Cedric Rossi, MD, PhD^1,2, Jan Boegeholz, MD³, Jordan S Goldstein, MD, MSc⁴, Shuyu Shi⁵, Shengqin Su^6*, Benoit Tessoulin, MD, PhD^7,8*, Stefan K. Alig, MD¹, Andrea Garofalo, BS, BA⁹, Mohammad Shahrokh Esfahani, PhD^10*, Joseph G. Schroers-Martin, MD¹¹, Chih Long Liu, PhD^9*, Mari Olsen, BS^9*, Xiaoman Kang, BS^12*, Feng Tian, PhD^9*, David Kurtz, MD, PhD^13,14, Takeshi Sugio, MD, PhD^9*, Troy Noordenbos^9,15*, Marc Andre, MD^16*, Luc-Matthieu Fornecker, MD, PhD^17*, Edith Julia^18*, Alexandra Traverse-Glehen, MD, PhD^19*, Olivier Casasnovas, MD^20*, Michael S. Binkley, MD, MS^21*, Maximilian Diehn, MD, PhD^10*, Herve Ghesquieres, MD, PhD^22* and Ash A. Alizadeh, MD, PhD⁹

¹Stanford University, Stanford, CA
²Department of Hematology, University Hospital F. Mitterrand, Dijon, France
³Divisions of Hematology and Oncology, Stanford University, Stanford, CA
⁴Department of Medicine, Divisions of Oncology and Hematology, Stanford University, Palo Alto, CA
⁵Dept. of Bioengineering, Schools of Engineering and Medicine, Stanford, CA
⁶Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, CA
⁷CRCI2NA, Integrated Research Center in Immunology and Oncology, Nantes University, Nantes, France
⁸Department of hematology, Nantes university hospital, Nantes, France
⁹Department of Medicine, Divisions of Oncology and Hematology, Stanford University, Stanford, CA
¹⁰Department of Radiation Oncology, Stanford University, Stanford, CA
¹¹Department of Medicine, Division of Oncology and Hematology, Stanford University, Menlo Park, CA
¹²Department of Medicine, Division of Oncology, Stanford University, Stanford, CA
¹³Division of Hematology, Department of Medicine, Stanford University, Stanford, CA
¹⁴Foresight Diagnostics, Boulder, CO
¹⁵Department of Pathology, Leiden University Medical Center, Leiden, Netherlands
¹⁶CHU UCL Namur Mont-Godinne, Yvoir, Belgium
¹⁷Institut De Cancérologie Strasbourg Europe, Hematology Department, Strasbourg, France
¹⁸Department of Hematology, Lyon Sud Hospital, Pierre Benite, France
¹⁹Hospices Civils de Lyon/Université Lyon 1, CHU Lyon-Sud, Pathology Department, Lyon, France
²⁰François Mitterand Hospital, Dijon, FRA
²¹Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA
²²Department of Hematology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France

Matin Salehi^1,2*, Maria Cristina Pirosa, MD^1,3,4, Alessio Bruscaggin, PhD^1*, Lodovico Terzi Di Bergamo^1,5*, Federico Jauk, MD^1,2*, Gabriela Forestieri^1*, Simone Bocchetta, PhD^1*, Deborah Piffaretti, PhD^6*, Riccardo Moia, MD^7*, Vanessa Cristaldi, PhD^8*, Martina Di Trani^9*, Georgia Alice Galimberti^1*, Katia Pini^1*, Valeria Spina^1*, Claudia Giordano, MD^10*, Adalgisa Condoluci, MD^1,2,4, Salvatore Annunziata^11*, Fabrizio Bergesio^12*, Renzo Boldorini^13*, Eugenio Borsatti^14*, Pietro Bulian^15*, Stephane Chauvie, PhD^16*, Marco Cuzzocrea^17*, Bernhard Gerber^18*, Michal Kurlapski^19*, Luigi Maria Larocca^20*, Andrea Rinaldi^21*, Marcello Rodari^22*, Grzegorz Romanowicz^23*, Gian Mauro Sacchetti^24*, Anastasios Stathis, MD^18*, Georg Stüssi, MD^2,18*, Ilaria Zangrilli^25*, Eleonora Calabretta^26*, Francesco Corrado, MD^26*, Antonello Pinto^27*, Luca Mazzucchelli^28*, Valter Gattei, MD²⁹, Jan Maciej Zaucha^30*, Armando Santoro, MD^31*, Stefan Hohaus^25*, Franco Cavalli, MD^32*, Emanuele Zucca, MD^2,32,33, Gianluca Gaidano, MD, PhD³⁴, Carmelo Carlo-Stella, MD^26,35, Alexandar Tzankov, MD, PhD^36*, Luca Ceriani, MD^2,17* and Davide Rossi, MD, PhD^1,2,33

