-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

632.O1.6 632. Chronic Myeloid Leukemia: Novel Molecules in Clinical Practice

Symposia: Chronic Myeloid Leukemia: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Adult, Clinical Practice (Health Services and Quality), Drug development, Clinical Research, CML, Chronic Myeloid Malignancies, Therapy sequence, Diseases, Treatment Considerations, Adverse Events, Myeloid Malignancies, Study Population, Human, Measurable Residual Disease
Sunday, December 8, 2024: 9:30 AM-11:00 AM
Harbor Ballroom DEFG (Manchester Grand Hyatt San Diego)
Moderators:
Dragana Milojkovic, MD, PhD, Imperial College Healthcare NHS Trust and Nobuko Hijiya, MD, Columbia University Medical Center
Disclosures:
Milojkovic: Ascentage Pharma: Honoraria; Incyte: Honoraria, Research Funding; Novartis: Honoraria, Research Funding; Pfizer: Honoraria, Research Funding.

This oral session is focussed on the outcome of clinical trials in chronic myeloid leukemia, with an emphasis on new results from studies using allosteric tyrosine kinase inhibitors, or the use of standard ATP binding competitors in novel situations. The intention is to convey new knowledge to clinicians who treat CML
9:30 AM

Jorge E. Cortes, MD1, Andreas Hochhaus, MD2, Timothy P Hughes, MD, MBBS, FRACP, FRCPA3, Jianxiang Wang, MD4, Dong-Wook Kim, MD, PhD5, Dennis Dong Hwan Kim, MD, PhD6, Jiri Mayer, MD7, Yeow Tee Goh, MD8, Philipp le Coutre, MD9*, Gabriel Etienne, MD, PhD10*, Naoto Takahashi, MD, PhD11, Inho Kim, MD, PhD12*, David Andorsky, MD13, Ghayas C. Issa, MD14, Felice Bombaci15*, Shruti Kapoor16*, Rajendra Jinwal, MD17*, Lillian Yau, PhD18* and Richard Larson, MD19*

1Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA
2Hematology and Medical Oncology, Universitätsklinikum Jena, Jena, Germany
3Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, Australia
4State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
5Uijeongbu Eulji Medical Center, Geumo-dong, Uijeongbu, Korea, Republic of (South)
6Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada
7Internal Medicine Hematology and Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic
8Department of Haematology, Singapore General Hospital, Singapore, Singapore
9Department of Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany
10Hematology, Institut Bergonié, Bordeaux, France
11Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
12Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
13Rocky Mountain Cancer Centers, Boulder, CO
14Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
15CML Patients Group, CML Advocates Network, Turin, Italy
16Novartis, East Hanover, NJ
17Novartis Healthcare Private Limited, Hyderabad, India
18Novartis Pharma AG, Basel, Switzerland
19University of Chicago, Chicago, IL

9:45 AM

David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA1,2,3,4, Naranie Shanmuganathan, MBBS, PhD, FRACP, FRCPA5,6,7, Agnes S. M. Yong, MD, PhD5,8,9,10, Jake Shortt11,12,13*, Lynette C.Y. Chee, MBBS, PhD, FRACP, FRCPA14,15,16, Nicholas Vialla17,18*, Ilona Cunningham, MBBS FRACP FRCPA19, David M Ross, MD, PhD, FRACP, FRCPA5,20,21,22,23*, Alwyn D'Souza, MBChB24*, Matthew P.F. Wright, MBBS, FRCPA, FRACP25*, Rosemary Harrup26,27*, Cecily Forsyth, MD28, Robin Filshie, PhD, FRACP, FRCPA29, Steven W Lane, MBBS, PhD, FRCPA, FRACP30,31,32, Peter J. Browett33, Carolyn S. Grove, MBBS, FRACP, FRCPA, PhD34,35,36,37, Mannu Walia, PhD38*, Susan Branford, PhD7,39,40,41, John Reynolds, BSc, MSc, PhD42,43*, Andrew P Grigg, MBBS, MD, FRACP, FRCPA44* and Timothy P Hughes, MD, MBBS, FRACP, FRCPA45,46,47,48

