65th ASH Annual Meeting & Exposition: Germline Predisposition That Intersects With Lymphoid Malignancies, Solid Tumors, and DNA Repair Pathways

Symposia: Scientific Workshop on Germline Predisposition to Hematopoietic Malignancies and Bone Marrow Failure Scientific Workshops

Room 29 (San Diego Convention Center)

Moderators:

Christopher N. Hahn, PhD, Molecular Pathology Research Laboratory, Centre for Cancer Biology and Grace Christou, MD, MSc, FRCPC, The Ottawa Hospital

Disclosures:

Christou: Jazz Pharma: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees.

Germline predisposition that intersects with lymphoid malignancies, solid tumors, and DNA repair pathways. Predisposition to lymphoid malignancies is probably less well characterised than to myeloid malignancies. This session will address a growing understanding of hereditary predisposition to lymphoid malignancies. Dr. Armanios – Inherited hematological malignancies in Long Telomere Syndrome. Dr. Lesmana – Germline mutations in POT1 in pediatric lymphoma. Dr. Reed – Lymphoid malignancy in Shwachman-Diamond syndrome. Dr. Sharma – Lymphoid malignancies in Ataxia telangiectasia. Dr. McReynolds – Fanconi anemia heterozygotes do not exhibit increased cancer risk.

Moderator Introduction

Christopher N. Hahn, PhD

University of South Australia, Adelaide, SA, Australia

Inherited Hematologic Malignancies in the Long Telomere Syndrome

Mary Armanios, MD

Johns Hopkins University School of Medicine, Baltimore, MD

Q + A

Mary Armanios, MD

Johns Hopkins University School of Medicine, Baltimore, MD

Germline POT1 Mutation Predisposing to Pediatric Burkitt Leukemia

Harry Layton Lesmana, MD

Department of Pediatric Hematology, Oncology and BMT, Cleveland Clinic, Cleveland, OH