Session: 628. Aggressive Lymphomas: Cellular Therapies: Poster III
Hematology Disease Topics & Pathways:
Research, Lymphomas, Non-Hodgkin lymphoma, Clinical Research, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Diseases, Therapy sequence, Real-world evidence, Aggressive lymphoma, Treatment Considerations, Biological therapies, Lymphoid Malignancies, Human
Anti-CD19 CAR T cell therapy with axicabtagene ciloleucel (axi-cel) and lisocabtagene maraleucel (liso-cel) was recently approved as second line (2L) therapy for patients (pts) with large B-cell lymphoma (LBCL) whose disease relapses within 12 months (mo) of completion of or is refractory to frontline therapy (early R/R). However, limited real-world data on CAR T outcomes for early R/R LBCL are available by line of therapy. We performed a retrospective multicenter study to evaluate the real-world outcomes of early R/R LBCL pts treated with CAR T in 2L as compared to the 3L+ setting.
Methods
Pts aged ≥ 18 years (yrs) with early R/R LBCL who received commercial axi-cel, tisagenlecleucel (tisa-cel), or liso-cel infusion from 4/2018 – 6/2023 at 9 academic US medical centers were identified from the Cell Therapy Consortium registry. Bridging therapy (BT) initiated prior to leukapheresis and continued until lymphodepleting chemotherapy (LDc) was not considered a separate treatment line. Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) were graded per ASTCT consensus criteria. Tumor response was assessed per Lugano criteria.
Results
As of 6/25/24, we identified 155 pts with early R/R disease of whom 51% had primary refractory disease. Among 53 (34%) pts receiving CAR T in 2L, 74% received axi-cel and 26% liso-cel, and among 102 (66%) pts receiving CAR T in 3L+, 48% received axi-cel, 24% tisa-cel and 28% liso-cel. Median age at leukapheresis was 63yrs (IQR: 56-70) with 26% >70yrs, 67% were male, 15% had an ECOG performance status (PS) ≥ 2, and 11% were non-Caucasian. Fludarabine/cyclophosphamide LDc was received by 76% of pts and bendamustine by 23%. Forty-seven percent of pts had elevated LDH pre-LDc, and 39% achieved an objective response to BT (complete or partial response). Baseline patient characteristics that differed between pts receiving 2L vs 3L+ CAR T were in disease status at time of referral (51% refractory in 2L vs 35% in 3L+, p<0.01), and CAR T product received (74% axi-cel in 2L vs 48% in 3L+, p<0.01).
Any grade CRS occurred in 68% of all pts (6% grade 3-4). Any grade ICANS occurred in 35% of pts (15% grade 3-4). There were no differences in rates of CRS or ICANS (no CRS/ICANS vs grade 1-2 vs 3-4) between pts receiving 2L vs 3L+ CAR T. Fifty (32%) pts died related to lymphoma. Fifteen deaths were unrelated to lymphoma with the most common causes of infection (4%), other malignancy (2%) and other causes (3%). Causes of death were similar between pts receiving 2L vs 3L+ CAR T.
Out of 137 (89%) pts evaluable at 30 days post-infusion, objective response rate (ORR) was 80% and complete response (CR) rate was 54%. Out of 122 (78%) pts evaluable at 90 days post-infusion, ORR was 70% and CR rate was 57%. There was no significant difference in either ORR or CR rate for those treated with 2L or 3L+ CAR T.
Median time of follow-up was 11.1 mo (range: 0.2-63 mo). Progression-free survival (PFS) at 9 mo was 48% (95%CI: 41-57%) for all pts. Pts treated with CAR T in 2L had a 9 mo PFS of 56% (95%CI: 44-71%) compared to 45% (95%CI: 36-56%) in 3L+ (p=0.18). Overall survival (OS) at 9 mo was 64% (95%CI: 57-72%) for all pts. Pts treated with CAR T in 2L had a 9 mo OS of 75% (95%CI: 63-88%) compared to 59% (95%CI: 50-69%) in 3L+ (p=0.11). Nine-month non-relapse mortality for all pts was 9% (95%CI: 4-13%) with no significant difference between 2L vs 3L+.
