-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

653.O1.6 653. Multiple Myeloma: Clinical and Epidemiological: Advancing Minimal Residual Disease (MRD): Detection, Impact on Prognosis and Treatment Decisions

Symposia: Multiple Myeloma: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Combination therapy, Adult, Epidemiology, Translational Research, Elderly, Clinical Research, Plasma Cell Disorders, Diseases, Treatment Considerations, Biological therapies, Real-world evidence, Lymphoid Malignancies, Monoclonal Antibody Therapy, Technology and Procedures, Study Population, Human, Measurable Residual Disease , Molecular testing
Saturday, December 7, 2024: 4:00 PM-5:30 PM
San Diego Ballroom AB (Marriott Marquis San Diego Marina)
Moderators:
Jean-Sébastien Claveau, MD, and Moshe E Gatt, MD, Hadassah-Hebrew University Medical Center
Disclosures:
No relevant conflicts of interest to declare.

The oral session focuses on the role of measurable residual disease (MRD) in the management of multiple myeloma (MM). This session explores various aspects, including the potential to discontinue lenalidomide maintenance therapy after sustained MRD negativity, the implications of MRD progression following quadruplet therapy and ASCT which has not been reported before, and the impact of MRD on progression-free survival in newly diagnosed patients. In addition, the session also examines the clinical significance of peripheral residual disease beyond conventional MRD measurements in the bone marrow; the use of single-cell whole-genome sequencing to study circulating tumor cells in relapsed/refractory MM, and the utility of soluble B-cell maturation antigen levels for monitoring disease in oligo- and non-secretory MM. Collectively, these studies highlight advancements in understanding MRD and its potential as a key marker for guiding treatment strategies and improving patient outcomes in multiple myeloma.
4:00 PM

Panagiotis Malandrakis, MD1*, Ioannis Ntanasis-Stathopoulos, MD, PhD, MSc1*, Ioannis V Kostopoulos, PhD2*, Vasiliki Spiliopoulou, MD1*, Despina Fotiou, MD1*, Foteini Theodorakakou, MD1*, Magdalini Migkou, MD1*, Nikolaos Kanellias1*, Evangelos Eleutherakis-Papaiakovou, MD1*, Efstathios Kastritis, MD1*, Maria Gavriatopoulou1*, Ourania Tsitsilonis, MD, PhD2*, Meletios Dimopoulos, MD1 and Evangelos Terpos, MD, PhD1

1Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
2Department of Biology, School of Science, National and Kapodistrian University of Athens (NKUA), Athens, Greece

4:15 PM

Sonja Zweegman, MD, PhD1, Thierry Facon, MD2, Vania Hungria, MD, PhD3, Nizar J. Bahlis, MD4, Christopher P. Venner, MD5,6, Marc Braunstein7*, Luděk Pour, MD8*, Josep Marti Tutusaus9*, Supratik Basu, MBBS, MD, FRCP, FRCPath10*, Yael C. Cohen11, Morio Matsumoto12*, Kenshi Suzuki, MD, PhD13, Cyrille Hulin, MD14*, Sebastian Grosicki, MD, PhD15*, Wojciech Maciej Legiec, MD16*, Meral Beksac17*, Angelo Maiolino, MD, PhD18*, Hiroyuki Takamatsu, MD, PhD19, Aurore Perrot, MD, PhD20, Mehmet Turgut, MD21*, Weiping Liu22*, Jianping Wang23*, Katherine Chastain, MD23, Jessica Vermeulen, MD, PhD24, Maria Krevvata, PhD23*, Lorena Lopez-Masi25*, Jodi Carey, BSN, RN23*, Melissa Rowe26*, Robin Carson, MD23 and Saad Z. Usmani, MD27

1Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands
2University of Lille, CHU Lille, Service des Maladies du Sang, Lille, France
3Clinica São Germano, São Paulo, Brazil
4Arnie Charbonneau Cancer Research Institute, University of Calgary, Calgary, Canada
5Department of Medical Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada
6BC Cancer – Vancouver Centre, University of British Columbia,, Vancouver, BC, Canada
7Department of Medicine, Division of Oncology-Hematology, NYU Long Island School of Medicine, Perlmutter Cancer Center, NYU Langone Hospital-Long Island, Mineola, NY
8University Hospital Brno, Brno, Czech Republic
9Hospital Mútua de Terrassa, Barcelona, Spain
10Royal Wolverhampton NHS Trust and University of Wolverhampton, CRN West Midlands, NIHR, Wolverhampton, United Kingdom
11Department of Hematology, Tel-Aviv Sourasky (Ichilov) Medical Center, and Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
12Department of Hematology, National Hospital Organization Shibukawa Medical Center, Gunma, Japan
13Japanese Red Cross Central Medical Center, Shibuya, Tokyo, Japan
14Hôpital Haut Lévêque, University Hospital, Pessac, France
15Department of Hematology and Cancer Prevention in Chorzów, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, Katowice, Poland
16Department of Hemato-Oncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland
17Ankara Liv Hospital, Istinye University, Ankara, Turkey
18Instituto Americas de Ensino, Pesquisa e Inovação, Rio de Janeiro, Brazil
19Department of Hematology, Kanazawa University Hospital, Kanazawa University, Kanazawa, Japan
20CHU de Toulouse, IUCT-O, Université de Toulouse, UPS, Service d’Hématologie, Toulouse, France
21Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey
22Janssen Research & Development, LLC, Shanghai, China
23Janssen Research & Development, LLC, Spring House, PA
24Janssen Research & Development, LLC, Leiden, Netherlands
25Janssen Research & Development, LLC, Raritan, NJ
26Janssen Research & Development, High Wycombe, United Kingdom
27Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

4:30 PM

Luciano J. Costa, MD, PhD1, Eva Medvedova, MD2*, Binod Dhakal, MBBS3, Bhagirathbhai R. Dholaria, MBBS4, Smith Giri5*, Saurabh Chhabra, MD6*, Susan Bal, MD7, Kelly Godby5*, Gayathri Ravi, MD7, Rebecca W. Silbermann8 and Natalie Callander, MD9

1Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Vestavia, AL
2Knight Cancer Institute, Oregon Health & Science University, Portland, OR
3Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
4Vanderbilt University Medical Center, Nashville, TN
5University of Alabama at Birmingham, Birmingham, AL
6Mayo Clinic, Phoenix, AZ
7Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
8Oregon Health and Science University, Portland, OR
9University of Wisconsin, Carbone Cancer Center, Madison, WI

4:45 PM

Elias K. Mai, MD1*, Hans Salwender, MD2*, Michael Hundemer, MD3*, Uta Bertsch, MD4*, Ema Pozek5*, Axel Benner6*, Roland Fenk, MD, PhD7*, Britta Besemer, MD8*, Christine Hanoun9*, Roland Schroers, MD10*, Ivana von Metzler, MD11*, Mathias Hänel, MD12, Christoph Mann, MD13*, Lisa Leypoldt, MD14*, Bernhard Heilmeier15*, Stefanie Huhn, PhD16*, Sabine Vogel, PhD17*, Christof Scheid18*, Igor Wolfgang Blau, MD, PhD19*, Steffen Luntz, MD20*, Niels Weinhold, PhD21*, Tobias A.W. Holderried, MD22*, Karolin Trautmann-Grill23*, Deniz Gezer, MD24*, Maika Klaiber-Hakimi25*, Martin Mueller, MD26*, Evgenii Shumilov27*, Wolfgang Knauf, MD28*, Christian Sebastian Michel, MD29*, Thomas Geer, MD30, Hendrik Riesenberg31*, Christoph Lutz32*, Marc S. Raab21*, Martin Hoffmann33*, Katja C. Weisel, MD34 and Hartmut Goldschmidt, MD21

1Medicine V, University Hospital Heidelberg, Heidelberg, Germany
2Asklepios Tumorzentrum Hamburg, Asklepios Hospital Hamburg Altona and St. Georg, Hamburg, Germany
3Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
4Internal Medicine V, Hematology, Oncology and Rheumatology, GMMG Studygroup, Heidelberg University Hospital, Heidelberg, Germany
5German Cancer Research Center, Heidelberg, DEU
6Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
7Department of Haematology, Oncology, and Clinical Immunology, University Hospital Düsseldorf, Düsseldorf, Germany
8Department of Internal Medicine II, University Hospital Tübingen, Tübingen, Germany
9Department of Hematology and Stem Cell Transplantation, West German Cancer Center and German Cancer consortium (DKTK partner site Essen), University Hospital Essen, University of Duisburg-Essen, Essen, Germany
10Knappschaftskrankenhaus Bochum, University Hospital Bochum, Bochum, Germany
11Department of Medicine II – Hematology and Oncology, Goethe-University Frankfurt, University Hospital, Frankfurt am Main, Germany
12Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany
13Department of Haematology, Oncology and Immunology, Philipps-University Marburg, Marburg, Germany
14University Medical Center Hamburg Eppendorf, Hamburg, Germany
15Clinic for Oncology and Hematology, Hospital Barmherzige Brueder Regensburg, Regensburg, Germany, Regensburg, DEU
16Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
17Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Germany
18Cologne University Hospital, Cologne, Germany
19Medizinische Klinik m. S. Hämatologie , Onkologie und Tumorimmunologie, Berlin, Germany, Berlin, Germany
20Coordination Centre for Clinical Trials (KKS), Heidelberg, Germany
21Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany
22Universitaetsklinikum Bonn (UKB), Bonn, Germany
23University Hospital Carl Gustav Carus, Dresden, Germany
24Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, DEU
25Clinic for Hematology, Oncology and Palliative Care, Marien Hospital Düsseldorf, Düsseldorf, Germany, Duesseldorf, DEU
26Klinikum Siloah Hannover, Hannover, Germany, Hannover, AL, DEU
27Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany
28Center for Hematology and Oncology, Bethanien, Frankfurt a.M., Germany, Frankfurt a.M., Germany
29Department of Internal Medicine III, University Hospital Mainz, Mainz, Germany
30Medizinische Klinik Schwäbisch-Hall, Schwabisch Hall, DEU
31Hematology / Oncology Center, Bielefeld, Germany, Bielefeld, Germany
32Hematology / Oncology Center, Koblenz, Germany, Koblenz, Germany
33Medical Clinic A, Clinic Ludwigshafen, Ludwigshafen, Germany, Ludwigshafen, Germany
34Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

