Yunqi Li^1*, Melissa A. Richard, PhD^2*, Linda Kachuri, PhD, MPH^3*, Yao Yu, PhD^4*, Ching-Ju Ruu Hsu^5*, Tracie C. Rosser, PhD^6*, Elizabeth J. Leslie, PhD^6*, Meenakshi Devidas, PhD, MBA⁷, Elizabeth A. Raetz, MD⁸, Mignon L. Loh, MD⁹, Stephen P. Hunger, MD¹⁰, Neetha Paul Eduthan, MS^11*, Matthew D. Galbraith, PhD^11*, Joaquin Espinosa, PhD^11*, Jun J. J. Yang, PhD¹², Stephanie L. Sherman, PhD^13*, Chad D. Huff, PhD^14*, Karen R. Rabin, MD, PhD¹⁵, Philip J. Lupo, PhD^16* and Adam J. de Smith, PhD¹⁷

¹Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Kansas City, MO
²Department of Pediatrics, Baylor College of Medicine, Houston, TX
³Department of Epidemiology and Population Health, Stanford University School of Medicine, San Francisco, CA
⁴Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
⁶Emory University, Atlanta, GA
⁷St Jude Children's Research Hospital, Memphis, TN
⁸Department of Pediatrics, NYU Langone Health, New York, NY
⁹Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Seattle, WA
¹⁰Childrens Hospital of Philadelphia, Philadelphia
¹¹Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO
¹²Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, MEMPHIS, TN
¹³Department of Human Genetics, Emory University, Atlanta, GA
¹⁴Department of Epidemiology, UT MD Anderson Cancer Center, Houston, TX
¹⁵Department of Pediatrics, Baylor College of Medicine, Baylor College of Medicine TX Children's Cancer Center, Houston, TX
¹⁶Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX
¹⁷Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA

Yoshihiro Hatta, MD¹, Fumihiko Hayakawa, MD, PhD², Etsuko Yamazaki, MD, PhD³, Tohru Murayama, MD^4*, Takeshi Saito, MD, PhD⁵, Satoru Takada^6*, Nobuaki Dobashi, MD⁷, Shuichi Ota, MD⁸, Yasuhisa Yokoyama^9*, Masatsugu Tanaka, M.D., Ph.D.^10*, Shinya Sato, MD^11*, Shigeki Ohtake, MD, PhD^12*, Emiko Sakaida, MD, PhD¹³, Yoshinobu Maeda, MD, PhD¹⁴, Takahiro Yamauchi, MD, PhD¹⁵, Itaru Matsumura, MD, PhD¹⁶, Yasushi Miyazaki, MD PhD¹⁷ and Hitoshi Kiyoi, MD, PhD¹⁸

¹Department of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
²Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, JPN
³Dept. Hematology, Yokohama Rosai Hospital, Yokohama, Japan
⁴Dept. Hematology, Hyogo Cancer Center, Akashi, Japan
⁵Division of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
⁶Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan
⁷Department of Clinical Oncology and Hematology, The Jikei University Daisan Hospital, Komae, Tky, JPN
⁸Sapporo Hokuyu Hospital, Sapporo, JPN
⁹Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
¹⁰Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan
¹¹Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, JPN
¹²Kanazawa University, Kanazawa, Japan
¹³Department of Hematology, Chiba University Hospital, Chiba, Japan
¹⁴Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
¹⁵Department of Hematology and Oncology, University of Fukui, Fukui, Japan
¹⁶Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-Sayama, JPN
¹⁷Nagasaki University, Nagasaki, Japan
¹⁸Nagoya University Graduate School of Medicine, Nagoya, Japan

Alfonso Piciocchi, MS^1*, Sabina Chiaretti, MD, PhD², Marta Cipriani, MS^3,4*, Monica Messina, PhD^1*, Loredana Elia^5*, Irene Della Starza, PhD^6*, Antonella Vitale^7*, Paola Fazi, MD^1*, Marco Vignetti, MD^8* and Robin Foa^9*

¹GIMEMA Foundation, Data Center and Health Outcomes Research Unit, Rome, Italy
²Division of Hematology, Department of Translational and Precision Medicine, Division of Hematology, Rome, Italy
³University of Rome La Sapienza, Department of Statistical Sciences, Rome, Italy
⁴Data Center and Health Outcomes Research Unit, GIMEMA Foundation, Rome, Italy
⁵Division of Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
⁶Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
⁷Division of Hematology, Department of Translational and Precision Medicine, Sapienza, Universitty of Rome, Rome, Italy
⁸Data Center and Health Outcomes Research Unit, GIMEMA foundation, Rome, Italy
⁹Hematology, University Sapienza and Hospital Umberto I, Rome, Italy

