66th ASH Annual Meeting: 101. Red Cells and Erythropoiesis, Excluding Iron: Effects of Inflammation on Erythropoiesis and the Niche

Symposia: Red Cells and Erythropoiesis, Excluding Iron Oral and Poster Abstracts
Oral

Research, Fundamental Science, Translational Research, Genetic Disorders, Hematopoiesis, Diseases, Immune Disorders, Immune mechanism, Immunology, Metabolism, Biological Processes, Emerging technologies, Metabolic Disorders, Technology and Procedures, Molecular biology, Study Population, Pathogenesis, Animal model, Omics technologies

Room 33 (San Diego Convention Center)

Moderators:

Robert Paulson, PhD, Pennsylvania State University and Merlin Nithya Gnanapragasam, PhD,

Disclosures:

No relevant conflicts of interest to declare.

This session contains presentations describing the structure or the erythroblastic niche at steady state and during anemia. In addition, the presentations describe the effect of pro-inflammatory signals on erythropoiesis and their contributions to anemia.

2:00 PM

163

Heterogeneity of the Erythromyeloblastic Island (EMBI) Niche during Baseline and Stress Erythropoiesis

Katie Seu, PhD^1,2, Laurel Romano, PhD²^*, Athina Ntoumaziou, MD²^*, Maria Stewart²^*, Jason C Gardner, PhD³^*, Robert Paulson, PhD⁴, Yi Tu, Zheng, PhD^1,2, Matthew Kofron^1,5^*, Lionel Blanc, PhD^6,7, Nathan Salomonis, PhD^1,8^* and Theodosia A. Kalfa, MD, PhD^1,2

¹Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
²Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati, Cincinnati, OH
⁴Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA
⁵Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁶Institute of Molecular Medicine, The Feinstein Institute For Medical Research, Manhasset, NY
⁷Department of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
⁸Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

2:15 PM

164

Reconstruction of Megaloblastic Anemia in a Novel Erythroblastic Island Humanized Mouse Model with Mature Circulating Human Red Blood Cells

Shuang Liu, PhD^1,2, Tong Zhou, MS³^*, Zijian Zhang, PhD^1,2^*, Tongxiao Cui, PhD⁴^*, Shuhua Yu, PhD^1,2^*, Jin Zhang, MS^1,2^*, Zhongyang Lv, MD⁵^*, Shuai Ding, PhD⁶^*, Dongquan Shi, MD⁵^*, Deshan Ren, PhD^1,2^*, Ran Xie, PhD^2,4^*, Peipei Xu, MD³^*, Harvey F. Lodish, PhD⁷ and Yan Li, PhD^1,2^*

¹Model Animal Research Center, Medical School of Nanjing University, Nanjing, China
²Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, China
³Department of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
⁴State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
⁵Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University,, Nanjing, China
⁶Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China
⁷Whitehead Institute for Biomedical Research, Cambridge, MA

2:30 PM

165

Lipid-Dependent Roles for SAMD14 in Stress Erythropoiesis

Pooja Roy, MS^*, Suhita Ray, PhD^*, Suyong Choi, PhD^*, Nicholas Woods, PhD^* and Kyle J Hewitt, PhD

Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE

2:45 PM

166

Endotoxemia As Possible Cause of Inflammatory Bowel Diseases-Associated Anemia

Kavita Bisht, PhD¹, Yoon-Kyo An¹^*, Svetlana Shatunova¹^*, Ran Wang¹^*, Valerie Barbier¹^*, Rabina Giri²^*, Anna Amiss¹^*, Yifu Tang¹^*, Kylie Alexander³^*, Susan Millard⁴^*, Ingrid G Winkler⁵^*, Allison Pettit¹^*, Jakob Begun⁶^* and Jean-Pierre Levesque, PhD¹^*

¹Mater Research Institute-The University of Queensland, Woolloongabba, QLD, Australia
²Mater Research Institute, Wolloongabba, AUS
³Mater Research Institute - The University of Queensland, Woolloongabba, AUS
⁴Mater Research Institute - The University of Queensland, Faculty of Medicine and, Woolloongabba, AUS
⁵Mater Research Institutee - The University of Queensland, Brisbane, AUS
⁶Mater Research Institute, Woolloongabba, AUS

3:00 PM

167

The Inflammatory Cytokine IL17 Tunes and Amplifies the Erythropoietic Response to Erythropoietin In Vivo

Qiu Chang Wu¹^*, Ashley Winward²^*, Aishwarya Swaminathan, PhD³^*, Logan Lalonde³^*, Merav Socolovsky, MBBS, PhD⁴ and Allon Moshe Klein, PhD⁵^*

¹Harvard Medical School, Boston, Massachusetts, USA, Boston, MA
²Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA
³University of Massachusetts Chan Medical School, Worcester, MA
⁴UMass Med. School, Worcester, MA
⁵Harvard Medical School, Boston, MA

3:15 PM

168

TNFα Plays Essential Role in Resolution of Anemia of Inflammation in Tnfαko Mice Treated with Heat-Killed Brucella Abortus

Vania Lo Presti¹^*, Ding-wen Chen, PhD²^*, Ana Martins³^*, Pankaj Sharma²^*, Yelena Ginzburg, MD⁴, Carlo Castruccio Castracani, PhD, PharmD⁵^*, Carla Casu²^*, Ritama Gupta, PhD⁶^*, Raffaella Gozzelino, PhD⁷^*, Edward Behrens, MD⁸^*, Laura F Bennett, Ph.D.⁸, Robert Paulson, PhD⁹, Peter Kurre, MD¹⁰, Stefano Rivella, PhD¹¹ and Amaliris Guerra, PhD²^*

¹The Children's Hospital of Philadelphia (CHOP), Philadelphia, PA
²Children's Hospital of Philadelphia, Philadelphia, PA
³NOVA Medical School, Lisbon, PRT
⁴Division of Hematology & Medical Oncology, Tisch Cancer Institute/ Icahn School of Medicine at Mount Sinai, New York, NY
⁵Dpt. of Pediatrics/Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
⁶Children’s Hospital of Philadelphia, Philadelphia, PA
⁷NOVA, Lisbon, PRT
⁸University of Pennsylvania, Philadelphia, PA
⁹Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA
¹⁰Comprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA
¹¹Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA

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^*signifies non-member of ASH

101.O2.6 101. Red Cells and Erythropoiesis, Excluding Iron: Effects of Inflammation on Erythropoiesis and the Niche