Lydian A. De Ligt, MD^1,2,3*, Eelke Brandsma^2*, Aafke E. Gaartman^2,4*, Guusje Van Gameren^2*, Colin Blans^2*, Martijn Veldthuis^2*, Hanke Matlung^2*, Bart J. Biemond⁴, Erfan Nur^2,4*, Emile Van Den Akker^2* and Robin Van Bruggen, PhD^2*

¹Department of Hematology, Amsterdam University Medical Centers, Amsterdam, AL, Netherlands
²Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
³Department of Pediatric Hematology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁴Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands

Gianluca Asti, MSc^1*, Saverio D'Amico, MSc^1,2*, Luciana Carota, PhD^3*, Davide Piscia, MSc^4*, Francesco Casadei, MSc^5*, Nono Saha Cyrille Merleau, PhD^6,7*, Patricia Alonso de Apellániz, MSc^8*, Anne Sophie Kubasch, MD⁹, Silke Gloaguen, MSc^9*, Nicole Modler, MSc^9*, Catalina Gonzalez Martin, MSc^10*, Cesare Rollo, PhD^11*, Juan Parras, PhD^8*, Mattia Delleani^1*, Elena Zazzetti, MSc^1*, Elisabetta Sauta, PhD^1*, Nico Curti, PhD^12*, Nicolas Riccardo Derus, PhD^12*, Gianluca Carlini, PhD^5*, Daniele Dall'Olio, PhD^13*, Claudia Sala, PhD^3*, Lorenzo Dall'Olio, PhD^5,12*, Luca Lanino, MD¹⁴, Giulia Maggioni, MD^1*, Alessia Campagna, MD^1*, Marilena Bicchieri, PhD^1*, Arturo Bonometti, MD^1*, Cesare Lancellotti, MD^15*, Daoud Rahal, MD^1*, Luca Di Tommaso, MD^1,16*, Tiziana Sanavia, PhD^11*, Piero Fariselli, PhD^11*, Matteo Zampini, PhD^17*, Matteo Brindisi^14*, Victor Savevski, MEng^1*, Uwe Platzbecker, MD¹⁸, Maria Diez-Campelo, MD, PhD^19*, Lin Pierre Zhao, MD, PhD^20*, Pierre Fenaux, MD²⁰, Torsten Haferlach, MD²¹, Vincent Planat, PhD^10*, Raffaella Colombatti, MD, PhD²², Maria Del Mar Mañú Pereira^23*, Anders Krogh, PhD^24*, Silvia Uribe, PhD^25*, Santiago Zazo, Prof., PhD^8*, Enrico Giampieri, PhD^3*, Gastone Castellani, PhD^26*, Matteo Giovanni Della Porta, MD^1,16* and Federico Alvarez, Prof, PhD^8*

¹IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
²Train s.r.l., Rozzano, Milan, Italy
³University of Bologna, Bologna, Italy
⁴Centro Nacional de Análisis Genómico - CNAG, Barcelona, Spain
⁵Data Science and Bioinformatics Laboratory, IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy
⁶Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany
⁷Center for Scalable Data Analytics and Artificial Intelligence, University of Leipzig, Leipzig, Germany
⁸Information Processing and Telecommunications Center, Universidad Politécnica de Madrid, Madrid, Spain
⁹Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, Leipzig, Germany
¹⁰Dedalus Spain, Madrid, Spain
¹¹Computational Biomedicine Unit, Department of Medical Sciences, University of Torino, Turin, Italy
¹²Department of Physics and Astronomy, University of Bologna, Bologna, Italy
¹³IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
¹⁴IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
¹⁵Struttura Complessa di Anatomia Patologica, Policlinico di Modena, Modena, Italy
¹⁶Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
¹⁷IRCCS Humanitas Research Hospital & Humanitas University, Rozzano - Milan, Italy
¹⁸Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
¹⁹Hospital Clínico Universitario de Salamanca, Salamanca, Spain
²⁰Hôpital Saint-Louis, Université de Paris 7, Paris, France
²¹MLL Munich Leukemia Laboratory, Munich, Germany
²²Department for Woman's and Child's Health, University of Padova, Padova, Italy
²³Translational Research in Cancer and Blood disorders in Children, Valll d'Hebron Research Institution, Barcelona, Spain
²⁴University of Copenhagen, Copenhagen, DNK
²⁵Escuela Técnica Superior de Ingeniería de Sistemas Informáticos, Universidad Politécnica de Madrid, Madrid, Spain
²⁶Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

Ramy El-Assal, B.S. in Neuroscience^1* and Aziz Nazha, MD²

¹The Ohio State University, Columbus
²Thomas Jefferson University, Department of Medical Oncology, Philadelphia, PA

Shruti Sridhar^1*, Michal Marek Hoppe^1*, Patrick Jaynes^1*, Gayatri Kumar^2*, Siddham Jasoria^3*, Ziwei Meng^4*, Yanfen Peng^1*, Sanjay De Mel, BSc, FRCPath, MRCP^5,6*, Limei Poon^5,6*, Esther Hian Li Chan^5,6*, Wee-Joo Chng^1,5,6,7, Soo Yong Tan^5,8*, Susan Swee-Shan Hue^5,8*, Siok-Bian Ng^1,5,8*, Chandramouli Nagarajan^9*, Nicholas Francis Grigoropoulos^9*, Shaoying Li^10*, Joseph D. Khoury¹¹, Pedro Farinha¹², Anja Mottok^12*, David W. Scott, MBChB, PhD¹², Xiaofei Ye^13*, Qiang Pan-Hammarström^14*, Vaibhav Rajan^4*, Kasthuri Kannan^2* and Anand Devaprasath D. Jeyasekharan, MBBS, MRCP, PhD^1,5,6,7*

¹Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
²Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Birla Institute of Technology & Science, Pilani, Pilani, India
⁴Department of Information Systems and Analytics, School of Computing, National University of Singapore, Singapore, Singapore
⁵NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⁶Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore
⁷Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⁸Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⁹Department of Haematology, Singapore General Hospital, Singapore, Singapore
¹⁰Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
¹¹Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
¹²BC Cancer Research Centre, Vancouver, BC, Canada
¹³Kindstar Global Precision Medicine Institute, Wuhan, China
¹⁴Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Ibrahim Karabayir^1*, Robert L. Davis, MD^2*, Lokesh Chinthala^3*, Parul Rai, MD, MBBS^4,5,6, Dan McGuire^3*, Jane S Hankins, MD, MS^4,7 and Oguz Akbilgic, PhD^8*

¹Wake Forest Baptist Health, Winston Salem, NC
²Center for Biomedical Informatics, University of Tennessee Health Science Center, Memphis, TN
³University of Tennessee Health Science Center, Memphis, TN
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN
⁶Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁷Departments of Hematology and Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN
⁸Wake Forest Baptist Health, Winston-Salem, NC

Meihua Long, PhD candidate^1,2*, Fan Jia^1,2*, Jili Deng^3*, Jianing Zhang^2*, Ziran Zhao, PhD^4,5, Yan Xie^2*, Lan Mi^2*, Yan Hou^1,2* and Yuqin Song, MD²

¹Department of Biostatistics, Peking University, Beijing, China
²Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China
³Department of Oncology, Sichuan Cancer Hospital and Institute, Chengdu, China
⁴National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⁵First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China