Edward Ayoub, PhD^1*, David Lehotzky, PhD^2*, Li Li, MD, PhD^1*, Muharrem Muftuoglu, MD¹, Yuki Nishida, MD, PhD¹, Vakul Mohanty, PhD^3*, Jake S Leighton^4*, Tallie Patsilevas^5*, Mahesh Basyal, BSc^1*, Andrea Bedoy^1*, Torsten Haferlach, MD⁶, Koichi Takahashi, MD, PhD⁷, Ken Chen, PhD^3*, Nicholas Navin^4*, Ghayas C. Issa, MD⁷, Gad Getz, PhD^8,9,10,11* and Michael Andreeff, MD, PhD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA
³Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵LICORbio logo LI-COR Biotechnology, Houston, TX
⁶MLL Munich Leukemia Laboratory, Munich, Germany
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Harvard Medical School, Boston, MA
⁹Krantz Family Center for Cancer Research and Dept. of Pathology, Massachusetts General Hospital, Boston, MA
¹⁰Broad Institute of MIT and Harvard, Cambridge, MA
¹¹Massachusetts General Hospital, Boston, MA

Curtis A Lachowiez, MD¹, Joshua F. Zeidner, MD², Ashley M. Eckel, MD, PhD^3*, Daniel T Peters, MD⁴, Jacob Fang, MD^5*, Amenech Ashango^6*, Andy Kaempf, MS^7*, Fangyan Dai, PhD^3*, Christopher A. Eide^8*, Stephen E. Kurtz, PhD^1*, Theodore P Braun, MD, PhD¹, Ronan T. Swords, MD, PhD, FRCP, FRCPath¹, Jennifer N. Saultz, DO¹, Jeffrey W. Tyner, PhD¹ and Daniel A Pollyea, MD⁹

¹Knight Cancer Institute, Oregon Health & Science University, Portland, OR
²Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
³Hematologics Inc., Seattle, WA
⁴Division of Hematology, University of North Carolina School of Medicine, Chapel Hill, NC
⁵University of Colorado, Denver, CO
⁶Hematologics Inc., Seattle
⁷Knight Cancer Institute, Biostatistics Shared Resource, Oregon Health & Science University, Portland, OR
⁸Knight Cancer Institute, Oregon Health and Science University, Portland, OR
⁹Division of Hematology, University of Colorado, Denver, CO

Mohammad Javad Najaf Panah, MS^1*, Alexandra McLean Stevens, MD², Michael Krueger^1*, Max P Rochette^1*, Sohani K Sandhu^1*, Lana E Kim^1*, Joanna S. Yi, MD³, Tsz-Kwong Man, PhD^1*, Michele S. Redell, MD¹ and Pavel Sumazin, PhD^1*

¹Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX
²Baylor College of Medicine/ Texas Children's Hospital, Houston, TX
³Texas Children's Cancer and Hematology Centers, Baylor College of Medicine/Texas Children's Hospital, Houston, TX

Makayla R Pardo^1,2, Dennis M Bonal, MSc, BSc^1,2, Seo-Ho Lee^2*, Anna Dorota Chorzalska, PhD^2,3*, Valeria Brown^2,4*, John L. Reagan, MD^2,3, Diana Olguta Treaba, MD^3,5* and Patrycja M. Dubielecka, PhD^2,3

¹Pathobiology Graduate Program, Brown University, Providence, RI
²Legorreta Cancer Center, Brown University, Providence, RI
³Warren Alpert Medical School, Brown University, Providence, RI
⁴The Warren Alpert Medical School of Brown University, Providence, RI
⁵Rhode Island Hospital, Department of Pathology and Laboratory Medicine, Providence, RI

Niccolò Bartalucci^1*, Francesco Mannelli^1*, Danilo Tarantino^1*, Barbara Scappini^2*, Alessio Enderti^1*, Giacomo Gianfaldoni^3*, Matteo Piccini^3*, Simone Romagnoli^1*, Daniele Colazzo^1*, Leonardo Signori^1*, Fiorenza Irushani^1*, Silvia Salmoiraghi^4*, Tiziana Ottone^5*, Alfonso Piciocchi^6*, Margherita Vannucchi^7*, Maria Chiara Siciliano^7*, Roberto Boccacci^7*, Silvia Orsi^8*, Alessia Civini^4*, Paola Fazi^6*, Raffaella Santi^9*, Marco Vignetti, MD^6*, Stefania Bortoluzzi^8*, Alberto Bosi^10*, Adriano Venditti¹¹, Alessandro Rambaldi¹², Maria Teresa Voso, MD⁵, Paola Guglielmelli, MD¹ and Alessandro M. Vannucchi¹

¹Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Florence, Italy
²Hematology Unit, Hematology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
³Hematology Unit, AOU Careggi, Florence, Italy
⁴FROM Research Foundation, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
⁵Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁶GIMEMA Foundation, Rome, Italy
⁷Department of Medical Biotechnology, Section of Pathology, University of Siena, Siena, Italy
⁸Department of Molecular Medicine, University of Padova, Padova, Italy
⁹Department of Health Sciences, Pathology Section, University of Florence, Florence, Italy
¹⁰University of Florence, Florence, ITA
¹¹Department of Onco-Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy
¹²Department of Oncology and Hematology, University of Milan and Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy

Morgan Drucker, MD^1,2, Dalia Dhingra, PhD^3*, Mark Wunderlich, MS^4*, John Perentesis, MD, FAAP^1,2,5*, Daniel Starczynowski, PhD^4,6,7, Robert L. Bowman, PhD⁸ and Linde A. Miles, PhD^1,4,6

¹Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
²Division of Oncology, Cancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Mission Bio Inc, South San Francisco, CA
⁴Division of Experimental Hematology and Cancer Biology, Cancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵CBDI-Oncology, University of Cincinnati Cancer Center, Cincinnati, OH
⁶University of Cincinnati Cancer Center, Cincinnati, OH
⁷University of Cincinnati College of Medicine, Cincinnati, OH
⁸Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA