Type: Oral
Session: 623. Mantle Cell, Follicular, Waldenstrom’s, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological: Novel Treatment Strategies and New Data on Old Standards for Follicular Lymphoma
Hematology Disease Topics & Pathways:
Research, Clinical trials, Lymphomas, Bispecific Antibody Therapy, Clinical Research, B Cell lymphoma, Diseases, Treatment Considerations, Biological therapies, Lymphoid Malignancies
Methods: Eligible pts had R/R CD19+ B-NHL that was R/R to ≥2 prior lines of therapy. Escalating doses of intravenous AZD0486 were administered in either a fixed target dose (day [D]1, D15 0.03–2.4 mg), single step-up dose (1SUD) schedule (D1 0.27–1 mg, D15 0.8–10 mg), or double SUD (2SUD) schedule (D1 0.27 mg, D8 1 mg, D15 2.4–15 mg) in cycle (C) 1. AZD0486 was then given every 2–4 weeks in 28-D Cs for C2–24. The primary objective was to assess safety, tolerability, and PK/PD and to determine the recommended phase 2 dose. Response was assessed by central imaging review per RECIL 2017 criteria. Minimal residual disease (MRD) was assessed by PhasED-Seq using Foresight CLARITY for Lymphoma test in plasma circulating tumor DNA. Cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) were graded per 2019 ASTCT criteria. Adverse events (AEs) were graded by CTCAE v5.0.
Results: As of March 15, 2024, 47 pts with R/R FL received AZD0486 at target doses of ≤0.8 mg (n=7), 2.4 mg (n=15 [2SUD, n=9]), 7.2 mg (n=20 [2SUD, n=16]), 10 mg (n=1), and 15 mg (n=4 [2SUD, n=4]). Overall, 18 (38.3%) pts had disease progression within 24 months of front-line chemoimmunotherapy (POD24). Median prior lines of therapy was 3 (range 2–12), 18 (38%) pts received prior lenalidomide–based therapy, 7 (15%) pts received prior chimeric antigen receptor T-cell therapy (CAR-T), and 4 (9%) received prior CD20 TCE therapy. The overall response rate (ORR) and complete response (CR) rate for evaluable pts receiving doses ≥2.4 mg (n=27) were 96% and 85%, respectively; 6/7 (86%) pts with CD20-negative disease at baseline achieved CR, including 2/2 pts who had progressed after prior CD20 TCE therapy. Given the improved safety profile of AZD0486 with 2SUD, the 2SUD cohorts were expanded, and the CR rate was 88% (7/8) at a target dose of 7.2 mg and 75% (6/8) at a target dose of 2.4 mg. Exposure-response analysis also indicated improved ORR with higher exposure to AZD0486 (P=0.042, 7.2 mg vs 2.4 mg) and a trend of improved CR rate with higher exposure. Of the 19 pts with CR evaluable for MRD in the 2.4 mg and 7.2 mg cohorts, 89% (17/19) achieved undetectable MRD by 12 weeks. With median follow-up of 8.2 (range, 0.3–29.3) months (mo), for pts who received ≥0.8 mg (n=32), estimated 12-mo progression-free survival was 72% and 12-mo duration of response was 77%. Among pts treated with 2SUD (n=29), 13 (45%) had grade 1 CRS (7% at target dose) and 1 (3%) pt experienced grade 1 ICANS (0% at target dose). No grade ≥2 events of CRS or ICANS were reported in pts who received 2SUD. There was no meaningful difference in CRS or ICANS events observed at target dose of 7.2 mg vs 2.4 mg. The most common (≥5%) grade ≥3 TEAEs in pts who received 2SUD were lymphopenia (28%), neutropenia (10%), decreased white blood cell count (10%), and hyperglycemia (7%). In all pts with FL, the higher target dose of 7.2 mg was not associated with increased rates of treatment-related grade ≥3 AEs, serious AEs, all-grade AEs, or frequency/severity of cytopenias or infections. Moreover, no pt at any dose discontinued due to treatment-related AEs. Dose-limiting toxicities were mitigated with 2SUD; no maximum tolerated dose has been reached.