5:00 PM

Noemi Puig, PhD1,2, Bruno Paiva, PhD3,4,5*, María T Cedena6*, Cristina Agullo7*, Teresa Contreras7*, Sergio Castro2*, Ana Maria Sureda Balari, MD, PhD8,9,10,11,12,13,14,15,16,17,18,19, Veronica Gonzalez-Calle, MD, PhD20*, Albert Oriol21,22,23,24*, Enrique M Ocio, MD, PhD25*, Laura Rosiñol Dachs26,27,28,29*, Yolanda González-Montes, MD, PhD30,31*, Joan Bargay32*, Esther González García, MD, PhD33*, Miguel Teodoro Hernández Garcia, MD, PhD34*, Angel Ramirez, MD, PhD35,36*, Alexia Suarez-Cabrera, MD, PhD37*, María-Jesús Blanchard, MD, PhD38*, Sebastián Garzón, MD, PhD39*, Luis Felipe Casado Montero40*, Valentin Cabanas Perianes, MD, PhD41*, Jaime Perez de Oteyza42*, Mercedes Gironella, MD43*, Joaquín Martínez-Lopez44,45*, Pilar Delgado, MD, PhD46*, Elena Prieto, MD, PhD47*, Juan-Jose Lahuerta Palacios, MD, PhD48*, Joan Bladé, MD, PhD49,50,51*, Jesús F. San-Miguel, MD, PhD52,53,54 and Maria- Victoria Mateos1,55,56,57,58,59

1Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC), CIBERONC, Salamanca, Spain, Salamanca, Spain
2Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), University of Salamanca, Salamanca, Spain
3Clínica Universidad de Navarra. Centro de Investigación Médica Aplicada., Pamplona, Spain
4Cancer Center Clinica Universidad de Navarra (CCUN)., Pamplona, Spain
5Clinica Universidad de Navarra (CCUN), Center for Applied Medical Research (CIMA), IDISNA, CIBER-ONC, Pamplona, Spain
6University Hospital 12 de octubre, Madrid, Spain
7Biochemistry Department, University Hospital of Salamanca, Salamanca, ESP
8Grupo Español de Trasplante Hematopoyético y Terapia Celular (GETH-TC), Spain, Spain
9Hospital Duran i Reynals, Barcelona, Spain
10Clinical Hematology Department, Institut Català d'Oncologia-L'Hospitalet, IDIBALL, Universitat de Barcelona, Barcelona, Spain
11Hospital de Sant Pau, Hematology Department, Autonomous University of Barcelona, Barcelona, Spain
12Blood Cell Barcelona Hematology Institute, Barcelona, Spain
13Clinical Hematology Department, Institut Català d’Oncologia-Hospitalet, IDIBELL, Barcelona, Spain
14Grupo Español de Trasplante Hematopoyético y Terapia Celular (GETH-TC), Madrid, Spain
15Bellvitge Health Sciences Campus, University of Barcelona, Barcelona, Spain
16EBMT Lymphoma Working Party, Paris, France
17Clinical Hematology Department, Institut Català d’Oncologia – L’Hospitalet, IDIBELL, Universitat de Barcelona, Barcelona, Spain
18Lymphoma Working Party, European Society for Blood and Marrow Transplantation, Paris, France
19Spanish CETLAM group, Spain, Spain
20Haematology Department, University Hospital of Salamanca, Research Biomedical Institute of Salamanca (IBSAL), CIBERONC and Center for Cancer Research-IBMCC (USAL-CSIC), Salamanca, Spain
21Dana-Farber Cancer Institute, Boston, MA
22Institut Josep Carreras and Institut Català d'Oncologia, Hospital Germans Trias i Pujol, Barcelona, Spain
23Institut Català d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Baldona, Barcelona, Spain
24Catalan Institute of Oncology and Josep Carreras Institute, Hospital Germans Trias i Pujol, Badalona, Spain
25Hospital Universitario Marqués de Valdecilla (IDIVAL), Universidad de Cantabria, Santander, Spain
26Hematopoietic Cell Transplantation Unit, Hospital Clínic de Barcelona, ICHMO, Barcelona, Spain
27Hematology Department, Hospital Clinic de Barcelona and Insitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
28Amyloidosis and Multiple Myeloma Unit, Department of Hematology, IDIBAPS, Hospital Clinic, Barcelona, Spain
29Hospital Clinic de Barcelona and Insitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
30Hematology, Institut d'Oncologia Dr. Josep Trueta, Girona, Spain
31Institut Català d'Oncologia Girona, Girona, Spain
32Hematology Department, Hospital Universitario Son Llàtzer. IdIsBa., Palma de Mallorca, Spain
33Hematology, University Hospital Cabueñes, Gijón, Spain
34Hospital Universitario de Canarias, La Laguna, ESP
35Hematology, Hospital Central de Asturias, Oviedo, Spain
36Servicio de Hematología, Hospital Universitario Central de Asturias, Oviedo, Spain
37Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas De Gran Canaria, Spain
38Hematology, Hospital Universitario Ramón y Cajal, Madrid, Spain
39Hematology, Hospital Universitario Jerez de la Frontera, Jerez de la Frontera, Cádiz, Spain
40Hematology, Hospital General Universitario de Toledo, Toledo, Spain
41Hematology, IMIB-Virgen de la Arrixaca University Hospital, University of Murcia, El Palmar, Murcia, Spain
42Universidad CEU San Pablo, Madrid, Spain
43Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain
44University of Complutense, Hospital 12 de Octubre, Madrid, Spain
45Department of Hematology, Hospital Universitario 12 de Octubre, CNIO, Universidad Complutense de Madrid, Madrid, Spain
46Hematology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain
47Hematology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
48Hematology, Hospital Universitario 12 de Octubre, Imas12, CIBERONC, Madrid, Spain
49Amyloidosis and Multiple Myeloma Unit, Department of Hematology, IDIBAPS, Hospital Clinic, Spain, Barcelona, Spain
50Hospital Clinic, IDIBAPS, Barcelona, Spain
51Hematology, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona; and GEM/PETHEMA, Barcelona, Spain
52Hemato-Oncology Program. Cima Universidad de Navarra. IdiSNA., Pamplona, Spain
53Hematology and Cell Therapy Department. Clinica Universidad de Navarra. IdiSNA., Pamplona, Spain
54Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Universidad de Navarra, CCUN, IDISNA, CIBER-ONC, Pamplona, Spain
55Instituto de Investigación Biomédica de Salamanca (IBSAL), Hospital Universitario de Salamanca, Salamanca, Spain
56Institute of Cancer Molecular and Cellular Biology, University Hospital of Salamanca, Salamanca, Spain
57University of Salamanca, Department of Medicine, Salamanca, Spain
58Complejo Asistencial Universitario de Salamanca/IBSAL/CIC/CIBERONC, Salamanca, Spain
59Centro de Investigacion Biomedica en Red de Cancer (CIBERONC)., Madrid, Spain

5:15 PM

Daisuke Ikeda, M.D.1,2*, Shuichi Aikawa3*, Chiho Misono3*, Mitsuaki Oura, M.D.4*, Fuminari Fujii, M.D.4*, Hajime Sakuma, M.D.4*, Masanori Toho, MD4*, Atsushi Uehara5*, Rikako Tabata, M.D.4*, Kentaro Narita, M.D.4*, Masami Takeuchi, M.D.4*, Tomohisa Watari3*, Yoshihito Otsuka, Ph.D.3* and Kosei Matsue, M.D., Ph.D.4

1Division of Hematology/Oncology, Kameda Medical Center, Kamogawa, Japan
2Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
3Department of Laboratory Medicine, Kameda Medical Center, Chiba, Japan
4Division of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan
5Division of Hematology/Oncology, Kameda Medical Center, Kamogawa-Shi, Japan

*signifies non-member of ASH