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5110 Association of Race, Ethnicity, and Social Deprivation on the Incidence and Severity of Adverse Events in Induction in Children with Acute Lymphoblastic Leukemia

Program: Oral and Poster Abstracts
Session: 906. Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Poster III
Hematology Disease Topics & Pathways:
Research, Lymphoid Leukemias, ALL, Clinical Research, Health outcomes research, Health disparities research, Pediatric, Diseases, Adverse Events, Lymphoid Malignancies, Study Population, Human
Monday, December 9, 2024, 6:00 PM-8:00 PM

Jason M Stevenson, MD1,2*, Anjali Khanna, MBBS, MPH1,2*, Ashleigh Hawk, MPH1,2*, Avery Morse1,2*, Oyin Alao, MPH1,2*, Katherine Jordan1,2*, Xu Ji, PhD1,2,3, Heeju Sohn, PhD4*, Sharon M. Castellino, MD, MSc1,2 and Tamara P. Miller, MD, MSCE1,2

1Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
2Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplant, Emory University School of Medicine, Atlanta, GA
3Department of Health Policy and Management, Emory University Rollins School of Public Health, Atlanta, GA
4Department of Sociology, Emory University, Atlanta, GA

Background: Anti-cancer therapies used to treat pediatric acute lymphoblastic leukemia (ALL) lead to high cure rates but can cause significant adverse events (AEs). Prior studies show that underserved children, especially those from racial and ethnic minority groups, have increased acuity of illness at presentation, higher rates of relapse, and decreased overall survival (OS). These disparities are multifactorial, but the association between race, ethnicity, and social deprivation with the development of AEs has not been comprehensively evaluated. This study aims to compare the incidence and severity of clinically-significant AEs during induction therapy for de novo pediatric ALL by race and ethnicity, social deprivation level, and the combined effect of these factors.

Methods: This single institution retrospective cohort study included children aged 0-21 years diagnosed and treated for ALL at Children’s Healthcare of Atlanta (CHOA) between January 1, 2010 and September 1, 2022. Demographic data were extracted from the electronic health record (EHR) and CHOA Cancer Registry. Incidence and severity, defined as the highest grade of each AE per the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), were manually abstracted from the EHR following a detailed chart abstraction guide. The following clinically-significant AEs were included: acute respiratory distress syndrome (ARDS), constipation, hyperglycemia, ileus, infection/sepsis, neuropathy, pancreatitis, seizure, stroke, thromboembolic events, and typhlitis. Addresses at diagnosis from eligible patients were used to map the Social Deprivation Index (SDI) for each year during 2010-2022 to the zip code tabulation areas of patient residence. The SDI was categorized into quintiles with quintile 1 representing the areas of lowest social deprivation and quintile 5 representing the areas of highest social deprivation. For each AE, the association of (a) race and ethnicity and (b) SDI quintiles with the incidence and severity was analyzed using multivariable logistic regression, adjusting for age at diagnosis and sex.

Results: Of the 814 patients in the cohort, 447 (54.8%) patients were male, median age at diagnosis was 7 years (IQR 3,11 years),181 (22.2%) were non-Hispanic Black, and 386 (47.4%) were non-Hispanic White. Considering all CTCAE grades, constipation (n=462, 56.8%) and hyperglycemia (n=800, 98.3%) were the most common AEs; ARDS, Ileus, pancreatitis, seizure, stroke, thromboembolic were rare (n=6-42, 1-5%). Non-Hispanic Black patients had significantly lower odds of ileus (0.13, 95% CI 0.02, 0.99), infection (0.63, 95% CI 0.43, 0.93), neuropathy (0.45, 95% CI 0.30, 0.70), and sepsis (0.49, 95% CI 0.25, 0.94) compared to non-Hispanic white patients. Non-Hispanic Black patients had a 2.16 times higher odds (95% CI 1.19, 3.92) of grade 3+ hyperglycemia compared to non-Hispanic white patients. Living in the highest quintile (SDI 5) conferred an independent risk (OR 2.61 (95% CI 1.09,6.68)) of grade 3+ hyperglycemia compared to those in the first quintile for SDI, after controlling for race, ethnicity, age, and sex. There was no statistically significant interaction between SDI quintile, race, and ethnicity.

Conclusions: In this study, non-Hispanic Black race and living in areas with the highest social deprivation were independent risks for severe hyperglycemia during induction. This finding highlights groups targetable for early hyperglycemic prevention and intervention. In this analysis limited to induction therapy for ALL, there was no evidence of interaction between race, ethnicity, and SDI on the incidence and severity of AEs. This suggests these factors may be independent in relation to development of AEs and that higher rates of relapse and decreased OS previously described in racial and ethnic minority groups may not be due to AEs experienced during ALL induction. Abstraction of ten additional clinically-significant AEs is ongoing. Future directions include analyses of all ALL chemotherapy courses, to help further elucidate any association between race, ethnicity, and social deprivation.

Disclosures: Castellino: BMS: Consultancy, Honoraria; SeaGen Inc.: Consultancy, Research Funding; Leukemia and Lymphoma Society: Membership on an entity's Board of Directors or advisory committees, Research Funding; Lymphoma Research Foundation: Membership on an entity's Board of Directors or advisory committees. Miller: AbbVie, Gilead Sciences, Thermo Fisher Scientific, and United Health Group: Current equity holder in publicly-traded company.

*signifies non-member of ASH