Session: 721. Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Toxicities: Poster I
Hematology Disease Topics & Pathways:
Research, Adult, Clinical Research, Treatment Considerations, Study Population, Human
Objective: Statistically evaluate the change in alloHSCT outcomes that occurred after adoption of universal PTCy, to assess the effect of the GVHD prophylaxis strategy, as well as other programmatic changes (graft source, conditioning regimens, donor selection).
Study Design: This is a single-center retrospective cohort study of adult patients who underwent alloHSCT at Cedars Sinai Medical Center between January 2010 and September 2021. We compared outcomes in the pre-PTCy era (2010 – 2016) to outcomes in the era of PTCy (2016 – 2021). 432 patients were included; 180 received PTCy-based GVHD prophylaxis, and 252 patients received non-PTCy GVHD prophylaxis. Kaplan-Meier estimates and Cox regression models were built to compare outcomes based on the type of GVHD prophylaxis received (Tac/MTX pre-2016 versus PTCy-tacrolimus-mycophenolate post-2016).
Results: Hospital stay was 29 ± 15.9 days (Median ± Std) in the pre-PTCy era, and 26 ±9.9 days in the PTCy era (p < 0.001). Post-transplant hospital stay was 23 ± 13 in the pre-PTC and 19 ± 8.5 days with PTCy (p < 0.001). The number of patients requiring opioids after transplant was greater in the pre-PTCy era compared to the post-PTCy era (94.12 % vs 81.01%, p <0.0001).
Overall Survival increased in the PTCy era compared to the pre-PTCy era (at 1 year, 87% versus 62%; p <0.0001), and the difference in OS persisted at 2 years and 3 years. Relapse-free survival was higher in the PTCy era (HR: 0.55, 95% CI (0.42-0.71); p<0.0001). There was no difference in the cumulative incidence of relapse at 1 year between the two groups (17% PTCy versus 26% pre-PTCy, p=0.0661). Non-Relapse Mortality at 1 year was lower in the PTCy group (10% PTCy versus 22% non-PTCy; p=0.0020).
Acute GVHD was lower in the PTCy group: grade II-IV at day 100 was 20% in PTCy, versus 33% in the non-PTCy group (p=0.0016); grade III-IV at day 100 was 5% versus 15% (p=0.0008). The 1-year cumulative incidence of cGVHD with peripheral-blood stem cell transplants was similar between the two groups, 39% in the PTCy era and 42% in the PTCy group (p=0.3321), but there was a difference in the rate of extensive cGVHD favoring use of PTCy (23% with PTCy versus 33% without, which approached significance; p = 0.053).
Patients in the PTCy era achieved higher one-year GVHD and relapse-free survival (GRFS) compared to patients in the pre-PTCy era (37%: PTCy versus 19%: non-PTCy, p <0.0001). In the multivariate Cox regression model, PTCy was associated with better OS [HR: 0.40, 95% CI (0.46-0.96); p=0.0001], better RFS [HR: 0.66, 95% CI (0.46-0.96); p=0.0300], and lower NRM [HR: 0.33, 95% CI (0.16-0.69); p=0.0034]. No difference in Relapse between the two groups was shown [HR:1.12, 95% CI (0.73-1.72); p=0.6053].
Conclusion: Patients who underwent alloHSCT utilizing PTCy displayed significantly improved overall survival at 1 year compared to patients treated with predominantly methotrexate and calcineurin inhibitors, significantly improved relapse-free survival (RFS), lower rate of NRM, lower rates of acute GVHD, with no difference in rates of cGVHD. Hospital stay was 6 days shorter and fewer patients required opiates (less mucositis with PTCy). These data support the utilization of PTCy for GVHD prophylaxis for all HLA donor match grades and graft sources.
Disclosures: Merin: Takeda: Consultancy; Kite: Consultancy; ADCT: Consultancy; Amgen: Research Funding; Ipsen: Consultancy. Linhares: Baptist Health South Florida: Current Employment; Institutional PI on SGN35-027 Part C trial with corresponding research funding by Seagen/Pfizer: Research Funding; Kyowa Kirin: Speakers Bureau; Pfizer, ADC, Abbvie, Novartis, BeiGene, BMS, Kyowa, Genentech, AstraZeneca, Kite, Janssen: Other: Advisory boards. Merchant: Amgen: Consultancy; Genmab: Consultancy, Speakers Bureau; IMMpact Bio: Research Funding; Oncovalent: Consultancy, Research Funding; Abbvie: Consultancy, Speakers Bureau; BMS: Speakers Bureau; Innate Pharma: Research Funding. Sasine: Kite Pharma: Consultancy; Genmab: Consultancy; Autolus: Consultancy. Vescio: Bristol Myers Squibb: Speakers Bureau; Janssen: Speakers Bureau; Karyopharm: Speakers Bureau; Amgen: Speakers Bureau; Alnylam: Speakers Bureau. Oveisi: Janssen: Consultancy, Research Funding; Pfizer: Honoraria.