Session: 908. Outcomes Research: Myeloid Malignancies: Poster II
Hematology Disease Topics & Pathways:
Clinical trials, Adult, Combination therapy, Research, Clinical Practice (Health Services and Quality), Drug development, Elderly, Clinical Research, Health outcomes research, Drug-drug interactions, Health disparities research, Therapy sequence, Real-world evidence, Treatment Considerations, Biological therapies, Adverse Events, Human, Study Population, Measurable Residual Disease
Population-based studies from publicly available databases have shown a disparity in the outcomes of patients (pts) with acute myeloid leukemia (AML) based on their racial background. However, such studies are limited as several aspects of socioeconomic (SE) data, an independent prognostic factor, still need to be captured. Area Deprivation Index (ADI) is one of the most advanced SE tools, incorporating 17 SE factors to rank neighborhoods based on disadvantaged status (Powell et al. Forefront, 2023). This abstract, reports the largest cohort of pts with molecular, cytogenetic (CG) and ADI data treated in a single institution.
Methods
Adult pts with AML available self-reported race and treated at MD Anderson Cancer Center from 3/2013 to 3/2023 were included. ADI data was downloaded from https://www.neighborhoodatlas.medicine.wisc.edu/May 10,2024. The MatchIt package was used to perform nearest neighbor matching without replacement, using a generalized linear model to estimate propensity scores based on the following covariates (gender, age, ELN 2022 risk, treatment intensity, ADI State Rank, and ADI National Rank), and aiming to match each racial unit (Non-Hispanic Black, NHB or Hispanic, H) with up to 9 Non-Hispanic Whites (NHW). Fisher’s exact test and Wilcoxon rank sum test were used to compare two groups. The probabilities of OS were estimated using Kaplan-Meier method. Backward multivariable analysis was used to predict factors influencing OS.
Results
2442 pts were identified (NHW-2032, NHB-202, H-109, and Asians, A-99). Data on Asians will not be reported in this abstract. In the MVA on unmatched cohort (n=2343), age ≥60 (HR-1.4, 95%CI 1.2-1.6, p<0.001), complex CG (HR-1.88, 1.6-2.2, p<0.001), TP53 mutation (m) (HR-1.3, 1.1-1.5, p=0.001 led to shorter OS and favorable/intermediate ELN 2022 risk (HR-0.42/0.84, 0.4-0.5/0/7-0.97, p<0.001/=0.02), intensive treatment (HR-0.82, 0.7-0.95, p=0.01), denovo AML (vs. secondary, HR-0.58, 0.5-0.7, p<0.001), allogeneic stem cell transplant (SCT, HR-0.33, 0.3-0.4, p<0.001) led to longer OS. Racial differences (NHB vs. NHW, HR-1.12, 0.94-1.3, p=0.22/H vs. NHW, HR-0.79, 0.6-1.03, p=0.08) did not affect OS. In the matched cohort (NHB, n=201 vs. NHW, n=1206), the only difference was SCT rate (13% vs. 20%, p=0.04). Clinical trial enrollment was similar (73% vs. 76%, p=0.37). In MVA, favorable risk (HR-0.39, 0.3-0.5, p<0.001), denovo AML (HR-0.59, 0.51-0.69, p<0.001), clinical trial (HR-0.7, 0.6-0.8, p<0.001), SCT (HR-0.32, 0.3-0.4, p<0.001) led to longer OS. Whereas age ≥60 (HR-1.5, 1.3-1.7, p<0.001), complex CG (HR-2.13, 1.7-2.6, p<0.001), TP53m (HR-1.3, 1.03-1.6, p=0.02) adversely affected OS. Strikingly, race did not affect OS (HR-1.08, 0.9-1.3, p=0.43). The median OS was 11.8 vs. 10.8 months (mo), p=0.32. Similarly, in the H (n=109) vs. NHW (n=981) matched cohort, the following mutations were more common in NHW: ASXL1 (2% vs. 9%, p=0.04), DNMT3A (9% vs. 21%, p=0.01), WT1 (0 vs. 6%, p=0.01). Clinical trial enrollment (69% vs. 75%, p=0.21); SCT rate (19% vs. 25%, p=0.20) was similar. The MVA showed favorable/intermediate risk (HR-0.32/0.75, 0.2-0.4/0.6-0.9, p<0.001/=0.01), denovo AML (HR-0.52, 0.4-0.6, p<0.001), clinical trial (HR-0.72, 0.6-0.9, p<0.001), SCT (HR-0.34, 0.3-0.4, p<0.001) led to longer OS, and age ≥60 (HR-1.6, 1.3-1.9, p<0.001), complex CG (HR-1.78, 1.4-2.3, p<0.001), TP53m (HR-1.4, 1.06-1.9, p=0.02) led to shorter OS. Race did not affect OS (HR-0.8, 0.6-1.05, p=0.10). The median OS was 14.3 vs. 14.9 mo, p=0.43. In NHB vs. H, (87 each) sAML was more common in H (23% vs. 38%, p=0.05) and IDH1 was more frequent in NHB (10% vs. 1%, p=0.04). In the MVA, favorable risk (HR-0.44, 0.2-0.9, p=0.02), denovo AML (HR-0.43, 0.3-0.7, p=0.002, SCT (HR-0.3, 0.2-0.6, p<0.001) led to longer OS and age ≥60 (HR-2.5, 1.6-3.9, p<0.001), complex CG (HR-2.3, 1.4-4, p=0.002) led to shorter OS. Race did not affect OS (HR-0.8, 0.6-1.2, p=0.35). The median OS was 17 vs. 14.3 mo, p=0.85.
Conclusion
There is a disparity in the outcomes of pts with AML from disadvantaged neighborhoods (higher ADI rank) regardless of racial background. There is an unmet need to improve the outcomes in this subgroup of pts. Our study showed that clinical trial treatment and SCT could help overcome this disparity. We plan to identify the barriers to clinical trial participation as the next step to improve outcomes of pts from higher ADI ranks.
Disclosures: Swaminathan: Sobi: Consultancy, Membership on an entity's Board of Directors or advisory committees. Abbas: Alamar Biosciences: Honoraria; Illumina: Honoraria, Other: Inkind Support, Research Funding; Molecular Partners: Consultancy; Ascentage: Research Funding; Blueprint Medicines Corporation: Research Funding; Genentech: Research Funding; GlaxoSmithKline: Research Funding; Enzyme By Design: Research Funding. Garcia-Manero: Aprea: Research Funding; Curis: Research Funding; Astex: Research Funding; Astex: Other: Personal fees; Forty Seven: Research Funding; Merck: Research Funding; Helsinn: Other: Personal fees; H3 Biomedicine: Research Funding; Genentech: Other: Personal fees; Onconova: Research Funding; Genentech: Research Funding; Amphivena: Research Funding; AbbVie: Research Funding; Bristol Myers Squibb: Other: Personal fees, Research Funding; Novartis: Research Funding; Helsinn: Research Funding; Janssen: Research Funding. Daver: Jazz: Consultancy; Pfizer: Consultancy, Research Funding; Gilead: Consultancy, Research Funding; Arog: Consultancy; Menarini Group: Consultancy; Hanmi: Research Funding; Bristol Myers Squibb: Consultancy, Research Funding; Syndax: Consultancy; KITE: Research Funding; Agios: Consultancy; FATE Therapeutics: Other: Consulting Fees, Research Funding; Trillium: Consultancy, Research Funding; Novimmune: Research Funding; Shattuck Labs: Consultancy; Trovagene: Research Funding; Astellas: Consultancy, Research Funding; Servier: Consultancy, Research Funding; Celgene: Consultancy; Glycomimetics: Research Funding; Novartis: Consultancy; Daiichi-Sankyo: Consultancy, Research Funding; Genentech: