-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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711.O1.6 711. Cell Collection and Processing: Hematopoietic Stem/Progenitor Cells Graft and Immune Effector Cells Clinically Relevant Abstract

Symposia: Cell Collection and Processing Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Biological therapies, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Diseases, Therapies, Myeloid Malignancies, Metabolic Disorders, Transplantation
Monday, December 11, 2023: 4:30 PM-6:00 PM
Room 6DE (San Diego Convention Center)
Moderators:
Nadim Mahmud, MBBS, PhD, Univ. of Illinois at Chicago and Yvette C Tanhehco, MD, PhD, Columbia University
Disclosures:
No relevant conflicts of interest to declare.
The oral abstract session will have 6 abstracts including hematopoietic stem/progenitor cell graft composition, impacts of cryopreservation as well as generation of immune effector cells. One of the highlights is manufacturing of second autologous CART after following prior CART. Identification of human long term hematopoietic stem cells based on c-MPL receptor expression levels will be discussed.
4:30 PM

Hugh R. MacMillan1*, Hans Minderman2*, Ashley Spahn3*, Orla Maguire2*, Elke Rücker-Braun, PhD4,5*, Bose Falk4,5*, Henning Baldauf4*, Heike Uhlemann4*, Nicole Heymann4*, Lisa Heiduschke4*, Kieran L. O'Loughlin2*, Alexander H. Schmidt, Dr.4*, Steven M. Devine, MD3, Jeffery J. Auletta, MD3, Falk Heidenreich, PhD5,6*, Jay Feinberg7*, Huy Pham, MD8, Marcel R.M. van den Brink9,10, Evan W. Newell, PhD1*, Johannes Schetelig, MD, MSc4,11, Stephen R. Spellman, MBS3* and Kate A. Markey, MBBS, PhD, FRACP, MPH1,12

1Fred Hutchinson Cancer Center, Seattle, WA
2Flow and Image Cytometry Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY
3CIBMTR® (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN
4DKMS Group gGmbH, Dresden, Germany
5University Hospital Dresden, Dresden, Germany
6DKMS Ggmbh, Clinical Trials Unit, Dresden, Germany
7Gift of Life Marrow Registry, Boca Raton, FL
8Seattle Apheresis Collection Center, National Marrow Donor Program, Seattle, WA
9Department of Immunology, Sloan Kettering Institute, New York, NY
10Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
11TU Dresden, Dresden, Saxony, Germany
12Division of Medicine, University of Washington, Seattle, WA

4:45 PM

Bekadja Med Amine Sr., MD, PhD1, Luuk Gras Sr., MD, PhD2*, Laurien Baaij III3*, Linda Koster III, MD, PhD3*, Ben Carpenter, MD, PhD4*, Emma Nicholson, MD, PhD5*, Victoria Potter6*, Annoek E.C. Broers7*, Didier Blaise, MD, PhD8,9, Jenny Louise Byrne, MD, PhD10*, Anne Huynh, MD11,12*, David Burns, MD, PhD13,14*, Péter Reményi, MD15*, Matthew P. Collin Sr., MD, PhD16, John G. Gribben, MD, DSc17, Jennifer Clay Sr., MD, PhD18*, Alessandra Tucci, MD19, Natalia De Las Heras, MD20*, Joanna Drozd-Sokolowska, MD, PhD21*, Kavita Raj, MD, PhD22, Meral Beksac, MD23, Stefan Schönland, MD24*, Patrick J Hayden, MD, PhD25*, Mahmoud Deeb Aljurf, MD, PhD26,27,28*, Donal P McLornan, MD, PhD22,29*, Laurent Garderet, MD, PhD30,31* and Dietger Niederwieser, MD, PhD32*

1Hematology and Cell Therapy, EHU 1st Novembre 1954 Bir el Djir Usto, Oran, Algeria
2EBMT Statistical Unit, Leiden, Netherlands
3EBMT Leiden Study Unit, Leiden, the Netherlands;, Leiden, Netherlands
4University College London Hospitals NHS Foundation Trust, London, United Kingdom
5Department of Haematology, Royal Marsden Hospital, London, United Kingdom
6Department of Haematological Medicine, King's College Hospital NHS, London, United Kingdom
7Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
8Program of Transplant and cellular immunotherapy, Department of Hematology, Institut Paoli Calmettes, Marseille, France
9Institut Paoli Calmettes, Marseille, FRA
10Nottingham University, Nottingham, ENG, GBR
11Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France
12Alexion Pharmaceuticals, Inc., Toulouse, FRA
13University Hospital Birmingham NHSTrust, Birmingham, United Kingdom
14University Hospital Birmingham NHS Trust, Stoke, United Kingdom
15Department of Hematology and Stem Cell Transplantation, South-Pest Central Hospital, Budapest, Hungary
16Northern Centre for Bone Marrow Transplantation, Newcastle University, Newcastle Upon Tyne, GBR
17Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
18Yorkshire Blood & Marrow Transplant Program, Leeds, United Kingdom
19Hematology, ASST Spedali Civili, Brescia, Italy
20Hospital Universitario de León, Leon, Spain
21Central Clinical Hospital, The Medical University of Warsaw, Warsaw, Poland
22University College London Hospitals NHS Trust, London, United Kingdom
23Ankara University School of Medicine, Hematology Department, Ankara, Turkey
24Universitätsklinikum Heidelberg, Heidelberg, Germany
25Trinity College Dublin, St. James's Hospital, Dublin, IRL
26King Faisal Specialist Hospital &Research Center, Riyadh, Saudi Arabia
27King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
28King Faisal Specialist Hospital & Research Centre, Oncology (Section of Adult Haematolgy/BMT) – Riyadh, Saudi Arabia, Riyadh, Saudi Arabia
29Department of Haematology, University College London Hospitals NHS Trust, London, ENG, United Kingdom
30Hôpital la pitié salpetriere, Paris, FRA
31Hopital Saint Antoine, Paris, FRA
32University Hospital Leipzig, Leipzig, DEU

5:00 PM

Daisuke Araki, MD1, Bryan Fisk2*, Christi Salisbury-Ruf, PhD1*, Neelam Redekar, PhD2* and Andre Larochelle, MD, PhD1

1Laboratory of Regenerative Therapies for Inherited Blood Disorders, Cellular and Molecular Therapeutics Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD
2Integrated Data Science Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

5:15 PM

Elke Rücker-Braun, PhD1,2*, Bose Falk1*, Kate A. Markey, MBBS, PhD, FRACP, MPH3,4, Hans Minderman5*, Henning Baldauf1*, Nicole Heymann1*, Heike Uhlemann1*, Lisa Heiduschke1*, Hugh R. MacMillan6*, Evan W. Newell, PhD6*, Kieran L. O'Loughlin7*, Ashley Spahn8*, Orla Maguire5*, Deborah Buk9*, Martin Bornhäuser, MD10,11*, Alexander H. Schmidt, Dr.1*, Steven M. Devine, MD12, Johannes Schetelig, MD, MSc1,11, Jeffery J. Auletta, MD8,13, Marcel R.M. van den Brink14, Stephen R. Spellman, MBS8* and Falk Heidenreich, PhD2,15*

1DKMS Group gGmbH, Dresden, Germany
2University Hospital Dresden, Dresden, Germany
3Division of Medicine, University of Washington, Seattle, WA
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
5Flow and Image Cytometry Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY
6Fred Hutchinson Cancer Center, Seattle, WA
7Flow and Immune Analysis Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY
8CIBMTR® (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN
9DKMS Donor Center gGmbH, Tübingen, Germany
10National Center for Tumor Diseases (NCT/UCC) Dresden, Technical University Dresden, Dresden, Germany
11Department of Internal Medicine 1, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
12Be the Match Foundation, Minneapolis, MN
13Hematology/Oncology/Bone Marrow Transplant and Infectious Diseases, Nationwide Children's Hospital, Columbus, OH
14Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
15DKMS Ggmbh, Clinical Trials Unit, Dresden, Germany

5:30 PM

Yi-Jiun Su, MD1,2*, Anne Marijn Kramer, MD, PhD3,4*, Mark P. Hamilton, MD2,4, Neha Agarwal, MS2,4*, Steven Feldman, PhD4*, Bita Sahaf, PhD, MSc4,5*, Adam Kuo, MS4,5*, Crystal L. Mackall, MD2,4,6, Lori S. Muffly, MD2,4, David B. Miklos, MD, PhD4,7 and Matthew J. Frank, MD, PhD4,7

1Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
2Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University School of Medicine, Palo Alto, CA
3Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University School of Medicine, Menlo Park, CA
4Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA
5Cancer Correlative Science Unit, Stanford University, Palo Alto, CA
6Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
7Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Palo Alto, CA

5:45 PM

Natalie J. Holl, MS, BS1*, Adam Fearnow1*, Stamatia C. Vorri, MD, MPhil1*, Ruyan Rahnama, MD, MSc1*, Ilias Christodoulou, MD2, Jun Choe1*, Alokesh Ghosal, PhD3*, Cynthia Ng, MS3*, Arjun Modi1*, Vinay Vyas, PhD, MSc3* and Challice L. Bonifant, MD, PhD1

1Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
2Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA
3Biopharmaceutical Development Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD

*signifies non-member of ASH