66th ASH Annual Meeting: 603. Lymphoid Oncogenesis: Basic: Molecular Insights into Acute Lymphoblastic Leukemias

Symposia: Lymphoid Oncogenesis: Basic Oral and Poster Abstracts
Oral

Research, Fundamental Science, Lymphoid Leukemias, ALL, Apoptosis, Adult, Acute Myeloid Malignancies, Translational Research, CHIP, Lymphomas, Genomics, Embryo/fetus, B Cell lymphoma, Hematopoiesis, Pediatric, T Cell lymphoma, Diseases, Immune mechanism, Neonatal, Immunology, Lymphoid Malignancies, Metabolism, Young adult , Biological Processes, Molecular biology, Technology and Procedures, Multi-systemic interactions, Study Population, Human, Pathogenesis, Omics technologies

Marriott Grand Ballroom 8-9 (Marriott Marquis San Diego Marina)

Moderators:

Sruti Shiva, PhD, University of Pittsburgh and Shai Izraeli, MD, Sheba Medical Center

Disclosures:

No relevant conflicts of interest to declare.

Description of oncogenic mechanisms of acute lymphoblastic leukemias

2:00 PM

199

The Fetal Specific Gene LIN28B Is Essential for Human Fetal B-Lymphopoiesis and Initiation of KMT2A-AFF1+ Infant Acute Lymphoblastic Leukemia

Rebecca E Ling, MD¹^*, Thomas Jackson, PhD¹^*, Natalina Elliott, PhD¹^*, Joe W Cross, MD, PhD¹^*, Lucy Hamer²^*, Arundhati S Wuppalapati¹^*, Alastair L Smith, PhD²^*, Catherine M Chahrour²^*, Okan Sevim, MSc³^*, Deena Iskander, MD, PhD⁴^*, Guanlin Wang, PhD²^*, Sorcha I O'Byrne, PhD¹^*, Siobhan Rice, PhD²^*, Joe R Harman, PhD²^*, Bethan Psaila, MD, PhD², Rhys G Morgan, PhD³^*, Irene Roberts, MD², Thomas A Milne² and Anindita Roy, MD, PhD¹

¹Department of Paediatrics, University of Oxford, Oxford, United Kingdom
²Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
³School of Life Sciences, University of Sussex, Brighton, United Kingdom
⁴Center for Haematology, Imperial College London, London, United Kingdom

2:15 PM

200

The Impact of Lineage on CNS Infiltration Dynamics in Infant Leukaemia

Alasdair Duguid, MBBChir¹^*, Camille Malouf, PhD²^*, Christina Halsey, MD, PhD³ and Katrin Ottersbach, PhD²^*

¹Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, SCO, United Kingdom
²Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom
³Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

2:30 PM

201

Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity

Alastair L Smith, PhD¹^*, Nicholas Denny, FRCPath, BMBCh²^*, Catherine M Chahrour³^*, Natalina Elliott, PhD⁴^*, Thomas Jackson, PhD⁴^*, Joe Harman⁵^*, Huimin Geng, PhD⁶^*, Irene Roberts, MD⁴, Nicholas Crump, PhD⁷^*, James Oliver Davies, MRCP, FRCPath²^*, Anindita Roy, MD, PhD⁴ and Thomas A Milne³

¹Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, ENG, United Kingdom
²Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
³Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁴Department of Paediatrics, University of Oxford, Oxford, United Kingdom
⁵Dark Blue Therapeutics, OXFORD, United Kingdom
⁶Department of Laboratory Medicine, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA
⁷Hugh & Josseline Langmuir Centre for Myeloma Research Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom

2:45 PM

202

In Vivo Genetic Screen Identifies Chromatin Remodeling Gene SET As a Collaborating Oncogenic Driver in Initiation and Maintenance of Acute Lymphoblastic Leukemia

James R. Allen¹^*, Luis Antonio Corchete Sanchez, PhD, MSc, BSc¹, Mohamed Nabil Bakr, PhD¹^*, Miriam Fernández-Lajarín, PhD²^*, Alexandra R Hazelwood¹^*, Nathan Ford¹^*, Alexandra Veloso, PhD³^*, Esther Rheinbay, PhD¹^* and David M. Langenau, PhD¹^*

¹Massachusetts General Hospital, Charlestown, MA
²Boston College, Chestnut Hill, MA
³KU Leuven - VIB, Leuven, BEL

3:00 PM

203

ETS1 Recruits the Canonical Baf Complex to Reactivate the Hematopoietic Stem Cell MYB Enhancer in the T-Cell Leukemia Context

Carea Mullin¹^*, Karena Hsijan Lin¹^*, Anna McCarter²^*, Elizabeth Choe¹^*, Shannon Liang¹^*, Qing Wang¹^*, Ashley Melnick, MSc¹^*, Zeel Shukla¹^*, Cher Sha³^*, Ashwin Iyer⁴^*, Rohan Kodgule, MD, MBBS⁵, Yamei Deng¹^*, Felipe Leprevost¹^*, Kelly R. Barnett, PhD⁶^*, Daniel Savic, PhD⁶, Alexey Nesvizhskii¹^*, Russell J. H. Ryan, MD⁷ and Mark Chiang, MD¹

¹University of Michigan, Ann Arbor, MI
²Stanford University, Stanford, CA
³Baylor College of Medicine, Houston, TX
⁴Regeneron Pharmaceuticals, Tarrytown, NY
⁵BJC Institute of Health at Washington University, St Louis, MO
⁶St. Jude Children's Research Hospital, Memphis, TN
⁷Department of Pathology, University of Michigan Medical School, Ann Arbor, MI

3:15 PM

204

Hnrnpc and m⁶a RNA Methylation Control Oncogenic Transcription and Metabolism in T-Cell Leukemia

Jonas De Kesel¹^*, Igor Fijalkowski¹^*, Tim Pieters, PhD²^*, Cristina Borin¹^*, Marino Caruso³^*, Wouter Sleeckx¹^*, Giulia Veltri, PhD⁴^*, Nitesh Devinarayan Sharma, PhD⁵^*, Kim De Keersmaecker, PhD⁶, Steven Goossens, PhD⁷, Tom Taghon⁸^*, Valentina Serafin, PhD⁹, Bruno Palhais⁸^*, Ksenia Matlawska-Wasowska, PhD¹⁰, Ana Milovanovic¹¹^*, Eva Maria Novoa¹¹^*, Eric Wang, PhD¹² and Panagiotis Ntziachristos, PhD¹³

¹Ghent University, Ghent, Belgium
²Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium
³Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven, Leuven, Belgium
⁴Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova – Italy, University of Padua, Padova, Italy
⁵University of Alabama, Birmingham, Birmingham, AL
⁶Leuven Cancer Institute, Holsbeek, Belgium
⁷Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
⁸Ghent University, Ghent, BEL
⁹Woman and Child Health Department, OncoHematology Lab, University of Padova, Padova, Italy
¹⁰University of Alabama at Birmingham, Birmingham, AL
¹¹Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain
¹²The Jackson Laboratory for Genomic Medicine, Farmington, CT
¹³Ghent University, Corneel Heymanslaan 10, Ghent, Belgium

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

603.O1.6 603. Lymphoid Oncogenesis: Basic: Molecular Insights into Acute Lymphoblastic Leukemias