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Anticoagulation SOS: Navigating Monitoring Conundrums

Program: Education Program
Hematology Disease Topics & Pathways:
Bleeding and Clotting, Diseases, Treatment Considerations
Monday, December 9, 2024: 10:30 AM-11:45 AM
Room 28 A-D (San Diego Convention Center)

Description:
Anticoagulation monitoring challenges are encountered commonly in clinical practice. This educational session will present clinically oriented approaches to understanding and managing anticoagulation monitoring challenges associated with direct oral anticoagulant (DOAC) use, heparin monitoring, and anticoagulation for antiphospholipid antibody syndrome.

Dr. Deborah Siegal will review the potential benefits and limitations of DOAC measurement. Clinical situations in which DOAC measurement may be helpful will be discussed and DOAC testing options will be presented based on the goal of measurement.

Dr. Cheryl Maier will review the definition of heparin resistance which varies depending on specific measurements of anticoagulation and the type of assay used. Multiple causes of heparin resistance will be covered using a case-based approach to help providers troubleshoot heparin resistance and develop alternative management strategies when heparin resistance is encountered.

Prof. Hannah Cohen will summarise the use of warfarin in patients with thrombotic antiphospholipid syndrome (APS). Using a case-based approach, she will highlight key considerations in the choice of oral anticoagulant, issues that may impact on accurate monitoring of warfarin anticoagulation in APS patients, and strategies to overcome these. She will also discuss the use and monitoring of low-molecular-weight/unfractionated heparin in APS patients in particular situations.

Chair:
Deborah Siegal, MD, MSc, University of Ottawa
Disclosures:
Siegal: Servier: Other: honoraria paid indirectly to research institute; Roche: Other: honoraria paid indirectly to research institute; BMS-Pfizer: Other: honoraria paid indirectly to research institute; Astra Zeneca: Other: honoraria paid indirectly to research institute.

Anticoagulation monitoring challenges are encountered commonly in clinical practice. This educational session will present clinically oriented approaches to understanding and managing anticoagulation monitoring challenges associated with direct oral anticoagulant (DOAC) use, heparin monitoring, and anticoagulation for antiphospholipid antibody syndrome.

Dr. Deborah Siegal will review the potential benefits and limitations of DOAC measurement. Clinical situations in which DOAC measurement may be helpful will be discussed and DOAC testing options will be presented based on the goal of measurement.

Dr. Cheryl Maier will review the definition of heparin resistance which varies depending on specific measurements of anticoagulation and the type of assay used. Multiple causes of heparin resistance will be covered using a case-based approach to help providers troubleshoot heparin resistance and develop alternative management strategies when heparin resistance is encountered.

Prof. Hannah Cohen will summarise the use of warfarin in patients with thrombotic antiphospholipid syndrome (APS). Using a case-based approach, she will highlight key considerations in the choice of oral anticoagulant, issues that may impact on accurate monitoring of warfarin anticoagulation in APS patients, and strategies to overcome these. She will also discuss the use and monitoring of low-molecular-weight/unfractionated heparin in APS patients in particular situations.

Deborah Siegal, MD, MSc

Department of Medicine, University of Ottawa, Ottawa, ON, Canada

Cheryl L Maier, MD, PhD

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA

Hannah Cohen, MD, FRCPath

University College London Hospitals NHS Foundation Trust, London, United Kingdom

See more of: Education Program