-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

604.O1.6 604. Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms: Resistance to Standard and Novel Therapies

Symposia: Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Acute Myeloid Malignancies, AML, Combination therapy, Apoptosis, Fundamental Science, Translational Research, Drug development, CHIP, Genomics, Hematopoiesis, Education, Diseases, Therapy sequence, Treatment Considerations, Myeloid Malignancies, Biological Processes, Molecular biology, Technology and Procedures, Gene editing, Study Population, Animal model
Monday, December 9, 2024: 10:30 AM-12:00 PM
Seaport Ballroom ABCD (Manchester Grand Hyatt San Diego)
Moderators:
Maria L Amaya, MD, PhD, University of Colorado and Raphael Itzykson, INSERM U944
Disclosures:
Amaya: Bristol Myers Squibb: Honoraria. Itzykson: Abbvie: Research Funding; Advesya: Research Funding.
10:30 AM

Edward C. Dominguez, PhD1*, Carly Roleder1*, Canping Chen2*, Zheng Xia, PhD2*, Sandra Wiley, PhD, MSc3, Matthew S. Davids, MD, MMSc4 and Alexey Danilov, MD, PhD1

1City of Hope, Duarte, CA
2Knight Cancer Institute, Oregon Health & Science University, Portland, OR
3MEI Pharma, San Diego, CA
4Department of Medical Oncology, Dana-Farber Cancer Institute, Inc., Boston, MA

10:45 AM

Viral Shah1,2,3*, George Giotopoulos, PhD4,5*, Hikari Osaki, PhD4,5*, Markus Meyerhöfer1,2,3*, Eshwar Meduri, PhD4,5*, Aarón Gallego-Crespo, M.Sc.1,2,3*, Malte Andreas Behrendt, M.Sc.1,2,3*, Maria Saura-Pañella, M.Sc.1,2,3*, Benedict Schubert, M.Sc.1,2,3*, Haiyang Yun, PhD6*, Sarah J Horton, PhD4,5*, Shuchi Agrawal Singh, PhD4,5*, Patricia S Hähnel, PhD1,2,3*, Faisal Basheer, PhD4,5*, Dave Lugo7*, Michael Kühn, MD1,2,3*, Borhane Guezguez, PhD1,2,3*, Matthias Theobald, MD1,2,3, Thomas Kindler, MD1,2,3*, Paolo Gallipoli, MD8, Paul Yeh, MD9*, Mark A. Dawson, MD10, Rab Prinjha, PhD11*, Brian J P Huntly, MD4,5* and Daniel Sasca, MD1,2,3*

1Department of Hematology and Oncology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
2University Cancer Center, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
3German Cancer Consortium (DKTK), Frankfurt/Mainz, Mainz, Germany
4Cambridge Stem Cell Institute, Cambridge, United Kingdom
5Department of Haematology, University of Cambridge, Cambridge, United Kingdom
6The Robert Bosch Center for Tumor Diseases, Stuttgart, Germany
7Pharmaron, Hoddesdon, United Kingdom
8Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom
9Monash Haematology, Monash Health and School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
10Department of Clinical Haematology, Peter MacCallum Cancer Centre, Melbourne, Australia
11Science@RabP Ltd, Bishop's Stortford, United Kingdom

11:00 AM

Timothy T. Ferng, MD1, Samantha M. Pintar, BA2*, Vanessa E. Kennedy, MD3, Shaheen Kabir, PhD1*, Theodore C. Tarver III, BS2*, Veronica Steri, PhD4*, Paul Phojanakong, BA4*, Juwita Hübner, MD5*, Carolina E. Morales, BS5*, Jose M. Rivera6*, Aaron C. Logan, MD, PhD7, Benjamin Braun, MD, PhD5*, Elliot Stieglitz, MD, PhD6, Luke A. Gilbert, PhD1* and Catherine C. Smith, MD8

1Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
2Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
3Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Palo Alto, CA
4Preclinical Therapeutics Core, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
5Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA
6Division of Hematology-Oncology, Dept. of Pediatrics, University of California San Francisco Benioff Children’s Hospital, San Francisco, CA
7Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA
8Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA

11:15 AM

Wallace Bourgeois1, Jevon Cutler, PhD2, Hannah E Rice3*, Brandon Regalado2*, Daniela V. Wenge, MD3*, Florian Perner, MD4, John G. Doench, PhD5*, Jerry M McGeehan, PhD6* and Scott A Armstrong, MD, PhD2

1Boston Children's/Dana-Farber, Boston, MA
2Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
3Dana-Farber Cancer Institute, Boston, MA
4Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany
5Broad Institute of MIT and Harvard, Cambridge, MA
6Syndax, Waltham, MA

11:30 AM

Fatemeh Alikarami, PhD1, Hongbo Xie2*, Simone Stefanie Riedel, PhD3, Haley Goodrow3*, Declan Barrett4*, Leila Mahdavi2*, Alexandra Lenard2*, Changya Chen1,5, Taylor Yamauchi6*, Etienne Danis, PhD7*, Zhendong Cao8*, Vu L. Tran9, Mabel M. Jung9, Yapeng Li10*, Hua Huang10*, Junwei Shi, PhD11*, Kai Tan, PhD12, David T. Teachey, MD1, Emery H. Bresnick13, Tobias Neff6* and Kathrin M. Bernt, MD2

1Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
2Children's Hospital of Philadelphia, Philadelphia, PA
3The Children's Hospital of Philadelphia, Philadelphia, PA
4Children's Hospital of Philadelphia, PHILADELPHIA, PA
5Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
6University of Colorado, Aurora, CO
7Biostatistics and Bioinformatics Shared Resource, University of Colorado Anschutz Medical Campus, Aurora, CO
8University of Pennsylvania, Philadelphia, PA
9Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI
10National Jewish Health, Denver, CO
11Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
12Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
13UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI

11:45 AM

Rasoul Pourebrahim, MD, PhD1, Priyanka Khanna, BSc2*, Dexin Yang3*, Muharrem Muftuoglu, MD4, Lauren B. Ostermann, BSc4*, Shayaun Khazaei, BSc2*, Ran Zhao, MSc4*, Amma Asare, MD, PhD5*, Richard A. Hajek, PhD5*, Sanghoon Lee, PhD5*, Sara Corvingo, PhD5*, Mihai Gagea, DVM6*, Anil Sood, MD5*, Ruoyan Li, PhD3*, Koichi Takahashi, MD, PhD7 and Michael Andreeff, MD, PhD4

1Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Missouri City, TX
2Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston
3Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston
4Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
5Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston
6Department of Veterinary Medicine & Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
7Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

*signifies non-member of ASH