Conclusion: AZD0486 offers high response rates in pts with R/R FL at target doses ≥2.4 mg. Responses were durable. 2SUD allows safe administration of the target dose up to at least 15 mg. The exposure-response analysis supports the target dose of 7.2 mg. Further studies of AZD0486 are planned as monotherapy and in combination regimens.
Disclosures: Nair: 280 Bio Inc.: Membership on an entity's Board of Directors or advisory committees. Jacobs: AbbVie: Consultancy, Research Funding, Speakers Bureau; Beigene: Consultancy, Research Funding, Speakers Bureau; AstraZeneca: Consultancy, Research Funding, Speakers Bureau; Pharmacyclics LLC, an AbbVie Company: Research Funding; Genentech: Consultancy; Galapagos: Consultancy; Lilly: Consultancy, Research Funding; SecuraBio: Consultancy; Regeneron: Research Funding; Adaptive: Speakers Bureau; Janssen: Consultancy. Kim: Roche/Genetech: Consultancy; IMBDx. Inc.: Consultancy, Honoraria; Yuhan: Consultancy; Daiichi Sankyo, HK inno.N, F. Hoffmann-La Roche Ltd/Genentech, Yuhan: Consultancy; Takeda: Consultancy, Honoraria; Samsung Bioepis: Consultancy; Amgen: Consultancy, Honoraria; Regeneron: Consultancy, Membership on an entity's Board of Directors or advisory committees; BeiGene: Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy; Janssen: Consultancy, Honoraria; Boryung: Consultancy; AstraZeneca/MedImmune: Consultancy. Maruyama: Mundipharma: Honoraria; Nippon Shinyaku: Honoraria; Astellas: Research Funding; Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Taiho: Research Funding; Otsuka: Research Funding; Novartis: Honoraria, Research Funding; Genmab: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; BMS: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; AstraZeneca: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; AbbVie: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Honoraria, Research Funding; Symbio: Honoraria, Research Funding; Sanofi: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Zenyaku: Honoraria, Research Funding; MSD: Honoraria, Research Funding; Kyowa Kirin: Honoraria, Research Funding; Chugai: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Eisai: Honoraria, Research Funding; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Ono: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Devata: Novo Nordisk: Current equity holder in publicly-traded company; AbbVie: Current equity holder in publicly-traded company; Bristol Myers Squibb: Current equity holder in publicly-traded company, Divested equity in a private or publicly-traded company in the past 24 months; Merck: Current equity holder in publicly-traded company, Divested equity in a private or publicly-traded company in the past 24 months; Johnson & Johnson: Current equity holder in publicly-traded company; Eli Lilly: Current equity holder in publicly-traded company, Divested equity in a private or publicly-traded company in the past 24 months; Bayer: Current equity holder in publicly-traded company; AstraZeneca: Current equity holder in publicly-traded company, Divested equity in a private or publicly-traded company in the past 24 months, Research Funding; Pfizer: Current equity holder in publicly-traded company, Divested equity in a private or publicly-traded company in the past 24 months; GSK: Current equity holder in publicly-traded company, Divested equity in a private or publicly-traded company in the past 24 months. Sawalha: ADC: Consultancy; Genmab: Honoraria, Research Funding; AbbVie: Research Funding; Beigene: Research Funding. Yoon: Abbvie, Beigene, Boryung, Celltrion, Kyowa Kirin, Janssen, Samyang and Sanofi: Honoraria, Research