Diego Luz, MD^1*, Bruno Kosa Lino Duarte, MD, PhD^2*, Yve Oliveira, MD^3*, Camila Piaia, MD^4*, Jordana S. R. Aragao, MD^5*, Ires Bezerra Massaut, MD^6*, Elvira Deolinda Rodrigues Pereira Velloso, MD, PhD⁷, Vanderson Rocha, MD, PhD, MS^8*, Eduardo Magalhães Rego, MD, PhD⁹ and Wellington F Silva, MD PhD¹⁰

¹Hematology, Instituto do Cancer do Estado de Sao Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
²Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
³Hematology, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
⁴Centro de Pesquisas Oncológicas (CEPON), Florianopolis, Brazil
⁵Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
⁶Centro de Pesquisas Oncológicas (CEPON), Florianópolis, BRA
⁷Hematology and Transfusion Medicine, Hospital das Clinicas, Sao Paulo, University of Sao Paulo, Sao Paulo, Brazil
⁸Service of Hematology, Transfusion and Cell Therapy, and Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31), Hospital das Clínicas, Faculty of Medicine, São Paulo University, São Paulo, Brazil., São Paulo, Brazil
⁹Instituto do Cancer do Estado de Sao Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BRA
¹⁰Instituto do Cancer do Estado de Sao Paulo (ICESP), Faculdade de Medicina, University of São Paulo (FMUSP), São Paulo, Brazil

Sara K. Silbert, MD¹, Cynthia Harrison^2*, D. Nathan Biery^2*, Alexandra Semchenkova^3*, Elena Zerkalenkova, PhD^3*, Anna Alonso-Saladrigues^4*, Kaylyn Utley, MD^5*, Ibrahim Aldoss, MD^6,7, Liping Zhao^8*, Sneha Fernandes, MBBS^9*, Jeremy D. Rubinstein, MD, PhD¹⁰, Naomi Torres Carapia^11*, Bill H. Chang, MD, PhD¹², Anant Vatsayan, MBBS^13,14, Barbara De Moerloose^15*, Holly L. Pacenta, MD^16*, Dennis John Kuo, MD, MS^17*, Gabriele Escherich, MD^18*, Benjamin J. Lee, PharmD^19*, Michele S. Redell, MD²⁰, Mandi R. Fitzjohn^21*, Daniel P. Larson, MD^22*, Nicolas Duployez, PharmD, PhD^23*, Raymund S. Cuevo^24*, Rui Rochelle He, PhD^25*, David S. Dickens^26*, Firas El Chaer, MD²⁷, Kelly Reed^28*, Matthias Wolfl^29*, Sunil S. Raikar, MD³⁰, Süreyya Savaşan, MD^31*, Latika Puri, MBBS^32*, Zhubin J. Gahvari, MD, MS³³, Aimee C. Talleur, MD³⁴, Hisham Abdel-Azim, MD³⁵, Aghiad Chamdin, MD^36*, Marlie R.M. Provost^37*, Vanessa A. Fabrizio, MD³⁸, Kerstin Mezger, MD^39*, Alexandra McLean Stevens^40*, Emily M. Hsieh, MD¹¹, Hao-Wei Wang, MD, PhD^41*, Constance M. Yuan, MD, PhD^41*, Ulrich A. Duffner, MD⁴², Jing Pan^43*, Sara Ghorashian, FRCPath, PhD^44*, Susana Rives^4*, Chloe Hoang^45*, Kara L. Davis, DO⁴⁶, Elad Jacoby, MD⁴⁷, Alexander Popov, MD^3*, Adam Lamble, MD^48* and Nirali N. Shah, M.D.⁴⁹