Factors included in multivariable analysis (MVA) were age at time of leukapheresis, ECOG PS, response to frontline therapy, CAR T product, elevated LDH pre-LDc, discrete number of lines of prior therapy, and response to BT. Factors associated with PFS on MVA were elevated LDH pre-LDc (HR 3.6, p<0.01) and ECOG PS (0,1,≥2) (HR 1.8, p=0.01). Factors associated with OS on MVA were elevated LDH pre-LDc (HR 2.7, p<0.01), discrete number of lines of prior therapy (HR 1.3, p<0.01), and ECOG PS (0,1, ≥2) (HR 1.9, p=0.02).
Conclusions
In this real-world analysis of pts with early R/R LBCL after frontline therapy, outcomes of pts treated with commercial CAR T in both the 2L and 3L+ setting yield favorable response and survival outcomes. While our analysis is limited by short follow-up and limited subgroup cohort size, our data suggest similar outcomes for early R/R LBCL pts treated with CAR T in 2L vs 3L+. Selection of more fit pts and efforts to reduce disease burden prior to infusion may improve survival outcomes for early R/R LBCL pts treated with CAR T regardless of line of therapy.
Disclosures: Ahmed: Kite/Gilead: Consultancy, Honoraria; Legend Biotech: Consultancy, Honoraria; BMS: Consultancy, Honoraria. Ahmed: Nektar: Research Funding; Janssen: Research Funding; Myeloid Therapeutics: Consultancy; Kite, a Gilead Company: Consultancy, Research Funding; Merck: Research Funding; Bristol Myers Squibb: Research Funding; Xencor: Research Funding; ADC Therapeutics: Consultancy. Chen: Novartis: Research Funding; BMS: Research Funding; ADC Therapeutics: Consultancy; Elsevier: Consultancy; Kite: Research Funding; Fate Therapeutics: Research Funding. Bachanova: Incyte: Research Funding; Citius: Research Funding. Maziarz: Orca: Research Funding; Kite, a Gilead Company: Consultancy, Research Funding; Incyte: Consultancy, Research Funding; Novartis: Consultancy, Other: participated in data and safety monitoring boards , Research Funding; Ori-cell Therapeutic: Honoraria; Gilead Sciences: Other: stock or other ownership; Artiva Bio: Other: Leadership Role; stock or other ownership; Athersys: Other: participated in data and safety monitoring boards, Patents & Royalties; Bristol Myers Squibb: Consultancy, Research Funding; CRISPR Therapeutics: Consultancy; Autolus: Consultancy; Vor BioPharma: Other: participated in data and safety monitoring boards; Century Therapeutics: Other: participated in data and safety monitoring boards. Oluwole: Daichi Sankyo: Research Funding; TGR: Consultancy; Novartis: Consultancy; Nektar: Consultancy; Kite, a Gilead Company: Consultancy, Research Funding, Speakers Bureau; Epizyme: Consultancy; Caribou Biosciences: Consultancy; ADC: Consultancy, Speakers Bureau; Pfizer: Consultancy, Honoraria, Research Funding; Allogene: Research Funding; Gilead Sciences: Consultancy, Honoraria; AbbVie: Consultancy; Cargo: Consultancy; Bioheng: Consultancy. Bishop: ADC Therapeutics: Honoraria, Speakers Bureau; GenMab: Honoraria, Speakers Bureau; AstraZeneca: Honoraria, Speakers Bureau; Iovance Biotherapeutics: Consultancy; Sana Biotechnology: Consultancy, Honoraria; In8bio: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Galapagos: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Achieve Clinics, In8Bio: Current holder of stock options in a privately-held company; Achieve Clinics, Arcellx, Autolus, BMS, Chimeric Therapeutics, CRISPR Therapeutics, In8Bio, Iovance Biotherapeutics, Kite-Gilead, Optum Health, Novartis, Sana Biotechnology: Consultancy; Bristol-Meyer-Squibb: Consultancy, Honoraria, Speakers Bureau; Chimeric Therapeutics: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; CRISPR Therapeutics: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Kite/Gilead: Consultancy, Honoraria, Research Funding, Speakers Bureau; Servier: Consultancy, Honoraria, Speakers Bureau; Incyte: Honoraria; Arcellx, Autolus, Bristol-Myers Squibb, CRISPR Therapeutics, Lyell, Gilead Sciences and Novartis: Research Funding; AbbVie, ADC Therapeutics, Bristol-Myers Squibb, Gilead Sciences, Incyte, Novartis, Sanofi and Servier: Honoraria, Speakers Bureau. Porter: Mirror Biologics: Consultancy; Tmunity.: Patents & Royalties; Novartis: Patents & Royalties, Research Funding; BMS: Research Funding; Novartis: Consultancy; Genentech: Current equity holder in publicly-traded company; Roche: Current equity holder in publicly-traded company; Janssen (Johnson and Johnson): Consultancy; Sana Biotechnology: Consultancy; Angiocrine: Consultancy; Kite/Gilead: Consultancy; Verismo Therapeutics. Research Funding: Novartis; BMS: Consultancy. Perales: AbbVie: Honoraria; OrcaBio: Consultancy, Current holder of stock options in a privately-held company; Sellas: Other: DSMB member; Celgene: Consultancy, Honoraria; Syncopation: Consultancy; Cidara Therapeutics: Other: DSMB member; Caribou Biosciences: Consultancy; Merck: Consultancy, Research Funding; Allovir: Consultancy; Allogene: Consultancy, Research Funding; Bristol-Myers Squibb: Consultancy, Honoraria; Kite/Gilead: Consultancy, Honoraria, Research Funding; Incyte: Consultancy, Honoraria, Research Funding; Novartis: Consultancy, Honoraria, Research Funding; Omeros: Consultancy, Current equity holder in publicly-traded company; Miltenyi Biotec: Consultancy, Honoraria, Research Funding; Nektar Therapeutics: Consultancy, Honoraria, Research Funding; Sanofi: Consultancy; VectivBio AG: Consultancy, Research Funding; Adicet: Consultancy; Vor Biopharma: Consultancy; Astellas: Honoraria; Karyopharm: Honoraria; MorphoSys: Honoraria; Takeda: Honoraria; Medigene: Other: DSMB member; Servier: Other: DSMB member. McGuirk: Sana technologies: Consultancy; Legend biotech: Consultancy; CRISPR therapeutics: Consultancy; Caribou bio: Consultancy; NEKTAR therapeutics: Consultancy; Autolus: Consultancy; Allo Vir: Consultancy; Envision: Consultancy; Kite: Consultancy; Novartis: Consultancy; BMS: Consultancy. Riedell: Nektar Therapeutics: Consultancy, Membership on an entity's Board of Directors or advisory committees; Fate Therapeutics: Research Funding; Intellia Therapeutics: Consultancy, Membership on an entity's Board of Directors or advisory committees; ADC Therapeutics: Consultancy, Membership on an entity's Board of Directors or advisory committees; Janssen: Consultancy, Membership on an entity's Board of Directors or advisory committees; Genentech/Roche: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Tessa Therapeutics: Research Funding; Cargo Therapeutics: Research Funding; Calibr: Research Funding; CRISPR Therapeutics: Research Funding; CVS Caremark: Consultancy, Membership on an entity's Board of Directors or advisory committees; Xencor: Research Funding; Pharmacyclics: Consultancy, Membership on an entity's Board of Directors or advisory committees; AbbVie: Consultancy, Membership on an entity's Board of Directors or advisory committees; Genmab: Consultancy, Membership on an entity's Board of Directors or advisory committees; Kite/Gilead: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; BMS: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Cellectis: Research Funding; Sana Biotechnology: Consultancy, Membership on an entity's Board of Directors or advisory committees; BeiGene: Consultancy, Membership on an entity's Board of Directors or advisory committees; Adaptive Biotechnologies: Honoraria. Landsburg: Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; GenMab: Honoraria; Calithera: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; ADC Therapeutics: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau.
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