¹Institute of Oncology Research, Laboratory of Experimental Hematology, Bellinzona, Switzerland
²Università della Svizzera italiana, Faculty of Biomedical Science, Lugano, Switzerland
³Università della Svizzera italiana, Faculty of Biomedical Science, S. Antonino, Switzerland
⁴Clinic of Hematology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
⁵Department of Health Science and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland
⁶Institute of Oncology Research, Laboratory of Experimental Hematology, Bellinzona, AL, Switzerland
⁷Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
⁸Department of Biomedical Sciences, University of Humanitas, Milan, Italy
⁹University of Humanitas, Milan, Italy
¹⁰Department of Clinical Medicine and Surgery, Federico II University Medical School, Naples, ITA
¹¹UOC Medicina Nucleare, GSTeP Radiopharmacy TracerGLab, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
¹²Medical Physics Division, AO Santa Croce e Carle, Cuneo, Italy
¹³Division of pathology, University of Eastern Piedmont, Novara, Italy
¹⁴Nuclear Medicine, Centro di Riferimento Oncologico, Aviano, Italy
¹⁵Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, Aviano, Italy
¹⁶Medical Physics Division, AO Santa Croce e Carle, Cuneo, Cuneo, Italy
¹⁷Imaging Institute of Southern Switzerland, Clinic of Nuclear Medicine and Molecular Imaging, Bellinzona, Switzerland
¹⁸Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale, Bellinzona, Switzerland
¹⁹Department of Hematology and Bone Marrow Transplantation, Medical University of Gdańsk, Gdańsk, Poland
²⁰Fondazione Policlinico Universitario A. Gemelli. IRCCS, Rome, ITA
²¹Genomics Facility, Institute of Oncology Research, Bellinzona, Switzerland, Bellinzona, Switzerland
²²Nuclear Medicine Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy
²³Department of Nuclear Medicine, Medical University of Gdańsk, Gdańsk, Poland
²⁴Divsion of Nuclear Medicine, AOU Maggiore della Carità, Novara, ITA
²⁵Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy
²⁶Department of Biomedical Sciences, Humanitas University, Milan, Italy
²⁷Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institut, Napoli, ITA
²⁸Division of Pathology, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
²⁹Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
³⁰Department of Haematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland
³¹IRCCS Humanitas Research Hospital, Rozzano, Italy
³²Fondazione per l’Istituto Oncologico di Ricerca, Bellinzona, Switzerland
³³Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
³⁴Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
³⁵Department of Oncology and Hematology, IRCCS Humanitas Research Hospital, Rozzano, Italy
³⁶Medical Genetics and Pathology, University of Basel, Basel, Switzerland

Shinya Rai, MD, PhD¹, Tomohiro Aoki, MD, PhD², Gerben Duns, PhD^1*, Aixiang Jiang, MS^1*, Andrew Lytle^1*, Yifan Yin^1*, Makoto Kishida^1*, Michael Yu Li, BS^1*, Denise Smorra^1*, Cecilia Lee^1*, Katy Milne^3*, Adele Telenius, MPhil, BSc^1*, Luke O`Brien^1*, Katsuyoshi Takata, MD, PhD⁴, Tomoko Miyata-Takata^1*, Merrill Boyle, BSc^1*, Susana Ben-Neriah^1*, Andrew P. Weng, MD^5*, Andrew Roth, PhD^6*, Brad H NelsonH^3*, Laura K. Hilton, PhD^1*, Pedro Farinha^1,7, Kerry J. Savage, MD, MSc¹, David W. Scott, MBChB, PhD¹ and Christian Steidl, MD, PhD¹