¹National Cancer Institute, NIH, Pediatric Oncology Branch, Bethesda, MD
²Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
³Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation
⁴Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona, Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain. Institut de Recerca Sant Joan de Déu, Barcelona Spain, Barcelona, Spain
⁵Children's Hospital Colorado, Aurora, CO
⁶City of Hope, Duarte, CA
⁷Hematology/HCT, City of Hope National Medical Center, Duarte, CA
⁸State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁹Great Ormond Street Hospital for Children London, London, United Kingdom
¹⁰Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
¹¹Children's Hospital Los Angeles, Los Angeles, CA
¹²Doernbecher Children's Hospital, Oregon Health & Science University, Portland, OR
¹³Children's National Hospital/ George Washington University School of Medicine and Health Sciences, Washington, DC
¹⁴Children's National Medical Center, Washington, DC
¹⁵Ghent University Hospital, Ghent, Belgium
¹⁶Cook Children's Hospital, Fort Worth, TX
¹⁷Rady Children's Hospital, University of California San Diego, San Diego, CA
¹⁸Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
¹⁹Department of Pharmacy, University of California Irvine, Orange, CA
²⁰Texas Children's Cancer Center/Baylor College of Medicine, Houston, TX
²¹Children's Hospital Colorado, Denver, CO
²²Mayo Clinic, Rochester, MN
²³Laboratory of Hematology, Centre Hospitalier Universitaire (CHU) Lille, Lille, France
²⁴Inova Schar Cancer Institute, Fairfax, VA
²⁵Inova Fairfax Hospital, Falls Church, VA
²⁶Department of Pediatrics, University of Iowa, Iowa City, IA
²⁷Department of Medicine, Division of Hematology and Oncology, University of Virginia Comprehensive Cancer Center, Charlottesville, VA
²⁸University of Virginia, Charlottesville, VA
²⁹University Children’s Hospital Würzburg, Würzburg, Germany
³⁰Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University and Children's Healthcare of Atlanta, Atlanta, GA
³¹Children's Hospital of Michigan, Detroit, MI
³²Loma Linda Children's Hospital, San Bernardino, CA
³³University of Wisconsin School of Medicine and Public Health, Madison, WI
³⁴Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN
³⁵School of Medicine Cancer Center, Children Hospital and Medical Center, Loma Linda University, Loma Linda, CA
³⁶Children's Hospital of Michigan, Central Michigan University, Detroit, MI
³⁷Rocky Mountain Hospital for Children, Denver, CO
³⁸University of Colorado Anschutz, Denver, CO
³⁹Clinic of Paediatric Haematology and Oncology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
⁴⁰Texas Children's Hospital Baylor College of Medicine, Houston, TX
⁴¹Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
⁴²Helen Devos Children's Hospital, Grand Rapids, MI
⁴³State Key Laboratory of Experimental Hematology, Boren Clinical Translational Center, Department of Hematology, Beijing Gobroad Boren Hospital, Bejing, China
⁴⁴UCL Great Ormond Street Institute of Child Health, London, ENG, GBR
⁴⁵Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD
⁴⁶Department of Pediatrics, Hematology, Oncology, and Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, CA
⁴⁷Department of Pediatric Hematology-Oncology, Safra Children's Hospital, Sheba Medical Center, Tel Aviv, Israel
⁴⁸Seattle Children's - Hematology-Oncology, Seattle, WA
⁴⁹Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD

Zubair Hassan Bodla^1,2*, Mariam Hashmi^1,2*, Fatima Niaz^3,4*, Austin Auyeung^1,2*, Muhammad Junaid Tariq, MBBS⁵, Muhammad Jahanzeb Khalil^6*, Farhan Khalid^7* and Christopher Bray^1,2*

¹University of Central Florida College of Medicine, Graduate Medical Education, Orlando, FL
²HCA Florida North Florida Hospital, Internal Medicine Residency Program, Gainesville, FL
³King Edward Medical University, Lahore, Pakistan
⁴Mayo Hospital, Lahore, Pakistan
⁵Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁶University of Alabama, Montgomery
⁷Monmouth Medical Center, Long Branch

Sergio Rodriguez-Rodriguez, MD, MSc¹, Fausto Alfredo Rios Olais², Analy Mora^3*, Christian Omar Ramos Peñafiel^4*, Victor Itaí Urbalejo Ceniceros, MD, PhD, MSc⁵, Yadith Karina Lopez-Garcia, MD^6*, Andres Gomez-De Leon, MD⁷, Nancy Delgado-López^8*, Mistral Castellanos Mares, MD^9*, Patricia Carolina Figueroa Hernandez, MD^9* and Roberta Demichelis, MD¹

¹Hematology and Oncology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
²Hematology and Oncology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Mexico
³Hematology and Oncology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad Hidalgo, Mexico
⁴Hematology Department, Hospital General de México, Mexico City, Mexico
⁵Hematology, Instituto Nacional de Cancerología, México, DF, Mexico
⁶Hospital Universitario Nuevo León, Nuevo León, Mexico
⁷Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Mexico, Monterrey, Mexico
⁸Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Mexico City, Mexico
⁹Hematology, Instituto Nacional de Cancerología, CDMX, Mexico

Gaixiang Xu^1,2,3,4*, Yinjun Lou, MD^2,4,5,6*, Huafeng Wang^2,5,7,8*, Wen-Juan Yu^2,5,8,9*, Liping Mao, MD^2,5,6*, Jian Huang^2,5,6,8, Chenying Li^10*, Shanshan Suo, MD^11*, Hongyan Tong, PhD^3,7,8,12* and Jie Jin^{4,7,9,13,14,15,16}

