Session: 732. Allogeneic Transplantation: Disease Response and Comparative Treatment Studies: Poster III
Hematology Disease Topics & Pathways:
Clinical Practice (Health Services and Quality), Lymphomas, T Cell lymphoma, Diseases, Aggressive lymphoma, Lymphoid Malignancies
Methods: We conducted a retrospective review of patients diagnosed with ATL from the EBMT registry who underwent allo-SCT from January 2004 to December 2021. All patients were ≥ 18 years and had a histologic diagnosis of ATL with HTLV-1 positive serology and/or PCR. We included any donor type and bone marrow (BM) or peripheral blood stem cells (PBSC). Cord blood transplants were excluded. Outcomes of interest were 2-year overall survival (OS) and 2-year progression free survival (PFS), relapse incidence (RI), non-relapse mortality (NRM), acute and chronic graft versus host disease (aGVHD and cGVHD).
Results: Seventy-three patients were included. Median age was 45 (range 26-67) years and 52% of patients were female. ATL subtype was acute (19%), chronic (6%), lymphomatous (73%) and smoldering (2%). Median time from diagnosis to allo-SCT was 8 months (range 3-93). Disease status at allo-SCT was complete remission in 69%, partial remission 21% and active/progressive disease 10%. Sixty-four (64%) patients had received 1 line of therapy before allo-SCT and 36% received 2 or more lines. Karnofsky performance status was ≥ 90% in 74% of the patients. Donor type was mismatched relative in 40%, matched family donor 33%, and unrelated 27% of the cases. Thirty-two (32%) of donors were haploidentical. Ninety-one (91%) of donors were HLTV negative. Graft source was PBSC in 89% and BM in 11% of the cases. Most of the patients (n=55, 75%) underwent a reduced intensity conditioning (RIC) regimen. The most common regimen was Busulfan-Fludarabine-Thiotepa in 19% of cases. Thirty percent (30%) of patients received total body irradiation (TBI). GvHD prophylaxis contained calcineurin inhibitors plus mycophenolate mofetil combinations in 43 (59%) patients. Twenty-eight (38%) patients received post-transplant cyclophosphamide (PTCy).
Median follow up of the cohort was 3.9 years (range 3-6.1). Two-year-OS was 49% (95% CI 37-60) and 2-year-PFS was 43% (95% CI 31-54). NRM and RI were 7% (95% CI 3-15%) and 35% (95% CI 38-61%) at two years, respectively. The cumulative incidence of grade II-IV acute GvHD was 7% (95% CI 3-15%) at 100 days. At two years, the cumulative incidence of chronic GvHD was 38% (95% CI 26-49%). At the time of the analysis 41 patients had died. Causes of death were progression in 26 (67%), HSCT related in 9 (23%), and other causes in 4 (10%) of the cases. In univariate analysis no statistically significant differences in NRM, aGVHD II-IV and cGVHD were identified according to conditioning regimen, number of prior lines of therapy, disease status, Karnofsky score or ATL subtype. OS and PFS were higher in patients in CR at allo-SCT (56% versus 33%, p=0.002 and 50% versus 27%, p=0.01, respectively). RI was lower in this group (44% versus 63%, p=0.01). This finding was confirmed on multivariate analysis. Non-CR was associated with lower PFS (HR 2.93, 95%CI 11.23-6.99; p=0.01) and OS (HR 4.12, 95%CI 1.65-10.29; p=0.002) and higher RI (HR 2.66, 95%CI 1.05-6.75; p=0.04). Haploidentical donor was associated with better OS (HR 0.46, 95%CI 0.23-0.94; p=0.03). Also, having received 2 or more lines of therapy prior to allo-SCT was associated to higher cGVHD (HR 4.52, 95%CI 1.76-11.63; p=0.002) and extensive cGVHD (HR 5.34, 95%CI 1.41-20.23; p=0.01).
Conclusions: Allo-SCT consolidation is a feasible consolidation strategy for ATL patients, especially for those reaching CR prior to the procedure. In a cohort with predominantly ATL lymphoma, the ATL subtype did not impact the outcome of transplant and disease progression remains the main cause of death.
Disclosures: Bazarbachi: Jansen: Honoraria, Research Funding; Amgen: Honoraria; Caribou: Honoraria; Pfizer: Research Funding; Biologix: Research Funding; Takeda: Honoraria; Roche: Honoraria, Research Funding. Carpenter: Bluebird Biotech: Honoraria; Vertex Pharmaceuticals Incorporated: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Sicre de Fontbrune: Sobi: Honoraria, Research Funding; Samsung: Honoraria, Research Funding; Alexion, AstraZeneca Rare Disease: Honoraria, Research Funding; Novartis: Honoraria, Research Funding. Nicholson: Kite/Gilead: Honoraria, Research Funding; Novartis: Honoraria; BMS/Celgene: Honoraria; Autolus: Membership on an entity's Board of Directors or advisory committees. Ciceri: ExCellThera: Membership on an entity's Board of Directors or advisory committees. Glass: Roche: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Gilead: Consultancy, Membership on an entity's Board of Directors or advisory committees; BMS: Consultancy, Membership on an entity's Board of Directors or advisory committees; Miltenyi: Consultancy; Abbvie: Consultancy; Sobie: Consultancy; JAZZ: Honoraria. Hermine: Alexion: Research Funding; BMS: Research Funding; Inatherys: Consultancy, Current equity holder in publicly-traded company, Patents & Royalties, Research Funding; Roche: Research Funding; AB Science: Consultancy, Current equity holder in publicly-traded company, Patents & Royalties, Research Funding; MSD Avenir: Research Funding. Sureda Balari: BMS/Celgene: Consultancy; Novartis: Consultancy; Janssen: Consultancy; Gilead: Consultancy; Takeda: Consultancy; Sanofi: Consultancy.