¹Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
²Princess Margaret Cancer Centre, Toronto, ON, Canada
³Deeley Research Centre, BC Cancer, Victoria, BC, Canada
⁴Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⁵Terry Fox Laboratory, BC Cancer, Vancouver, BC, Canada
⁶Department of Molecular Oncology, BC Cancer, Vancouver, BC, Canada
⁷Department of Pathology, University of British Columbia, Vancouver, BC, Canada

Julia C. Kuehn, MD^1*, Roman Sankowski, MD^2*, Nicolas N. Neidert, MD^3*, Elena Grabis^4*, Jurik A. Mutter, PhD^5*, Stefan K. Alig, MD⁶, Junyi Zhang^3*, Christian Klingler, PhD^7*, Lavanya Ranganathan^7*, Fabian Hummel^1*, Sabine Bleul^1*, Eliza M. Lauer, MD^1*, Dieter Henrik Heiland, MD^8*, Marco Prinz, MD^9,10,11*, Katharina J. Müller, MD^12*, Louisa von Baumgarten, MD^13*, Justus Duyster, MD^14*, Elisabeth Schorb, MD^15*, Maximilian Diehn, MD, PhD^16*, Ash A. Alizadeh, MD, PhD¹⁷, Peter C. Reinacher, MD^18* and Florian Scherer, MD^1,19

¹Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
²Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, DEU
³Department of Neurosurgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
⁴Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany
⁵Divisions of Oncology and Hematology, Department of Medicine, Stanford University, Stanford, CA
⁶Divisions of Oncology and Hematology, Stanford University School of Medicine, Stanford, CA
⁷Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany
⁸Department of Neurosurgery,, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
⁹Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹⁰Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany
¹¹Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany
¹²Department of Neurology, University Hospital, LMU Munich, Munich, Germany
¹³Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany
¹⁴Department of Medicine I, Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹⁵Department of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹⁶Department of Radiation Oncology, Stanford University, Stanford, CA
¹⁷Department of Medicine, Divisions of Oncology and Hematology, Stanford University, Stanford, CA
¹⁸Department of Stereotactic and Functional Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹⁹German Cancer Consortium (DKTK) partner site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany

Dylan C Gagler^1*, Hussein Ghamlouch, PhD^1,2*, Di Zhang, MS^1*, Patrick Blaney, MS^1*, Marine Armand, PhD^3*, Alexandre Eeckhoutte, PhD^3*, Amina Joudat^4*, Michael Degaud^5*, Michela Esposito^4*, Gaurav Varma, MD, MSPH^1,6, Yubao Wang, PhD^1*, Sanxiong Liu, PhD^1*, Oscar B Lahoud, MD⁷, David Kaminetzsky^8*, Marc J Braunstein, MD, PhD¹, Florence Nguyen-Khac, MD, PhD^9*, Brian A. Walker, PhD¹⁰, Damien Roos-Weil^11*, Faith E Davies, MD¹, Olivier Bernard, PhD^4* and Gareth Morgan, M.D., Ph.D.^1*

¹Perlmutter Cancer Center, Multiple Myeloma Research Program, NYU Langone Health, New York, NY
²CHU Amiens-Picardie, Amiens, FRA
³INSERM, Villejuif, FRA
⁴INSERM, Villejuif, France
⁵Hopital Pitié SalpetrièRe, Paris, FRA
⁶Blood and Marrow Transplantation and Cellular Therapy, NYU Langone Health, New York, NY
⁷NYU Perlmutter Cancer Center, NYU Grossman School of Medicine, Brooklyn, NY
⁸Perlmutter Cancer Center, Multiple Myeloma Research Program, NYU Langone, New York, NY
⁹Hopital Pitie-Salpetriere, Paris, France
¹⁰Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN
¹¹Hôpital Pitié-Salpétrière, Paris, FRA

Chenguang Wang, PhD¹, Ashley Wolfe^2*, Xiangrong Geng^1* and Ryan A. Wilcox, MD, PhD³

¹Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
²Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI
³Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI