Naranie Shanmuganathan, MBBS, PhD, FRACP, FRCPA^1,2,3,4, Carol Wadham^4*, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^2,5,6, Nur Hezrin Shahrin^4*, Adelina Fernandes^7*, Muneeza Maqsood^4*, Chung Hoow Kok, PhD, BSc⁴, Verity A Saunders^8*, Ilaria Stefania Pagani, PhD^8*, Rosalie Kenyon^4*, Ming Lin^4*, David M Ross, MD, PhD, FRACP, FRCPA^9*, Timothy P Hughes, MD, MBBS, FRACP, FRCPA⁶ and Susan Branford, PhD¹⁰

¹Department of Haematology, Central Adelaide Local Health Network, Adelaide, SA, Australia
²Australasian Leukaemia and Lymphoma Group (ALLG), Melbourne, Australia
³South Australian Health and Medical Research Institute, Adelaide, Australia
⁴Centre for Cancer Biology and SA Pathology, Adelaide, Australia
⁵Royal Adelaide Hospital, Adelaide, SA, Australia
⁶South Australian Health and Medical Research Institute, Adelaide, SA, Australia
⁷University of Adelaide, Adelaide, Australia
⁸Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, Australia
⁹Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia
¹⁰Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia

Fabio Stagno, MD, PhD¹, Rosalba Cucci^2*, Giovanni Marsili^3*, Fausto Castagnetti, MD, PhD⁴, Sara Galimberti, MD^5*, Barbara Izzo^6*, Federica Sorà, MD^7*, Simona Soverini, PhD⁸, Monica Messina, PhD^3*, Alfonso Piciocchi^3*, Massimiliano Bonifacio, MD^9*, Daniela Cilloni, MD^10*, Alessandra Iurlo, MD^11*, Giovanni Martinelli, M.D.¹², Gianantonio Rosti, MD^13*, Paola Fazi^3*, Marco Vignetti, MD^3*, Massimo Breccia^14*, Alessandro Allegra, MD^1* and Fabrizio Pane¹⁵

¹Hematology Section, AOU Policlinico "G. Martino", University of Messina, Messina, Italy, Messina, Italy
²GIMEMA Foundation, Roma, Italy
³GIMEMA Foundation, Rome, Italy
⁴Department of Medical and Surgical Sciences, Institute of Hematology “Seràgnoli”, University of Bologna, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
⁵Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy
⁶Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Napoli, Napoli, Italy
⁷Institute of Hematology, Policlinico Universitario A. Gemelli, “Cattolica” University, Rome, ROME, Italy
⁸Department of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Castel Maggiore, Bologna, Italy
⁹Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area, University of Verona, Verona, Italy
¹⁰SCDU Hematology and Cellular Therapies, AO Ordine Mauriziano di Torino, Torino, Italy
¹¹Hematology, Foundation IRCCS Ca’Granda Ospedale Maggiore Policlinico, Milan, Italy
¹²IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
¹³IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola (FC), Italy
¹⁴Department of Translational and Precision Medicine, Az., Hematology-Sapienza University, Rome, Italy
¹⁵Division of Hematology and Bone Marrow Transplantation, Department of Medicine and Surgery University of Naples Federico II, Napoli, Italy

Chung Hoow Kok, PhD, BSc^1,2,3, Verity A Saunders^4*, Naranie Shanmuganathan, MBBS, PhD, FRACP, FRCPA^5,6,7,8,9,10, Liu Liu^11*, Yazad Daruis Irani, BSc, MSc, PhD^11,12*, Jade Clarson^11*, Phuong Dang^4*, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^13,14,15,16, Agnes S. M. Yong, MD, PhD^5,17, Susan Branford, PhD^8,18,19, Javier Pinilla-Ibarz, MD, PhD²⁰, Richard A. Larson, MD²¹, Jorge E. Cortes, MD²², Michael J. Mauro, MD²³, James E Thompson, MD²⁴, Neil P. Shah, MD, PhD²⁵, Martha Wadleigh, MD²⁶, Ehab L. Atallah, MD²⁷, Jerald P. Radich, MD²⁸, Timothy P Hughes, MD, MBBS, FRACP, FRCPA^13,15,29,30 and David M Ross, MD, PhD, FRACP, FRCPA^{5,16,31,32,33*}

¹Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
²Centre for Cancer Biology and SA Pathology, Adelaide, Australia
³Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia
⁴Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, Australia
⁵South Australian Health and Medical Research Institute, Adelaide, Australia
⁶Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
⁷School of Medicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
⁸School of Pharmacy and Medical Science, University of South Australia, Adelaide, Australia
⁹Department of Haematology, Central Adelaide Local Health Network, Adelaide, SA, Australia
¹⁰Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia
¹¹Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia
¹²Department of Anatomical Pathology, Flinders University, Adelaide, Australia
¹³South Australian Health and Medical Research Institute, Adelaide, SA, Australia
¹⁴University of Adelaide, Adelaide, SA, Australia
¹⁵Australasian Leukaemia and Lymphoma Group (ALLG), Melbourne, Australia
¹⁶Royal Adelaide Hospital, Adelaide, SA, Australia
¹⁷Haematology Department, Royal Perth Hospital, Perth, Australia
¹⁸SA Pathology, Adelaide, SA, Australia
¹⁹Centre for Cancer Biology, Adelaide, Australia
²⁰Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
²¹Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
²²Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA
²³Myeloproliferative Neoplasms Program, Memorial Sloan Kettering Cancer Center, New York, NY
²⁴Leukemia Service, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
²⁵University of California San Francisco, San Francisco, CA
²⁶Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²⁷Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
²⁸Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Rsch. Ctr., Seattle, WA
²⁹Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia
³⁰Department of Haematology and Bone Marrow Transplantation, Royal Adelaide Hospital, Adelaide, Australia
³¹Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia
³²Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
³³Department of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia

Shaun D. Patterson, PhD, MSc, BSc^1*, Isla Nosratzadeh, MSc, BSc^1*, Robin Young, PhD^2*, Alan Hair, PhD^1*, Jennifer Cassels, BSc^1*, Richard E. Clark, MBBS, MD, FRCP, FRCPath^3*, Heather G Jørgensen, PhD^1*, Helen Wheadon, PhD^1* and Mhairi Copland, PhD, MBBChir, FRCP, FRCPath¹

¹School of Cancer Sciences, University of Glasgow, Paul O'Gorman Leukaemia Research Centre, Glasgow, United Kingdom
²Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom
³Royal Liverpool University Hospital, Liverpool, United Kingdom

Anna Sicuranza, PhD^1*, Adele Santoni, MD^2*, Paola Pacelli^3*, Sara Freducci, MD^4*, Emanuele Pacini^5*, Elisabetta Abruzzese, MD⁶, Daniele Cattaneo^7*, Alessandra Iurlo, MD, PhD^8*, Luigiana Luciano, MD⁹, Sara Galimberti, MD^10*, Valentina Giai, MD, PhD^11*, Olga Mulas, MD^12*, Giovanni Caocci, MD¹³, Federica Sorà^14*, Isabella Capodanno, MD^15*, Monica Crugnola, MD^16*, Antonella Gozzini, MD^17*, Sabina Russo, MD^18*, Mario Annunziata, MD^19,20*, Claudio Fozza, MD^21*, Anna Marina Liberati, MD²², Alessandra Cartocci^23*, Elisabetta Zappone^24*, Emanuele Cencini, MD^25*, Vincenzo Sammartano^5*, Elena Bestoso^26*, Cristina Marzano^27*, Dania Tocci^28*, Teresa Miracapillo^4*, Camilla Turriziani^28*, Donatella Raspadori^24* and Monica Bocchia, MD^29*

¹Hematology, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy, Siena, Italy
²UOC Ematologia, Azienda ospedaliero-universitaria Senese, Siena, Italy
³Hematology Unit, Department of Medical Science, Surgery and Neuroscience, Univer, Siena, ITA
⁴Dept of Medical sciences, surgery and neurosciences., Hematoly Unit. University of Siena, Siena, Italy
⁵University of Siena, Siena, Italy
⁶Department of Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma 2, Roma, I, Italy
⁷FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO, MILANO, ITA
⁸Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
⁹Hematology Unit, Federico II University, Napoli, Italy
¹⁰Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy
¹¹Hematology, AOU Città della Salute e della Scienza di Torino, Turin, Italy
¹²Department of Medical Sciences and Public Health, University of Cagliari, Businco Hospital, Cagliari, Italy
¹³University of Cagliari, Monserrato, Italy
¹⁴Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
¹⁵Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy
¹⁶Hematology Unit and BMT, University Hospital of Parma, Parma, Italy
¹⁷Hematology, AOU Careggi, University of Florence, Florence, Italy
¹⁸Division of Hematology, Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva,, Hematology Section, AOU Policlinico "G Martino", University of Messina, Italy, Messina, Italy
¹⁹Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli, Napoli, ITA
²⁰Hematology, San Giuseppe Moscati Hospital, Aversa, Italy
²¹Hematology Unit – Azienda Ospedaliera Universitaria of Sassari, University of Sassari, Sassari, Italy
²²A.O. Santa Maria di Terni – Università degli Studi di Perugia, Terni–Perugia, Italy
²³Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, ITA
²⁴Hematology Unit, Azienda Ospedaliera Universitaria Senese, Siena, ITA
²⁵Division of Hematology, Azienda Ospedaliera Universitaria Senese & University of Siena, Siena, Italy
²⁶Hematology Unit, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy, Siena, Italy
²⁷University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, ITA
²⁸Dept of Medical sciences, surgery and neurosciences., Hematoly Unit. University of Siena, Siena, Italy
²⁹Hematology, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy

Susan Branford, PhD¹, Adelina Fernandes^2*, Carol Wadham^3*, Muneeza Maqsood^3*, Nur Hezrin Shahrin^3*, David M Ross, MD, PhD, FRACP, FRCPA^4*, Agnes S. M. Yong, MD, PhD⁵, Ming Lin^3*, Rosalie Kenyon^3*, Dominik Kaczorowski^6*, Verity A Saunders^7*, Ilaria Stefania Pagani, PhD^8*, John Toubia^9*, Joe McConnell^3*, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA¹⁰, Chung Hoow Kok, PhD, BSc³, Timothy P Hughes, MD, MBBS, FRACP, FRCPA⁷ and Naranie Shanmuganathan, MBBS, PhD, FRACP, FRCPA¹¹

¹Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia
²University of Adelaide, Adelaide, Australia
³Centre for Cancer Biology and SA Pathology, Adelaide, Australia
⁴Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia
⁵South Australian Health and Medical Research Institute, Adelaide, Australia
⁶SA Pathology and Centre for Cancer Biology, Adelaide, Australia
⁷Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, Australia
⁸South Australian Health & Medical Research Institute (SAHMRI), Adelaide, AUS
⁹Centre For Cancer Biology, Adelaide, AUS
¹⁰South Australian Health and Medical Research Institute, Adelaide, SA, Australia
¹¹Department of Haematology, Central Adelaide Local Health Network, Adelaide, SA, Australia