Wei-Ying Jen, MD, FRCPath, MA^1*, Elias Jabbour², Fadi G. Haddad, MD^1*, Lewis Nasr^1*, Nicholas J. Short, MD¹, Marianne Zoghbi^1*, Cedric Nasnas^1*, Ghayas C. Issa³, Musa Yilmaz, MD^1*, Naval Daver, MD¹, Naveen Pemmaraju, MD¹, Lucia Masarova, MD¹, Farhad Ravandi, MD, MBBS¹, Nitin Jain, MD¹, Wuliamatu Deen^3*, Christopher Loiselle, BS^3*, Lourdes Waller^3*, Glenda Banks^3*, Rebecca Garris^1* and Hagop M. Kantarjian, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²University of Texas M.D. Anderson Cancer Ctr., Houston, TX
³The University of Texas MD Anderson Cancer Center, Houston, TX

Shanshan Suo, MD^1*, Wen-Juan Yu^1*, Ying Lu^2*, Jiejing Qian, MD^1*, Liping Mao, MD^1*, Jin Wang^3*, Lijing Shen^4*, Bingzong Li, MD, PhD⁵, Huafeng Wang^1*, Wenyuan MAI^1*, Wanzhuo Xie^1*, Xiaomin Wang^6*, Dan Zhao^7*, Yuanfang Liu^3*, Chuan He^5* and Jie Jin¹

¹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China;, Hangzhou, China
²Department of Hematology, The Affiliated People's Hospital of Ningbo University, Ningbo, CHN
³Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁴Department of Hematology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
⁵The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
⁶Department of Hematology, the First Hospital of Shanxi Medical University, Taiyuan, China
⁷Department of Hematology, Yuncheng Central Hospital, Yuncheng, China

Ibrahim Aldoss, MD^1,2, Jianying Zhang, PhD^3*, Marjorie Robbins, PhD, MSc, BSc^4*, Vaibhav Agrawal, M.D.², Ahmed Aribi, MD^2*, Hoda Pourhassan, MD⁵, Paul B. Koller, MD², Amanda Blackmon, DO, MS^2*, Karamjeet S. Sandhu, MD², Haris Ali, MD², Brian J. Ball, MD², Andrew Artz, MD, MS⁶, Monzr M. Al Malki, MD⁷, Amandeep Salhotra, MD⁷, Zhaohui Gu, PhD⁶, Asucena Leon Beltran^3*, Christina Lai^3*, Michelle Afkhami^3*, Lucy Y. Ghoda, PhD^8*, Stephen J. Forman, MD, FACP^1,9, Guido Marcucci, MD¹⁰, Anthony Stein, MD² and Vinod Pullarkat, MD¹¹

¹Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA
²Hematology/HCT, City of Hope National Medical Center, Duarte, CA
³City of Hope National Medical Center, Duarte, CA
⁴Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁵Hematology/HCT, City of Hope, Duarte, CA
⁶City of Hope, Duarte, CA
⁷Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
⁸Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
⁹Department of Hematology and HCT, City of Hope National Medical Center, Duarte, CA
¹⁰Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
¹¹Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte, CA

Ibrahim Aldoss, MD¹, Josep-Maria Ribera, MD, PhD², Hagop Kantarjian, MD³, Pau Montesinos, PhD, MD^4*, Jessica T. Leonard, MD⁵, David Gomez-Almaguer, MD⁶, Maria R. Baer, MD⁷, Carlo Gambacorti-Passerini, MD⁸, James McCloskey, MD⁹, Yosuke Minami, MD, PhD¹⁰, Cristina Papayannidis, MD, PhD^11*, Vanderson Rocha, MD, PhD, MS^12*, Philippe Rousselot, MD, PhD^13*, Pankit Vachhani, MD¹⁴, Eunice S. Wang, MD¹⁵, Meliessa Hennessy, MPH^16*, Niti Patel, PhD^16*, Alexander Vorog, MD^16*, Bingxia Wang, PhD^16* and Elias Jabbour¹⁷

¹City of Hope National Medical Center, Duarte, CA
²ICO Badalona-Hospital Universitari Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute, Badalona, Spain
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Spain
⁵Oregon Health and Science University, Portland, OR
⁶Hospital Universitario, UANL; Dr. José Eleuterio Gonzalez, Monterrey, Mexico
⁷Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
⁸University Milano-Bicocca, Monza, Italy
⁹Hackensack University Medical Center, Hackensack, NJ
¹⁰National Cancer Center Hospital East, Kashiwa, Japan
¹¹IRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia “Seràgnoli”, Bologna, Italy
¹²Instituto do Câncer do Estado de São Paulo, University of São Paulo, São Paulo, Brazil
¹³Centre Hospitalier de Verailles, UMR1184, University Versailles Paris-Saclay, Versailles, France
¹⁴University of Alabama at Birmingham, Birmingham, AL
¹⁵Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹⁶Takeda Development Center Americas, Inc., Lexington, MA
¹⁷University of Texas M.D. Anderson Cancer Ctr., Houston, TX

Eric S. Schafer¹, Yueh-Yun Chi, PhD^2*, Jemily Malvar, MS^3*, Teresa Rushing, PharmD^4*, Andrew Doan, MD^5*, Holly L. Pacenta, MD^6*, Reuven J. Schore, MD⁷, Richard Sposto^8*, Roy Leong^4*, Paul S. Gaynon, MD⁵, Jeffrey E. Rubnitz, MD, PhD⁹, Julio C. Barredo, MD¹⁰, Tamra Slone, MD^11*, Melinda Pauly, MD¹², Alan S. Wayne, MD⁴, Deepa Bhojwani, MD¹³ and Terzah M. Horton, MD, PhD^14*

¹Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX
²Biostatistics, Children's Hospital of Los Angeles, Los Angeles, CA
³Biostatistics, Children's Hospital Los Angeles, Los Angeles, CA
⁴Children's Hospital of Los Angeles, Los Angeles, CA
⁵Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA
⁶Cook Children's Hospital, Fort Worth, TX
⁷Pathology, Children's National Medical Center, Washington, DC
⁸Children's Hospital Los Angeles, Los Angeles, CA
⁹Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
¹⁰Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL
¹¹Univ. of TX, Southwestern, Dallas, TX
¹²Children’s Healthcare of Atlanta, Atlanta, GA
¹³Hematology/Oncology, Children's Hospital of Los Angeles, Los Angeles, CA
¹⁴Baylor, Houston, TX

Tamer Othman, MD¹, Paul B. Koller, MD², NI-Chun Tsai, MS^3*, Dat Ngo, PharmD^4*, Jason Chen^5*, Amanda Blackmon, DO, MS^2*, Hoda Pourhassan, MD⁶, Vaibhav Agrawal, M.D.², Idoroenyi Amanam, MD⁷, Brian J. Ball, MD², Salman Otoukesh, MD², Amandeep Salhotra, MD⁸, Shukaib Arslan, MD², Monzr M. Al Malki, MD⁸, Haris Ali, MD², Karamjeet S. Sandhu, MD², Ahmed Aribi, MD^2*, Andrew Artz, MD, MS⁹, Forest Marc Stewart, MD², Eileen Patricia Smith, MD², Anthony Stein, MD², Guido Marcucci, MD², Ryotaro Nakamura, MD¹⁰, Vinod Pullarkat, MD², Ibrahim Aldoss, MD² and Matthew Genyeh Mei, MD^9*

¹City of Hope, San Lorenzo, CA
²Hematology/HCT, City of Hope National Medical Center, Duarte, CA
³Computational and Quantitative Medicine, City of Hope National Medical Center, Duarte, CA
⁴Pharmacy, City of Hope National Medical Center, DUARTE, CA
⁵Pharmacy, City of Hope, Duarte, CA
⁶Hematology/HCT, City of Hope, Duarte, CA
⁷Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
⁸Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
⁹City of Hope, Duarte, CA
¹⁰Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Comprehensive Cancer Center, Duarte, CA

Britta Julia Vormoor, MD^1*, Tobias Menne, PhD^2*, Joshua Savage, PhD^3*, Amit Patel, PhD^4*, Anna Castleton^5*, Adele Kay Fielding, MBBS, PhD⁶, Donna Lancaster^7*, Anne Louise Latif^8*, Nick Morley^9*, Geoff Shenton^10*, Gareth Veal, PhD^11*, Julie Irving^12*, Pam Kearns, MBChB, PhD, FRCPC^3*, Lucinda Billingham^3* and Josef Vormoor, MD PhD¹³

¹Princess Maxima Center for Pediatric Oncology, Utrecht, Utrecht, Netherlands
²Newcastle Upon Tyne NHS Hospitals Foundation Trust, Newcastle, United Kingdom
³Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom
⁴University of Birmingham, Birmingham, United Kingdom
⁵The Christie Hospital NHS Trust, Manchester, United Kingdom
⁶UCL Cancer Institute, London, United Kingdom
⁷Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
⁸Beatson West of Scotland Cancer Centre, GLASGOW, United Kingdom
⁹Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
¹⁰Great North Children’s Hospital, Newcastle, United Kingdom
¹¹Newcastle University, Newcastle, United Kingdom
¹²Newcastle University, Newcastle Upon Tyne, ENG, GBR
¹³Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands

Marlise R. Luskin, MD¹, Shai Shimony, MD^2*, Julia Keating, MS^3*, Wendy Stock, MD⁴, Hanno Hock, MD, PhD⁵, Jacqueline S. Garcia, MD², Maximilian Stahl, MD⁶, Ilene Galinksy^7*, Rebecca Leonard^2*, Howard Weiner^8*, Yael Flamand, MS^7*, Donna S. Neuberg, ScD³, Richard M Stone, MD⁷, Anthony G. Letai⁷, Eric S. Winer, MD⁷, Marina Y. Konopleva⁹, Nitin Jain, MD¹⁰ and Daniel J. DeAngelo⁷

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁴The University of Chicago Medical Center, Chicago, IL
⁵Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA
⁶Dana Farber Institute, Boston, MA
⁷Dana-Farber Cancer Institute, Boston, MA
⁸University of Chicago, Chicago, IL
⁹Department of Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY
¹⁰Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Susan R Rheingold, MD¹, Lingyun Ji, PhD^2*, Lia Gore, MD³, Xinxin Xu, MS^4*, Deepa Bhojwani, MD⁵, Nirali N. Shah, M.D.⁶, Elizabeth A. Raetz, MD⁷, Mignon L. Loh, MD⁸ and Maureen M. O'Brien, MD⁹

¹Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Population and Public Health Sciences, University of Southern California,, Los Angeles, CA
³Center for Cancer and Blood Disorders, University of Colorado Cancer Center, Aurora, CO
⁴Children's Oncology Group, Monrovia, CA
⁵Hematology/Oncology, Children's Hospital of Los Angeles, Los Angeles, CA
⁶Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD
⁷Department of Pediatrics, NYU Langone Health, New York, NY
⁸Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Seattle, WA
⁹Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Selina M Luger, MD, FRCPC¹, Zhuoxin Sun, PhD^2*, Ryan J Mattison, MD³, Elisabeth Paietta, PhD^4*, Kathryn G. Roberts, PhD^5*, Yanming Zhang, M.D.⁶, Janis Racevckis^7*, Hillard M. Lazarus, MD⁸, Jacob M. Rowe, MB, BS⁹, Daniel A. Arber, MD¹⁰, Matthew J. Wieduwilt, MD^11*, Michaela Liedtke, MD¹², Julie Bergeron, MD¹³, Brent L. Wood, MD, PhD¹⁴, Yaqi Zhao, MSc^15*, Gang Wu, PhD^15*, Ti-Cheng Chang^15*, Wenchao Zhang^15*, Keith W Pratz, MD^16,17, Shira N. Dinner, MD¹⁸, Noelle V. Frey, MD, MS¹⁷, Steven D. Gore, MD^19,20, Bhavana Bhatnagar, DO²¹, Ehab L. Atallah, MD²², Geoffrey L Uy, MD²³, Deepa Jeyakumar, MD²⁴, Tara L Lin, MD²⁵, Cheryl L. Willman, MD^26*, Daniel J. DeAngelo², Elad Sharon, MD, MPH^27*, Richard F. Little, MD, MPH²⁸, Harry P. Erba, MD, PhD²⁹, Richard M Stone, MD², Charles G. Mullighan, MBBS, MD⁵, Mark R. Litzow, MD³⁰ and Martin S. Tallman, MD³¹

¹Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
²Dana-Farber Cancer Institute, Boston, MA
³Carbone Comprehensive Cancer Center, Madison, WI
⁴Montefiore Medical Ctr. North Div, Bronx, NY
⁵Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁶Cytogenetics Laboratory, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Montefiore Medical Center - Moses Campus, Bronx, NY
⁸Case Western Reserve University, Cleveland, OH
⁹Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel
¹⁰University of Chicago, Chicago, IL
¹¹University of Oklahoma Stephenson Cancer Center, Oklahoma City, OK
¹²Stanford Cancer Center, Palo Alto, CA
¹³CEMTL, installation Maisonneuve-Rosemont, Montreal, QC, Canada
¹⁴Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
¹⁵St. Jude Children's Research Hospital, Memphis, TN
¹⁶John Hopkins University, Philadelphia, PA
¹⁷Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA
¹⁸Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
¹⁹Division of Cancer Prevention, National Cancer Institute, Rockville, MD
²⁰Yale University, New Haven, CT
²¹Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH
²²Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
²³Division of Oncology, Washington University School of Medicine, Saint Louis, MO
²⁴Hematopoietic Stem Cell Transplantation and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA
²⁵Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Medical Center, Westwood, KS
²⁶Mayo Clinic, Rochester, MN
²⁷NCI Cancer Therapy Evaluation program (CTEP), Bethesda, MD
²⁸Division of Cancer Prevention, National Cancer Institute, Washington, DC
²⁹University of Alabama At Birmingham, Durham, NC
³⁰Division of Hematology, Mayo Clinic, Rochester, MN
³¹Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Highland Park, IL

Wei-Ying Jen, MD, FRCPath, MA^1*, Elias Jabbour², Fadi G. Haddad, MD^1*, Nicholas J. Short, MD¹, Nitin Jain, MD¹, Tapan M. Kadia, MD¹, Naval Daver, MD¹, Gautam Borthakur, MD¹, Lewis Nasr^1*, Courtney D. DiNardo, MD, MSc¹, Marianne Zoghbi^1*, Jovitta Jacob, RN^3*, Edith Roy^3*, Christopher Loiselle, BS^3*, Anna Milton^3*, Juan Rivera^3*, Rebecca Garris^1*, Farhad Ravandi, MD, MBBS¹ and Hagop M. Kantarjian, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²University of Texas M.D. Anderson Cancer Ctr., Houston, TX
³The University of Texas MD Anderson Cancer Center, Houston, TX

Changcheng Chen, MD^1*, Shuhong Shen, MD, PhD¹ and Wenting Hu, MD^2*

¹Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
²Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Mojtaba Bakhtiari, MD^1*, Travon Baxter, MS^2*, Manoj Bhasin, PhD^1,3,4,5, Deborah DeRyckere, PhD⁶ and Swati Bhasin, PhD^1,5

¹Department of Pediatrics, Emory University, Atlanta, GA
²Pediatrics, Emory University, Atlanta, GA
³Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA
⁴Department of Biomedical Informatics, Emory University, Atlanta, GA
⁵Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
⁶Aflac Cancer & Blood Disorders Center, Children’s Healthcare of Atlanta, and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA

Prof. Uttam Kumar Nath, MD, DM, Karthik Kumar, MD^*, Adamya Gupta, MD^*, Reshma Benson, MD^* and DR Arjun Kachhwaha, MD, MBBS^*

All India Institute of Medical Sciences, Rishikesh, Rishikesh, India

Ahmed Sayed, MBBS^1*, Malak Munir, MBBS^1*, Sanam Ghazi, MD^2*, Mussammat Ferdousi, MD^2*, Satyam Krishan, MD^3*, Adnan Shaaban, MD^2*, Alma Habib, MD⁴, Onaopepo Kola-Kehinde, BS^5*, Patrick Ruz, BS^5*, Sarah Khan, BS^2*, Sneha Sharma, DO^2*, Alexa Mera, MD^6*, Narendranath Epperla, MD, MS⁵ and Daniel Addison, MD^7*

¹Ain Shams University, Faculty of Medicine, Cairo, Egypt, Cairo, Egypt
²Cardio-Oncology Program, Division of Cardiology, The Ohio State University Medical Center, Columbus, OH, USA, Columbus
³Division of Cardiology, University of Oklahoma Medical Center, Oklahoma City, OK, USA, Oklahoma City
⁴Department of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH
⁵The Ohio State University, Columbus, OH
⁶Division of Rheumatology, The Ohio State University, Columbus, OH, USA, Columbus
⁷Department of Cardiology, The Ohio State University Wexner Medical Center, Columbus, OH

Leiah J. Brigitha^1,2*, Rob Pieters, MD, PhD, MSc¹, Marta F. Fiocco, Prof. Dr.^1,3,4*, Hester A. de Groot-Kruseman, PhD^1*, Marc Bierings, MD⁵, Cor Van Den Bos, MD, PhD^1*, Valerie de Haas, MD, PhD^6*, Peter M. Hoogerbrugge, MD, PhD¹, Wim J.E. Tissing, MD, PhD^7*, Margreet A. Veening, Dr.^1* and Inge M. Van Der Sluis, Dr.¹

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Pediatric Oncology and Hematology, Erasmus MC–Sophia Children’s Hospital, Rotterdam, Netherlands
³Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands
⁴Mathematical Instit, Leiden University, Leiden, Netherlands
⁵Princess Máxima Center, University Hospital for Children, Utrecht, Netherlands
⁶Princes Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁷Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands