Luke R. Smart, MD^1,2,3,4, Emmanuela Eusebio Ambrose, MD^5,6, Mwesige Charles, BScHLS^7*, Kathryn McElhinney, BS^4*, Teresa S. Latham, MA^4*, Susan E. Stuber, MA^3,4* and Russell E. Ware^1,4

¹Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
²Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH
³Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Paediatric department, haematology section, Bugando Medical Centre, Mwanza, Tanzania
⁶Catholic University of Health and Allied Sciences, Mwanza, Tanzania, United Republic of
⁷Bugando Medical Centre, Mwanza, Tanzania, United Republic of

Amira Idrizovic, MSc, PhDc^1,2*, Marissa J.M. Traets, MD^3*, Anna Collado Gimbert, MD^1,4*, Sara Reidel, MSc^1*, Sigrid van der Veen, MSc^5*, Anne-Laure Pham Hung D'Alexandry D'Orengiani, PhD^6*, Mirco D'Agnolo, MS^7*, Emmanuel Adu, MSc^8*, Mickael MARIN, Engineering degree^9*, Emmanuelle Bourdelier, Technician^10*, Elisabetta Mezzalira, RN, MS, PhDc^11*, Betzabel Cajiao Garcia, MSc^12*, Santiago Zazo, Prof., PhD^13*, Tiziana Sanavia, PhD^14*, Cesare Rollo, PhD^14*, David Beneitez, MD^15,16*, Bart J. Biemond, MD, PhD¹⁷, Erfan Nur, MD, PhD¹⁸, Karin Fijnvandraat, MD, PhD^19*, Saskia EM Schols, MD, PhD^20*, Anita W. Rijneveld, MD, PhD²¹, Marjon H. Cnossen, MD, PhD^22*, Aida Kidane, MD^23,24*, Nicolas Hebert, PhD^25*, Maria Paola Boaro, MD^26*, Slimane Allali^27*, Caroline Le van kim, Prof.^28*, Anna Ruiz Llobet, MD^29*, Béatrice Gulbis, MD, PhD^30*, Federico Alvarez, Prof, PhD^31*, Piero Fariselli, PhD^14*, Petros Kountouris, PhD^32*, Raffaella Colombatti, MD, PhD^33*, Pablo Bartolucci, MD, PhD^34*, Mariane De Montalembert, MD, PhD³⁵, Richard van Wijk, PhD³⁶, Eduard J. Van Beers, MD, PhD³⁷, Maria Del Mar Mañú Pereira^1* and Minke A.E. Rab, MD, PhD^3,38

¹Rare Anemia Disorders Research Laboratory, Cancer and Blood Disorders in Children, Vall d'Hebron Research Institute / Vall d'Hebron University Hospital, Barcelona, Spain
²Genetics and Microbiology department, Universitat Autonoma de Barcelona, Barcelona, Spain
³Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht, Netherlands
⁴Pediatric Oncology and Hematology, Vall d'Hebron Barcelona Hospital, Barcelona, Spain
⁵Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands
⁶University Paris-Est-Créteil, IMRB, Inserm U955, Laboratory of excellence LABEX, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Créteil, FRA
⁷Department of Women's and Child's Health, University of Padova, Padova, Italy
⁸University Paris-Est-Créteil, IMRB, Inserm U955, Laboratory of excellence LABEX, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Creteil, France
⁹Necker, Université Paris Cité, INSERM, BIGR, PARIS, FRA
¹⁰Institut de Recherche Saint Louis, Université Paris Cité, Inserm, CNRS, Paris, France
¹¹Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, Università degli Studi di Padova, Padova, Italy
¹²Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, University Medical Center Utrecht, Utrecht, Netherlands
¹³Centro de I+D+i en Procesado de la Información y Telecomunicaciones (IPTC), Universidad Politécnica de Madrid, Madrid, Spain
¹⁴Computational Biomedicine Unit, Department of Medical Sciences, University of Torino, Turin, Italy
¹⁵Vall d’Hebron Hospital Universitari and General Hospital, Barcelona, ESP
¹⁶Hematology Department, Vall d'Hebron Hospital Universitari/Vall d'Hebron Research Institute (VHIR)/Vall d'Hebron Institute of Oncology (VHIO)/Universitat Autònoma de Barcelona (UAB)/ERN-EuroBloodNet, Barcelona, Spain
¹⁷Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
¹⁸Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands
¹⁹Department of Pediatric Hematology, Amsterdam UMC, Emma Children's Hospital, Amsterdam, Netherlands
²⁰Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
²¹Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
²²Department of Pediatric Hematology and Oncology, Erasmus MC Sophia Children’s Hospital, Erasmus University Medical Center, Rotterdam, Netherlands
²³Department of Pediatric Hematology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands
²⁴Section on Social and Cognitive Developmental Neuroscience, National Institutes of Mental Health, Bethesda, MD
²⁵University Paris-Est-Créteil, IMRB, Inserm U955, Laboratory of excellence LABEX, Établissement Français du Sang (EFS), Créteil, France
²⁶Department of Women’s and Children’s Health, Padova University, Padova, Italy
²⁷Sickle Cell Center, Pediatrics Department, Necker Hospital for Sick Children, APHP, Paris Cité University, Paris, FRA
²⁸Necker Hospital, University Paris Cité/Inserm, Paris, France
²⁹Pediatric Hematology, Hospital Sant Joan de Déu, Barcelona, Barcelona, ESP
³⁰Centre of Human genetics, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium
³¹Universidad Politécnica de Madrid, Madrid, Spain
³²Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, CYP
³³Department for Woman's and Child's Health, University of Padova, Padova, Italy
³⁴University Paris-Est-Créteil, IMRB, Inserm U955,, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Creteil, France
³⁵Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants Malades Hospital, Neuilly, France
³⁶Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, Netherlands
³⁷Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
³⁸Department of Hematology, Erasmus MC, Rotterdam, Netherlands

Soumitri Sil, PhD¹, Jan Mooney, PhD^1*, Taylor Adkins, MBA^1*, Cynthia Sinha, PhD^2*, Maria Anjanette Nunez, DPT^3*, Staci Thomas^4*, Katie Beasley^4*, Amy Lang, PhD^5*, Bridget N Murphy, PhD^6*, Tinu Akintobi^4*, Justin Williams, PhD^1*, Keenan Batts, DPT^7*, Aschli Kurzhals^4*, Nitya Bakshi, MBBS, MS⁸, Trisha Kesar, PhD^2*, Greg Myer, PhD^2*, Charles T. Quinn, MD, MS⁹, Carlton Dampier, MD¹⁰, Lori E. Crosby, PsyD¹¹ and Susmita Kashikar-Zuck, PhD^4*

¹Emory University/Children's Healthcare of Atlanta, Atlanta, GA
²Emory University School of Medicine, Atlanta
³Emory University School of Medicine, Atlanta, GA
⁴Cincinnati Children's Hospital Medical Center, Cincinnati
⁵Cincinnati Children's Hospital Medical Center, CINCINNATI, OH
⁶Behavioral Medicine and Clinical Psychology, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH
⁷Emory University, Atlanta
⁸Yale School of Medicine, New Haven
⁹Division of Hematology, Cincinnati Children's Hospital Med. Ctr., Cincinnati, OH
¹⁰Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA
¹¹Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Olufunke Y. Martin, MD^1,2, Matthew Hays, MS^3*, Sean Thompson, MD^4* and Seethal A Jacob, MD, MS^5,6

¹Center for Cancer and Blood Disorders, Children's Medical Center Dallas, Dallas, TX
²Division of Pediatric Hematology-Oncology, The University of Texas Southwestern Medical Center, Dallas, TX
³Department of Biostatistics and Health Science Data, Indiana University School of Medicine and Richard M. Fairbanks School of Public Health, Indianapolis, IN
⁴Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN
⁵Department of Pediatrics, Division of Children’s Health Services Research, Indiana University School of Medicine, Indianapolis, IN
⁶Division of Pediatric Hematology, Oncology, and Stem Cell Transplant, Riley Hospital for Children, Indianapolis, IN

Bushra Zucca, MD^1*, Alina Ferster, MD², Laurence Rozen, PharmD, PhD^3*, Anne Demulder, MD, PhD^3*, Laurence Dedeken, MD^4*, Anna Vanderfaeillie, MD^2*, Phu-Quoc Le, MD, PhD^4,5, Denis Noubouossie, MD, PhD^6* and Nicolas Lefèvre, MD, PhD^1*

¹Laboratory of Pediatrics, Université Libre de Bruxelles, Brussels, Belgium
²Department of Pediatrics, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium
³LHUB-ULB, Laboratory of Hematology, Université Libre de Bruxelles, Brussels, Belgium
⁴Department of Hematology-Oncology, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium
⁵Department of Pediatrics, Centre Hospitalier Etterbeek-Ixelles, Brussels, Belgium
⁶Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

Christine Saber, MD^1,2*, Elizabeth Meinert-Spyker^3*, Lara Abdelmohsen^3*, Brian J Philips, PhD^1*, Joel Dzidzorvi Kwame Disu, BSc, MSc^3*, Nahom Mossazghi, BS, MS^3*, Nelly Kiriza, MD, MPH^1,2*, Seyed Mehdi Nouraie, MD, PhD^4*, Olubusola Oluwole, MD, MS^1,2, Laura M. DeCastro, MD, MHSc^1,2, Adam C Straub, PhD^1,5*, Enrico M Novelli, MD, MS^1,2, Sossena Wood, PhD, BSc^3* and Julia Xu, MD, MS^1,2

¹Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
²Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
³Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA
⁴Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁵Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA