Session: 624. Hodgkin Lymphomas: Clinical and Epidemiological: Poster I
Hematology Disease Topics & Pathways:
Research, Hodgkin lymphoma, Lymphomas, Elderly, Clinical Research, Diseases, Real-world evidence, Adverse Events, Lymphoid Malignancies, Human, Study Population
Methods: This retrospective multicenter study was conducted at five medical centers in the US and Israel. Older pts age ≥60 consecutively diagnosed with HL between 03/2013-04/2023 were identified. Data on demographics, comorbidities (including cumulative illness rating scale-geriatrics [CIRS-G] score), AEs, treatment reductions, interruptions, PFS and OS were manually collected from electronic medical records.
Results: 136 pts were treated with BV-based regimens. Pt characteristics included a median age of 71 years (range 60-91), 65% male, a median CIRS-G score of 5 (range 0-16), 34% with a history of other malignancy, 54% stage IV disease, 29% with bone marrow involvement, 67% with B symptoms, 46% EBV positive in tumor, and 32% with non-nodular sclerosis histology.
Of these pts, 56 (41%) received CON BV-AVD, 54 (40%) were treated with SEQ BV-AVD; the rest (26, 19%) received BV monotherapy or BV-based palliative regimens.
Patients treated with CON BV-AVD were younger compared to those treated with SEQ BV-AVD (median 69 vs. 72 years old, p=0.049); Other baseline characteristics did not differ significantly between the two groups.
At a median follow up of 2.3 years (range 0.06-10.4), 2-year PFS and OS were 65% (95% CI 56-74%) and 83% (95% CI 76-90%), respectively. After excluding 26 pts treated with palliative regimens, 2-year PFS and OS were 73% (95% CI 64-83%) and 86% (95% CI 80-94%), respectively. We found no significant difference in PFS between SEQ and CON BV-AVD (76% vs. 70% 2-year PFS; p=0.5). In a multivariable Cox regression analysis including age and treatment regimen (SEQ or CON), the regimen was not statistically significant (p=0.2) with no difference in OS (p=0.7).
The most common AEs were neuropathy (all 44%/CON 45%/ SEQ 48%), infections (all 29%/CON 29%/ SEQ 26%), and neutropenic fever (all 16%/CON 28%/SEQ 11%), leading to treatment interruption in 33% of pts and treatment reduction in 52%, primarily involving BV. Of 107 patients treated with curative intent with full treatment data, 78 (73%) completed six cycles of AVD. However, only 58 (54%) completed the treatment as initially planned, mainly due to toxicity. Patients on CON BV-AVD were significantly more likely to complete treatment as planned when compared to those on SEQ (74% vs 34%, p<0.001). Rate of treatment interruption between cycles, or dose reduction did not differ significantly between CON and SEQ regimens.
During the study follow-up, 20 patients treated with curative intent died: 5 from infections (2 CON/3 SEQ including 3 from COVID-19), 7 from disease progression (4 CON/3 SEQ), and 8 from other comorbidities (2 CON/ 6 SEQ).
Among 36 pts who relapsed or had primary refractory disease, 4 died upon progression, and 2 were missing information after progression. Thirteen underwent treatment with PD-1-based combinations, while 17 received alternative chemotherapies.
Conclusions: In a multicenter study, evaluating the real-world outcomes of frontline BV in elderly HL pts, both CON and SEQ BV-AVD regimens demonstrated comparable efficacy and safety to those reported previously and to each other. More SEQ pts discontinued the treatment plan. SEQ BV-AVD had similar outcomes to CON BV-AVD, even after adjusting for age, indicating SEQ may not mitigate the adverse outcomes associated with older age. Recently, SWOG 1826 reported nivolumab-AVD over BV-AVD in advanced stage HL (Herrera et al., ASCO and ICML 2023) with similar findings in geriatric subsets (Torka et al, ICML 2023; Rutherford et al, ASH 2023). These finding support combining anti-PD-1 in frontline treatment for older patients.
Disclosures: Kambhampati: Genentech: Research Funding; Genmab: Consultancy, Research Funding; Ipsen: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Abbvie: Consultancy; ADC-Therapeutics: Research Funding. Gurion: Gilead: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Roche: Consultancy, Honoraria; Medison: Consultancy, Honoraria; AbbVie: Consultancy, Honoraria; Lilly: Consultancy, Honoraria; Novartis: Consultancy, Honoraria. Stuver: Pfizer: Research Funding. Noy: Cornerstone Pharma: Honoraria, Research Funding; PER: Honoraria; NSCI: Honoraria; OncLIve: Honoraria; janssen Global: Consultancy, Other: drug provided for research; Medallion Healthcare: Honoraria; health advance: Consultancy; EUSA: Consultancy; guidepoint global: Consultancy; clearview: Consultancy; epizyme: Consultancy; AstraZeneca: Consultancy; ADC therapeutics: Consultancy; Beigene: Consultancy. Herrera: ADC Therapeutics: Consultancy, Research Funding; Karyopharm: Consultancy; Adicet Bio: Consultancy; Caribou Biosciences: Consultancy; Regeneron: Consultancy; Tubulis: Consultancy; Gilead Sciences: Research Funding; KiTE Pharma: Research Funding; Allogene Therapeutics: Consultancy; AbbVie: Consultancy; Pfizer: Consultancy; Genmab: Consultancy; Takeda: Consultancy; AstraZeneca: Consultancy, Research Funding; Seattle Genetics: Consultancy, Research Funding; Merck: Consultancy, Research Funding; Roche/Genentech: Consultancy, Research Funding; Bristol Myers Squibb: Consultancy, Research Funding. Moskowitz: ADC therapeutics: Research Funding; Beigene: Research Funding; Brystal-Meyers Squibb: Research Funding; Incyte: Research Funding; Merck: Research Funding; Miragen Therapeutics: Honoraria; Seattle Genetics: Honoraria, Research Funding; Secura Bio: Research Funding; Takeda Therapeutics: Honoraria; Tessa Therapeutics: Honoraria.
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