Consultancy, Research Funding. Kadia: ASTEX: Research Funding; Regeneron: Research Funding; Incyte: Research Funding; Ascentage: Research Funding; Pfizer: Research Funding; Amgen: Research Funding; AstraZeneca: Research Funding; Abbvie: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; BMS: Consultancy, Research Funding; Novartis: Honoraria; JAZZ: Research Funding; Servier: Consultancy; Rigel: Honoraria; Sellas: Consultancy, Research Funding; DrenBio: Consultancy, Research Funding; Cellenkos: Research Funding. DiNardo: BMS: Consultancy, Honoraria, Research Funding; Astellas: Consultancy, Honoraria; Amgen: Consultancy; AstraZeneca: Honoraria; Abbvie: Consultancy, Honoraria, Research Funding; ImmuneOnc: Research Funding; Servier: Consultancy, Honoraria, Other: meetingsupport, Research Funding; Schrodinger: Consultancy, Honoraria; Riegel: Honoraria; Notable Labs: Honoraria; Immunogen: Honoraria; Genetech: Honoraria; GSK: Consultancy, Honoraria; GenMab: Consultancy, Honoraria, Other: data safety board; Cleave: Research Funding; Jazz: Consultancy, Honoraria; Rigel: Research Funding; Gilead: Consultancy; Astex: Research Funding; Foghorn: Research Funding; Loxo: Research Funding; Stemline: Consultancy. Borthakur: Pacylex, Novartis, Cytomx, Bio Ascend: Membership on an entity's Board of Directors or advisory committees; Catamaran Bio, AbbVie, PPD Development, Protagonist Therapeutics, Janssen: Consultancy; Astex Pharmaceuticals, Ryvu, PTC Therapeutics: Research Funding. Jabbour: AbbVie, Adaptive Biotechnologies, Amgen, Astellas Pharma, BMS, Genentech, Incyte, Pfizer, Takeda: Consultancy; AbbVie, Adaptive Biotechnologies, Amgen, Ascentage Pharma Group, Pfizer, Takeda: Research Funding. Pemmaraju: Blueprint Medicines: Consultancy, Honoraria; Immunogen: Consultancy; Roche Molecular Diagnostics: Honoraria; Affymetrix/Thermo Fisher Scientific: Research Funding; Triptych Health Partners: Consultancy; Cellectis: Research Funding; Daiichi Sankyo: Research Funding; Celgene: Honoraria, Other: Travel Expenses; ClearView Healthcare Partners: Consultancy; Bristol-Myers Squibb: Consultancy; Protagonist Therapeutics: Consultancy; Incyte: Honoraria; Novartis: Honoraria, Research Funding; Aptitude Health: Honoraria; Pacylex: Consultancy; DAVA Oncology: Honoraria, Other: Travel Expenses; Mustang Bio: Honoraria, Other: Travel Expenses, Research Funding; Neopharm: Honoraria; LFB Biotechnologies: Honoraria; CareDx: Honoraria; Springer Science + Business Media: Honoraria; Astellas: Consultancy; CTI BioPharma: Consultancy; Stemline Therapeutics: Honoraria, Other: Travel Expenses, Research Funding; Plexxikon: Research Funding; Samus Therapeutics: Research Funding; Blueprint Medicines OncLive PeerView Institute for Medical Education: Consultancy, Other: advisory board; AbbVie: Honoraria, Other: Travel Expenses, Research Funding; ASH Committee on Communications ASCO Cancer.NET Editorial Board: Other: Leadership; Karger Publishers: Other: Licenses; National Institute of Health/National Cancer Institute (NIH/NCI): Research Funding; HemOnc Times/Oncology Times: Other: uncompensated. Ohanian: Bio-Path Holdings, Inc.: Consultancy. Jain: Kite, a Gilead Company: Consultancy, Honoraria, Other: Travel Support, Research Funding; MEI Pharma: Consultancy, Honoraria, Other: Travel