66th ASH Annual Meeting: 701. Experimental Transplantation: Basic and Translational: GVHD, Mucosal Immunology and the Microbiome

Symposia: Experimental Transplantation: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Apoptosis, Adult, Translational Research, Bioinformatics, GVHD, Immune mechanism, Diseases, Immune Disorders, Immunology, Metabolism, Computational biology, Biological Processes, Microbiome, Technology and Procedures, Study Population, Human, Animal model, Omics technologies

Room 6B (San Diego Convention Center)

Moderators:

Mary Mansour Riwes, DO, University of Michigan and Daigo Hashimoto, MD, Hokkaido University

Disclosures:

Hashimoto: Astellas Pharma Inc. Japan: Honoraria; Janssen Pharmaceutical K.K.: Honoraria; Nippon Kayaku Co.,Ltd.: Honoraria; Novartis Japan: Honoraria; Eisai Co., Ltd.: Honoraria; Daiichi Sankyo Co., Ltd.: Honoraria; Chugai Pharmaceutical Co., Ltd.: Honoraria.

2:00 PM

259

Increased Fiber Intake Results in Better Overall Survival and Lower GI-aGVHD in Allo-HCT Recipients and Pre-Clinical Gvhd Models

Jenny Paredes, PhD¹, Teng Fei, PhD²^*, Anqi Dai, MS³^*, Ruben Ramos, PhD³^*, Peter Adintori, MS³^*, Anastasia Kousa, PhD⁴^*, Chi L Nguyen, PhD⁴^*, Kristen Victor³^*, Romina Ghale³^*, Charlotte Pohl, BA³^*, Harold K Elias, MD^3,5, Oriana Miltiadous, MD³^*, Sebastien Monette⁶^*, Ana Gradissimo, PhD³^*, Justin Cross, PhD³^*, Jonathan U. Peled, MD, PhD⁷, Marina Burgos da Silva, PhD⁸^* and Marcel R.M. van den Brink, MD, PhD¹

¹Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
²Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
³Memorial Sloan Kettering Cancer Center, New York, NY
⁴City of Hope National Medical Center, Duarte, CA
⁵National Institutes of Health, Bethesda, MD
⁶MSKCC, New York, NY
⁷Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York

2:15 PM

260

Gvhd-Induced Inflammatory Memory in Intestinal Stem Cells Enhances IFN-γ-Induced Antigen Presentation and Apoptosis of Intestinal Epithelial Cells

Toru Miyajima, MD¹^*, Daigo Hashimoto, MD, PhD²^*, Keisuke Kojima, MD²^*, Shihori Tsukamoto, MD²^*, Tomoe Ichiki, MD²^*, Yumika Saito, MD²^*, Wenyu Li²^*, Zixuan Zhang²^*, Shinpei Harada, MD²^*, Hajime Senjo, MD², Yuki Yokoi, PhD³^*, Yuta Hasegawa, MD, PhD²^*, Hiroyuki Ohigashi, MD, PhD²^*, Takahide Ara, MD, PhD²^*, Kiminori Nakamura, PhD³^*, Koji Taniguchi, MD, PhD⁴^* and Takanori Teshima, MD, PhD²

¹Department of Hematology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, HOK, Japan
²Department of Hematology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan
³Innate Immunity Laboratory, Hokkaido University Faculty of Advanced Life Science, Sapporo, Japan
⁴Department of Pathology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan

2:30 PM

261

An Interleukin 27 Dependent Lysosomal Thiol Reductase Regulates Regulatory T Cell Survival and Mitochondrial Fitness during Graft Versus Host Disease

Jonathan Florentin, PhD^*, Alison Moe, PhD^*, Ravi K Shah, PhD^*, Jacek Zielonka, PhD^*, Mark Castleberry, PhD, Alex Myers, BA^*, Marlenny Vargas-Cortes, BS^*, Jessica L Schmeling, BS^*, Anthony E Zamora, PhD^* and William R Drobyski, MD

Medical College of Wisconsin, Milwaukee, WI

2:45 PM

262

Stabilization of HIF-1α By the Prolyl Hydroxylase Inhibitor Roxadustat Reduces Gastrointestinal Graft-Versus-Host Disease

Vasantharaja Raguraman, PhD¹^*, Shanid Mohiyuddin, PhD¹^*, Catherine Benge, MD²^*, Linnea Banker, MD²^*, Tyler Plank¹^*, Richard D Hammer, MD²^*, Senthilnathan Palaniyandi, PhD¹^* and Gerhard C Hildebrandt, MD¹

¹Department of Medicine, Ellis Fischel Cancer Center, University of Missouri, Columbia, MO
²Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, MO

3:00 PM

263

Targeting the Hypoxic Microenvironment in Cutaneous Chronic Graft-Versus-Host Disease through PI3Kδ Inhibition

Yuxi Xu, MS^1,2^*, Ziyi Hu^2,3^*, Guancui Yang³^*, Yuxuan He³^*, Qing Xu³^*, Ya Zhou³^*, Qi Wang³^*, Xiaodong Xie³^*, Rui Wang³^*, Shijie Yang, PhD³^*, Xiaoqi Wang, MD³^*, Qingxiao Song, MD, PhD^2,3 and Xi Zhang, PhD^2,4

¹Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, AL, China
²Jinfeng Laboratory, Chongqing, China
³Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, China
⁴Medical Center of Hematology, Xinqiao Hospital of Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, China

3:15 PM

264

Immunomodulatory Microbial Metabolites Protect Against Graft-Vs-Host Disease and Enhance Anti-Leukemia Responses in Mice and Patients Receiving Stem Cell Transplantation

Sascha Göttert¹^*, Erik Thiele-Orberg²^*, Kaiji Fan¹^*, Paul Heinrich³^*, Daniel Wolff, MD⁴^*, Daniela Weber²^*, Florian Bassermann, MD⁵^*, Petra Hoffmann⁶^*, Matthias Edinger, MD⁷^*, Natalie Koehler⁸^*, André Gessner⁹^*, Wolfgang Herr, MD², Simon M Heidegger, M.D⁵^*, Ernst Holler, MD, PhD²^* and Hendrik Poeck, MD²

¹University Hospital Regensburg, Regensburg, Germany
²Internal Medicine III - Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
³University of Regensburg, Munich, Germany
⁴Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Bonn, Germany
⁵Hospital Rechts der Isar, Internal Medicine III - Hematology and Oncology, Technical University of Munich, Munich, Germany
⁶University of Regensburg, Regensburg, DEU
⁷Internal Medicine III - Hematology and Oncology, University Hospital Regensburg, Regensburg, DEU
⁸Department of Internal Medicine I, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
⁹Institute of Clinical Microbiology and Hygiene, Regensburg, DEU

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^*signifies non-member of ASH

701.O1.6 701. Experimental Transplantation: Basic and Translational: GVHD, Mucosal Immunology and the Microbiome