Type: Oral
Session: 908. Outcomes Research: Myeloid Malignancies: Patient Reported Outcomes and their Association with Clinical Outcomes in Patients with Myeloid Malignancies
Hematology Disease Topics & Pathways:
Clinical Practice (Health Services and Quality)
Methods: We examined the prevalence of suboptimal SRH and its association with subsequent all-cause and cause-specific late mortality among myeloid malignancy patients treated with BMT. Study participants were drawn from BMTSS and included patients with AML, MDS or CML, who were transplanted between 1974 and 2014 at three participating sites and had survived ≥2y post-BMT. Participants (≥18y) completed a survey at a median of 10y from BMT and were followed for a median of 6y after survey completion for vital status and cause of death. Survivors provided information on sociodemographic characteristics, chronic health conditions (as diagnosed by their healthcare providers), health behaviors, and SRH (single item, rated as excellent, very good, good, fair or poor; excellent, very good or good SRH were classified as good SRH and all else as suboptimal SRH). National Death Index (NDI) Plus, Accurint database, and medical records provided vital status through December 2021. Multivariable regression analyses determined the association between SRH and all-cause mortality (Cox regression) and cause-specific mortality (recurrence-related [RRM] and non-recurrence related mortality [NRM]) (sub-distribution hazard regression) after adjusting for relevant sociodemographic, clinical variables, therapeutic exposures, post-BMT chronic health conditions and development of post-BMT relapse. Factors associated with suboptimal SRH were analyzed using multivariable logistic regression.
Results: Of the 1,276 participants (AML/MDS: n=910; CML: n=365); 86.6% allogeneic BMT; median age at BMT 42y; 50.6% males; 76.3% non-Hispanic white. Overall, 322 (25.3%) BMT survivors reported suboptimal SRH, and 267 died after survey completion (20.9%). BMT survivors who reported suboptimal SRH had a 2.1-fold increased hazard of all-cause mortality (95%CI=1.6-2.8), 1.9-fold increased hazard of RRM (95%CI:0.9-4.1), and 1.4-fold increased hazard of NRM (95%CI:0.8-2.6) compared to those who reported good SRH, after adjusting for age at survey, BMT era (1974-1989; 1990-2004; 2005-2014), sex, race/ethnicity, socioeconomic status (SES: <college and <$50,000; <college and ≥$50,000; ≥college and <$50,000; ≥college and ≥$50,000), age at BMT, BMT type/cGvHD (autologous BMT; allogeneic BMT/no cGvHD; allogeneic BMT/cGvHD), conditioning intensity/TBI, (NMA/no TBI; NMA/TBI; MAC/no TBI; MAC/TBI), post-BMT relapse, grades 3-4 chronic health conditions, psychological distress, smoking and alcohol consumption. Low socioeconomic status, pain, psychological distress, lack of exercise and severe/life threating chronic health conditions were associated with suboptimal SRH.
Conclusions: This single-item measure could serve to identify vulnerable sub-populations that could benefit from interventions to mitigate the risk for subsequent mortality.
Disclosures: Forman: Allogene: Consultancy, Membership on an entity's Board of Directors or advisory committees; Lixte Bio: Consultancy, Membership on an entity's Board of Directors or advisory committees. Armenian: Pfizer: Research Funding.
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