¹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, Hangzhou, China
²Zhejiang Provincial Clinical Research Center for Hematological disorders, Hangzhou, China;, Hangzhou, China
³Zhejiang Provincial Key Lab of Hematopoietic Malignancy, Zhejiang University, Hangzhou, Zhejiang, Hangzhou, China
⁴Zhejiang University Cancer Center, Hangzhou, China
⁵Zhejiang Provincial Key Lab of Hematopoietic Malignancy, Zhejiang University, Hangzhou, Zhejiang, PR China;, Hangzhou, China
⁶Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China;, Hangzhou, China
⁷The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
⁸Zhejiang University Cancer Center,, Hangzhou, China
⁹The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
¹⁰First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, CHN
¹¹Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China;, Hangzhou, China
¹²Zhejiang Provincial Clinical Research Center for Hematological disorders, Hangzhou, Zhejiang, Hangzhou, China
¹³First Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China
¹⁴Zhejiang Provincial Key Lab of Hematopoietic Malignancy, Zhejiang University, Hangzhou, China
¹⁵The First Affiliated Hospital, College of Medicine, Zhejiang University, Hematology, Hangzhou, China
¹⁶Zhejiang Provincial Clinical Research Center for Hematological disorders, Hangzhou, China

Maria D. Leon-Camarena, MD¹, Jennifer M. Geris, PhD, MPH^2*, Maria Isabel Castellanos, MD^3*, Olga Taylor^4*, Veronica Garcia-Morales^2*, Austin L Brown, PhD^4*, Pagna Sok^4*, Van Thu Huynh⁵, Kathleen Ludwig, MD^6*, Laura J. Klesse, MD, PhD^6*, Sandi Pruitt, PhD, MPH^7*, Amy Hughes, PhD^7*, Kevin Wells Tien, MD², Kenneth Matthew Heym, MD^8*, Timothy Griffin, MD^9*, Rodrigo Erana, MD^2*, Juan C. Bernini, MD^2*, Philip J. Lupo, PhD^10*, M. Monica Gramatges, MD, PhD¹¹, Michael E. Scheurer, PhD² and Karen R. Rabin, MD, PhD¹²

¹Internal Medicine, Dell Medical School at University of Texas, Austin, TX
²Department of Pediatrics, Baylor College of Medicine, Houston, TX
³University of California San Francisco, San Francisco, CA
⁴Baylor College of Medicine, Houston, TX
⁵Children’s Hospitals of Orange County, Orange, CA
⁶University of Texas Southwestern, Dallas, TX
⁷Peter O’ Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX
⁸Department of Pediatrics, Cook Children's Medical Center, Fort Worth, TX
⁹Department of Hematology-Oncology, The Children’s Hospital of San Antonio/Baylor College of Medicine, San Antonio, TX
¹⁰Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX
¹¹Pediatric Hematology-Oncology, Texas Children's Hospital, Houston, TX
¹²Department of Pediatrics, Baylor College of Medicine, Baylor College of Medicine TX Children's Cancer Center, Houston, TX

Zixuan Li, MS^1*, Danyue Peng, PhD^1*, Jun Deng, MD, PhD^2*, Lv Xiong, MSc^1*, Ping Yin, PhD^3*, Jing Hu, PhD^3*, Chenjing Qian, MD^1*, Lan Yao, PhD^1*, Hua Yin, MD^4*, Mei Hong, MD^5* and Qiuling Wu, PhD^6*

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
³Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⁴Institute of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing, China
⁵Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⁶Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, AL, China

Karam Ashouri, MD¹, Brian Hom^1*, Yekta Rahimi, MD^2*, Karen Resnick, MD^1*, Vinay Nittur, MD^1*, Jennifer Hwang, MD^1*, Blake Adnani, MD^2*, Mollee Chu, MD^1*, Anush Aram Ginosyan, MD^1*, Robert Ireland, MD^1*, Eljie Isaak Bragasin^1*, Shirley Ye, MD², Lakshmi Savitala-Damerla^3*, Kimberly Schiff^3*, Preet M. Chaudhary, MD, PhD³, Imran Siddiqi, MD, PhD^3*, Abdullah Ladha, MD^3*, Amir Ali, PharmD, BCOP³, Karrune Woan, MD, PhD^3*, Eric Tam, MD^3* and George Yaghmour, MD³

¹Keck School of Medicine, University of Southern California, Los Angeles, CA
²Keck School of Medicine, University of Southern California, Los Angeles
³Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA

Runxia Gu, MD^*, Wenbin Liu, MD^*, Yihan Mei^*, Le Li^*, Chunlin Zhou^*, Yan Li, MD^*, Yuntao Liu^*, Shuning Wei^*, Dong Lin^*, Kaiqi Liu^*, Qiuyun Fang, MD^*, Xiaoyuan Gong, MD^*, Benfa Gong^*, Shaowei Qiu, MD^*, Bingcheng Liu, MD^*, Yingchang Mi, MD, Hui Wei, MD^*, Ying Wang^* and Jianxiang Wang, MD

National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China