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3811 Factors Associated with Quality of Life Impairments in Patients with Myeloproliferative Neoplasms: Looking Beyond Symptom Burden

Program: Oral and Poster Abstracts
Session: 908. Outcomes Research: Myeloid Malignancies: Poster II
Hematology Disease Topics & Pathways:
Research, MPN, Clinical Research, Chronic Myeloid Malignancies, Patient-reported outcomes, Diseases, Myeloid Malignancies
Sunday, December 8, 2024, 6:00 PM-8:00 PM

Chi-Joan How, MD1, Bridget Coffey2*, Christina M. Dieli-Conwright3*, Gabriela S. Hobbs, MD4, Hermioni L Amonoo, MD5, Areej El-Jawahri, MD6 and Richard Newcomb, MD7*

1Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA
2Massachusetts General Hospital, Boston
3Dana Farber Cancer Institute, Boston
4Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA
5Harvard Medical School, Boston, MA
6Massachusetts General Hospital, Allston, MA
7Massachusetts General Hospital, Winthrop, MA

INTRODUCTION: Patients with myeloproliferative neoplasms (MPNs) including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF) experience inflammatory symptoms, thrombotic complications, and increased risk of progression to more aggressive leukemias that result in quality of life (QOL) impairments. However, the relationship between symptoms, psychological distress, illness perception, coping, and perception of prognosis and QOL are unknown. Understanding these factors at the time of MPN diagnosis and how these factors interact with symptomology is important for effective patient education on living with MPN and informs development of novel supportive care interventions.

OBJECTIVES: We sought to describe psychological distress, illness perception, coping, and perception of prognosis in newly diagnosed patients with MPN and evaluate their associations with QOL when controlling for symptom burden.

METHODS: We conducted cross-sectional analyses of data from 34 adults newly diagnosed with MPN at a single academic center. We enrolled consecutive patients who were diagnosed <3 months prior to study enrollment. We obtained patient demographics, clinical characteristics, and patient reported outcomes to assess MPN symptom burden (MPN Symptom Assessment Form Total Symptom Score [MPN SAF TSS]), psychological distress (Hospital Anxiety and Depression Scale [HADS-A/D]), illness perception (Brief Illness Perception Questionnaire [BIPQ]), coping (Brief COPE), and QOL (Functional Assessment of Cancer Therapy [FACT-G]). Clinically significant symptoms and psychological distress were defined as MPN SAF TSS scores >10 and HADS-A or HADS-D score >7. Moderately and severely threatening perceptions of illness were defined as BIPQ scores 42-49 and >50. We used the median split method to define higher and lower use of approach-oriented (positive re-framing, problem solving, seeking emotional support) and avoidant-oriented (denial, avoidance, and disengagement) coping strategies. We used unadjusted linear and logistic regression models to identify factors that are associated with QOL. Multivariate linear regression models controlling for symptom burden were used to independently examine associations between psychological distress, illness perception, or coping with QOL.

RESULTS: We enrolled 34 patients with MPN (13 ET; 12 PV; 8 MF; 1 MPN-U; median age 68.1; range 33.31-82.06; 52.9% female). Mean MPN SAF TSS score was 14.88 with no significant differences among MPN subtypes (p=0.84). Clinically significant anxiety or depression was seen in 17.65% and 11.76% of MPN patients, respectively. 27.27% of MPN patients had moderately or severely threatening perceptions of their illness. 41.2% of MPN patients highly used approach-oriented coping strategies at the time of diagnosis, and 35.3% of MPN patients highly used avoidant-oriented coping mechanisms. On univariate analysis, MPN SAF TSS (B=-19.07; p<0.001), BIPQ (B=-33.38; p<0.001 for scores >50; B=-13.813; p=0.04 for scores 42-49), HADS-A (B=-23.87; p=0.001) and D scores (B=-37.547; p<0.001), and avoidant-oriented coping strategies (B=-17.35; p=0.004) were associated with lower FACT-G scores, corresponding to more impaired QOL. BIPQ (B=-13.821; p<0.001), HADS-A (B=-20.47; p<0.001) and HADS-D (B=-30.86; p<0.001) scores, and high use of avoidant-oriented coping strategies (B=-11.73; p=0.04) remained significantly associated with lower FACT-G scores even when controlling for symptom burden.

CONCLUSIONS: A significant proportion of newly diagnosed patients with MPN experience psychological distress, report moderately to severely threatening illness perception, and highly use avoidant coping strategies. Symptom burden remains associated with QOL decrements. However, our analysis also suggests that QOL is impacted by other aspects of illness which are independent of symptoms, including anxiety, depression, perception of disease severity, and maladaptive coping. Supportive care interventions to address patients’ disease understanding and expectations, coping needs, and psychological distress are needed in this vulnerable population.

Disclosures: How: PharmaEssentia: Consultancy; Merck: Consultancy. Hobbs: Pfizer: Honoraria; Incyte: Honoraria, Research Funding; Novartis: Honoraria; Sobi: Honoraria; Cogent: Honoraria; GSK: Honoraria; BMS: Honoraria; Abbvie: Honoraria; Pharmaessentia: Honoraria; Regeneron: Other: spouse employment. El-Jawahri: Novartis: Consultancy; GSK: Consultancy; Tuesday Health: Consultancy; Incyte: Consultancy. Newcomb: Vertex Pharmaceuticals: Current equity holder in publicly-traded company.

*signifies non-member of ASH