Support; Bristol Myers Squibb: Consultancy, Honoraria, Other: Travel Support, Research Funding; TransThera Sciences: Research Funding; NovalGen: Research Funding; Incyte: Research Funding; AstraZeneca: Consultancy, Honoraria, Other: Travel Support, Research Funding; TG Therapeutics: Consultancy, Honoraria, Other: Travel Support; Newave: Research Funding; Pharmacyclics: Consultancy, Honoraria, Other: Travel Support, Research Funding; BeiGene: Consultancy, Honoraria, Other: Travel Support; ADC Therapeutics: Research Funding; Pfizer: Research Funding; MingSight: Honoraria, Research Funding; Cellectis: Consultancy, Honoraria, Other: Travel Support, Research Funding; Aprea Therapeutics: Research Funding; Medisix: Research Funding; Dialectic Therapeutics: Research Funding; Servier: Research Funding; Genentech: Consultancy, Honoraria, Other: Travel Support, Research Funding; Fate Therapeutics: Research Funding; Loxo Oncology: Research Funding; Takeda: Research Funding; Precision Biosciences: Consultancy, Honoraria, Other: Travel Support, Research Funding; Janssen: Consultancy, Honoraria, Other: Travel Support; Ipsen: Consultancy, Honoraria, Other: Travel Support; CareDx: Consultancy, Honoraria, Other: Travel Support; Adaptive Biotechnologies: Consultancy, Honoraria, Other: Travel Support, Research Funding; AbbVie: Consultancy, Honoraria, Other: Travel Support, Research Funding. Short: Pfizer Inc.: Honoraria; Adaptive Biotechnologies: Honoraria; NextCure: Research Funding; Takeda Oncology: Honoraria, Research Funding; Xencor: Research Funding; Amgen: Honoraria; Novartis: Honoraria; Stemline Therapeutics: Research Funding; BeiGene: Honoraria; Astellas Pharma, Inc.: Honoraria, Research Funding; Autolus: Honoraria; Sanofi: Honoraria; GSK: Consultancy, Research Funding. Bose: GSK: Honoraria; Disc Medicine: Research Funding; Ionis Pharmaceuticals: Research Funding; Incyte: Honoraria, Research Funding; Blueprint: Honoraria, Research Funding; BMS: Honoraria, Research Funding; AbbVie: Honoraria; Astellas: Research Funding; Telios: Research Funding; PharmaEssentia: Honoraria; Novartis: Honoraria; MorphSys: Honoraria, Research Funding; Karyopharm: Honoraria; Kartos: Honoraria, Research Funding; CTI Biopharma Corp: Honoraria, Research Funding; Cogent: Honoraria, Research Funding; Pfizer: Research Funding; NS Pharma: Research Funding; Promedior: Research Funding. Popat: Bayer: Research Funding; T Scan: Research Funding; Abbvie: Research Funding; Incyte: Research Funding. Shpall: National Marrow Donor Program: Other: Board of Directors/Management; Adaptimmune Limited: Other: Scientific Advisor; FibroBiologics: Other: Scientific Advisor; Zelluna Immunotherapy: Other: Scientific Advisor; Axio Research: Current Employment, Other: Scientific Advisor. Kantarjian: AbbVie, Amgen, Ascentage, Ipsen Biopharmaceuticals, KAHR Medical, Novartis, Pfizer, Shenzhen Target Rx, Stemline,Takeda: Consultancy, Honoraria. Ravandi: Syndax: Honoraria; Astellas: Consultancy, Honoraria; Abbvie: Consultancy, Honoraria; Xencor: Research Funding; Prelude: Consultancy, Honoraria, Research Funding; Amgen: Research Funding; Syros: Consultancy, Honoraria, Research Funding; BMS: Consultancy, Honoraria; Astyex/Taiho: Research Funding.
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