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4921 Real-World Clinician Adherence to Screening and Preventive Practices Guidelines for Subsequent Neoplasms Among Allogeneic Hematopoietic Cell Transplant Survivors in the United States

Program: Oral and Poster Abstracts
Session: 723. Allogeneic Transplantation: Long-term Follow-up, Complications, and Disease Recurrence: Poster III
Hematology Disease Topics & Pathways:
Clinical Practice (Health Services and Quality), Study Population, Human
Monday, December 9, 2024, 6:00 PM-8:00 PM

Neel S. Bhatt, MBBS, MPH1,2, Elizabeth M Hellewell, BS3*, Kevin Ng, M.S.3*, Ted Gooley, PhD4*, Anthony D. Sung, MD5, Allison O. Taylor, MD, MS6*, Sanghee Hong, MD7, Nausheen Ahmed, MD8, Cherie Morey, MD9*, Sarah Fitzmaurice9*, Vanessa E. Kennedy, MD10, Michelle Lauer11*, Andrew D. Trunk, MD12, Betty K. Hamilton, MD13, Akshay Sharma, MBBS14, Zoey Phelps-Bergeron15*, LaQuisa Hill, MD16*, Rawan Faramand, MD17, Hien Liu, MD18, Lena E Winestone, MD19, Geoffrey Cheng19, Manuel Espinoza-Gutarra, MD20, Omer Jamy, MD20, Maria Odstrcil Bobillo, MD21*, Brian McClune, DO21, Mariam T. Nawas, MD22, Samuel J. Yates, MD, MSc23, Miki Nishitani, MD, BS24, Takuto Takahashi, MD, PhD24*, Jane Koo, MD25*, Kasiani C Myers, MD26, Kris Michael Mahadeo, MD27, Andrea Bauchat, DO28*, Laurie K Pearson, MD29, Ritika Walia, MD30*, Kelsea Seago, PharmD, RPh31*, Spencer Yingling, PharmD32*, Cory Edgar, PA-C33*, Amy Browning, APRN33* and Catherine J. Lee, MD, MSc2

1Department of Pediatrics, Division of Hematology/Oncology, University of Washington School of Medicine, Seattle, WA
2Fred Hutchinson Cancer Center, University of Washington, Seattle, WA
3Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
4University of Washington, Seattle, WA
5Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University School of Medicine, Durham, NC
6Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC
7Division of Hematologic Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC
8Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Medical Center, Westwood, KS
9Division of hematologic malignancies and cellular therapeutics, University of Kansas Cancer Center, Westwood, KS
10Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Palo Alto, CA
11Stanford University, Stanford, CA
12Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Shaker Heights, OH
13Cleveland Clinic Foundation, Cleveland, OH
14Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN
15Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children’s Research Hospital, Memphis, TN
16Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Methodist Hospital, Houston, TX
17Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center, Tampa, FL
18Department of Blood and Marrow Transplant and Cellular Immunotherapy, , H. Lee Moffitt Cancer Center, Tampa, FL
19Division of Allergy, Immunology, & BMT, Department of Pediatrics, UCSF Benioff Children's Hospitals, San Francisco, CA
20O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL
21Huntsman Cancer Institute, University of Utah, Division of Hematology and Hematologic Malignancies, Salt Lake City, UT
22Department of Medicine, Section of Hematology/Oncology, University of Chicago, Oak Park, IL
23Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
24Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Boston, MA
25Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
26Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
27Pediatric Transplant and Cellular Therapy, Duke University, Durham, NC
28Pediatric Transplantation and Cellular Therapy, Duke University, Durham, NC
29UMass Memorial Medical Center, Department of Medicine, Waltham, MA
30UMass Memorial Medical Center, Department of Medicine, Worcester, MA
31West Virginia University Medicine, Morgantown, WV
32West Virginia University Medicine, Morgantown
33AdventHealth, Orlando, FL

Background: Prior studies have reported variable adherence to screening/prevention guidelines from allogeneic hematopoietic cell transplant (HCT) survivors’ perspective (Khera N et al. Biol Blood Marrow Transplant. 2011 Jul;17(7):995-1003). However, no prior study has assessed clinician adherence to these guidelines. To address this knowledge gap, we aimed to examine clinician adherence to the recommended assessments for subsequent neoplasms (SN) screening according to the 2011 guidelines (Majhail NS et al. Biol Blood Marrow Transplant. 2012 Mar;18(3):348-71).

Methods: A retrospective, multi-center cohort study of patients (pts) who underwent HCT for hematologic malignancies between 01/01/2016-12/31/2016 was conducted. Pts who were alive and disease free for at least 3 years post-HCT were included. Data on key screening practices focusing on breast, skin, and cervical neoplasm were abstracted from electronic medical records (EMR). “Adherence” was defined by evidence of an order or test result for each screening test between 1-3 years post-HCT. Two separate multivariable logistic regression models were created to assess the factors associated with adherence to SN screening. Model 1 included a best subset of patient-, disease-, and treatment-related factors such as patient age, sex, race/ethnicity, highest education, preferred language, disease diagnosis, HCT-comorbidity index (HCT-CI) score, history of prior malignancy, conditioning intensity, total body irradiation (TBI) use, history of acute and/or chronic GVHD, and high-dose corticosteroid use, and post-HCT follow-up care providers. Model 2 consisted of HCT-center related factors such as type of center (academic vs. non-academic), center volume, availability of survivorship clinic, provision of survivorship care plan to pts, referring providers, or primary care providers. Odds ratio (OR) and 95% confidence interval (CI) were provided.

