66th ASH Annual Meeting: HIT-and-Run: Challenges in Diagnosis and Management of Heparin-Induced Thrombocytopenia

Education Program

Bleeding and Clotting, Clinical Practice (Health Services and Quality), Diseases, Immune Disorders

Room 28 A-D (San Diego Convention Center)

Description:
In hospitalized patients, the diagnosis and management of heparin induced thrombocytopenia (HIT) is a recurrent challenge. To this end, this session will 1) provide evidence-based practical guidance in the diagnosis and management of suspected and confirmed HIT; 2) classify anti-platelet factor 4 (PF4) antibody mediated disorders (autoimmune HIT), their relationship to heparin exposure, and the role of rapid PF4 and platelet activation assays in diagnosis; and 3) review alternative management strategies when heparin cessation and non-heparin anticoagulants are insufficient in patients who have refractory HIT, experience acute bleeding, or are planned to undergo cardiac surgery. Emphasizing evidence-based strategies, this session will provide practical approaches and system-level interventions for high-quality care.

Chair:

Toyosi Onwuemene, MD, MS, Duke University

Disclosures:

Onwuemene: Sanofi: Honoraria.

In hospitalized patients, the diagnosis and management of heparin induced thrombocytopenia (HIT) is a recurrent challenge. To this end, this session will 1) provide evidence-based practical guidance in the diagnosis and management of suspected and confirmed HIT; 2) classify anti-platelet factor 4 (PF4) antibody mediated disorders (autoimmune HIT), their relationship to heparin exposure, and the role of rapid PF4 and platelet activation assays in diagnosis; and 3) review alternative management strategies when heparin cessation and non-heparin anticoagulants are insufficient in patients who have refractory HIT, experience acute bleeding, or are planned to undergo cardiac surgery. Emphasizing evidence-based strategies, this session will provide practical approaches and system-level interventions for high-quality care.

Practical Guide to the Diagnosis and Management of Heparin-Induced Thrombocytopenia

Jori E. May, MD

Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

Approaches to Management of HIT in Complex Scenarios, including Cardiac Surgery

Toyosi Onwuemene, MD, MS

Division of Hematology, Department of Medicine, Duke University, Durham, NC

Demystifying Autoimmune HIT: What It Is, When to Test, and How to Treat

Marie Scully, MD

University College London, London, ENG, United Kingdom

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