-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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654A.O2.6 654. Multiple Myeloma: Pharmacologic Therapies: Into the Future: New Drugs and Combinations in Multiple Myeloma

Symposia: Multiple Myeloma: Pharmacologic Therapies Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Combination therapy, Adult, Drug development, Bispecific Antibody Therapy, Elderly, Clinical Research, Plasma Cell Disorders, Diseases, Treatment Considerations, Biological therapies, Immunotherapy, Lymphoid Malignancies, Adverse Events, Study Population, Human, Measurable Residual Disease
Monday, December 9, 2024: 4:30 PM-6:00 PM
Hall B (San Diego Convention Center)
Moderators:
Alissa Visram, MD, MPH, and Hamza Sloan Hashmi, MD,
Disclosures:
Visram: GSK: Honoraria; Janssen: Honoraria, Research Funding; BMS: Honoraria, Research Funding; Forus Therapeutics: Honoraria; Amgen: Honoraria; Takeda: Honoraria; Sanofi: Honoraria.
This Session Brings Phase 1 and Phase 2 Trials Introducing Drugs with New Mechanism of Action or New Combinations Being Disclosed For the First Time in Multiple Myeloma. The Session Contains New Immunotherapy Antibodies, Combinations with Bispecific T-Cell Engagers, Combinations with New CELMoDs and First Data Disclosure of Agents Exploring New Targets in Relapsed and Refractory Multiple Myeloma.
4:30 PM

Joshua Richter, MD1, Sheeba K. Thomas, MD2, Amrita Y Krishnan, MD, FACP3, Jacob P. Laubach4*, Adam D. Cohen, MD5, Suzanne Trudel, MD, MSc6, Luciano J. Costa, MD, PhD7, Nizar J. Bahlis, MD8, Peter A. Forsberg, MD9, Rayan Kaedbey10, Rafael Fonseca, MD11, Andrew Spencer, MBBS12*, Paula Rodríguez-Otero, MD, PhD13*, Maria-Victoria Mateos, MD, PhD14, Chihunt Wong15*, James Cooper15*, Tulika Tyagi15*, Rin Nakamura15*, Voleak Choeurng15* and Alexander M. Lesokhin, MD16

1Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
2The University of Texas MD Anderson Cancer Center, Houston, TX
3Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Irvine, CA
4Dana-Farber Cancer Institute, Boston, MA
5Abramson Cancer Center and University of Pennsylvania, Philadelphia, PA
6Princess Margaret Cancer Centre, Toronto, ON, Canada
7O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
8Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada
9University of Colorado School of Medicine, Aurora, CO
10Jewish General Hospital, McGill University, Montreal, QC, Canada
11Mayo Clinic in Arizona, Phoenix, AZ
12Alfred Health-Monash University, Melbourne, VIC, Australia
13Clínica Universidad de Navarra, Pamplona, Spain
14Instituto de Investigación Biomédica de Salamanca (IBSAL), Hospital Universitario de Salamanca, Salamanca, Spain
15Genentech, Inc., South San Francisco, CA
16Memorial Sloan Kettering Cancer Center, New York, NY

4:45 PM

Sikander Ailawadhi, MD1, Asher A. Chanan-Khan, MD2, Jack Khouri, MD3, Costas K. Yannakou, MBBS, PhD4*, Zi Chen, MD, PhD5*, Yanyan Wang, MD5*, Huanshan Guo, MD6*, Hengbang Wang, PhD5*, Mingyu Li, PhD7*, Mohammad Ahmad, MD7*, Dajun Yang, MD, PhD5,7* and Yifan Zhai, MD, PhD5,6,7

1Mayo Clinic, Jacksonville, FL
2Division of Hematology-Oncology, Mayo Clinic-Florida, Jacksonville, FL
3Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
4Molecular Oncology and Cancer Immunology, Epworth HealthCare, Melbourne, VIC, Australia
5Ascentage Pharma (Suzhou) Co., Ltd., Suzhou, China
6Guangzhou Healthquest Pharma Co., Ltd., Guangzhou, China
7Ascentage Pharma Group Inc., Rockville, MD

5:00 PM

Emma Searle, MD, PhD1,2*, Victoria Campbell, MD, PhD3*, Charlotte Pawlyn, PhD4,5, Ceri Bygrave, MBBCh MRCP FRCPath6*, Sarah Gooding, MD, PhD7*, James Cavet, PhD FRCP FRCPath1*, Matthew W. Jenner8*, Vivek Radhakrishnan9*, Steve Knapper, MRCP, FRCPath, DM10*, Dima el-Sharkawi5*, Jenny O'Nions11*, Tomasz Knurowski, MD12*, Karen Clegg, PhD12*, Will Henry West, PhD, MSc, MBA12*, Debbie Haynes, BSc12*, Kris Frese, PhD12* and Tim Somervaille, PhD FRCP FRCPath1

1The Christie NHS Foundation Trust, Manchester, United Kingdom
2The Christie NHS Foundation Trust and University of Manchester, Manchester, United Kingdom
3Department of Haematology, Western General Hospital, Edinburgh, United Kingdom
4Institute of Cancer Research, Sutton, United Kingdom
5The Royal Marsden NHS Foundation Trust, London, United Kingdom
6Department of Haematology, Cardiff & Vale University Health Board, Cardiff, United Kingdom
7MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, ENG, United Kingdom
8University Hospital Southampton, Southampton, United Kingdom
9University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
10Cardiff University School of Medicine, Cardiff, United Kingdom
11Department of Haematology, University College London Hospital, London, United Kingdom
12CellCentric Ltd, Cambridge, United Kingdom

5:15 PM

Michael H. Tomasson1*, Eli Gabayan2*, Syed Abbas Ali3, Gabriel Afram4*, Sona Ghorashi5*, Trish Creel5*, Luisa Paccagnella6*, Carolyn Lou5* and Ola Landgren7

1Department of Internal Medicine, University of Iowa, Iowa City, IA
2Beverley Hills Cancer Center, Beverly Hills, CA
3Department of Oncology, The Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
4Pfizer Inc, Solna, Sweden
5Pfizer Inc, New York, NY
6Pfizer Inc, Cambridge, MA
7Sylvester Comprehensive Cancer Center, Miami, FL

5:30 PM

Irwindeep Sandhu, MD1*, Paul G. Richardson2, Albert Oriol3*, Darrell White4, Richard Leblanc, MD, FRCPC5, Noopur Raje6, Enrique M. Ocio7, Aurore Perrot, MD, PhD8, Thierry Facon9*, Cesar Rodriguez, MD10*, Ralph Wäsch11, Meletios A. Dimopoulos, MD12, Tracy T. Chow13*, Allison Gaudy13*, Jing Gong13*, Zehua Zhou13*, Tiziana Civardi14*, Joseph T. Hadala13*, Yue Zhu13*, Jessica Katz13 and Marc S. Raab15*

1University of Alberta, Edmonton, AB, Canada
2Dana-Farber Cancer Institute, Boston, MA
3Catalan Institute of Oncology and Josep Carreras Institute, Hospital Germans Trias i Pujol, Badalona, Spain
4Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada
5Hôpital Maisonneuve-Rosemont, Université de Montréal, Montreal, Canada
6Massachusetts General Hospital, Boston, MA
7Hospital Universitario Marqués de Valdecilla (IDIVAL), Universidad de Cantabria, Santander, Spain
8Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
9Centre Hospitalier Universitaire (CHU) Lille, Service des Maladies du Sang, University of Lille, Lille, France
10Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
11Department of Medicine, University of Freiburg Medical Center, Freiburg, Germany
12National and Kapodistrian University of Athens, Athens, Greece
13Bristol Myers Squibb, Princeton, NJ
14Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
15Heidelberg Myeloma Center, Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany

5:45 PM

Hang Quach, MD, FRACP, FRCPA, MBBS1, Bradley Augustson, MBBS, FRACP, FRCPA2*, Hanlon Sia, MBBS FRACP FRCPA3*, Nishi Shah, MBBS, MPH4, Eben I Lichtman, MD5, Michaela Liedtke, MD6, Camille Martinet7*, Vinu Menon8*, Andrew Garton, PhD9*, Maria Pihlgren10*, Beata Holkova, MD11, Cyril Konto, MD8, Lida Pacaud, MD12* and Amit Khot, MD, FRACP, FRCPath, MBBS, MRCP13*

1St. Vincent's Hospital Melbourne, East Melbourne, Australia
2Sir Charles Gairdner Hospital and Linear Clinical Research, Perth, Western Australia, Australia
3Pindara Private Hospital, Gold Coast, Australia
4Montefiore Einstein Comprehensive Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
5Division of Hematology, University of North Carolina School of Medicine, Durham, MA
6Stanford University Cancer Center, Stanford, CA
7Medqualis, Montreal, Canada
8Ichnos Sciences, New York, NY
9Ichnos Sciences Inc., New York
10Ichnos Sciences SA, Epalinges, Switzerland
11Ichnos Sciences Inc, New York
12Ichnos Sciences Inc., New York, NY
13Peter MacCallum Cancer Center, Melbourne, VIC, AUS

*signifies non-member of ASH