oslo, Oslo, Norway
14Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland
15Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom
16ICAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland

3:00 PM

Ammelie Svea Boje1*, Anna Langner, PhD1*, Carina Lynn Gehlert, PhD1*, Carmen Reitinger, PhD2*, Falk Nimmerjahn, PhD2*, Eva Maria Murga Penas, PhD3*, Sonja Bendig4,5*, Guranda Chitadze, MD, PhD4,5*, Monika Brüggemann, MD5,6*, Katharina Diemer, MD1*, Alexander Jochimsen1*, Dorothee Winterberg, PhD1*, Natalie Baum, PhD1*, Steffen Krohn1*, Thomas Valerius, MD5,7*, Friedrich Stölzel7*, Martin Gramatzki, MD1, Katja Klausz, PhD1,5*, Christian Kellner, PhD8* and Matthias Peipp, PhD1,5*

1Division of Antibody-Based Immunotherapy, Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
2Division of Genetics, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
3Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany, Kiel, Germany
4Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
5Clinical Research Unit CATCH ALL (KFO 5010/1) funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
6Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein, Kiel, Germany
7Division of Stem Cell Transplantation and Cellular Immunotherapies, University Hospital Schleswig-Holstein, Kiel, Germany
8Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, LMU University Hospital, LMU Munich, Munich, Germany

3:15 PM

Fuguo Liu1,2*, Mubin Tarannum, PhD1*, Yingjie Zhao3*, Yiming J Zhang2*, James Dongjoo Ham4*, Kewen Lei2*, Yuhao Qiang2*, Xingyu Deng1*, Maily Nguyen1*, Dinh Khanhlinh1*, Shaobo Yang1*, Alaa Kassim Ali, PhD1, Grace Caroline Birch, PhD1*, Yuwen Yin2*, Junru Cui2*, Fangfeng Yuan2*, Jerome Ritz, MD1, Jianzhu Chen2* and Rizwan Romee, MD1,5,6

1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
2Koch Institute For Integrative Cancer Research at MIT, Cambridge, MA
3Koch Institute For Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA
4Massachusetts Institute of Technology, Koch Institute For Integrative Cancer Research, Cambridge, MA
5Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
6Brigham & Women's Hospital, Boston, MA

3:30 PM

Tom Leedom1*, Basia Muz, PhD, MSc2*, Kristann Magee2*, Jayakumar Vadakekolathu, PhD3*, Laura Arthur, PhD4*, Melissa Tran, MSc1*, Lena Luukkonen, BS1*, Nitin Mahajan, PhD, MSc, MS5*, Alexander Hamil, PhD1*, John Muth, MSc6*, Melissa M Berrien-Elliott, PhD7*, Todd A Fehniger8, Sergio Rutella, MD, PhD, FRCPath9 and Jan K Davidson-Moncada, MD, PhD, MSc10

1Wugen, San Diego
2Wugen, St Louis
3John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom
4Wugen, Saint Louis, MO
5Wugen, St Louis, MO
6Wugen, St. Louis, MO
7St Louis University, St Louis
8Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
9John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, ENG, United Kingdom
10Wugen, Washington, DC

3:45 PM

Jieun Jang, MD, PhD1,2, Mila Stanojevic1*, Sara Piccinelli, MD, PhD1*, Michal Sheffer, PhD1*, Grace Caroline Birch, PhD1*, Roman M. Shapiro, MD1, Maximilian Stahl, MD3, John Koreth, MD, MBBS, PhD, DPhil1, Catherine J. Wu, MD4*, Robert J. Soiffer, MD5, Jerome Ritz, MD1, Mubin Tarannum, PhD4* and Rizwan Romee, MD1

1Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
2Yonsei University College of Medicine, Seoul, South Korea
3Dana Farber Cancer Institute, Boston, MA
4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
5Dana-Farber Cancer Inst., Boston, MA

4:00 PM

Gordon Victor Hoffmann1*, Adrian Gottschlich, MD1,2,3,4*, Johannes Sam, PhD5*, Samuel Gebhardt5*, Lisa Rohrbacher, MSc2,6*, Sayantan Nandi, PhD1*, Emanuele Carlini1*, Tobias Herold, MD2,3, Michael von Bergwelt-Baildon, MD, PhD2,4,7*, Stefan Endres, MD, Prof1,3,8*, Marion Subklewe, MD3,4,6,9, Peter Bruenker, PhD5*, Christian Klein, PhD5 and Sebastian Kobold, MD1,3,8*

1Division of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany
2Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
3German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
4Bavarian Cancer Research Center (BZKF), Munich, Germany
5Roche Innovation Center Zürich, Pharma Research & Early Development, Zurich, Switzerland
6Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany
7germ, Munich, Germany
8Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany
9Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany

*signifies non-member of ASH