66th ASH Annual Meeting: 201. Granulocytes, Monocytes, and Macrophages: From Inflammation to Hemophagocytic Lymphohistiocytosis

Symposia: Granulocytes, Monocytes, and Macrophages Oral and Poster Abstracts
Oral

Research, Adult, Clinical trials, Fundamental Science, Translational Research, Clinical Practice (Health Services and Quality), Clinical Research, Diseases, Immunodeficiency, Immune Disorders, Biological Processes, Study Population, Human, Animal model

Room 6DE (San Diego Convention Center)

Moderators:

Jerry Lee, Universitu of California San Francisco and Betsy J. Barnes, DPhil, Northwell

Disclosures:

No relevant conflicts of interest to declare.

In this exciting oral session new molecular players in inflammation with potential clinical relevance will be illustrated. Also, new potentially high-impact pre-clinical and clinical studies will be reported.

2:45 PM

805

ELA026, a Monoclonal Antibody Targeting Signal Regulatory Protein-α/β1/γ, Rapidly Controls Inflammation and Improves 2-Month Survival in Treatment-Naïve Malignancy-Associated Hemophagocytic Lymphohistiocytosis

Abhishek Maiti, MBBS¹, Naval Daver, MD², William T. Johnson, DO³, Gaurav Goyal, MD⁴, Catherine M. Broome, MD⁵, Satyen Gohil, MD PhD⁶^*, Jan Van Laar⁷^*, Javier Lopez Jimenez, MD, PhD⁸^*, David McCall, MD⁹, Hayley Lane¹⁰^*, Benjamin Kim, MD, MPhil¹⁰, Sandip Panicker, PhD¹⁰, Gary Patou, MD¹⁰^*, Stephen Moore¹¹^*, Brian Mangal¹²^*, Kelly Covert¹³^*, Graham Carl Parry, PhD¹³^*, Kathy Dong, MBA, PharmD¹¹^*, Carl Allen¹⁴^* and Swaminathan P Iyer, MD¹⁵^*

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²MD Anderson Cancer Center, Houston, TX
³Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Research Collaborator (limited-tenure), Division of Hematology, Mayo Clinic, Birmingham, AL
⁵Division of Hematology, MedStar Georgetown University Hospital, Washington, DC, USA, Washington
⁶University College London Hospitals NHS Foundation Trust, London, United Kingdom
⁷Erasmus University Medical Center, Rotterdam, NLD
⁸Hosp Universitario Ramon Y Cajal, Madrid 28034, ESP
⁹Division of Pediatrics, MD Anderson, Bellaire, TX
¹⁰Star Therapeutics, Inc., South San Francisco, CA
¹¹Electra Therapeutics, South San Francisco, CA
¹²Solara Consulting Corp, North Vancouver, Canada
¹³Electra Therapeutics Inc., South San Francisco, CA
¹⁴Texas Children's Cancer Center, Houston, TX
¹⁵Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX

3:00 PM

806

Rovadicitinib in Patients with Hemophagocytic Lymphohistiocytosis: A Single Arm, Open-Label, Phase I Study

Zhao Wang¹^*, Jingshi Wang¹^*, Lin Wu¹^*, Deli Song¹^*, Yubo Pi¹^*, Dawei Ding²^*, Yao Chen²^* and Xunqiang Wang²^*

¹Beijing Friendship Hospital, Capital Medical University, Beijing, China
²Chia Tai Tianqing Pharmaceutical Group Co., Ltd, Nanjing, China

3:15 PM

807

The Ectopyrase CD73 Is a Critical Checkpoint in Thromboinflammation

Sumith R Panicker, PhD¹^*, Jintao Wang, PhD²^*, Wyatt Becicka, BS/MS³^*, Gustaf Wigerblad, PhD⁴^*, Gil Berreby, BS³^*, Evan Garrad, BS/MD³^*, Jaideep Moitra, PhD³^*, Takeo Fujii, MD, MPH⁵^*, Suchhanda Agasti, PhD³^*, Eries Jay Moreno, BSc, BA³^*, Elizabeth Murray³^*, Bernard Toney³^*, Sharon Osgood, MSN⁶^*, Bretagne Cowling, MSN³^*, Rebecca Huffstutler, CRNP⁶^*, Katherine Carney, CRN³^*, Elisa Ferrante³^*, Francesca Elmer, BS³^*, Nigel Mackman, PhD⁷, Alessandra Brofferio, MD⁸^*, Jason Knight, MD²^*, Manfred Boehm, MD⁹^*, Benjamin Tourdot, PhD¹⁰ and Yogendra Kanthi, MD¹¹^*

¹National Institution of Health, Bethesda, MD
²University of Michigan, Ann Arbor, MI
³NHLBI, Bethesda, MD
⁴NIAMS/NIH, Bethesda, MD
⁵NCI, NIH, bethesda, MD
⁶NHLBI, bethesda, MD
⁷University of North Carolina At Chapel Hill, Chapel Hill, NC
⁸National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁹NIH/NHLBI, Bethesda, MD
¹⁰Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH
¹¹National Heart, Lung and Blood Institute, Bethesda, MD

3:30 PM

808

Serine Threonine Protein Kinase 25 (STK25) Is a New Mediator of Myelopoiesis and Myeloid Cell Effector Function(s) during Injury and Inflammation

Matthew R Rice¹^*, Bharati Matta²^*, Leianna Brune²^*, Julia E Froese²^*, Hazel F Wright²^*, Amanda F Beneat²^*, Vaishali J Jha³^*, Lionel Blanc, PhD⁴ and Betsy J. Barnes, DPhil⁵

¹Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
²Feinstein Institutes for Medical Research, Manhasset, NY
³Feinstein Institute for Medical Research, Manhasset, NY
⁴Department of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
⁵Feinstein Institutes for Medical Research, Northwell, Manhasset, NY

3:45 PM

809

Targeting PRMT5 in Primary Hemophagocytic Lymphohistiocytosis: A Novel Therapeutic Approach Using a Perforin-Deficient Mouse Model

Sheldon Steyn¹^*, Chia-Jo Chen, MS²^*, Rachel Saadey¹^*, Charlene Mao, MS³^*, Peggy A Scherle, PhD⁴, Neha Bhagwat, PhD⁵, Kris Vaddi, PhD⁴^*, Eric Brooks³^*, Michael B. Jordan, MD⁶, Robert Baiocchi, MD, PhD⁷ and Polina Shindiapina, MD, PhD⁸^*

¹The Ohio State University, Columbus, OH
²Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Division of Hematology, Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, OH
⁴Prelude Therapeutics, Wilmington, DE
⁵Prelude Therapeutics Incorporated, Wilmington, DE
⁶Divisions of Immunobiology, and Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁷Department of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH
⁸Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH

4:00 PM

810

Pharmacological and Mechanism Study of a New RIPK1 Inhibitor Via Necroptosis to Treat Hemophagocytic Lymphohistiocytosis

Jinbing Zhu^1,2,3^*, Jinjin Wang^2,3,4^*, Ailin Zhao, MD^2,3,4^* and Ting Niu, MD, PhD^5,6,7

¹Department of Hematology, West China Hospital, Sichuan University., Chengdu, AL, China
²National Facility for Translational Medicine (Sichuan), West China Hospital, Sichuan University., Chengdu, China
³State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University., Chengdu, China
⁴Department of Hematology, West China Hospital, Sichuan University., Chengdu, China
⁵Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
⁶Department of Hematology, West China Hospital of Sichuan University, Chengdu, China
⁷National Facility for Translational Medicine (Sichuan), West China Hospital, Sichuan University, Chengdu, China

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^*signifies non-member of ASH

201.O1.6 201. Granulocytes, Monocytes, and Macrophages: From Inflammation to Hemophagocytic Lymphohistiocytosis