Session: 907. Outcomes Research: Plasma Cell Disorders: Poster III
Hematology Disease Topics & Pathways:
Clinical Practice (Health Services and Quality)
Methods: We examined the prevalence of suboptimal SRH and its association with subsequent all-cause mortality after BMT among survivors of PCD. Study participants were drawn from BMTSS and included PCD patients who were transplanted between 1974 and 2014 at three participating sites, and had survived ≥2y post-BMT. Participants (≥18y) completed a survey at a median of 6y from BMT and were followed for a median of 4y after survey completion for vital status and cause of death. Survivors provided information on sociodemographic characteristics, chronic health conditions (as diagnosed by their healthcare providers), health behaviors, and SRH (single item, rated as excellent, very good, good, fair or poor; excellent, very good or good SRH were classified as good SRH and all else as suboptimal SRH). National Death Index (NDI) Plus, Accurint database, and medical records provided vital status through December 2021. Multivariable regression analyses determined the association between SRH and all-cause mortality (Cox regression) after adjusting for relevant sociodemographic, clinical variables and therapeutic exposures. Factors associated with suboptimal SRH were analyzed using multivariable logistic regression.
Results: The cohort included 595 participants; 96.0% autologous BMT; median age at BMT 59y; 57.8% males; 66.9% non-Hispanic whites. Overall, 185 (31.1%) survivors reported suboptimal SRH and 177 died after survey completion (29.8%). BMT survivors who reported suboptimal SRH had a 2.5-fold greater hazard of all-cause mortality (95%CI=1.8-3.4) compared to those who reported good SRH, after adjusting for age at survey, year of BMT, sex, race/ethnicity, socioeconomic status (SES), age at BMT, risk of relapse at BMT (standard; high), post-BMT relapse and grades 3-4 chronic health conditions. Pain, male sex, psychological distress, lack of exercise, smoking, post-BMT relapse and pre-BMT radiation were associated with suboptimal SRH.
Conclusions: This single-item measure could serve to identify vulnerable sub-populations of PCD patients with sub-optimal self-rated health that could benefit from interventions to mitigate the risk for late mortality.
Disclosures: Forman: Allogene: Consultancy, Membership on an entity's Board of Directors or advisory committees; Lixte Bio: Consultancy, Membership on an entity's Board of Directors or advisory committees. Armenian: Pfizer: Research Funding.
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