-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

642.O1.6 642. Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Frontline Targeted Therapy Combinations

Symposia: Chronic Lymphocytic Leukemia: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Lymphoid Leukemias, Combination therapy, Research, Clinical trials, Adult, CLL, Translational Research, Clinical Research, Checkpoint Inhibitor, Diseases, Treatment Considerations, Biological therapies, Immunology, Lymphoid Malignancies, Biological Processes, Study Population, Human, Measurable Residual Disease
Monday, December 9, 2024: 4:30 PM-6:00 PM
Marriott Grand Ballroom 8-9 (Marriott Marquis San Diego Marina)
Moderators:
Jacob D. Soumerai, MD, Massachusetts General Hospital Cancer Center and Deborah M. Stephens, DO, Huntsman Cancer Institute
Disclosures:
Soumerai: AstraZeneca: Consultancy, Honoraria, Research Funding; TG Therapeutics: Research Funding; Beigene: Consultancy, Research Funding; BostonGene: Research Funding; Adaptive Biotechnologies: Research Funding; Bristol Myers Squibb: Consultancy; LOXO@Lilly: Consultancy; Roche/Genentech: Consultancy, Research Funding; Takeda: Research Funding; GlaxoSmithKline: Research Funding; Moderna: Research Funding.

Targeted therapy continues to make a big impact on treatment goals in patients with CLL. Various combinations and strategies for combination therapy will be presented.
4:30 PM

Jennifer R. Brown, MD, PhD1, John F. Seymour, MBBS, PhD2, Wojciech Jurczak, MD, PhD3, Andrew Aw, MD4*, Malgorzata Wach, MD5*, Arpad Illes, MD6*, Alessandra Tedeschi, MD7*, Carolyn Owen, MD8, Alan P Skarbnik, MD9, Daniel Lysak, MD10*, Ki-Seong Eom, MD, PhD11*, Martin Šimkovič, MD12*, Miguel Arturo Pavlovsky, MD13, Arnon P. Kater, MD, PhD14, Barbara F. Eichhorst, MD15, Kara Miller, MS16*, Veerendra Munugalavadla, PhD16, Ting Yu, MD16, Marianne de Borja, MS17* and Paolo Ghia, MD, PhD18,19

1Dana-Farber Cancer Institute, Boston, MA
2Peter MacCallum Cancer Centre, Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC, Australia
3Maria Sklodowska-Curie National Institute of Oncology, Kraków, Poland
4University of Ottawa, Ottawa, ON, Canada
5Medical University of Lublin, Lublin, Poland
6University of Debrecen, Debrecen, Hungary
7ASST Grande Ospedale Metropolitano Niguarda, Niguarda Cancer Center, Milano, Italy
8University of Calgary and Foothills Medical Centre, Calgary, Canada
9Novant Health Cancer Institute, Charlotte, NC
10Fakultní Nemocnice Plzen, Pilsen, Czech Republic
11Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
12Hradec Králové, University Hospital and Charles University in Prague, Hradec Kralove, Czech Republic
13FUNDALEU, Clinical Research Center, Buenos Aires, Argentina
14Amsterdam University Medical Center, Amsterdam, on behalf of HOVON, Netherlands
15University Hospital Cologne, Cologne, Germany
16AstraZeneca, South San Francisco, CA
17AstraZeneca, Mississauga, Canada
18Università Vita-Salute San Raffaele, Milano, Italy
19IRCCS Ospedale San Raffaele, Milano, Italy

4:45 PM

Lindsey Roeker, MD1, Anthony R. Mato, MD2*, Andrew D. Zelenetz, MD, PhD3, Jae H. Park, MD4, Mark Blaine Geyer, MD1, Andriy Derkach, PhD5*, David Nemirovsky5*, Prioty Islam, MD1*, Lorenzo Falchi, MD6, Maria Lia Palomba, MD3, Anita Kumar, MD3, Gilles Salles, MD, PhD3, Jennifer Kimberly Lue, MD3, Aaron D. Goldberg7, Deborah M. Stephens, DO8, Victoria Duffy6*, Gail Panton6*, Dianna Tyznar6*, Colleen Dorsey6*, Dhara Soni6*, Claire Hutzler6*, Lauren Nogan6*, Alexandra Allen6*, Tenzin Nyima6*, Thu Quynh Nguyen, BSc9*, Monica Shah, BA10*, Tamotha R Cook8*, Jennifer Abillar-Wright6*, Jamila Brutus, NP6*, Carissa Laudati, NP6*, Bejal Kikani11*, Catherine C Coombs, MD12*, Michael R. Silvestrone6*, Christopher E. Jensen8*, Bita Fakhri, MD, MPH13 and Meghan C. Thompson, MD1

1Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
2Hematology & Oncology, Cayuga Medical Center, Ithaca, NY
3Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
4Cell Therapy Service and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
5Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
6Memorial Sloan Kettering Cancer Center, New York, NY
7Department of Medicine; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
8University of North Carolina Chapel Hill, Chapel Hill, NC
9Stanford Cancer Institute, Palo Alto, CA
10Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
11UNC Chapel Hill, Chapel Hill, NC
12University of California Irvine Health, Orange, CA
13Stanford University School of Medicine, Stanford, CA

5:00 PM

Nitin Jain, MD1, Alessandra Ferrajoli, MD1, Mahesh Swaminathan, MD1, Patrick K. Reville, MD, MPH1, Jan A. Burger, MD, PhD 1, Vanthana Bharathi, MD1*, Himachandana Atluri, MD1, Hua-Jay J Cherng, MD2, Alex Bataller, MD, PhD1*, Elias Jabbour, MD1, Tapan M. Kadia, MD1, Gautam Borthakur, MD1, Koichi Takahashi, MD, PhD1, Kelly S. Chien, MD1, Musa Yilmaz, MD1*, Naveen Pemmaraju, MD1, Naval Daver, MD1, Fadi G. Haddad, MD1, Yesid Alvarado Valero, MD1, Jo Ishizawa, MD, PhD1, Guillermo Montalban-Bravo, MD1, Naveen Garg, MD3*, Hyunsoo Hwang, MS4*, Wei Qiao, PhD4*, Cameron Garcia, RN1*, Anna Evangelio, RN1*, Ana Ayala, RN1*, Deepa Sampath, PhD5, Varsha Gandhi, PhD6, Michael J. Keating, MBBS1, Hagop M. Kantarjian, MD1 and William G. Wierda1

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Division of Hematology & Oncology, Columbia University Irving Medical Center, Long Island City, NY
3Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX
4Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
5Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX
6Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX

5:15 PM

Jacob D. Soumerai, MD1, Chan Y. Cheah, MBBS DMSc2,3,4, Mary Ann Anderson, MBBS, PhD, FRACP, FRCPA5,6*, Masa Lasica, MBBS, BMedSci, FRACP, FRCPA7*, Emma Verner, MBBS8,9*, Stephen S. Opat, MBBS, FRACP, FRCPA10, Shuo Ma, MD, PhD11, Robert Weinkove, MBBS, PhD, FRACP, FRCPath12,13*, Raul Cordoba, MD, PhD14, Paolo Ghia, MD, PhD15,16, Sophie Leitch17*, David Westerman, MBBS, FRCPA, FRACP18,19, Sheel Patel20*, Yiqian Fang21*, Wei Ding20*, Haiyi Guo21* and Constantine S. Tam, MD, MBBS22

1Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA
2Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
3Medical School, University of Western Australia, Perth, Western Australia, Australia
4Linear Clinical Research, Nedlands, Western Australia, Australia
5Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
6Centre of Excellence for Cellular Immunotherapy and Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia
7St Vincent’s Hospital, Melbourne, Australia
8University of Sydney, Sydney, NSW, Australia
9Concord Repatriation General Hospital, Concord, NSW, Australia
10Lymphoma Research Group, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia
11Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL
12Te Rerenga Ora Blood and Cancer Centre, Te Whatu Ora Health New Zealand Capital Coast & Hutt Valley, Wellington, New Zealand
13Cancer Immunotherapy Programme, Malaghan Institute of Medical Research, Wellington, New Zealand
14Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
15Università Vita-Salute San Raffaele, Milano, Italy
16IRCCS Ospedale San Raffaele, Milan, Italy
17Haematology Service, Health New Zealand - Te Whatu Ora - Waitemata, Auckland, New Zealand
18University of Melbourne, Melbourne, VIC, Australia
19Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
20BeiGene USA, Inc, San Mateo, CA
21BeiGene (Shanghai) Co, Ltd, Shanghai, China
22Alfred Hospital and Monash University, Melbourne, VIC, Australia

5:30 PM

Mark-David Levin1, Sabina Kersting, MD, PhD2*, Julie Dubois, MD, PhD3*, Bronno van der Holt, PhD4,5*, Caspar da Cunha-Bang, MD, PhD6*, Doreen te Raa, MD, PhD7*, Cecile Idink, MB, PhD8*, Fransien De Boer, MD, PhD9*, Jolanda Droogendijk, MD10*, Koen de Heer, MD, PhD11*, Leonie van der Burg, MD12*, Marten R. Nijziel, MD, PhD13, Lidwine Tick, MD, PhD14*, Henriettte Levenga, MD15*, Matthijs Silbermann, MD16*, Inge Ludwig, MD, MSc17*, Aart Beeker, MD18, Mar Bellido, MD, PhD19*, Anne-Marie Van Der Kevie-Kersemaekers, PhD20*, Clemens Mellink20*, Ine Meulendijks4*, Sjoerd Zoun-van den Dool4*, Martine Abrahamse-Testroote21*, Gerben Zwezerijnen22*, Carsten Utoft Niemann, MD, PhD23* and Arnon P. Kater, MD, PhD24

1Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
2Department of Hematology, Haga Ziekenhuis, Den Haag, Netherlands
3Department of Hematology, University of Amsterdam, Amsterdam, Netherlands
4ErasmusMC, Rotterdam, Netherlands
5Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
6Department of Hematology, Rigshospitalet, Copenhagen, Denmark
7Ziekenhuis Gelderse Vallei, Ede, Netherlands
8Zorgsaam, Terneuzen, NLD
9Ikazia Hospital, Rotterdam, Netherlands
10Elisabeth Tweesteden ziekenhuis, Tilburg, NLD
11Department of Internal Medicine, Flevoziekenhuis, Almere, Netherlands
12Antonius ziekenhuis, Sneek, Netherlands
13Maxima Medical Center Eindhoven/Veldhoven, Eindhoven, Noord-Brabant, NLD
14Maxima Medisch Centrum, Eindhoven, Netherlands
15Groene Hart ziekenhuis, Gouda, Netherlands
16Ter Gooi ziekenhuis, XZ HILVERSUM, NLD
17Department of Hematology, Bernhoven Hospital, Uden, Netherlands
18Spaarne Ziekenhuis, Hoofddorp, Netherlands
19University Medical Center Groningen and University of Groningen, Groningen, Netherlands
20AmsterdamUMC, Amsterdam, NLD
21ErasmusMC, Rotterdam, NLD
22Cancer Center Amsterdam, Amsterdam UMC Radiology and Nuclear Medicine, Amsterdam, Netherlands
23Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
24Amsterdam University Medical Center, Amsterdam, on behalf of HOVON, Netherlands

5:45 PM

Patrick K. Reville, MD, MPH1, Sogand Sajedi, PhD1, Alessandra Ferrajoli, MD1, Jan A. Burger, MD, PhD 1, Michael J. Keating, MBBS1, Naveen Garg, MD2*, Qing Deng, PhD3*, Michael R. Green, PhD4, Hussein A. Abbas, MD, PhD1, William G. Wierda1 and Nitin Jain, MD1

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX
3Department of Lymphoma & Myeloma, The University of Texas at MD Anderson Cancer, Houston, TX
4Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX

*signifies non-member of ASH