66th ASH Annual Meeting: 506. Bone Marrow Microenvironment: The Bone Marrow Microenvironment in Normal Hematopoiesis

Symposia: Bone Marrow Microenvironment Oral and Poster Abstracts
Oral

Research, Fundamental Science, Translational Research, CHIP, Hematopoiesis, Diseases, Biological Processes, Emerging technologies, Technology and Procedures, Profiling, Study Population, Imaging, Animal model, Omics technologies

Room 7 (San Diego Convention Center)

Moderators:

Xin Gao, PhD, and Bradley Wayne Blaser, MD, PhD,

Disclosures:

No relevant conflicts of interest to declare.

12:00 PM

559

Spatial Transcriptomics Characterize Dynamic and Polarized Niche for Embryonic Hematopoiesis at Single-Cell Level

Xinjian Mao, PhD¹, Ning Zhang, Ph.D.¹^*, Xi He, MD,. Ph.D.¹^*, Laura F Bennett, Ph.D.², Kate Hall¹^*, Kaitlyn Petentler¹^*, Allison Scott¹^*, Seth Malloy¹^*, Jeff Haug¹^*, Hua Li, Ph.D.¹^*, Anoja Perera¹^*, Jay Unruh, Ph.D.¹^*, Brian Slaughter¹^*, Paul Trainor, Ph.D.¹^*, Nancy Speck, Ph.D.² and Linheng Li, Ph.D.^1,3

¹Stowers Institute for Medical Research, Kansas City, MO
²University of Pennsylvania, Philadelphia, PA
³Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS

12:15 PM

560

Bone Marrow Adipocyte Secreted Resistin Is a Positive Regulator of Long-Term Hematopoietic Stem Cell Engraftment and Myelopoiesis

Parash Prasad, PhD¹, Angelo D'Alessandro, PhD², Grace Oh, BSc³^*, Ashley Wellendorf³^*, Mercedes Ricote, PhD⁴^*, Nathan Salomonis, PhD⁵^* and Jose ANTONIO Cancelas, MD⁶

¹Dana Farber Cancer Institute, Boston, MA
²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
³Cincinnati Children's Hospital Medical Center, Cincinnati
⁴Centro Nacional de Biotecnologia, Madrid, ESP
⁵Division of Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH
⁶Dana-Farber Cancer Institute, Boston, MA

12:30 PM

561

Sympathetic Neuron Expressed Neuropeptide Y Is Crucial for Bone Marrow Niche Function and Hematopoietic Stem Cell Repopulation

Dinisha Kamble, PhD^*, Yan QI, BS^* and Pratibha Singh, PhD

Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN

12:45 PM

562

Procr⁺ Endothelial Progenitor Cells Modulate Adult Hematopoiesis and Microenvironment Homeostasis Via Notch Signaling

Chang Xu¹^*, Xue Lv, PhD²^*, Yanling Lv³^*, Shangda Yang⁴^*, Qi Chen⁵^*, Tao Cheng⁶ and Hui Cheng⁴^*

¹State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, Tianjin, AL, CHN
³State Key Laboratory of Experimental Hematology, Tianjin, CHN
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
⁵Center for cell lineage and development, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, China
⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

1:00 PM

563

Compartmentalized Niche and Spatially Heterogenous Inflammatory Landscape Regulate Tet2^+/-- Mediated Clonal Hematopoiesis

Kevin Lee, BSc^1,2, Cih-Li Hong, D.V.M.^2,3^*, Gulzada Kulzhanova, M.S.^1,2^*, Senthil Sivakumar⁴^*, Lauren Benoodt, Ph.D.^5,6^*, Zi Yin, B.S.⁷^*, Jeevisha Bajaj, Ph.D.^6,8, Chia-Lung Wu, Ph.D.^1,2^*, Laura M. Calvi, M.D.^2,6,9,10 and Shu-Chi A. Yeh, Ph.D.^1,2,3,6

¹Department of Biomedical Engineering, University of Rochester, Rochester, NY
²Department of Orthopedics, Center of Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY
³Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY
⁴Department of Biology, University of Rochester, Rochester, NY
⁵Genomics Research Center, University of Rochester Medical Center, Rochester, NY
⁶Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
⁷Institute of Optics, University of Rochester, Rochester, NY
⁸Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY
⁹Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, NY
¹⁰Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester

1:15 PM

564

Leptin Receptor+ Stromal Cells Create a Perisinusoidal Niche for Thrombopoiesis in the Bone Marrow By Synthesizing Cxcl14

Yuanyuan Xue, phd¹^*, Salma Merchant, PhD²^*, Amanda Reyes²^*, Maowu Luo³^* and Sean J. Morrison, PhD⁴

¹UTSouthwestern Medical Center, Dallas, TX
²Children’s Research Institute at the University of Texas Southwestern Medical Center, Dallas, TX
³Department of Pathology at the University of Texas Southwestern Medical Center, Dallas, TX
⁴Children’s Medical Center Research Institute at UT Southwestern, University of Texas Southwestern Medical Center, Dallas, TX

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^*signifies non-member of ASH

506.O1.6 506. Bone Marrow Microenvironment: The Bone Marrow Microenvironment in Normal Hematopoiesis