66th ASH Annual Meeting: 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Epigenetic and Metabolic Control of Hematopoiesis

Symposia: Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, CHIP, Bioinformatics, Hematopoiesis, Metabolism, Biological Processes, Molecular biology, Technology and Procedures, Gene editing, Study Population, Animal model

Room 6DE (San Diego Convention Center)

Moderators:

Raquel Espin Palazon, PhD, Iowa State University and Hideyuki Oguro, PhD, University of Connecticut Health Center

Disclosures:

No relevant conflicts of interest to declare.

This session delves into novel insights on the regulation of hematopoietic stem and progenitor cells (HSPCs) under both steady-state and stress conditions, with a focus on metabolomic and proteostatic controls, as well as the roles of inflammatory responses.

9:30 AM

Dnmt3a Controls Hematopoietic Stem Cells Via DNA Methylation-Independent Regulation of Telomeres

Infencia Xavier Raj, BS, MS¹, Won Kyun Koh, PhD²^*, Jessica Harrison³^*, Christine RC Zhang, PhD⁴, Barbara Soares, PhD⁵^*, Aishwarya Krishnan, MS², Hassan Bjeije⁴^*, Tyler M Parsons, PhD², Wentao Han⁶, Andrew L Young, MD, PhD⁷, Ting Wang, PhD³^*, Luis Batista, PhD⁵ and Grant A Challen, PhD⁴

¹Division of Oncology, Washington University In St. Louis, Saint Louis, MO
²Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO
³Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO
⁴Division of Oncology, Washington University School of Medicine, St. Louis, MO
⁵Hematology, Washington University School of Medicine in St. Louis, St. Louis, MO
⁶Division of Oncology, Washington University School of Medicine, Saint Louis, MO
⁷Division of Hematology, Washington University School of Medicine in St. Louis, St. Louis, MO

9:45 AM

Chromatin Modifier Hmga1 Maintains Hematopoietic Stem Cell Integrity in Stress Conditions

Jie Bai, PhD¹, Supannika Sorin¹^*, Arusyak Ivanyan¹^*, Mihoko Iimori¹^*, Ai Hamashima¹^*, Gang Huang, PhD^2,3, Kimi Araki, PhD^4,5^* and Goro Sashida, MD, PhD¹

¹Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
²Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, TX
³Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX
⁴Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan
⁵Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan

10:00 AM

Stable Contribution of Lineage-Restricted Stem Cells to Steady-State Aged Human Hematopoiesis

Tetsuichi Yoshizato, MD, PhD¹, Christer Nilsson, MD, PhD^2,3^*, Francesca Grasso, PhD³^*, Kari Högstrand, PhD⁴^*, Stefania Mazzi, PhD³^*, Axel Winroth, MD⁴^*, Madeleine Lehander, PhD³^*, Indira Barbosa³^*, Gunilla Walldin³^*, Teresa Mortera-Blanco, PhD³^*, Monika Jansson³^*, Affaf Aliouat, PhD⁵^*, Ellen Markljung, PhD⁶^*, Amy Hillen⁶^*, Edwin Chari⁴^*, Eva Hellstrom Lindberg, MD, PhD^2,3^*, Warren Kretzschmar, PhD³^*, Petter Woll, PhD⁴^* and Sten Eirik Waelgaard Jacobsen, MD, PhD^4,5,7^*

¹Center for Hematology and Regenerative Medicine (HERM) - Department of Medicine Huddinge, Karolinska Institutet, Solna, Sweden
²Division of Hematology, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
³Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
⁴Center for Hematology and Regenerative Medicine (HERM) - Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
⁵MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁶Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
⁷Department of Hematology, Karolinska University Hospital, Stockholm, Sweden

10:15 AM

Resolving Human Hematopoietic Stem Cell Functional Heterogeneity with ATP2B1 Surface Expression

Angelica Varesi^1,2, Murtaza S. Nagree, PhD²^*, Andy G.X. Zeng, BSc^1,2, Sayyam Shah²^*, Hyerin Kim²^*, John Edgar Dick^1,2 and Stephanie Z. Xie, PhD²

¹Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
²Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada

10:30 AM

Force Triggers Mitochondrial Biogenesis Necessary for Hematopoietic Stem Cell Specification Via mTORC1

Paulina D. Horton, B.S.¹^*, Sandeep P. Dumbali, PhD¹^*, Travis I. Moore, PhD¹^*, Momoko Yoshimoto, MD, PhD² and Pamela L. Wenzel, PhD¹

¹Department of Integrative Biology & Pharmacology, University of Texas Health Science Center at Houston, Houston, TX
²Western Michigan University Homer Stryker MD. School of Medicine, Kalamazoo, MI

10:45 AM

Clec16a-Mediated Mitophagy Modulates Zebrafish Definitive Hematopoiesis

Shuyang Cai, MD¹^*, Honghu Li, MD²^*, Ruxiu Tie, MD³^*, Qian Luo⁴^*, He Huang³^* and Jiahui Lu¹^*

¹Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
²Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
³Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁴Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, HANGZHOU, China

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^*signifies non-member of ASH

501.O2.6 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Epigenetic and Metabolic Control of Hematopoiesis