-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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Ticketed Session denotes that this is a ticketed session.

651.O2.6 651. Multiple Myeloma and Plasma Cell Dyscrasias: Basic and Translational: Genomic and Epigenomic Insights into Myeloma Outcomes

Symposia: Multiple Myeloma and Plasma Cell Dyscrasias: Basic and Translational Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Fundamental Science, Adult, Translational Research, Bispecific Antibody Therapy, Plasma Cell Disorders, Genomics, Bioinformatics, Clinical Research, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Diseases, Immunology, Treatment Considerations, Biological therapies, Lymphoid Malignancies, Computational biology, Biological Processes, Technology and Procedures, Molecular biology, Profiling, Human, Study Population, Measurable Residual Disease , Omics technologies
Saturday, December 7, 2024: 2:00 PM-3:30 PM
San Diego Ballroom AB (Marriott Marquis San Diego Marina)
Moderators:
Leo Rasche, MD, Department of Internal Medicine II, University Hospital Wurzburg and Mark Bustoros, MD, Weill Cornell Medicine/New York Presbyterian Hospital
Disclosures:
Rasche: Amgen: Honoraria; BMS: Honoraria; GSK: Honoraria; Janssen: Honoraria; Skyline Dx: Research Funding; Pfizer: Honoraria. Bustoros: Menarini: Consultancy; Karyopharm: Consultancy; Epizyme: Consultancy; Takeda: Consultancy; BMS: Consultancy; Janssen: Consultancy.
2:00 PM

Francesco Maura, MD1, Ciara Louise Freeman, PhD, MSc, FRCPC, MRCP2, Holly Lee3*, Kylee H Maclachlan, PhD, BSc, FRACP, FRCPA4, Michael Durante, MD, PhD5*, Bachisio Ziccheddu1*, Meghan Menges2*, Benjamin Diamond, M.D.1*, Marios Papadimitriou1*, Ariosto Siqueira Silva, PhD2*, Praneeth Reddy Sudalagunta, PhD2*, Noemie Leblay, PhD3*, Sungwoo Ahn, PhD6*, Ethan Fuller7*, Edward Briercheck7*, Phaedra Agius2*, Doris K. Hansen, MD2, Xiaofei Song, PhD8*, Xiaohong Zhao, MD, PhD2*, Mark B. Meads, PhD2*, Jamie Teer2*, Ross S Firestone, MD, PhD4, Juan-Jose Garces, PhD4*, Tomas Jelinek9, Rachid Baz, MD2, Melissa Alsina, MD2*, Anusuyam Ramasubramanian7*, Eric Smith, MD, PhD7, Sergio Giralt, MD4, Sham Mailankody, MD, MBBS10, Paola Neri, MD, PhD3, Saad Z. Usmani, MD11, Frederick Locke, MD12, Nizar J. Bahlis, MD3, Ola Landgren1 and Kenneth H. Shain, MD, PhD2

1University of Miami, Miami
2Moffitt Cancer Center, Tampa, FL
3Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Canada
4Memorial Sloan Kettering Cancer Center, New York
5Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
6Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada
7Dana Farber Cancer Institute, Boston
8Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
9Department of Hematooncology, University Hospital Ostrava, Ostrava, Ostrava-Mesto, Czech Republic
10Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York
11Memorial Sloan Kettering Cancer Center, New York, NY
12Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL

2:15 PM

Kylee H Maclachlan, PhD, BSc, FRACP, FRCPA1, Juan-Jose Garces, PhD2*, Tala Shekarkhand, MS3*, Sridevi Rajeeve, MD1*, Hamza Sloan Hashmi, MD3*, Hani Hassoun, MD3, Malin Hultcrantz, MD3, Neha Korde, MD3, Carlyn Rose Tan, MD1, Sham Mailankody, MD, MBBS3, Anish Simhal, PhD4*, David J. Chung, MD, PhD5, Gunjan L. Shah, MD6, Michael Scordo, MD7, Sergio Giralt, MD8, Alexandra Maria Poos, PhD9*, Lukas John, MD10*, Yanming Zhang, MD11, Robert Cimera, MS12*, Maria E. Arcila, M.D.13*, Juan E Arango Ossa14*, Umesh Bhanot, MD15*, Mala Jain, MD16*, Tala Merghoub, MD17*, Heather J. Landau, MD6, Alexander M. Lesokhin, MD1, Saad Z. Usmani, MD3, Niels Weinhold, PhD18*, Francesco Maura, MD19 and Urvi A. Shah, MD3

1Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
2Memorial Sloan Kettering Cancer Center, New York
3Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
4Medical Physics Department, Memorial Sloan Kettering Cancer Center, New York
5Transplant and Cellular Therapy Services, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
6Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
7Transplant and Cellular Therapy Services, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY
8Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, New York, NY
9Heidelberg Myeloma Center, Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
10Heidelberg Myeloma Center, Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
11Cytogenetics Laboratory, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
12Cytogenetics Laboratory, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY
13Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
14Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
15Pathology Department, Memorial Sloan Kettering Cancer Center, New York
16Department of Pathology, Weill Cornell Medical Center, New York
17Memorial Sloan Kettering Cancer Center, New York, NY
18Heidelberg Myeloma Center, Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany
19University of Miami, Coral Gables, FL

2:30 PM

Marcella Kaddoura, MD1, J Erin Wiedmeier-Nutor, MD, MPH2, Vikas A. Gupta, MD PhD3, Bachisio Ziccheddu4*, Suganti Shivaram, M.B.B.S5*, Hongwei Tang, PhD6*, Rodrigo Fonseca, MD7*, Michael Durante, MD, PhD8*, Shannon M Matulis, PhD9*, Tomas Jelinek, MD, PhD10*, Ola Landgren11, Constantine S Mitsiades, MD12, P. Leif Bergsagel, MD13, Esteban Braggio, PhD14, Lawrence H. Boise, PhD15, Rafael Fonseca, MD16, Shaji Kumar, MD17, Francesco Maura, MD18 and Linda B. Baughn, PhD5

1Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
2Division of Hematology, Mayo Clinic, Phoenix, AZ
3Winship Cancer Institute of Emory University, Atlanta, GA
4Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami
5Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
6Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
7Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ
8University of Miami Miller School of Medicine, Miami, FL
9Department of Hematology and Medical Oncology and the Winship Cancer Institute, Emory University, Atlanta, GA
10Department of Hematooncology, University Hospital Ostrava and Faculty of Medicine University of Ostrava, Ostrava, Czech Republic
11Sylvester Comprehensive Cancer Center, Miami, FL
12Dana-Farber Cancer Institute, Boston, MA
13Division of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ
14Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ
15Emory University, Atlanta, GA
16Division of Hematology, Mayo Clinic, Paradise Valley, AZ
17Division of Hematology, Mayo Clinic, Rochester, MN
18University of Miami, Coral Gables, FL

2:45 PM

Michael O'Dwyer, MD1, Aideen Edele Ryan, BSc, PhD1*, Aoise O'Neill1*, Catherine Guerin-Charbonnel2,3*, Soraya Wuilleme, PhD4*, Jill Corre, PharmD, PhD5*, Herve Avet Loiseau, MD, PhD5, Li Peng, PhD6*, Philippe Moreau, MD, PhD7* and Stephane Minvielle, PhD2,7*

1School of Medicine, University of Galway, Galway, Ireland
2Centre de Recherche en Cancérologie et Immunologie, 5INSERM, CNRS, Université d'Angers, Nantes, France
3Institut de Cancérologie de l’Ouest, Nantes, France
4Hematology Biology, University Hospital Hotel Dieu, Nantes, France
5Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
6Palleon Pharmaceuticals, Waltham, MA
7Department of Hematology, Nantes University Hospital, Nantes, France

3:00 PM

Benjamin G. Barwick, PhD1, Robert M Chavez2*, Doris R. Powell3*, Yu Zhang, MS4*, Mark Hamilton, MD5, Daniel Auclair, PhD6, George Mulligan, PhD5, Karen N Conneely, PhD7*, Jonathan J Keats, PhD8, Paula M Vertino, PhD, BS9*, Lawrence H. Boise, PhD2 and Sagar Lonial, MD10*

1Hematology/Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA
2Emory University, Atlanta, GA
3Department of Hematology and Medical Oncology, Winship Cancer Institute, Atlanta, GA
4Winship Cancer Institute / Hematology and Medical Oncology, Emory University, Atlanta, GA
5Multiple Myeloma Research Foundation, Norwalk, CT
6AstraZeneca, Waltham, MA
7Department of Human Genetics, Emory University School of Medicine, Atlanta, GA
8TGen, Phoenix, AZ
9University of Rochester, Rochester, NY
10Winship Cancer Institute of Emory University, Atlanta, GA

3:15 PM

Palak Bajaj1*, Ola Landgren2, Damian J. Green, MD3 and David G. Coffey, MD4

1Cancer Biology, Miller School of Medicine, University of Miami, Miami, FL
2Sylvester Comprehensive Cancer Center, Miami, FL
3Division of Transplantation and Cellular Therapy, University of Miami, Miami, FL
4Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL

*signifies non-member of ASH