Session: 623. Mantle Cell, Follicular, Waldenstrom’s, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological: Poster III
Hematology Disease Topics & Pathways:
Research, Acute Myeloid Malignancies, Epidemiology, Clinical Research, Diseases, Lymphoid Malignancies, Adverse Events
Methods: The articles included in this systematic review and meta-analysis were retrieved through an extensive search of Google Scholar, PubMed, and Cochrane CENTRAL databases. Additional articles were identified by skimming the reference lists of similar systematic reviews and meta-analyses. The search included relevant articles from inception to July 2024 using a detailed search via MeSH (medical subject heading) terms and keywords. The review adheres to the Cochrane methodology and follows the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A Comprehensive Meta-Analysis (CMA) version 3 was utilized for all statistical analyses.
Results: Data from 16 studies were pooled to evaluate the incidence of secondary malignancies in HCL patients. A subgroup analysis compared incidence rates based on therapeutic interventions: non-purine analogs, purine analogs, and a combination of both. Additionally, the time from HCL diagnosis to the development of secondary malignancies was analyzed. The cumulative incidence of secondary malignancies among HCL patients was 12.1% (95% CI: 9.5 – 15.3). Subgroup analysis revealed a higher incidence in patients treated with purine analogs (13.7%) than those treated with non-purine analogs (4.8%). Patients receiving a combination of both therapies had an incidence of 11.9%. The differences were statistically significant (p<0.0001), with a z-score of -14.138. Of the 16 studies, 9 reported the time duration from HCL diagnosis to secondary malignancy development, with a pooled mean time of 111.66 months (95% CI: 88.82 – 134.49). The mean time varied across treatment groups: 85.25 months for non-purine analogs, 114.97 months for combination therapies, and 120.01 months for purine analogs, but these differences were not statistically significant (p = 0.106).
Conclusions: The incidence of secondary malignancies in HCL patients is significantly influenced by the type of frontline treatment, with purine analogs being associated with a higher risk compared to non-purine analogs. These findings highlight the importance of long-term surveillance and careful consideration of treatment options to mitigate the risk of secondary malignancies. Further research is necessary to understand the mechanisms driving these associations and to develop strategies for reducing secondary malignancy risk in HCL patients.
Disclosures: No relevant conflicts of interest to declare.