Session: 906. Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Poster II
Hematology Disease Topics & Pathways:
Research, ALL, AML, APL, Clinical Research, Health disparities research, Pediatric, Diseases, Lymphoid Malignancies, Myeloid Malignancies, Study Population, Human
Methods: This post-hoc analysis pooled parent/guardian-reported survey data from US pediatric patients with acute lymphoblastic leukemia enrolled in a multicenter phase III therapeutic trial (NCT03020030) conducted at 6 Northeastern sites, with survey data from pediatric patients diagnosed with a hematologic malignancy (acute leukemias, non-Hodgkin lymphomas, Hodgkin lymphoma and Langerhans cell histiocytosis) enrolled in a single-center sociodemographic banking study. Survey data for both cohorts were collected within 6-weeks of child’s diagnosis from 2017-2023. For patients participating in both the phase III trial and sociodemographic banking study, data from the trial were utilized. Consistent with published pediatric oncology disparities analyses, insurance was dichotomized as sole public coverage (Medicaid or Children’s Health Insurance Program) versus any private coverage (private or dual private/public). Income was dichotomized as low-income (parent-reported annual household income <200% federal poverty level [FPL]) and higher-income (≥200% FPL). HMH was defined as food, housing or utility insecurity measured using validated scales; participants with affirmative responses to any HMH domain were considered HMH-exposed. We calculated HMH frequency by insurance type, as well as the frequency of public versus private insurance across HMH-exposed and low-income families.
Results: The analytic cohort included 349 patients, with a median age of 6.9 years (IQR 3.9-12.4), with 6% self-identifying as Asian, 13% as Black, and 25% as Hispanic ethnicity; 22% spoke a primary language other than English. Thirty-seven percent (n=130) had public insurance, and 63% (n=219) private insurance. Thirty-five percent (n=121) of the cohort reported HMH-exposure, and 30% (n=104) reported low-income, with 19% (n=65) reporting both. Participants with public insurance were significantly more likely to report HMH (n=83/130, 64%) than those with private insurance (n=38/219, 17%; p<0.0001). Among participants with HMH, 31% (n=38) had private insurance and 69% (n=83) had public insurance. Among participants with low-income, 25% (n=26) had private insurance and 75% (n=78) public insurance.
Conclusions: Though HMH is experienced more frequently by families with public insurance, use of public insurance to proxy modifiable household-level poverty-exposures—HMH or low-income—fails to identify up to one-third of families with these exposures. These findings highlight the inadequacy of insurance status to proxy social risk. Insurance-associated survival disparities are well defined across pediatric hematologic malignancies, but provide no opportunity for intervention to mitigate these inequities. Supportive care equity interventions targeting both HMH and income-poverty are currently in development. These data highlight the immediate need for systematic collection of family-reported social determinants of health data across the cooperative group setting to facilitate targeted health equity intervention.
Disclosures: Kelly: Seagen: Membership on an entity's Board of Directors or advisory committees. Silverman: Servier: Honoraria; Jazz: Consultancy.