1Department of Haematology, Central Adelaide Local Health Network, Adelaide, SA, Australia
2University of Adelaide, Adelaide, SA, Australia
3Australasian Leukaemia and Lymphoma Group (ALLG), Melbourne, Australia
4Royal Adelaide Hospital, Adelaide, SA, Australia
5South Australian Health and Medical Research Institute, Adelaide, Australia
6Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
7School of Medicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
8Haematology Department, Royal Perth Hospital, Perth, Australia
9University of Western Australia, Perth, Australia
10South Australian Health and Medical Research Institute, Adelaide Medical School and Precision Cancer Medicine, Adelaide, Australia
11Monash Health & Monash University, Melbourne, Australia
12Monash University and Monash Health, Melbourne, VIC, Australia
13Monash University, Clayton, AUS
14Department of Clinical Haematology and Bone Marrow Transplant Service, The Royal Melbourne Hospital, Parkville, Australia
15Department of Medicine, The University of Melbourne, Parkville, VIC, Australia
16Department of Clinical Haematology, The Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
17University of New South Wales, Sydney, Australia
18Hematology Department, Liverpool Hospital, Liverpool, AUS
19Haematology Department Concord Hospital, Concord and University of Sydney, Sydney, Australia
20Department of Haematology and Bone Marrow Transplantation, Royal Adelaide Hospital and SA Pathology, Adelaide, Australia
21Department of Haematology, Flinders Medical Centre, Bedford Park, Australia
22Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia
23Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
24Haematology Department,, Wellington Hospital, University of Otago, Wellington, New Zealand
25Fiona Stanley Hospital, Murdoch, WEA, AUS
26Royal Hobart Hospital, Tasmania, Australia
27Royal Hobart Hospital and University of Tasmania, Tasmania, Australia
28Central Coast Local Health District (Gosford and Wyong Hospitals), Gosford, Australia
29St. Vincent's Hospital Melbourne, Fitzroy, VIC, AUS
30Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia
31The University of Queensland, Brisbane, Australia
32Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia
33Dept of Molecular Medicine and Pathology, Auckland Hospital and The University of Auckland School of Medicine, Auckland, New Zealand
34Department of Haematology, Sir Charles Gairdner Hospital and PathWest, Perth, Australia
35Sir Charles Gairdner Hospital, Nedlands, Australia
36PathWest & Sir Charles Gairdner Hospital, Nedlands, Australia
37School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
38Australasian Leukaemia and Lymphoma Group, Melbourne, Australia
39School of Medicine, University of Adelaide, Adelaide, Australia
40SA Pathology, Adelaide, SA, Australia
41Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia
42Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
43Department of Malignant Haematology, Transplantation and Cellular Therapy Services, Alfred Health, Melbourne, Australia
44Austin Hospital, Melbourne, VIC, AUS
45Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, Australia
46Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia
47Department of Haematology and Bone Marrow Transplantation, Royal Adelaide Hospital, Adelaide, Australia
48South Australian Health and Medical Research Institute, Adelaide, SA, Australia

10:00 AM

Qian Jiang, MD1,2,3, Li Weiming4*, Yanli Zhang, MD5*, Qiang Wang, MD6*, Suning Chen, MD, PhD7*, Bingcheng Liu8*, Zhuogang Liu9*, Jie Jin, M.D.10, Zhenfang Liu, MD11*, Jianyu Weng, MD, PhD12*, Xin Du13*, Xielan Zhao14*, Li Meng, MD15*, Lie Lin, M.D.16*, Wanlin Ye17*, Shujie Yan, PhD17*, Yihan Wang, PhD17* and Jingrong Cao, PhD17

1National Clinical Research Center for Hematologic Disease, Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, Beijing, China
2Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
3Peking University People’s Hospital, Beijing, China
4Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
5Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
6Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
7The First Affiliated Hospital of Soochow University, Suzhou, China
8State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
9Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, China
10Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
11The First Affiliated Hospital of Guangxi Medical University, Nanning, China
12Guangdong Provincial People's Hospital, Guangdong, China
13Department of Hematology, Shenzhen Second People's Hospital, Shenzhen, China
14Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
15Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
16Department of Hematology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China
17Shenzhen TargetRx, Inc., Shenzhen, China

10:15 AM

Franck E. Nicolini, MD, PhD1,2, Aude Charbonnier, MD, PhD1,3*, Martine Escoffre-Barbe, MD1,4*, Eric Jourdan, MD, PhD1,5*, Gabrielle Roth-Guepin, MD1,6*, Marc G. Berger, MD, PhD1,7*, Shanti Ame, MD, PhD1,8*, Marion Simonet, MD1,9*, Hyacinthe A Johnson-Ansah, MD1,10*, Viviane Dubruille, MD1,11*, Amandine Charbonnier, MD1,12*, Philippe Rousselot, MD PhD1,13*, Corentin Orvain1,14*, Bertrand Joly, MD1,15*, Jean-Christophe Ianotto, MD, PhD, HDR1,16*, Emilie Cayssials, MD, PhD1,17*, Mathieu Meunier1,18*, Anne Parry, MD1,19*, Valerie Coiteux, MD1,20*, Laurence Legros, MD, PhD1,21,22*, Hacene Zerazhi, MD1,23*, Gabriel Etienne, MD, PhD1,24*, Philippe Quittet, MD1,25*, Ollivier Legrand, MD26*, Amelie Penot, MD1,27*, Lydia Roy, MD1,28*, Charlotte Doublet, MD1,29*, Stéphane Morisset1,30*, Romaine Mayet, PhD31*, Gwenaëlle Garin, PhD32*, Stéphanie Dulucq, PharmD, PhD1,33* and Françoise Huguet, MD1,34*

