Session: 627. Aggressive Lymphomas: Pharmacologic Therapies: Poster II
Hematology Disease Topics & Pathways:
Research, Clinical trials, Clinical Research
Eligible patients were aged older than70 years or older than 60 years with ECOG PS ≥ 2, newly diagnosed DLBCL. Patients were administered a maximum of 8 28-day cycles of 10 mg oral lenalidomide from days 1 to 21, IV rituximab 375 mg/m2 and sintilimab 200mg on day 1, with response assessment after cycles 4 and 8. Patients with partial response or complete response (CR) at cycle 8 were administered lenalidomide 10 mg/d from days 1 to 21 for every 28 cycles for a total of 2 years or until progression or unacceptable toxicity. The primary endpoint in this study was complete response rate (CRR) after 8 cycles or at the end of the induction treatment. The secondary end point was 2-year overall survival, progression-free survival, overall response rate (ORR) and treatment-emergent adverse events.
Until April 9, 2024, A total of 18 older DLBCL patients were enrolled and 14 of them was evaluated. The median age of the patients in this study was 75 years old (range 68-70) and 2 (11.1%) patients had a poor performance status with an ECOG score of 2 or greater. 12 (85.7%) patients achieved an overall response at the end of the induction treatment, with 11 (78.6%) achieving a complete response. With a median follow up of 8.9 months, the 1-year progression-free survival and overall survival were 80.8% and 92.9%, respectively. Common grade 3–4 adverse events were hematological toxicities (neutropenia in 4 patients (28.6%), thrombocytopenia in 3 patients (21.4%), anemia in 3 (21.4%). No treatment-related deaths were reported.
A chemotherapy-free sR2 regimen is clinically effective and safe and warrants further investigation in older patients with DLBCL.
Disclosures: No relevant conflicts of interest to declare.
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