Funding; Asan Medical Center, University of Ulsan College of Medicine: Current Employment; Abbvie, Abclon, Beigene, BMS, GI cell, GI innovation, GC cell, Verismo, Janssen, Lilly, Novartis, Roche, and Pharos Bio: Consultancy; Regeneron: Membership on an entity's Board of Directors or advisory committees. Tam: Lilly: Honoraria; Gilead: Honoraria; Novartis: Honoraria; AstraZeneca: Honoraria; AbbVie: Honoraria, Research Funding; Janssen: Honoraria, Research Funding; BeiGene: Honoraria, Research Funding. Izutsu: Pfizer, Janssen, Gilead, Daiichi Sankyo: Honoraria, Research Funding; Beigene, Yakult, Otsuka: Consultancy, Research Funding; Incyte, Bayer, O Oncology, Regeneron: Research Funding; MSD, AstraZeneca, Genmab, Chugai, BMS, Kyowa Kirin, Novartis, AbbVie: Consultancy, Honoraria, Research Funding; AstraZeneca, Eli Lily, Astellas, Ono Pharmaceuticals, Eisai, Chugai, Janssen, Symbio, Bristol Myers Squibb, Daiichi Sankyo, Otsuka, Abbvie, Takeda, Eli Lilly, Genmab, Kyowa Kirin, MSD, Astellas, Pfizer, MeijiSeika Pharma, Novartis, Nihon Kayaku, Gilead,: Honoraria; MSD, AstraZeneca, Abbvie, Incyte, Bristol Myers Squibb, Novartis, Bayer, Pfizer, Janssen, Yakult, Kyowa Kirin, Daiichi Sankyo, Chugai, Beigene, Genmab, LOXO Oncology, Otsuka, Regeneron, Gilead: Research Funding; AstraZeneca, Zenyaku, Ono Pharmaceuticals, Mitsubishi Tanabe Pharma, Eisai, Chugai, Bristol Myers Squibb, Takeda, Otsuka, Abbvie, Zenyaku, Kyowa Kirin, MSD, Carna Biosciences, Novartis, Yakult, Nihon Shinyaku, Abe Pharma, Eisai,Beigene: Consultancy; Ono Pharma, Symbio, Takeda: Consultancy, Honoraria. Matasar: Regeneron Pharmaceuticals, Inc.: Honoraria; Takeda: Honoraria; BMS/Celgene: Honoraria; Genmab: Membership on an entity's Board of Directors or advisory committees; Johnson & Johnson: Consultancy, Honoraria, Research Funding; Pfizer: Honoraria; Merck: Current equity holder in publicly-traded company; GM Biosciences: Consultancy, Research Funding; Allogene: Membership on an entity's Board of Directors or advisory committees; Pharmacyclics: Consultancy, Honoraria, Research Funding; Epizyme: Honoraria; Kite: Honoraria; AstraZeneca: Honoraria; ADC Therapeutics: Honoraria; Immunovaccine Technologies: Research Funding; Seattle Genetics: Consultancy, Honoraria, Research Funding; Roche: Consultancy, Honoraria, Research Funding; IMV Therapeutics: Honoraria; Bayer: Consultancy, Honoraria, Research Funding; Genentech: Consultancy, Honoraria, Research Funding. Ramakrishnan: Novartis: Research Funding; BMS: Research Funding; Gracell/AstraZeneca: Research Funding; Janssen: Research Funding; Poseida: Research Funding; Pfizer: Research Funding; Kite: Research Funding; Marker: Research Funding; Cellectis: Honoraria; Juno: Research Funding; Autolus: Research Funding; Sumitomo: Research Funding; Schrodinger: Research Funding; Macrogenics: Research Funding; Fate: Research Funding; Chimeric: Research Funding; Sanofi: Research Funding; Kadmon: Research Funding. Brennan: AstraZeneca: Current Employment, Current equity holder in publicly-traded company. Zhu: Novartis Institute for BioMedical Research: Ended employment in the past 24 months; AstraZeneca: Current Employment. Lesley: AstraZeneca: Current Employment, Current equity holder in publicly-traded company; Amgen: Current equity holder in publicly-traded company. Oki: AstraZeneca: Current Employment. Sermer: AstraZeneca: Current Employment. Gaballa: Regeneron: Consultancy; Eli Lilly: Honoraria; Genmab: Consultancy; Gilead: Consultancy; Abbvie: Consultancy; Beigene: Consultancy; AstraZeneca: Consultancy; ADC Therapeutics: Consultancy, Honoraria; Ipsen: Consultancy; Genetech: Consultancy.