Edward C. Dominguez, PhD^1*, Carly Roleder^1*, Canping Chen^2*, Zheng Xia, PhD^2*, Sandra Wiley, PhD, MSc³, Matthew S. Davids, MD, MMSc⁴ and Alexey Danilov, MD, PhD¹

¹City of Hope, Duarte, CA
²Knight Cancer Institute, Oregon Health & Science University, Portland, OR
³MEI Pharma, San Diego, CA
⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Inc., Boston, MA

Viral Shah^1,2,3*, George Giotopoulos, PhD^4,5*, Hikari Osaki, PhD^4,5*, Markus Meyerhöfer^1,2,3*, Eshwar Meduri, PhD^4,5*, Aarón Gallego-Crespo, M.Sc.^1,2,3*, Malte Andreas Behrendt, M.Sc.^1,2,3*, Maria Saura-Pañella, M.Sc.^1,2,3*, Benedict Schubert, M.Sc.^1,2,3*, Haiyang Yun, PhD^6*, Sarah J Horton, PhD^4,5*, Shuchi Agrawal Singh, PhD^4,5*, Patricia S Hähnel, PhD^1,2,3*, Faisal Basheer, PhD^4,5*, Dave Lugo^7*, Michael Kühn, MD^1,2,3*, Borhane Guezguez, PhD^1,2,3*, Matthias Theobald, MD^1,2,3, Thomas Kindler, MD^1,2,3*, Paolo Gallipoli, MD/PhD⁸, Paul Yeh, MD^9*, Mark A. Dawson, MD¹⁰, Rab Prinjha, PhD^11*, Brian J P Huntly, MD^4,5* and Daniel Sasca, MD^1,2,3*

¹Department of Hematology and Oncology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
²University Cancer Center, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
³German Cancer Consortium (DKTK), Frankfurt/Mainz, Mainz, Germany
⁴Cambridge Stem Cell Institute, Cambridge, United Kingdom
⁵Department of Haematology, University of Cambridge, Cambridge, United Kingdom
⁶The Robert Bosch Center for Tumor Diseases, Stuttgart, Germany
⁷Pharmaron, Hoddesdon, United Kingdom
⁸Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom
⁹Monash Haematology, Monash Health and School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
¹⁰Department of Clinical Haematology, Peter MacCallum Cancer Centre, Melbourne, Australia
¹¹Science@RabP Ltd, Bishop's Stortford, United Kingdom

Timothy T. Ferng, MD¹, Samantha M. Pintar, BA^2*, Vanessa E. Kennedy, MD³, Shaheen Kabir, PhD^1*, Theodore C. Tarver III, BS^2*, Veronica Steri, PhD^4*, Paul Phojanakong, BA^4*, Juwita Hübner, MD^5*, Carolina E. Morales, BS^5*, Jose M. Rivera^6*, Aaron C. Logan, MD, PhD⁷, Benjamin Braun, MD, PhD^5*, Elliot Stieglitz, MD, PhD⁶, Luke A. Gilbert, PhD^1* and Catherine C. Smith, MD⁸

¹Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
²Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
³Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Palo Alto, CA
⁴Preclinical Therapeutics Core, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
⁵Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA
⁶Division of Hematology-Oncology, Dept. of Pediatrics, University of California San Francisco Benioff Children’s Hospital, San Francisco, CA
⁷Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA
⁸Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA

Wallace Bourgeois¹, Jevon Cutler, PhD², Hannah E Rice^3*, Brandon Regalado^2*, Daniela V. Wenge, MD^3*, Florian Perner, MD⁴, John G. Doench, PhD^5*, Jerry M McGeehan, PhD^6* and Scott A Armstrong, MD, PhD²

¹Boston Children's/Dana-Farber, Boston, MA
²Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
³Dana-Farber Cancer Institute, Boston, MA
⁴Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany
⁵Broad Institute of MIT and Harvard, Cambridge, MA
⁶Syndax, Waltham, MA

Fatemeh Alikarami, PhD¹, Hongbo Xie^2*, Simone Stefanie Riedel, PhD³, Haley Goodrow^3*, Declan Barrett^4*, Leila Mahdavi^2*, Alexandra Lenard^2*, Changya Chen^1,5, Taylor Yamauchi^6*, Etienne Danis, PhD^7*, Zhendong Cao^8*, Vu L. Tran⁹, Mabel M. Jung⁹, Yapeng Li^10*, Hua Huang^10*, Junwei Shi, PhD^11*, Kai Tan, PhD¹², David T. Teachey, MD¹, Emery H. Bresnick¹³, Tobias Neff^6* and Kathrin M. Bernt, MD²

¹Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
²Children's Hospital of Philadelphia, Philadelphia, PA
³The Children's Hospital of Philadelphia, Philadelphia, PA
⁴Children's Hospital of Philadelphia, PHILADELPHIA, PA
⁵Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁶University of Colorado, Aurora, CO
⁷Biostatistics and Bioinformatics Shared Resource, University of Colorado Anschutz Medical Campus, Aurora, CO
⁸University of Pennsylvania, Philadelphia, PA
⁹Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI
¹⁰National Jewish Health, Denver, CO
¹¹Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
¹²Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
¹³UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI

Rasoul Pourebrahim, MD, PhD¹, Priyanka Khanna, BSc^2*, Dexin Yang^3*, Muharrem Muftuoglu, MD⁴, Lauren B. Ostermann, BSc^4*, Shayaun Khazaei, BSc^2*, Ran Zhao, MSc^4*, Amma Asare, MD, PhD^5*, Richard A. Hajek, PhD^5*, Sanghoon Lee, PhD^5*, Sara Corvingo, PhD^5*, Mihai Gagea, DVM^6*, Anil Sood, MD^5*, Ruoyan Li, PhD^3*, Koichi Takahashi, MD, PhD⁷ and Michael Andreeff, MD, PhD⁴

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Missouri City, TX
²Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston
³Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston
⁴Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston
⁶Department of Veterinary Medicine & Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX