66th ASH Annual Meeting: Clonal Hematopoiesis Lesions and Gene Editing

Symposia: Scientific Workshop on Clonal Hematopoiesis Scientific Workshops

Room 8 (San Diego Convention Center)

Moderator:

and Michael R. Savona, MD, Vanderbilt University Medical Center

Disclosures:

No relevant conflicts of interest to declare.

The speakers will discuss how gene editing technologies allow creation of novel tools to study the pathophysiology of specific Clonal Hematopoiesis (CH) mutations, and the factors that lead to progression to hematological cancer. They will also begin to discuss how we can also use gene editing to repair mutated genes and modulate the deleterious effects of CH mutations.

Moderator Introduction

Michael R. Savona, MD

Vanderbilt University Medical Center, Nashville, TN

Gene Editing to Model Clonal Hematopoiesis

Ravi Majeti, MD, PhD

Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA

Modeling Deleterious Clonal Hematopoiesis Mutations In Vivo

Esther A. Obeng, MD, PhD

St. Jude Children's Research Hospital, Memphis, TN

Using Intraallelic Gene Conversion to Reduce Variant Allele Frequencies of Deleterious CH Mutations

Michael R. Savona, MD

Vanderbilt University Medical Center, Nashville, TN

Panel Discussion

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