Results: A total of 440 pts from 19 HCT centers with a median age at HCT of 46 (range 0-77) years were included in the analysis. Forty two percent were females, 18% were of non-White race, 12% were of Hispanic or Latino ethnicity, and 5% preferred a language other than English. A quarter of recipients had an HCT-CI score ≥3 and 7% had a prior history of a solid tumor. AML (43%), ALL (22%), and MDS (11%) were the most common indications for HCT. Seventy one percent received myeloablative conditioning and TBI was used in 42% of the patients. History of acute and chronic GVHD was noted in 57% and 52% of the patients, respectively. Half of the pts had a history of high dose corticosteroid exposure.

Adherence to breast cancer, skin cancer, and cervical cancer screening were noted in 49%, 34%, and 41% of the pts, respectively. Increasing pt age was significantly associated with increase in breast cancer screening adherence [OR 1.08, 95% CI 1.03-1.12, p<0.001]. No other clinical or HCT-center factors were associated with breast cancer screening adherence. Compared to those with HCT-CI score of 0, the odds of skin cancer screening adherence were lower with HCT-CI score of 1 [0.29, 0.11-0.77, p=0.012] and 2 [0.14, 0.03-0.56, p=0.006], but not ≥3 [0.73, 0.31-1.74, p=0.48]. Exposure to high dose corticosteroids was also associated with lower odds of skin cancer adherence [0.47, 0.26-0.83, p=0.01], whereas exposure to TBI was associated with higher skin cancer screening adherence [1.93, 1.05-3.55, p=0.03]. Increasing annual number of transplants [1.01, 1.00-1.01, p<0.001] and provision of survivorship care plan to pts [2.53, 1.45-4.42, p<0.001] were associated with increased skin cancer screening adherence. While a similar association between higher annual number of HCT and cervical cancer screening adherence was noted [1.01, 1.00-1.02, p=0.008], an inverse association was noted with the provision of survivorship care plan to pts [0.15, 0.03-0.80, p=0.03]. History of chronic GVHD was also associated with higher odds of cervical cancer screening.

Conclusions: To our knowledge, this is the first report of EMR-based clinician adherence to screening/prevention guidelines for HCT survivors in the United States. More than half of the eligible survivors did not undergo subsequent neoplasm screening. We found several factors associated with adherence, which will provide an opportunity to develop and test interventions to improve clinician adherence to screening and preventive practice guidelines.

Disclosures: Bhatt: Atheneum: Consultancy; Slingshot Insights: Consultancy; Putnam Associates: Consultancy; Aptitude Health: Consultancy. Sung: Novartis: Research Funding; Clasado: Other: Research product; Acrotech: Consultancy; DSM/iHealth: Other: Research product; Janssen: Consultancy; Geron: Consultancy; Seres: Research Funding; Targazyme: Consultancy; Enterome: Research Funding; BlueSpark Technologies: Other: Research product; Merck: Research Funding. Hong: Guidepoint: Other: Consulting. Ahmed: Legend Biotech: Consultancy, Honoraria; Kite/Gilead: Consultancy, Honoraria; BMS: Consultancy, Honoraria. Kennedy: Astellas: Consultancy. Hamilton: Maat Pharma: Other: ad hoc advisory board; Rigel: Other: ad hoc advisory board; Incyte: Consultancy; Nkarta: Other: Ad hoc advisory board; CSL Behring: Other: Adjudication committee; Angiocrine: Other: DSMB; ACI group: Consultancy; Orca Bio: Research Funding; Sanofi: Other: ad hoc advisory board. Sharma: Editas Medicine: Consultancy; Medexus Inc.: Consultancy; Novartis: Other: Clinical Trial site-PI; Beam Therapeutics: Other: Clinical Trial site-PI; CRISPR Therapeutics: Other: Clinical Trial site-PI, Research Funding; Vertex Pharmaceuticals: Consultancy, Other: Clinical Trial site-PI; Sangamo Therapeutics: Consultancy. Hill: Kite, a Gilead Company: Speakers Bureau; Gilead Sciences: Speakers Bureau; March Biosciences: Consultancy. Faramand: Orca Bio: Research Funding; Novartis: Research Funding; Sanofi: Consultancy, Honoraria; Autolus: Membership on an entity's Board of Directors or advisory committees; Kite/Gilead: Membership on an entity's Board of Directors or advisory committees. Liu: BioLineRx: Consultancy, Honoraria. Myers: Incyte: Research Funding; Elixirgen Therapeutics: Research Funding. Mahadeo: Jazz: Consultancy, Other: PI; Adaptimmune: Other: PI; Syndax: Other: PI; Vertex: Consultancy; ATARABio: Consultancy, Research Funding. Yingling: Bristol Myers Squibb: Current Employment, Current holder of stock options in a privately-held company. Edgar: Takeda Pharmaceuticals: Honoraria, Speakers Bureau; Jazz Pharmaceuticals: Honoraria, Speakers Bureau. Lee: ScientiaCME: Consultancy; Sanofi: Consultancy, Honoraria, Speakers Bureau; Aptitude Health: Consultancy; SEI: Consultancy; Incyte: Consultancy, Honoraria, Research Funding.

*signifies non-member of ASH