1Centre Léon Bérard, Fi-LMC, Lyon, France
2Hematology department & CRCL INSERM U1052, Centre Léon Bérard, Lyon, France
3Department of Hematology, Institut Paoli-Calmettes, Marseilles, France
4Hematology department, Hôpital de Pontchaillou, Rennes, France
5Hematology department, Institut de Cancérologie du Gard, CHU de Nîmes, Nimes, France
6Department of Clinical Hematology, CHRU Nancy, Vandoeuvre Les Nancy, France
7Laboratoire d'Hématologie Biologique, CHU Estaing, Clermont-Ferrand, France
8Department of hematology, Institut de Cancérologie de Strasbourg, Strasbourg, France
9Hematology department, Centre Hospitalier Universitaire, Besançon, France
10Caen University Hospital, Normandy, Hematology Institute, Caen, France
11Hematology department, Hôtel Dieu, CHU de Nantes, Nantes, France
12Clinical Hematology Department, Amiens-Picardie University Hospital, Amiens, France
13Hematology department, Centre Hospitalier de Versailles, UMR1184, University Versailles Paris-Saclay, Le Chesnay, France
14Hematology Clinic, Angers University Hospital, Angers, France
15Hematology department, Centre Hospitalier Francilien Sud, Corbeil-Essonne, France
16Hematology department, Centre Hospitalier Universitaire de Brest, Brest, France
17Hematology department & CIC, CHU Poitiers & INSERM CIC 1402, Poitiers, France
18Department of Hematology CHU Grenoble Alpes, Grenoble, France
19Department of Hematology, Annecy Genevois Hospital Center, Pringy, France
20Hôpital Huriez, Hematology department, Centre Hospitalier Universitaire, Lille, France
21Service d’Hématologie-Clinique Ambulatoire (SHCA), APHP, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
22INSERM UMRS-MD1197, Hôpital Paul Brousse, Villejuif, France
23Oncologie Médicale et Hématologie clinique, CH d'Avignon - Hôpital Henri Duffaut, Avignon, France
24Hematology, Institut Bergonié, Bordeaux, France
25Hematology department, CHU Montpellier, Hôpital Saint Eloi, Montpellier, France
26Clinical Hematology and Cellular Therapy Department, Sorbonne University, Saint Antoine Hospital, INSERM UMRs U938, Paris, France
27Department of hematology, Centre Hospitalier Universitaire Dupuytren, Limoges, France
28Hematology Department, Henri Mondor University Hospital, UPEC, IMRB, Assistance Publique Hopitaux de Paris, Créteil, France
29Hematology department, Centre Hospitalo-Universitaire, Saint-Etienne, Saint Priest en Jarez, France
30Hematology department, Centre Léon Bérard, Lyon, France
31DRC, Centre Léon Bérard, Lyon, France
32DRC, Centre Léon Bérard, Lyon, FRA
33Laboratory of Hematology, Hôpital Haut Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac, France
34Hematology Department, Institut Universitaire du Cancer-Oncopole & CHU de Toulouse, Toulouse, France

10:30 AM

Ehab L. Atallah, MD1, Moshe Y. Levy, MD2*, Paul B. Koller, MD3, Koji Sasaki, MD4, Srinivas K Tantravahi, MD5, David Andorsky, MD6, Celesteann T Bremer, MD7*, Joshua F. Zeidner, MD8, Marlise R. Luskin, MD9, Reinhold Munker, MD10*, Daisy Yang, Pharm.D., BCOP11*, Dramane Laine, PhD11*, John Sabo11*, Ennan Gu12*, Michael J. Mauro, MD13 and Jorge E. Cortes, MD14

1Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
2Baylor Scott & White Health, Dallas, TX
3Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
4Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
5University of Utah, Huntsman Cancer Institute, Salt lake city
6Rocky Mountain Cancer Centers, Boulder, CO
7Virginia Oncology Associates, Virginia Beach, VA
8Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
9Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
10University of Kentucky College of Medicine, Lexington, KY
11Novartis Pharmaceuticals Corporation, East Hanover, NJ
12Novartis Pharmaceuticals Corporation, Cambridge, MA
13Myeloproliferative Neoplasms Program, Memorial Sloan Kettering Cancer Center, New York, NY
14Georgia Cancer Center, Augusta, GA

10:45 AM

Li Weiming, MD1*, Yanli Zhang, MD2*, Huanling Zhu, MD3*, Yunfan Yang, MD3*, Na Xu4*, Bingcheng Liu5*, Zi Chen, MD, PhD6*, Wei Chu, MD6*, Yifan Zhai, MD, PhD6,7 and Yu Hu, MD1*

1Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
3Department of Hematology, West China Hospital of Sichuan University, Chengdu, China
4Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
5State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
6Ascentage Pharma (Suzhou) Co., Ltd., Suzhou, China
7Ascentage Pharma Group Inc., Rockville, MD

*signifies non-member of ASH