Type: Oral
Session: 907. Outcomes Research: Plasma Cell Disorders: Quality Matters and Key Outcomes in Multiple Myeloma
Hematology Disease Topics & Pathways:
Research, Clinical Research, Health outcomes research, Patient-reported outcomes
Methods: Dyads (MM patients and spouse/partners) were enrolled in a prospective longitudinal study; assessments were administered prior to and post-ASCT at 90 days and 1 year. Measures included the Fried frailty phenotype, functional impairment [Short Physical Performance Battery (SPPB)], distress (Impact of Event Scale-Revised), depression [Center for Epidemiologic Studies Depression (CES-D)], couples’ satisfaction index (CSI-16), spousal strain (MIDUS), self-reported health [Karnofsky Performance Status (KPS) self), PROMIS HRQoL (Global 10, fatigue) were measured.
Results: Among dyads (n=62), pre-ASCT discordance in health measures (SPPB, IADL, fatigue, frailty) were evident with concordance among only social support (r=0.37, p=0.04) and self-reported health (KPS self, r=-0.41, p=0.02). Age was associated with lower functional scores [SPPB ß=-0.03 (SE:0.016), p=0.04] and men had greater changes in function peri-transplant [SPPB ß=0.92 (SE:0.329), p<0.01] compared to women. Among MM pts depression symptoms (CES-D) were significantly (p<0.01) associated with frailty (ß=0.05), and HRQoL (PROMIS Fatigue ß=0.61, PROMIS Global ß=-0.44) before and after transplant (not shown). The average distress effect on frailty was significant across groups. However, the distress effect in pts (ß=0.027 (SE: 0.008), p=0.0017) was greater than spouses (ß=0.003 (SE: 0.0096), p=0.77). ] Pre-ASCT, average couple satisfaction effect on self-reported health was significant (p=0.05), however the couple satisfaction effect was greatest in spouses [ß=0.49 (SE:0.121), p=<0.01]. Couples’ satisfaction was associated with improved physical function [SPPB ß=0.04 (SE:0.0213), p=0.05] pre-ASCT. Spousal strain impacted fatigue peri-ASCT [pre ASCT ß=4.44, (SE:2.37), p=0.07; post ASCT ß=3.81, (SE:1.83), p=0.05] and frailty only pre-ASCT [ß=0.52, (SE:0.24), p=0.04].
Conclusions: Physical frailty and psychologic distress are interconnected in MM patients and spouses. Importantly, the supportive role of spouse/partners and a couples’ perceived relationship health also impact MM ASCT recovery. Targeting programs for physical and emotional survivorship are imperative for both MM patient and spouse/partners.
Disclosures: Rosko: Sanofi: Research Funding; Physicians Education Resource LLC: Honoraria; Curio Science: Honoraria; FDA: Consultancy; Clinical Care Options CMM: Honoraria. Cottini: Sanofi: Honoraria, Membership on an entity's Board of Directors or advisory committees. Khan: Amgen: Speakers Bureau; Sanofi: Research Funding, Speakers Bureau; BMS: Research Funding, Speakers Bureau. Devarakonda: Janssen: Other: Advisory board. Bumma: sanofi: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Amgen: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau.